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The map label for this gene is mutS [H]

Identifier: 17231130

GI number: 17231130

Start: 4390136

End: 4391305

Strand: Direct

Name: mutS [H]

Synonym: alr3638

Alternate gene names: 17231130

Gene position: 4390136-4391305 (Clockwise)

Preceding gene: 17231128

Following gene: 17231131

Centisome position: 68.45

GC content: 45.21

Gene sequence:

>1170_bases
GTGAATCCTTTATTGGATGAGAGAAAGGCGACTGTCGAAGCAGACCACCAATGGATTGCTAATTTAGAAGTGGATGAAAG
GGCGAGAACAGGAATCCCCTTGCTTAAGGTAGGATTTAACGAAACTTTTGGCTATTACATTAGTATTTCCCGCGCCAAAG
CTGACCAAGTACCCGCCAATTACATCCGCAAGCAAACCCTAAAAAATGAGGAACGTTACATCACCCCAGAATTGAAGGAA
AGGGAAGCCAGGATTCTCACAGCGCGGGATGATTTACATAAGTTGGAATATGAGGTTTTTGTCACCTTACGGGAAGAAGT
AGGAGAACAAGCCGAAGCCATTCGCCATCTTTCCCGCGCCGTAGCCGCCGCCGATGTGTTGTGTGGTTTAGCTGAGTTGG
CGGTTTATCAAGGTTATTGTCGTCCCGAAATGGTGAATGGACGAGAGTTAAAAATAGTTGACGGTCGCCATCCCGTGGTG
GAACAGTCCTTACCTGCGGGCTTCTTTGTGCCAAATTCTACAGAGTTAGGGAATATTGAAGAAACTTCCCCACTCCCCGA
TTTAATTATTCTCACTGGGCCTAATGCTAGTGGTAAAAGTTGTTACCTGCGTCAAGTGGGATTAATTCAATTAATGGCGC
AGATAGGGAGTTTTGTCCCGGCTAAGTCTGCTAGGTTGGGAGTATGCGATCGCATTTTTACCCGTGTCGGTGCTGTGGAT
GATTTAGCAACGGGTCAATCTACATTTATGGTAGAAATGAATGAGACAGCAAATATTCTCAATCATGCCACATCTAGATC
CCTAGTCTTGTTAGATGAAATTGGCAGAGGAACCGCAACATTTGACGGTCTTTCTATTGCTTGGGCTGTTGCAGAATATC
TGGCAATGGAGATTCGTTCCCGGACAATTTTTGCCACTCATTACCACGAATTAAATGAACTGGCGGGAATGTTACCCAAT
GTGGCTAATTATCAGGTGACAGTCAAGGAATTACCAGACCAAATCATCTTTCTCCACCAAGTCCAACCAGGAGGCGCTGA
TAAATCTTATGGTATTGAAGCGGGAAGGTTAGCGGGTTTACCAACCGTCGTCATTCAAAGGGCGAAACAAGTCATGGGTC
AGATTGAGAAACATAGTAAGATTGCGATGGGTTTACGTGAAGGTCTTTAG

Upstream 100 bases:

>100_bases
CAGTTGCGTCAATGTTCAGAGTCCCGGTTTTTGTTAACGATCGCTTGACTTTCAAGACAGTCGCTTGCATCTCAAAGAAG
GCGGCTTGATTCGTCCTGGC

Downstream 100 bases:

>100_bases
GATTTTCATGGAACATCCAATTCTGATACAGAAAATAACGTTTAGTTCTTGTAGACTATCTTATGTATACATACTCAGAA
CTGAGCCATAAGTTTTTAAC

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MNPLLDERKATVEADHQWIANLEVDERARTGIPLLKVGFNETFGYYISISRAKADQVPANYIRKQTLKNEERYITPELKE
REARILTARDDLHKLEYEVFVTLREEVGEQAEAIRHLSRAVAAADVLCGLAELAVYQGYCRPEMVNGRELKIVDGRHPVV
EQSLPAGFFVPNSTELGNIEETSPLPDLIILTGPNASGKSCYLRQVGLIQLMAQIGSFVPAKSARLGVCDRIFTRVGAVD
DLATGQSTFMVEMNETANILNHATSRSLVLLDEIGRGTATFDGLSIAWAVAEYLAMEIRSRTIFATHYHELNELAGMLPN
VANYQVTVKELPDQIIFLHQVQPGGADKSYGIEAGRLAGLPTVVIQRAKQVMGQIEKHSKIAMGLREGL

Sequences:

>Translated_389_residues
MNPLLDERKATVEADHQWIANLEVDERARTGIPLLKVGFNETFGYYISISRAKADQVPANYIRKQTLKNEERYITPELKE
REARILTARDDLHKLEYEVFVTLREEVGEQAEAIRHLSRAVAAADVLCGLAELAVYQGYCRPEMVNGRELKIVDGRHPVV
EQSLPAGFFVPNSTELGNIEETSPLPDLIILTGPNASGKSCYLRQVGLIQLMAQIGSFVPAKSARLGVCDRIFTRVGAVD
DLATGQSTFMVEMNETANILNHATSRSLVLLDEIGRGTATFDGLSIAWAVAEYLAMEIRSRTIFATHYHELNELAGMLPN
VANYQVTVKELPDQIIFLHQVQPGGADKSYGIEAGRLAGLPTVVIQRAKQVMGQIEKHSKIAMGLREGL
>Mature_389_residues
MNPLLDERKATVEADHQWIANLEVDERARTGIPLLKVGFNETFGYYISISRAKADQVPANYIRKQTLKNEERYITPELKE
REARILTARDDLHKLEYEVFVTLREEVGEQAEAIRHLSRAVAAADVLCGLAELAVYQGYCRPEMVNGRELKIVDGRHPVV
EQSLPAGFFVPNSTELGNIEETSPLPDLIILTGPNASGKSCYLRQVGLIQLMAQIGSFVPAKSARLGVCDRIFTRVGAVD
DLATGQSTFMVEMNETANILNHATSRSLVLLDEIGRGTATFDGLSIAWAVAEYLAMEIRSRTIFATHYHELNELAGMLPN
VANYQVTVKELPDQIIFLHQVQPGGADKSYGIEAGRLAGLPTVVIQRAKQVMGQIEKHSKIAMGLREGL

Specific function: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity [H]

COG id: COG0249

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutS family [H]

Homologues:

Organism=Homo sapiens, GI284813531, Length=348, Percent_Identity=35.3448275862069, Blast_Score=222, Evalue=4e-58,
Organism=Homo sapiens, GI36949366, Length=355, Percent_Identity=33.5211267605634, Blast_Score=215, Evalue=6e-56,
Organism=Homo sapiens, GI4504191, Length=353, Percent_Identity=38.2436260623229, Blast_Score=205, Evalue=5e-53,
Organism=Homo sapiens, GI4557761, Length=366, Percent_Identity=34.9726775956284, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI26638666, Length=396, Percent_Identity=33.8383838383838, Blast_Score=173, Evalue=3e-43,
Organism=Homo sapiens, GI4505253, Length=396, Percent_Identity=33.8383838383838, Blast_Score=173, Evalue=3e-43,
Organism=Homo sapiens, GI26638664, Length=397, Percent_Identity=33.7531486146096, Blast_Score=168, Evalue=7e-42,
Organism=Homo sapiens, GI262231786, Length=357, Percent_Identity=34.1736694677871, Blast_Score=153, Evalue=3e-37,
Organism=Escherichia coli, GI1789089, Length=378, Percent_Identity=50, Blast_Score=342, Evalue=3e-95,
Organism=Caenorhabditis elegans, GI17508445, Length=349, Percent_Identity=35.5300859598854, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17508447, Length=398, Percent_Identity=32.1608040201005, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17539736, Length=284, Percent_Identity=32.3943661971831, Blast_Score=144, Evalue=9e-35,
Organism=Caenorhabditis elegans, GI17534743, Length=365, Percent_Identity=27.6712328767123, Blast_Score=143, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6324482, Length=370, Percent_Identity=35.4054054054054, Blast_Score=211, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6321912, Length=276, Percent_Identity=38.768115942029, Blast_Score=193, Evalue=5e-50,
Organism=Saccharomyces cerevisiae, GI6319935, Length=358, Percent_Identity=33.2402234636872, Blast_Score=192, Evalue=9e-50,
Organism=Saccharomyces cerevisiae, GI6320302, Length=354, Percent_Identity=32.7683615819209, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6320047, Length=328, Percent_Identity=30.4878048780488, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6321109, Length=370, Percent_Identity=28.9189189189189, Blast_Score=132, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24664545, Length=351, Percent_Identity=37.6068376068376, Blast_Score=214, Evalue=7e-56,
Organism=Drosophila melanogaster, GI24584320, Length=240, Percent_Identity=44.1666666666667, Blast_Score=205, Evalue=4e-53,
Organism=Drosophila melanogaster, GI62471629, Length=124, Percent_Identity=44.3548387096774, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005748
- InterPro:   IPR007695
- InterPro:   IPR000432
- InterPro:   IPR007861
- InterPro:   IPR007860
- InterPro:   IPR007696
- InterPro:   IPR016151 [H]

Pfam domain/function: PF01624 MutS_I; PF05188 MutS_II; PF05192 MutS_III; PF05190 MutS_IV; PF00488 MutS_V [H]

EC number: NA

Molecular weight: Translated: 43040; Mature: 43040

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS00486 DNA_MISMATCH_REPAIR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPLLDERKATVEADHQWIANLEVDERARTGIPLLKVGFNETFGYYISISRAKADQVPAN
CCCCCCCHHHHHHCCCCEEECCCHHHHHHCCCCEEEECCCCCCEEEEEEECCCCCCCCHH
YIRKQTLKNEERYITPELKEREARILTARDDLHKLEYEVFVTLREEVGEQAEAIRHLSRA
HHHHHHHCCCCCEECCCHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHH
VAAADVLCGLAELAVYQGYCRPEMVNGRELKIVDGRHPVVEQSLPAGFFVPNSTELGNIE
HHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCHHHCCCCCEECCCCCCCCCCC
ETSPLPDLIILTGPNASGKSCYLRQVGLIQLMAQIGSFVPAKSARLGVCDRIFTRVGAVD
CCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHH
DLATGQSTFMVEMNETANILNHATSRSLVLLDEIGRGTATFDGLSIAWAVAEYLAMEIRS
HHCCCCCEEEEEECHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHC
RTIFATHYHELNELAGMLPNVANYQVTVKELPDQIIFLHQVQPGGADKSYGIEAGRLAGL
CEEEEHHHHHHHHHHHHCCCCCCCEEEHHHCCCEEEEEEEECCCCCCCCCCCCCCHHCCC
PTVVIQRAKQVMGQIEKHSKIAMGLREGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNPLLDERKATVEADHQWIANLEVDERARTGIPLLKVGFNETFGYYISISRAKADQVPAN
CCCCCCCHHHHHHCCCCEEECCCHHHHHHCCCCEEEECCCCCCEEEEEEECCCCCCCCHH
YIRKQTLKNEERYITPELKEREARILTARDDLHKLEYEVFVTLREEVGEQAEAIRHLSRA
HHHHHHHCCCCCEECCCHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHH
VAAADVLCGLAELAVYQGYCRPEMVNGRELKIVDGRHPVVEQSLPAGFFVPNSTELGNIE
HHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCHHHCCCCCEECCCCCCCCCCC
ETSPLPDLIILTGPNASGKSCYLRQVGLIQLMAQIGSFVPAKSARLGVCDRIFTRVGAVD
CCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHH
DLATGQSTFMVEMNETANILNHATSRSLVLLDEIGRGTATFDGLSIAWAVAEYLAMEIRS
HHCCCCCEEEEEECHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHC
RTIFATHYHELNELAGMLPNVANYQVTVKELPDQIIFLHQVQPGGADKSYGIEAGRLAGL
CEEEEHHHHHHHHHHHHCCCCCCCEEEHHHCCCEEEEEEEECCCCCCCCCCCCCCHHCCC
PTVVIQRAKQVMGQIEKHSKIAMGLREGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA