Click here to switch to the map view.

The map label for this gene is fmt

Identifier: 17230952

GI number: 17230952

Start: 4171067

End: 4172095

Strand: Direct

Name: fmt

Synonym: alr3460

Alternate gene names: 17230952

Gene position: 4171067-4172095 (Clockwise)

Preceding gene: 17230949

Following gene: 17230955

Centisome position: 65.03

GC content: 43.05

Gene sequence:

>1029_bases
ATGAAAATTGTATTTTTTGGTACACCTGAATTTGCTGTTCCTACTTTAGAAAAATTGCTAATTAACCCTGAATTTGATGT
TTTAGCCGTTATTACTCAACCGGATAAACGTCGGGAACGTGGGAATAAATTAACACCTTCGCCTGTAAAAAATGTGGCGA
TGTCCTACAGTCAGTGGGAGAACATCGCTCATGATTTACCAGTATGGCAACCGGAAAGGATAAAAAAAGATACTGAAACT
TTGAATAGACTTAAGGAATTAGACGTAGATGCCTTTGTTGTGGTGGCCTATGGGCAAATTTTGCCACAAAAAATCCTTAA
TATACCGAAATTGGGTTCCGTGAACGTACATGGGTCGATTTTGCCCCAGTACCGAGGTGCTGCACCTATTCAATGGTGTT
TGTATAACGGGGAAACAGAAACGGGGATCACGACAATGTTAATGGATGTCGGTATGGATACTGGGGCAATGCTACTGAAA
GCAACCACACCCATAGGCTTGCTCGATAATGCTGATGATGTAGCCCAGAAACTATCTGTGATTGGTGGAGATTTATTAAT
AGAAACCTTACACAAGCTACAGCAAAAGGAGATTCAACCAATCCCGCAAGATAATGCTGCTGCGACTTATGCTTCTTTAA
TTCAAAAGCAAGATTATGGTTTAGATTGGTCAAGGAGTGCGCTGCAACTGCACAATCAAATTAGAGGATTTTACCCAAAT
TGTATAACTACCTTCCGTAACCAACCTCTGAAGATTACAGCCTCCTTTCCCCTTGGTGCTGCTTACCGTGAGGAACTACC
ACCAGAATTACAGAAAATGTTGCAAAAATTGCCTGATTTATCACAGATATCGGGTAGCCCAGGAGAAGTAGTCAGCATAA
CCAAGGGAGTTGGTGCGATCGCTCAAACTGGCGAAGGACTTTTACTTTTACGAGAGGTTCAGCTACCTGGCAAACGCCCC
CAGTCGGGCTGGGATTTTGTTAATGGTACGCGGCTGACGGTGGGGGAAGTGTTAGGAAATGGCAGCTAG

Upstream 100 bases:

>100_bases
TATTGGGTAATGAGAAGTGGTGAGGACAAGAAGTAGGGGAGCGAAGGGAAAAGATATACTGGCAACTGACCACTGGCAAC
TGACCACTGATTAATAACTA

Downstream 100 bases:

>100_bases
TGAGGTTTCATAATAACGGCAGGACTCGCAAGGGCCGTGGGGATTGACTGCACAGCGAATGATTTCTGAGTGGGCATTAA
ATCTACAGGTGGCATCACCT

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MKIVFFGTPEFAVPTLEKLLINPEFDVLAVITQPDKRRERGNKLTPSPVKNVAMSYSQWENIAHDLPVWQPERIKKDTET
LNRLKELDVDAFVVVAYGQILPQKILNIPKLGSVNVHGSILPQYRGAAPIQWCLYNGETETGITTMLMDVGMDTGAMLLK
ATTPIGLLDNADDVAQKLSVIGGDLLIETLHKLQQKEIQPIPQDNAAATYASLIQKQDYGLDWSRSALQLHNQIRGFYPN
CITTFRNQPLKITASFPLGAAYREELPPELQKMLQKLPDLSQISGSPGEVVSITKGVGAIAQTGEGLLLLREVQLPGKRP
QSGWDFVNGTRLTVGEVLGNGS

Sequences:

>Translated_342_residues
MKIVFFGTPEFAVPTLEKLLINPEFDVLAVITQPDKRRERGNKLTPSPVKNVAMSYSQWENIAHDLPVWQPERIKKDTET
LNRLKELDVDAFVVVAYGQILPQKILNIPKLGSVNVHGSILPQYRGAAPIQWCLYNGETETGITTMLMDVGMDTGAMLLK
ATTPIGLLDNADDVAQKLSVIGGDLLIETLHKLQQKEIQPIPQDNAAATYASLIQKQDYGLDWSRSALQLHNQIRGFYPN
CITTFRNQPLKITASFPLGAAYREELPPELQKMLQKLPDLSQISGSPGEVVSITKGVGAIAQTGEGLLLLREVQLPGKRP
QSGWDFVNGTRLTVGEVLGNGS
>Mature_342_residues
MKIVFFGTPEFAVPTLEKLLINPEFDVLAVITQPDKRRERGNKLTPSPVKNVAMSYSQWENIAHDLPVWQPERIKKDTET
LNRLKELDVDAFVVVAYGQILPQKILNIPKLGSVNVHGSILPQYRGAAPIQWCLYNGETETGITTMLMDVGMDTGAMLLK
ATTPIGLLDNADDVAQKLSVIGGDLLIETLHKLQQKEIQPIPQDNAAATYASLIQKQDYGLDWSRSALQLHNQIRGFYPN
CITTFRNQPLKITASFPLGAAYREELPPELQKMLQKLPDLSQISGSPGEVVSITKGVGAIAQTGEGLLLLREVQLPGKRP
QSGWDFVNGTRLTVGEVLGNGS

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family

Homologues:

Organism=Homo sapiens, GI238814322, Length=214, Percent_Identity=30.8411214953271, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI21614513, Length=248, Percent_Identity=25.8064516129032, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI164663775, Length=336, Percent_Identity=26.1904761904762, Blast_Score=75, Evalue=6e-14,
Organism=Escherichia coli, GI1789683, Length=333, Percent_Identity=38.4384384384384, Blast_Score=204, Evalue=8e-54,
Organism=Escherichia coli, GI1788589, Length=258, Percent_Identity=29.0697674418605, Blast_Score=102, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI133930964, Length=249, Percent_Identity=28.1124497991968, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI45550868, Length=334, Percent_Identity=27.8443113772455, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI28571984, Length=246, Percent_Identity=28.4552845528455, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24585660, Length=249, Percent_Identity=26.5060240963855, Blast_Score=85, Evalue=8e-17,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): FMT_NOSS1 (Q8YRI6)

Other databases:

- EMBL:   BA000019
- PIR:   AE2238
- RefSeq:   NP_487500.1
- ProteinModelPortal:   Q8YRI6
- SMR:   Q8YRI6
- STRING:   Q8YRI6
- GeneID:   1107058
- GenomeReviews:   BA000019_GR
- KEGG:   ana:alr3460
- NMPDR:   fig|103690.1.peg.3767
- eggNOG:   COG0223
- HOGENOM:   HBG571560
- OMA:   IMQMDEG
- ProtClustDB:   PRK00005
- BioCyc:   NSP103690:ALR3460-MONOMER
- HAMAP:   MF_00182
- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR001555
- InterPro:   IPR015518
- Gene3D:   G3DSA:3.10.25.10
- Gene3D:   G3DSA:3.40.50.170
- PANTHER:   PTHR11138
- TIGRFAMs:   TIGR00460

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N; SSF50486 FMT_C_like; SSF53328 formyl_transf

EC number: =2.1.2.9

Molecular weight: Translated: 37660; Mature: 37660

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00373 GART

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIVFFGTPEFAVPTLEKLLINPEFDVLAVITQPDKRRERGNKLTPSPVKNVAMSYSQWE
CEEEEECCCCHHHHHHHHHHCCCCCCEEEEEECCHHHHHCCCCCCCCHHHHHHHHHHHHH
NIAHDLPVWQPERIKKDTETLNRLKELDVDAFVVVAYGQILPQKILNIPKLGSVNVHGSI
HHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHCCCCCCCCCCCCCC
LPQYRGAAPIQWCLYNGETETGITTMLMDVGMDTGAMLLKATTPIGLLDNADDVAQKLSV
CCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHH
IGGDLLIETLHKLQQKEIQPIPQDNAAATYASLIQKQDYGLDWSRSALQLHNQIRGFYPN
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCH
CITTFRNQPLKITASFPLGAAYREELPPELQKMLQKLPDLSQISGSPGEVVSITKGVGAI
HHHHHCCCCEEEEECCCCCHHHHHHCCHHHHHHHHHCCCHHHHCCCCCCEEEECCCCCHH
AQTGEGLLLLREVQLPGKRPQSGWDFVNGTRLTVGEVLGNGS
HHCCCCEEEEEEECCCCCCCCCCCCCCCCCEEEHHHHHCCCC
>Mature Secondary Structure
MKIVFFGTPEFAVPTLEKLLINPEFDVLAVITQPDKRRERGNKLTPSPVKNVAMSYSQWE
CEEEEECCCCHHHHHHHHHHCCCCCCEEEEEECCHHHHHCCCCCCCCHHHHHHHHHHHHH
NIAHDLPVWQPERIKKDTETLNRLKELDVDAFVVVAYGQILPQKILNIPKLGSVNVHGSI
HHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHCCCCCCCCCCCCCC
LPQYRGAAPIQWCLYNGETETGITTMLMDVGMDTGAMLLKATTPIGLLDNADDVAQKLSV
CCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHH
IGGDLLIETLHKLQQKEIQPIPQDNAAATYASLIQKQDYGLDWSRSALQLHNQIRGFYPN
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCH
CITTFRNQPLKITASFPLGAAYREELPPELQKMLQKLPDLSQISGSPGEVVSITKGVGAI
HHHHHCCCCEEEEECCCCCHHHHHHCCHHHHHHHHHCCCHHHHCCCCCCEEEECCCCCHH
AQTGEGLLLLREVQLPGKRPQSGWDFVNGTRLTVGEVLGNGS
HHCCCCEEEEEEECCCCCCCCCCCCCCCCCEEEHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840