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The map label for this gene is asnC

Identifier: 17231150

GI number: 17231150

Start: 4412796

End: 4414187

Strand: Direct

Name: asnC

Synonym: alr3658

Alternate gene names: 17231150

Gene position: 4412796-4414187 (Clockwise)

Preceding gene: 17231149

Following gene: 17231151

Centisome position: 68.8

GC content: 43.68

Gene sequence:

>1392_bases
ATGGTAAATCGACGAATTGCAGAAATATTGCGGAGTGGTCAACCTGATGAGTCTCTGGTAGTTCAAGGCTGGGTAAGAAC
AAAGCGTGAACTTAAGGGATTTGCTTTTATTGAAGTTAATGACGGCTCATCATTAGGTAATTTGCAAGTTGTCATCAATC
AGGATTTGCCAGACTACGCAGTAATTGTCAAACAACTAAACACAGGTGCATCAGTTGAGGTAAACGGCGTATTGGTGGCT
TCCCAAGGAAAAGGACAGCGTATTGAATTAAAAGCCGAAGCAGTGAAAGTTTATGGTGAAGCTGACCCCGAAACTTATCC
ACTGCAAAAGAAACGCCACTCTTTTGAATTTTTACGCACAATTGGACATTTGCGATCGCGTACTAATTCCTTCGGTGCAG
TGTTCCGTGTCCGTAATGCTTGTTCCGCAGCCATTCACCAATTCTTCCAGGAAAGGGGCTTTTTGTGGGTACACACCCCC
ATCATCACCGCTAGCGACTGCGAAGGCGCAGGGGAACTATTTAGCGTCACCAGCTTGGATTTAAAGCAGATTCCCCGCAC
AGAAAATCAAGGAATTGATTACAGCCAAGACTTTTTTGCTAAACCCACCTACTTAACAGTCAGTGGACAACTAGAAGCCG
AAGTCATGGCGATGGCTTTTAGTAACGTCTACACCTTCGGCCCCACCTTCCGTGCAGAAAACTCCAACACCTCCCGCCAC
TTGGCAGAATTTTGGATGGTTGAGCCAGAAATGGCATTTTGCGACTTAGAAGGCGATATGGATTTAGCAGAGGCTTTTCT
CAAACACATTTTTAATCATGTGTTGGAAAAATGCCCAGAAGACATGGAATTTTTCAATCAACGCATTGATAATACTGTCT
TAGCAACAGCCGAAAATATTATTAATAATCAATTTGAACGTCTGACTTACACCGATGCCATCAAACTTTTAGAAAAAGCT
GATGTTAAATTTGAATATCCCGTAAGTTGGGGCTTAGATTTACAATCAGAACACGAACGTTACCTAGCAGAACAACTCTT
CAAAAAGCCAGTCATCGTTACAGATTACCCCGCACAGATTAAAGCCTTTTATATGCGGTTGAGCGACGATGAAAAAACAG
TCCGCGCGATGGATGTCCTTGCACCAAAAATTGGGGAAATCATTGGTGGTTCCCAAAGAGAAGAACGTTTAGATGTGTTG
GAACGCCGAGTATTAGCACAAGGAATGCAGCCTGAAGATTTGTGGTGGTATCTCGATTTACGTCGTTATGGTACTGTTCC
TCACGCTGGTTTCGGCTTGGGTTTTGAACGACTCGTGCAATTTATCACAGGAATGGGCAATATTCGGGATGTAATTCCCT
TCCCCCGGACACCACAAAACGCTGAGTTTTAG

Upstream 100 bases:

>100_bases
TTTCTTGGCGTAGCCTGAAAAAACCTTTCTGGCAAGCCGTCCGCTTTGGTGGAATGGGCGTTATTATAGGCTGGATATTA
AAGTCCTGTGCTGGGTAAAT

Downstream 100 bases:

>100_bases
TAGAAGCAGTCGTCAAATAACGCGATGTGCGACTATCTTGATTCTTAATTTTGAATTTTTAATTGGTAGAATCTTGCTCC
CATCCTTTACTAGAGAAGGG

Product: asparaginyl-tRNA synthetase

Products: NA

Alternate protein names: Asparagine--tRNA ligase; AsnRS

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MVNRRIAEILRSGQPDESLVVQGWVRTKRELKGFAFIEVNDGSSLGNLQVVINQDLPDYAVIVKQLNTGASVEVNGVLVA
SQGKGQRIELKAEAVKVYGEADPETYPLQKKRHSFEFLRTIGHLRSRTNSFGAVFRVRNACSAAIHQFFQERGFLWVHTP
IITASDCEGAGELFSVTSLDLKQIPRTENQGIDYSQDFFAKPTYLTVSGQLEAEVMAMAFSNVYTFGPTFRAENSNTSRH
LAEFWMVEPEMAFCDLEGDMDLAEAFLKHIFNHVLEKCPEDMEFFNQRIDNTVLATAENIINNQFERLTYTDAIKLLEKA
DVKFEYPVSWGLDLQSEHERYLAEQLFKKPVIVTDYPAQIKAFYMRLSDDEKTVRAMDVLAPKIGEIIGGSQREERLDVL
ERRVLAQGMQPEDLWWYLDLRRYGTVPHAGFGLGFERLVQFITGMGNIRDVIPFPRTPQNAEF

Sequences:

>Translated_463_residues
MVNRRIAEILRSGQPDESLVVQGWVRTKRELKGFAFIEVNDGSSLGNLQVVINQDLPDYAVIVKQLNTGASVEVNGVLVA
SQGKGQRIELKAEAVKVYGEADPETYPLQKKRHSFEFLRTIGHLRSRTNSFGAVFRVRNACSAAIHQFFQERGFLWVHTP
IITASDCEGAGELFSVTSLDLKQIPRTENQGIDYSQDFFAKPTYLTVSGQLEAEVMAMAFSNVYTFGPTFRAENSNTSRH
LAEFWMVEPEMAFCDLEGDMDLAEAFLKHIFNHVLEKCPEDMEFFNQRIDNTVLATAENIINNQFERLTYTDAIKLLEKA
DVKFEYPVSWGLDLQSEHERYLAEQLFKKPVIVTDYPAQIKAFYMRLSDDEKTVRAMDVLAPKIGEIIGGSQREERLDVL
ERRVLAQGMQPEDLWWYLDLRRYGTVPHAGFGLGFERLVQFITGMGNIRDVIPFPRTPQNAEF
>Mature_463_residues
MVNRRIAEILRSGQPDESLVVQGWVRTKRELKGFAFIEVNDGSSLGNLQVVINQDLPDYAVIVKQLNTGASVEVNGVLVA
SQGKGQRIELKAEAVKVYGEADPETYPLQKKRHSFEFLRTIGHLRSRTNSFGAVFRVRNACSAAIHQFFQERGFLWVHTP
IITASDCEGAGELFSVTSLDLKQIPRTENQGIDYSQDFFAKPTYLTVSGQLEAEVMAMAFSNVYTFGPTFRAENSNTSRH
LAEFWMVEPEMAFCDLEGDMDLAEAFLKHIFNHVLEKCPEDMEFFNQRIDNTVLATAENIINNQFERLTYTDAIKLLEKA
DVKFEYPVSWGLDLQSEHERYLAEQLFKKPVIVTDYPAQIKAFYMRLSDDEKTVRAMDVLAPKIGEIIGGSQREERLDVL
ERRVLAQGMQPEDLWWYLDLRRYGTVPHAGFGLGFERLVQFITGMGNIRDVIPFPRTPQNAEF

Specific function: Unknown

COG id: COG0017

COG function: function code J; Aspartyl/asparaginyl-tRNA synthetases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI226491502, Length=449, Percent_Identity=46.5478841870824, Blast_Score=412, Evalue=1e-115,
Organism=Homo sapiens, GI4758762, Length=457, Percent_Identity=29.7592997811816, Blast_Score=173, Evalue=4e-43,
Organism=Homo sapiens, GI45439306, Length=341, Percent_Identity=28.4457478005865, Blast_Score=128, Evalue=1e-29,
Organism=Escherichia coli, GI1787161, Length=450, Percent_Identity=59.3333333333333, Blast_Score=563, Evalue=1e-161,
Organism=Escherichia coli, GI1788173, Length=273, Percent_Identity=23.4432234432234, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17556372, Length=439, Percent_Identity=30.9794988610478, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI71984122, Length=465, Percent_Identity=30.3225806451613, Blast_Score=194, Evalue=7e-50,
Organism=Caenorhabditis elegans, GI17551876, Length=347, Percent_Identity=27.9538904899135, Blast_Score=119, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6319872, Length=469, Percent_Identity=37.1002132196162, Blast_Score=317, Evalue=3e-87,
Organism=Saccharomyces cerevisiae, GI6321807, Length=446, Percent_Identity=30.0448430493274, Blast_Score=181, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6323011, Length=349, Percent_Identity=30.6590257879656, Blast_Score=134, Evalue=2e-32,
Organism=Drosophila melanogaster, GI19922416, Length=468, Percent_Identity=37.3931623931624, Blast_Score=303, Evalue=2e-82,
Organism=Drosophila melanogaster, GI19921528, Length=472, Percent_Identity=28.3898305084746, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI17136276, Length=340, Percent_Identity=28.2352941176471, Blast_Score=119, Evalue=6e-27,

Paralogues:

None

Copy number: 80 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): SYN_NOSS1 (P58692)

Other databases:

- EMBL:   BA000019
- PIR:   AC2263
- RefSeq:   NP_487698.1
- ProteinModelPortal:   P58692
- SMR:   P58692
- STRING:   P58692
- GeneID:   1107256
- GenomeReviews:   BA000019_GR
- KEGG:   ana:alr3658
- NMPDR:   fig|103690.1.peg.3965
- eggNOG:   COG0017
- HOGENOM:   HBG745843
- OMA:   EPEMAFC
- PhylomeDB:   P58692
- ProtClustDB:   PRK03932
- BioCyc:   NSP103690:ALR3658-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00534
- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR004522
- InterPro:   IPR002312
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365
- Gene3D:   G3DSA:2.40.50.140
- PANTHER:   PTHR22594
- PRINTS:   PR01042
- TIGRFAMs:   TIGR00457

Pfam domain/function: PF00152 tRNA-synt_2; PF01336 tRNA_anti; SSF50249 Nucleic_acid_OB

EC number: =6.1.1.22

Molecular weight: Translated: 52734; Mature: 52734

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS50862 AA_TRNA_LIGASE_II; PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVNRRIAEILRSGQPDESLVVQGWVRTKRELKGFAFIEVNDGSSLGNLQVVINQDLPDYA
CCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEEECCCCHHH
VIVKQLNTGASVEVNGVLVASQGKGQRIELKAEAVKVYGEADPETYPLQKKRHSFEFLRT
HHHHHHCCCCCEEEEEEEEECCCCCCEEEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHH
IGHLRSRTNSFGAVFRVRNACSAAIHQFFQERGFLWVHTPIITASDCEGAGELFSVTSLD
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECEEEECCCCCCCCEEEEECCH
LKQIPRTENQGIDYSQDFFAKPTYLTVSGQLEAEVMAMAFSNVYTFGPTFRAENSNTSRH
HHHCCCCCCCCCCCCHHHCCCCCEEEEECCCHHHHHHHHHHHHEECCCCEECCCCCCHHH
LAEFWMVEPEMAFCDLEGDMDLAEAFLKHIFNHVLEKCPEDMEFFNQRIDNTVLATAENI
HHHHHEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHH
INNQFERLTYTDAIKLLEKADVKFEYPVSWGLDLQSEHERYLAEQLFKKPVIVTDYPAQI
HHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCHHHHHHHHHHHHHCCEEEECCCHHH
KAFYMRLSDDEKTVRAMDVLAPKIGEIIGGSQREERLDVLERRVLAQGMQPEDLWWYLDL
HHHHEEECCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEH
RRYGTVPHAGFGLGFERLVQFITGMGNIRDVIPFPRTPQNAEF
HHCCCCCCCCCCCCHHHHHHHHHCCCCCHHCCCCCCCCCCCCC
>Mature Secondary Structure
MVNRRIAEILRSGQPDESLVVQGWVRTKRELKGFAFIEVNDGSSLGNLQVVINQDLPDYA
CCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEEECCCCHHH
VIVKQLNTGASVEVNGVLVASQGKGQRIELKAEAVKVYGEADPETYPLQKKRHSFEFLRT
HHHHHHCCCCCEEEEEEEEECCCCCCEEEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHH
IGHLRSRTNSFGAVFRVRNACSAAIHQFFQERGFLWVHTPIITASDCEGAGELFSVTSLD
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECEEEECCCCCCCCEEEEECCH
LKQIPRTENQGIDYSQDFFAKPTYLTVSGQLEAEVMAMAFSNVYTFGPTFRAENSNTSRH
HHHCCCCCCCCCCCCHHHCCCCCEEEEECCCHHHHHHHHHHHHEECCCCEECCCCCCHHH
LAEFWMVEPEMAFCDLEGDMDLAEAFLKHIFNHVLEKCPEDMEFFNQRIDNTVLATAENI
HHHHHEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHH
INNQFERLTYTDAIKLLEKADVKFEYPVSWGLDLQSEHERYLAEQLFKKPVIVTDYPAQI
HHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCHHHHHHHHHHHHHCCEEEECCCHHH
KAFYMRLSDDEKTVRAMDVLAPKIGEIIGGSQREERLDVLERRVLAQGMQPEDLWWYLDL
HHHHEEECCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEH
RRYGTVPHAGFGLGFERLVQFITGMGNIRDVIPFPRTPQNAEF
HHCCCCCCCCCCCCHHHHHHHHHCCCCCHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11759840