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The map label for this gene is hmuU [H]

Identifier: 17230732

GI number: 17230732

Start: 3912261

End: 3913298

Strand: Direct

Name: hmuU [H]

Synonym: alr3240

Alternate gene names: 17230732

Gene position: 3912261-3913298 (Clockwise)

Preceding gene: 17230730

Following gene: 17230733

Centisome position: 61.0

GC content: 47.88

Gene sequence:

>1038_bases
ATGAAACTAAAGCAGCGACAGCAAAAAATGTTCAAGAATGTTAGCGCTGCTTCTAGAAATGAAGCGCGGGTATTTTTAGC
TACTTTATTTTTAGTTGTTGTTCTCATTTTGGCAGTAGGCGCTTCTTTATCGTTTGGTGCTGTCCCCATGACACCAGAAC
AATTGTGGCTAGCGATTTGGCGACAGGGAGAGCAAATTTATCAAACCATTCTGTGGGACTTGCGCCTACCAAGGACTATA
GCAGCGATTTTGGTGGGTGCAGCTTTAGGAATGTCAGGTTCCCTACTCCAGGGAATGTTACGCAACGGACTAGCCGACCC
CTTTTTACTGGGGATTTCTGCGGGTGCTGGTTTGGTAGCGATCGCCATGTTTAGTTTAGGGGTATTCTTAGCTTGGGTTC
CCTTGGCGGCCTGGGTTGGGGGAGTACTGACTACAGTGATTGTCTATTTTTTAGCCAGGACTGGGGATGGTATTTCTGTA
GAAAGGTTGATTTTGGGTGGTGTGGCGGTAAGTGCCATGTTTGGGGCGATACAGTCTGTGTTGCTACTGTTAACAGAAGA
TGGCAGGATACAGGCCGCCTTAAATTGGCTGATTGGCAGTTTAAATGGCCGGGGATGGGCAGAAGTGACTACGGCTGGTG
CTTATATTAGTGTGGCATTAGTCTTGGGATGTTTATTAGCGCGATCGGTGAACTTATTGAACCTGGGGGATGAATTAGCC
GTAAGTTTGGGAGTTTCCTTGGGGCGATCGCGCATTTTCATCGGCGGAGTTGCTACACTATTAGCCGCAGGTGCCGTCAG
TATTGGCGGCTTGATTGGTTTTGTTGGTTTAATAGTACCCCACGGTATCCGCTTACTAGTAGGCACAGATTATCGCGCCG
TCTTACCACTCAGCGCCTTGGGAGGTGCATTAGTCATGACCATTGCAGACTTACTTTCCCGTCTGGGTGCAGTAGAACTC
CCAGTTGGTTCCGTCACCGCGTTGCTAGGTTCACCGTTATTTATTTGGTTACTTTATCGTCGTAAAAGCGGAATTTGA

Upstream 100 bases:

>100_bases
TATTCAATTAGAATTATTCTCACTCTTAGTAGATTTGATATCCATTACCACTATATTCCTATTACGTCAAGCATCTATTA
TCAGCAGTCCAGATTAATCC

Downstream 100 bases:

>100_bases
ACTTCTTGATTACGAATTATTCTTATGCCTCTAGAAACGCAAAACTTAACGGGTGGATATACAGCGAAAACTGTAGTTAA
TAACATCTCCTTAGCAATTG

Product: permease protein of ferrichrome ABC transporter

Products: ADP; phosphate; iron dicitrate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MKLKQRQQKMFKNVSAASRNEARVFLATLFLVVVLILAVGASLSFGAVPMTPEQLWLAIWRQGEQIYQTILWDLRLPRTI
AAILVGAALGMSGSLLQGMLRNGLADPFLLGISAGAGLVAIAMFSLGVFLAWVPLAAWVGGVLTTVIVYFLARTGDGISV
ERLILGGVAVSAMFGAIQSVLLLLTEDGRIQAALNWLIGSLNGRGWAEVTTAGAYISVALVLGCLLARSVNLLNLGDELA
VSLGVSLGRSRIFIGGVATLLAAGAVSIGGLIGFVGLIVPHGIRLLVGTDYRAVLPLSALGGALVMTIADLLSRLGAVEL
PVGSVTALLGSPLFIWLLYRRKSGI

Sequences:

>Translated_345_residues
MKLKQRQQKMFKNVSAASRNEARVFLATLFLVVVLILAVGASLSFGAVPMTPEQLWLAIWRQGEQIYQTILWDLRLPRTI
AAILVGAALGMSGSLLQGMLRNGLADPFLLGISAGAGLVAIAMFSLGVFLAWVPLAAWVGGVLTTVIVYFLARTGDGISV
ERLILGGVAVSAMFGAIQSVLLLLTEDGRIQAALNWLIGSLNGRGWAEVTTAGAYISVALVLGCLLARSVNLLNLGDELA
VSLGVSLGRSRIFIGGVATLLAAGAVSIGGLIGFVGLIVPHGIRLLVGTDYRAVLPLSALGGALVMTIADLLSRLGAVEL
PVGSVTALLGSPLFIWLLYRRKSGI
>Mature_345_residues
MKLKQRQQKMFKNVSAASRNEARVFLATLFLVVVLILAVGASLSFGAVPMTPEQLWLAIWRQGEQIYQTILWDLRLPRTI
AAILVGAALGMSGSLLQGMLRNGLADPFLLGISAGAGLVAIAMFSLGVFLAWVPLAAWVGGVLTTVIVYFLARTGDGISV
ERLILGGVAVSAMFGAIQSVLLLLTEDGRIQAALNWLIGSLNGRGWAEVTTAGAYISVALVLGCLLARSVNLLNLGDELA
VSLGVSLGRSRIFIGGVATLLAAGAVSIGGLIGFVGLIVPHGIRLLVGTDYRAVLPLSALGGALVMTIADLLSRLGAVEL
PVGSVTALLGSPLFIWLLYRRKSGI

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790740, Length=307, Percent_Identity=39.0879478827362, Blast_Score=165, Evalue=5e-42,
Organism=Escherichia coli, GI1790741, Length=298, Percent_Identity=37.5838926174497, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1788004, Length=278, Percent_Identity=37.410071942446, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1786804, Length=325, Percent_Identity=35.0769230769231, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1786805, Length=283, Percent_Identity=38.5159010600707, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1786347, Length=320, Percent_Identity=31.5625, Blast_Score=105, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 36066; Mature: 36066

Theoretical pI: Translated: 10.80; Mature: 10.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLKQRQQKMFKNVSAASRNEARVFLATLFLVVVLILAVGASLSFGAVPMTPEQLWLAIW
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
RQGEQIYQTILWDLRLPRTIAAILVGAALGMSGSLLQGMLRNGLADPFLLGISAGAGLVA
HCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHCCCHHHHH
IAMFSLGVFLAWVPLAAWVGGVLTTVIVYFLARTGDGISVERLILGGVAVSAMFGAIQSV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
LLLLTEDGRIQAALNWLIGSLNGRGWAEVTTAGAYISVALVLGCLLARSVNLLNLGDELA
HHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCHHHH
VSLGVSLGRSRIFIGGVATLLAAGAVSIGGLIGFVGLIVPHGIRLLVGTDYRAVLPLSAL
HHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHH
GGALVMTIADLLSRLGAVELPVGSVTALLGSPLFIWLLYRRKSGI
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MKLKQRQQKMFKNVSAASRNEARVFLATLFLVVVLILAVGASLSFGAVPMTPEQLWLAIW
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
RQGEQIYQTILWDLRLPRTIAAILVGAALGMSGSLLQGMLRNGLADPFLLGISAGAGLVA
HCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHCCCHHHHH
IAMFSLGVFLAWVPLAAWVGGVLTTVIVYFLARTGDGISVERLILGGVAVSAMFGAIQSV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
LLLLTEDGRIQAALNWLIGSLNGRGWAEVTTAGAYISVALVLGCLLARSVNLLNLGDELA
HHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCHHHH
VSLGVSLGRSRIFIGGVATLLAAGAVSIGGLIGFVGLIVPHGIRLLVGTDYRAVLPLSAL
HHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHH
GGALVMTIADLLSRLGAVELPVGSVTALLGSPLFIWLLYRRKSGI
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron dicitrate [Periplasm]; H2O [C]

Specific reaction: ATP + iron dicitrate [Periplasm] + H2O = ADP + phosphate + iron dicitrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]