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The map label for this gene is hisI

Identifier: 17230755

GI number: 17230755

Start: 3935526

End: 3936176

Strand: Reverse

Name: hisI

Synonym: all3263

Alternate gene names: 17230755

Gene position: 3936176-3935526 (Counterclockwise)

Preceding gene: 17230756

Following gene: 17230754

Centisome position: 61.37

GC content: 46.85

Gene sequence:

>651_bases
ATGTCCTTCATCGATTCACTCTCACCACAAAATGTTATCCCCGTCGAAGAAATCCGCTACGATGAACGGGGTTTAGTGCC
AGCAATTGTGCAAGATTATTTGGATGGCACAGTCCTAATGATGGCGTGGATGAATCGGGAGTCTTTACAAAAGACTTTAG
ATACAGGGGAAACTTGGTTTTGGAGTCGTTCCCGACAGGAATTCTGGCATAAGGGCGGAACTTCTGGCCATACCCAAAAG
GTACAAAGCATACGTTATGACTGTGACAGTGATGCACTGTTAGTAGGGGTGGAGCAGATTGGAGATATTGCTTGCCATAC
TGGCGAACGCAGTTGTTTTCATCAGGTGGAAGGGAAAATCGTGGCGCCACCAGGGGATACATTATCCCAGGTATTTCAGG
TGATTTGCGATCGCCGGAATCACCCTACAGAAAGTTCCTATACCAGCAAGTTGTTTGCAGGTGGCGATAATAAGATTTTA
AAGAAGATTGGTGAGGAATCGGCTGAAGTCGTCATGGCTTGTAAGGATGACGACCAAGAGGCGATCGCTGGTGAGGTGGC
AGATTTGCTATACCACACTTTGGTGGCTTTGGCTCACCATCAAGTAGATATAAAGGCAGTTTATCGGAAGTTGCAAGAAC
GCAGGCGTTAG

Upstream 100 bases:

>100_bases
TTTACAAGGATGAAAAATTTTACTCGAAAAAATCATGCCAGCTGCTCTATACAGAATGGTATCGTGAAACTATGAATCAT
TCTCATTAAATTTAGCTGGT

Downstream 100 bases:

>100_bases
GGACTGGGGACTGGGGATTGGGAGATGAGGAAGAATGAAAATTAACTTTTCTACTCCCTATTCCCTCAAACATAATTGAG
GTAGGGGGAGCAATCAAGGA

Product: bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein

Products: NA

Alternate protein names: Phosphoribosyl-AMP cyclohydrolase; PRA-CH; Phosphoribosyl-ATP pyrophosphatase; PRA-PH

Number of amino acids: Translated: 216; Mature: 215

Protein sequence:

>216_residues
MSFIDSLSPQNVIPVEEIRYDERGLVPAIVQDYLDGTVLMMAWMNRESLQKTLDTGETWFWSRSRQEFWHKGGTSGHTQK
VQSIRYDCDSDALLVGVEQIGDIACHTGERSCFHQVEGKIVAPPGDTLSQVFQVICDRRNHPTESSYTSKLFAGGDNKIL
KKIGEESAEVVMACKDDDQEAIAGEVADLLYHTLVALAHHQVDIKAVYRKLQERRR

Sequences:

>Translated_216_residues
MSFIDSLSPQNVIPVEEIRYDERGLVPAIVQDYLDGTVLMMAWMNRESLQKTLDTGETWFWSRSRQEFWHKGGTSGHTQK
VQSIRYDCDSDALLVGVEQIGDIACHTGERSCFHQVEGKIVAPPGDTLSQVFQVICDRRNHPTESSYTSKLFAGGDNKIL
KKIGEESAEVVMACKDDDQEAIAGEVADLLYHTLVALAHHQVDIKAVYRKLQERRR
>Mature_215_residues
SFIDSLSPQNVIPVEEIRYDERGLVPAIVQDYLDGTVLMMAWMNRESLQKTLDTGETWFWSRSRQEFWHKGGTSGHTQKV
QSIRYDCDSDALLVGVEQIGDIACHTGERSCFHQVEGKIVAPPGDTLSQVFQVICDRRNHPTESSYTSKLFAGGDNKILK
KIGEESAEVVMACKDDDQEAIAGEVADLLYHTLVALAHHQVDIKAVYRKLQERRR

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PRA-PH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=199, Percent_Identity=40.7035175879397, Blast_Score=149, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6319819, Length=200, Percent_Identity=34, Blast_Score=92, Evalue=7e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS2_NOSS1 (Q8YS28)

Other databases:

- EMBL:   BA000019
- PIR:   AH2213
- RefSeq:   NP_487303.1
- ProteinModelPortal:   Q8YS28
- STRING:   Q8YS28
- GeneID:   1106861
- GenomeReviews:   BA000019_GR
- KEGG:   ana:all3263
- NMPDR:   fig|103690.1.peg.3570
- eggNOG:   COG0139
- HOGENOM:   HBG294308
- OMA:   VMACKDD
- PhylomeDB:   Q8YS28
- ProtClustDB:   PRK02759
- BioCyc:   NSP103690:ALL3263-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01019
- InterPro:   IPR023019
- InterPro:   IPR008179
- InterPro:   IPR021130
- InterPro:   IPR002496
- ProDom:   PD002610
- TIGRFAMs:   TIGR03188

Pfam domain/function: PF01502 PRA-CH; PF01503 PRA-PH

EC number: =3.5.4.19; =3.6.1.31

Molecular weight: Translated: 24397; Mature: 24266

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFIDSLSPQNVIPVEEIRYDERGLVPAIVQDYLDGTVLMMAWMNRESLQKTLDTGETWF
CCCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHCHHHHHHHHHCCCCEE
WSRSRQEFWHKGGTSGHTQKVQSIRYDCDSDALLVGVEQIGDIACHTGERSCFHQVEGKI
CCCHHHHHHHCCCCCCHHHHHHHHHCCCCCCCEEEEHHHHHHHHHCCCCHHHHHHHCCEE
VAPPGDTLSQVFQVICDRRNHPTESSYTSKLFAGGDNKILKKIGEESAEVVMACKDDDQE
ECCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCHHHHHHHCCCHHHEEEEECCCCHH
AIAGEVADLLYHTLVALAHHQVDIKAVYRKLQERRR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SFIDSLSPQNVIPVEEIRYDERGLVPAIVQDYLDGTVLMMAWMNRESLQKTLDTGETWF
CCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHCHHHHHHHHHCCCCEE
WSRSRQEFWHKGGTSGHTQKVQSIRYDCDSDALLVGVEQIGDIACHTGERSCFHQVEGKI
CCCHHHHHHHCCCCCCHHHHHHHHHCCCCCCCEEEEHHHHHHHHHCCCCHHHHHHHCCEE
VAPPGDTLSQVFQVICDRRNHPTESSYTSKLFAGGDNKILKKIGEESAEVVMACKDDDQE
ECCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCHHHHHHHCCCHHHEEEEECCCCHH
AIAGEVADLLYHTLVALAHHQVDIKAVYRKLQERRR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840