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The map label for this gene is clpP

Identifier: 17231175

GI number: 17231175

Start: 4443275

End: 4443973

Strand: Direct

Name: clpP

Synonym: alr3683

Alternate gene names: 17231175

Gene position: 4443275-4443973 (Clockwise)

Preceding gene: 17231173

Following gene: 17231176

Centisome position: 69.28

GC content: 44.64

Gene sequence:

>699_bases
ATGCTTGTATCGCAGTCGGCAAATCACTCCATCAACAGTTTAAGTCGATTTGGAATGTCCTCACACCTCAACGGCATAGG
CAACATCGTGCCAATGGTCGTAGAACAATCTGGTATGGGAGAAAGAGCCTTCGACATCTACTCCCGCCTACTGCGAGAGC
GGATTATCTTTTTAGGAACTCCTATCGACGATGCTGTAGCCAACACAATTGTTGCCCAGTTGTTGTTTTTGGACGCGGAA
GACTCGGAAAAAGATATCCAACTCTATATCAACTCCCCTGGTGGATCTGTCTACGCAGGCATGGCAATCTATGATACAAT
TCAGCAAATCCGTCCCGATGTTGTTACTATATGTTTTGGGTTAGCAGCAAGCATGGGGGCATTTTTGTTAACAGCAGGAA
CTAAAGGTAAACGTATGTCCCTACCTGATTCCCGCATTATGATTCACCAACCCCTGGGTGGCGCTCAAGGTCAAGCCATT
GATATAGAAATCCAAGCAAGGGAAATTCTTTACATTAAGGCTCAGTTGAACCAGTTATTGGCTAATCATACTGGTCAACC
CCTAGAAAGAATTGAAGCAGATACCGATCGCGACTTCTTTATGTCAGCAGAAGAAGCAAAAAATTACGGTTTGATCGATC
AAGTCATCTCCAGACAAAATCTTCCCACAGCAGGGGAAAACGTCACCATCGTGAAATAA

Upstream 100 bases:

>100_bases
TAATGGTTAACACATAGGTGAATCAAAATCTCATTTATTAACACAAAGGCAGCTATATGTTGCCAAAATCTCTGTCCCAA
CTATCTCCAATTGTCCTTGT

Downstream 100 bases:

>100_bases
GAGGCTGGTATGTCTAAGTACGACTCCCATTTAAAATGTTCTTTCTGTGGCAAGTCTCAAGAGCAGGTGCGGAAATTGAT
CGCAGGGCCGGGAGTCTACA

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 2

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MLVSQSANHSINSLSRFGMSSHLNGIGNIVPMVVEQSGMGERAFDIYSRLLRERIIFLGTPIDDAVANTIVAQLLFLDAE
DSEKDIQLYINSPGGSVYAGMAIYDTIQQIRPDVVTICFGLAASMGAFLLTAGTKGKRMSLPDSRIMIHQPLGGAQGQAI
DIEIQAREILYIKAQLNQLLANHTGQPLERIEADTDRDFFMSAEEAKNYGLIDQVISRQNLPTAGENVTIVK

Sequences:

>Translated_232_residues
MLVSQSANHSINSLSRFGMSSHLNGIGNIVPMVVEQSGMGERAFDIYSRLLRERIIFLGTPIDDAVANTIVAQLLFLDAE
DSEKDIQLYINSPGGSVYAGMAIYDTIQQIRPDVVTICFGLAASMGAFLLTAGTKGKRMSLPDSRIMIHQPLGGAQGQAI
DIEIQAREILYIKAQLNQLLANHTGQPLERIEADTDRDFFMSAEEAKNYGLIDQVISRQNLPTAGENVTIVK
>Mature_232_residues
MLVSQSANHSINSLSRFGMSSHLNGIGNIVPMVVEQSGMGERAFDIYSRLLRERIIFLGTPIDDAVANTIVAQLLFLDAE
DSEKDIQLYINSPGGSVYAGMAIYDTIQQIRPDVVTICFGLAASMGAFLLTAGTKGKRMSLPDSRIMIHQPLGGAQGQAI
DIEIQAREILYIKAQLNQLLANHTGQPLERIEADTDRDFFMSAEEAKNYGLIDQVISRQNLPTAGENVTIVK

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=199, Percent_Identity=57.286432160804, Blast_Score=233, Evalue=1e-61,
Organism=Escherichia coli, GI1786641, Length=192, Percent_Identity=67.1875, Blast_Score=276, Evalue=9e-76,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=56.4516129032258, Blast_Score=221, Evalue=2e-58,
Organism=Drosophila melanogaster, GI20129427, Length=206, Percent_Identity=54.3689320388349, Blast_Score=225, Evalue=2e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP2_NOSS1 (Q8YQX8)

Other databases:

- EMBL:   BA000019
- PIR:   AD2266
- RefSeq:   NP_487723.1
- ProteinModelPortal:   Q8YQX8
- SMR:   Q8YQX8
- STRING:   Q8YQX8
- MEROPS:   S14.001
- GeneID:   1107281
- GenomeReviews:   BA000019_GR
- KEGG:   ana:alr3683
- eggNOG:   COG0740
- HOGENOM:   HBG558421
- OMA:   SPMEAQD
- PhylomeDB:   Q8YQX8
- ProtClustDB:   CLSK516839
- BioCyc:   NSP103690:ALR3683-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127
- TIGRFAMs:   TIGR00493

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 25341; Mature: 25341

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 124-124 ACT_SITE 149-149

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVSQSANHSINSLSRFGMSSHLNGIGNIVPMVVEQSGMGERAFDIYSRLLRERIIFLGT
CCCCCCCCCCHHHHHHHCHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHEEECC
PIDDAVANTIVAQLLFLDAEDSEKDIQLYINSPGGSVYAGMAIYDTIQQIRPDVVTICFG
CHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCEEEHHHHHHHHHHHCHHHHHHHHH
LAASMGAFLLTAGTKGKRMSLPDSRIMIHQPLGGAQGQAIDIEIQAREILYIKAQLNQLL
HHHHHHHEEEECCCCCCEECCCCCEEEEECCCCCCCCCEEEEEEECCEEEEHHHHHHHHH
ANHTGQPLERIEADTDRDFFMSAEEAKNYGLIDQVISRQNLPTAGENVTIVK
HCCCCCHHHHHCCCCCCHHHCCHHHHCCCCHHHHHHHHCCCCCCCCCEEEEC
>Mature Secondary Structure
MLVSQSANHSINSLSRFGMSSHLNGIGNIVPMVVEQSGMGERAFDIYSRLLRERIIFLGT
CCCCCCCCCCHHHHHHHCHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHEEECC
PIDDAVANTIVAQLLFLDAEDSEKDIQLYINSPGGSVYAGMAIYDTIQQIRPDVVTICFG
CHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCEEEHHHHHHHHHHHCHHHHHHHHH
LAASMGAFLLTAGTKGKRMSLPDSRIMIHQPLGGAQGQAIDIEIQAREILYIKAQLNQLL
HHHHHHHEEEECCCCCCEECCCCCEEEEECCCCCCCCCEEEEEEECCEEEEHHHHHHHHH
ANHTGQPLERIEADTDRDFFMSAEEAKNYGLIDQVISRQNLPTAGENVTIVK
HCCCCCHHHHHCCCCCCHHHCCHHHHCCCCHHHHHHHHCCCCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840