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The map label for this gene is ltaE [H]

Identifier: 17230788

GI number: 17230788

Start: 3978123

End: 3979160

Strand: Direct

Name: ltaE [H]

Synonym: alr3296

Alternate gene names: 17230788

Gene position: 3978123-3979160 (Clockwise)

Preceding gene: 17230786

Following gene: 17230789

Centisome position: 62.02

GC content: 36.8

Gene sequence:

>1038_bases
ATTAATAGCAACTTAGAACAGTTTGCCAGTGACAACTACGCTGGTATTTGTCCAGAAGCAATGAACTATATGATTCAAGC
TAATCAAGGTAGTGCGCCAGCTTATGGAAATGATGAATGGACGCAAAAAGCAACAGACTATTTTCGAGAACTTTTTGAAA
TTGATTGCGAAGTATTTTTTACTTTTAACGGTACAGCAGCAAATTCATTATCTTTAGCTGCACTTTGTCAGTCATATCAC
AGCGTTATTTGTCATGAAACAGCACATATAGAAACAGATGAATGTGGCGCACCAGAGTTTGCGTCTAATGGTTCTAAGTT
GTTACTTGCTAAAGGAGAAAATGGTAAGTTAACACCACAAGAGATAGAGTCTGTAATCACGAAGCGAGTTGATATTCATT
ATCCTAAACCAAAAGTAATTAGTATTACTCAAGCTACAGAATTAGGGACTTTATATTCTATAGAAGAACTTTTAGATATT
AAAAAAGTTGCCCAAAAGTATCAATTAAAAATTCACATGGACGGCGCACGCTTTGCCAATGCAGTTGCAGCCATGAATAA
AAGTCCGGCAGAGATGAGTTGGAAAAGTGGCGTGGATGTATTGTGTTTTTGTGGGACAAAAAATGGTATGGCATTAGGGG
AAGCCATTATATTTTTTAATCGAGCATTGGCAGAAGATTTTGATTATCGTTGTAAACAAGCAGGACAATTAGCATCAAAA
ATGCGGTTTATTTCTGCGCCGTGGTTAGGTTTGTTAGAAACTGGTGCGTGGTTGAAAAATGCTCAACACGCGAATCAATG
TGCGGCTTATTTAGAGAATGAATTGTTAAAAATAGAAGGTGTGGAAATTATGTTTCCCCGTGAAGTAAATGCAGTTTTTG
TCAAACTGCCAGAGCAAGTTATCAATGGCTTAAAAGCAAACAATTGGTTGTTTTATACTTTTATTGGGGTAGGTGGTGTA
CGCTTTATGTGTTCTTGGAATACCACCAAAAGCAGAATTGATGAATTAGTTGGAGATATTAAAACAGGATTGGGCTAA

Upstream 100 bases:

>100_bases
GCTTGAGGATATATTCAATGAAATTATTCACGAAATTTGATTGAATATAATCTGATTGGCCAAAGTTGGTAGTCGTAGTA
GATAAATGAATTTAAAAATG

Downstream 100 bases:

>100_bases
ATTGTGGGTAAGAGTAGCAGTCAATTTATGAGAAGCTAAACTAATTATATAAATCATACTAAGTAAGACAAATACATAAG
ATTTTTCGATTACTGTGTAT

Product: low specificity L-threonine aldolase

Products: NA

Alternate protein names: Low specificity L-TA [H]

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MNSNLEQFASDNYAGICPEAMNYMIQANQGSAPAYGNDEWTQKATDYFRELFEIDCEVFFTFNGTAANSLSLAALCQSYH
SVICHETAHIETDECGAPEFASNGSKLLLAKGENGKLTPQEIESVITKRVDIHYPKPKVISITQATELGTLYSIEELLDI
KKVAQKYQLKIHMDGARFANAVAAMNKSPAEMSWKSGVDVLCFCGTKNGMALGEAIIFFNRALAEDFDYRCKQAGQLASK
MRFISAPWLGLLETGAWLKNAQHANQCAAYLENELLKIEGVEIMFPREVNAVFVKLPEQVINGLKANNWLFYTFIGVGGV
RFMCSWNTTKSRIDELVGDIKTGLG

Sequences:

>Translated_345_residues
MNSNLEQFASDNYAGICPEAMNYMIQANQGSAPAYGNDEWTQKATDYFRELFEIDCEVFFTFNGTAANSLSLAALCQSYH
SVICHETAHIETDECGAPEFASNGSKLLLAKGENGKLTPQEIESVITKRVDIHYPKPKVISITQATELGTLYSIEELLDI
KKVAQKYQLKIHMDGARFANAVAAMNKSPAEMSWKSGVDVLCFCGTKNGMALGEAIIFFNRALAEDFDYRCKQAGQLASK
MRFISAPWLGLLETGAWLKNAQHANQCAAYLENELLKIEGVEIMFPREVNAVFVKLPEQVINGLKANNWLFYTFIGVGGV
RFMCSWNTTKSRIDELVGDIKTGLG
>Mature_345_residues
MNSNLEQFASDNYAGICPEAMNYMIQANQGSAPAYGNDEWTQKATDYFRELFEIDCEVFFTFNGTAANSLSLAALCQSYH
SVICHETAHIETDECGAPEFASNGSKLLLAKGENGKLTPQEIESVITKRVDIHYPKPKVISITQATELGTLYSIEELLDI
KKVAQKYQLKIHMDGARFANAVAAMNKSPAEMSWKSGVDVLCFCGTKNGMALGEAIIFFNRALAEDFDYRCKQAGQLASK
MRFISAPWLGLLETGAWLKNAQHANQCAAYLENELLKIEGVEIMFPREVNAVFVKLPEQVINGLKANNWLFYTFIGVGGV
RFMCSWNTTKSRIDELVGDIKTGLG

Specific function: Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde. Can also act on L-erythro- phenylserine, L-threo-phenylserine, L-beta-3,4- methylenedioxyphenylserine and L-beta-3,4-dihydroxyphenylserine [H]

COG id: COG2008

COG function: function code E; Threonine aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine aldolase family [H]

Homologues:

Organism=Caenorhabditis elegans, GI193206520, Length=196, Percent_Identity=32.1428571428571, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI193206524, Length=196, Percent_Identity=32.1428571428571, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI193206522, Length=196, Percent_Identity=32.1428571428571, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320789, Length=337, Percent_Identity=23.7388724035608, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001597
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01212 Beta_elim_lyase [H]

EC number: =4.1.2.5 [H]

Molecular weight: Translated: 38228; Mature: 38228

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSNLEQFASDNYAGICPEAMNYMIQANQGSAPAYGNDEWTQKATDYFRELFEIDCEVFF
CCCCHHHHHCCCCCCCCHHHHCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEE
TFNGTAANSLSLAALCQSYHSVICHETAHIETDECGAPEFASNGSKLLLAKGENGKLTPQ
EECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCEEEEEECCCCCCCHH
EIESVITKRVDIHYPKPKVISITQATELGTLYSIEELLDIKKVAQKYQLKIHMDGARFAN
HHHHHHHHHHEEECCCCCEEEEECHHHCCHHHHHHHHHHHHHHHHHHEEEEEECHHHHHH
AVAAMNKSPAEMSWKSGVDVLCFCGTKNGMALGEAIIFFNRALAEDFDYRCKQAGQLASK
HHHHHCCCCCCCHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MRFISAPWLGLLETGAWLKNAQHANQCAAYLENELLKIEGVEIMFPREVNAVFVKLPEQV
HHHHCCCCHHHHHHCHHHHCHHHHHHHHHHHHHCCEEECCEEEECCCCCCEEEEECHHHH
INGLKANNWLFYTFIGVGGVRFMCSWNTTKSRIDELVGDIKTGLG
HCCCCCCCEEEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNSNLEQFASDNYAGICPEAMNYMIQANQGSAPAYGNDEWTQKATDYFRELFEIDCEVFF
CCCCHHHHHCCCCCCCCHHHHCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEE
TFNGTAANSLSLAALCQSYHSVICHETAHIETDECGAPEFASNGSKLLLAKGENGKLTPQ
EECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCEEEEEECCCCCCCHH
EIESVITKRVDIHYPKPKVISITQATELGTLYSIEELLDIKKVAQKYQLKIHMDGARFAN
HHHHHHHHHHEEECCCCCEEEEECHHHCCHHHHHHHHHHHHHHHHHHEEEEEECHHHHHH
AVAAMNKSPAEMSWKSGVDVLCFCGTKNGMALGEAIIFFNRALAEDFDYRCKQAGQLASK
HHHHHCCCCCCCHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MRFISAPWLGLLETGAWLKNAQHANQCAAYLENELLKIEGVEIMFPREVNAVFVKLPEQV
HHHHCCCCHHHHHHCHHHHCHHHHHHHHHHHHHCCEEECCEEEECCCCCCEEEEECHHHH
INGLKANNWLFYTFIGVGGVRFMCSWNTTKSRIDELVGDIKTGLG
HCCCCCCCEEEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9464392 [H]