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The map label for this gene is gltX [H]

Identifier: 17230697

GI number: 17230697

Start: 3870802

End: 3872244

Strand: Reverse

Name: gltX [H]

Synonym: all3205

Alternate gene names: 17230697

Gene position: 3872244-3870802 (Counterclockwise)

Preceding gene: 17230698

Following gene: 17230690

Centisome position: 60.37

GC content: 46.78

Gene sequence:

>1443_bases
GTGACTGTTAGAGTCAGAATCGCCCCTAGTCCAACAGGGAATTTACACATTGGTACAGCTAGAACAGCCGTATTTAACTG
GCTGTTTGCCCGCCACCACGGCGGCACATTTATTTTACGAATTGAAGACACAGATTTAGAGCGATCGCGTCCCGAATACA
CGGAAAATATCATGACGGGATTGCGTTGGTTAGGGTTGAATTGGGATGAGGGGCCATTTTTCCAATCCCAACGCCTCGAC
CTTTATCAAAAAGCCGTAAAACAACTTTTAGATCAGGGTTTAGCCTATCGCTGCTACACCACATCAGAAGAACTAGAAGC
CCTACGAGAAGGGCAAAAAGCTAAAGGTGAAGCCCCGCGTTACGACAACCGTCACCGCCACCTTACCCCAGAACAAGAAG
CCGAATTTAAAGCCCAAGGACGCAGTTTTGTCATCCGCTTTAAAATCGATGATGAGCGAGAAATCGTCTGGAATGACTTA
GTACGGGGTAAGATGTCTTGGCGAGGCAGTGATTTAGGCGGTGATATGGTCATCGCCCGTGCTTCCGAAAATGATACTGG
TCAGCCGTTATATAATTTCGTTGTGGTGATTGATGACATCGATATGCAAATCAGTCATGTCATCCGGGGAGAAGACCACA
TTGCCAATACAGCCAAGCAAATTCTGCTATACGAAGCCTTTGGGGCAAAAATCCCAGAGTTCGCCCATACTCCCCTAATT
TTAAATATGGAAGGGCGTAAGCTCTCCAAGCGGGATGGAGTGACTTCCATTTCTGACTTTAAGCAAATGGGTTTCACATC
CGAAGGTTTAGTCAACTACATGACCTTGCTTGGTTGGTCGCCACCAGATTCTACCCAAGAAATATTTACCTTAGAAGCAG
CCGCCAAAGAATTTACTTTTGAGCGGGTGAATAAAGCCGGGGCAAAATTTGACTGGGCGAAACTAGATTGGTTGAACAGT
CAATATATTCACAATACCCCAGTTGATCAGTTGACTGATTTACTCATTCCCTATTGGGAAGCGGCTGGATATTCATTGGC
TGGGGGACGCGATCGCCCTTGGTTAGAACAGTTGGTGGGTTTACTTAGCGCCAGCTTGACCCGGTTAACCGATGCGGTAG
ATATGAGCAAACTGTTTTTTACTGAGACAGTGGAATTGAGCGAAGAAGGTAGCAAACAATTGCAGCAAGAAGGTTCTAAA
GCCGTGCTTGAGGCAATTATCGCCGCCTTGGAGACTCAAGCGCAACTCACAGAAACGGCTGCCCAAGACATAATTAAGCA
GGTGGTGAAAGGTCAAAATGTGAAGAAAGGTTTAGTCATGCGATCGCTCAGAGTCGCCCTCACCGGTGATGTGCATGGCC
CAGACTTAATTCAATCTTGGTTGCTCTTGAATCAGATTGGCTTGGATAAGCCACGCTTGAATCAGGCGATCGCAGTTAGC
TAG

Upstream 100 bases:

>100_bases
AACTTTTCTGTAGAGTCCGTGTTTCCTAGATTGATCTCAGGACTCAGAAGCTTAAGTATTAAGCTAAATTTAATCATGCT
TTGCGAGAGAGAGAAATACT

Downstream 100 bases:

>100_bases
AACGTAATGTGGTGGGCAATGCCCACCCTACGAGATAAATTACTCAGCACTGAGATTTAAAGCTTTATACTAAAAGCGGC
AACAGCTAACGCGCCCCAGC

Product: glutamyl-tRNA synthetase

Products: NA

Alternate protein names: Glutamate--tRNA ligase; GluRS [H]

Number of amino acids: Translated: 480; Mature: 479

Protein sequence:

>480_residues
MTVRVRIAPSPTGNLHIGTARTAVFNWLFARHHGGTFILRIEDTDLERSRPEYTENIMTGLRWLGLNWDEGPFFQSQRLD
LYQKAVKQLLDQGLAYRCYTTSEELEALREGQKAKGEAPRYDNRHRHLTPEQEAEFKAQGRSFVIRFKIDDEREIVWNDL
VRGKMSWRGSDLGGDMVIARASENDTGQPLYNFVVVIDDIDMQISHVIRGEDHIANTAKQILLYEAFGAKIPEFAHTPLI
LNMEGRKLSKRDGVTSISDFKQMGFTSEGLVNYMTLLGWSPPDSTQEIFTLEAAAKEFTFERVNKAGAKFDWAKLDWLNS
QYIHNTPVDQLTDLLIPYWEAAGYSLAGGRDRPWLEQLVGLLSASLTRLTDAVDMSKLFFTETVELSEEGSKQLQQEGSK
AVLEAIIAALETQAQLTETAAQDIIKQVVKGQNVKKGLVMRSLRVALTGDVHGPDLIQSWLLLNQIGLDKPRLNQAIAVS

Sequences:

>Translated_480_residues
MTVRVRIAPSPTGNLHIGTARTAVFNWLFARHHGGTFILRIEDTDLERSRPEYTENIMTGLRWLGLNWDEGPFFQSQRLD
LYQKAVKQLLDQGLAYRCYTTSEELEALREGQKAKGEAPRYDNRHRHLTPEQEAEFKAQGRSFVIRFKIDDEREIVWNDL
VRGKMSWRGSDLGGDMVIARASENDTGQPLYNFVVVIDDIDMQISHVIRGEDHIANTAKQILLYEAFGAKIPEFAHTPLI
LNMEGRKLSKRDGVTSISDFKQMGFTSEGLVNYMTLLGWSPPDSTQEIFTLEAAAKEFTFERVNKAGAKFDWAKLDWLNS
QYIHNTPVDQLTDLLIPYWEAAGYSLAGGRDRPWLEQLVGLLSASLTRLTDAVDMSKLFFTETVELSEEGSKQLQQEGSK
AVLEAIIAALETQAQLTETAAQDIIKQVVKGQNVKKGLVMRSLRVALTGDVHGPDLIQSWLLLNQIGLDKPRLNQAIAVS
>Mature_479_residues
TVRVRIAPSPTGNLHIGTARTAVFNWLFARHHGGTFILRIEDTDLERSRPEYTENIMTGLRWLGLNWDEGPFFQSQRLDL
YQKAVKQLLDQGLAYRCYTTSEELEALREGQKAKGEAPRYDNRHRHLTPEQEAEFKAQGRSFVIRFKIDDEREIVWNDLV
RGKMSWRGSDLGGDMVIARASENDTGQPLYNFVVVIDDIDMQISHVIRGEDHIANTAKQILLYEAFGAKIPEFAHTPLIL
NMEGRKLSKRDGVTSISDFKQMGFTSEGLVNYMTLLGWSPPDSTQEIFTLEAAAKEFTFERVNKAGAKFDWAKLDWLNSQ
YIHNTPVDQLTDLLIPYWEAAGYSLAGGRDRPWLEQLVGLLSASLTRLTDAVDMSKLFFTETVELSEEGSKQLQQEGSKA
VLEAIIAALETQAQLTETAAQDIIKQVVKGQNVKKGLVMRSLRVALTGDVHGPDLIQSWLLLNQIGLDKPRLNQAIAVS

Specific function: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction:glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) [H]

COG id: COG0008

COG function: function code J; Glutamyl- and glutaminyl-tRNA synthetases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI134288884, Length=488, Percent_Identity=35.2459016393443, Blast_Score=238, Evalue=8e-63,
Organism=Homo sapiens, GI62241042, Length=290, Percent_Identity=25.5172413793103, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1788743, Length=456, Percent_Identity=41.8859649122807, Blast_Score=355, Evalue=3e-99,
Organism=Escherichia coli, GI226510925, Length=255, Percent_Identity=33.3333333333333, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1786895, Length=351, Percent_Identity=25.3561253561254, Blast_Score=87, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71993394, Length=472, Percent_Identity=30.7203389830508, Blast_Score=206, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6324540, Length=466, Percent_Identity=32.4034334763949, Blast_Score=240, Evalue=4e-64,
Organism=Saccharomyces cerevisiae, GI6324742, Length=134, Percent_Identity=35.8208955223881, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6321192, Length=298, Percent_Identity=23.8255033557047, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24665321, Length=475, Percent_Identity=36.8421052631579, Blast_Score=269, Evalue=4e-72,

Paralogues:

None

Copy number: 1,800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008925
- InterPro:   IPR020751
- InterPro:   IPR001412
- InterPro:   IPR004527
- InterPro:   IPR000924
- InterPro:   IPR020061
- InterPro:   IPR020058
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00749 tRNA-synt_1c [H]

EC number: =6.1.1.17 [H]

Molecular weight: Translated: 54153; Mature: 54022

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVRVRIAPSPTGNLHIGTARTAVFNWLFARHHGGTFILRIEDTDLERSRPEYTENIMTG
CEEEEEECCCCCCCEEECHHHHHHHHHHHHEECCCEEEEEEECCCCCCCCCHHHHHHHHH
LRWLGLNWDEGPFFQSQRLDLYQKAVKQLLDQGLAYRCYTTSEELEALREGQKAKGEAPR
HHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHCCHHCCCCCCC
YDNRHRHLTPEQEAEFKAQGRSFVIRFKIDDEREIVWNDLVRGKMSWRGSDLGGDMVIAR
CCCCCCCCCCCHHHHHHHCCCEEEEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCEEEEE
ASENDTGQPLYNFVVVIDDIDMQISHVIRGEDHIANTAKQILLYEAFGAKIPEFAHTPLI
CCCCCCCCCEEEEEEEEECCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEE
LNMEGRKLSKRDGVTSISDFKQMGFTSEGLVNYMTLLGWSPPDSTQEIFTLEAAAKEFTF
EEECCCCCHHHCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHEEHHHHHHHHHH
ERVNKAGAKFDWAKLDWLNSQYIHNTPVDQLTDLLIPYWEAAGYSLAGGRDRPWLEQLVG
HHHHHCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
LLSASLTRLTDAVDMSKLFFTETVELSEEGSKQLQQEGSKAVLEAIIAALETQAQLTETA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
AQDIIKQVVKGQNVKKGLVMRSLRVALTGDVHGPDLIQSWLLLNQIGLDKPRLNQAIAVS
HHHHHHHHHCCCCCHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCEECC
>Mature Secondary Structure 
TVRVRIAPSPTGNLHIGTARTAVFNWLFARHHGGTFILRIEDTDLERSRPEYTENIMTG
EEEEEECCCCCCCEEECHHHHHHHHHHHHEECCCEEEEEEECCCCCCCCCHHHHHHHHH
LRWLGLNWDEGPFFQSQRLDLYQKAVKQLLDQGLAYRCYTTSEELEALREGQKAKGEAPR
HHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHCCHHCCCCCCC
YDNRHRHLTPEQEAEFKAQGRSFVIRFKIDDEREIVWNDLVRGKMSWRGSDLGGDMVIAR
CCCCCCCCCCCHHHHHHHCCCEEEEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCEEEEE
ASENDTGQPLYNFVVVIDDIDMQISHVIRGEDHIANTAKQILLYEAFGAKIPEFAHTPLI
CCCCCCCCCEEEEEEEEECCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEE
LNMEGRKLSKRDGVTSISDFKQMGFTSEGLVNYMTLLGWSPPDSTQEIFTLEAAAKEFTF
EEECCCCCHHHCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHEEHHHHHHHHHH
ERVNKAGAKFDWAKLDWLNSQYIHNTPVDQLTDLLIPYWEAAGYSLAGGRDRPWLEQLVG
HHHHHCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
LLSASLTRLTDAVDMSKLFFTETVELSEEGSKQLQQEGSKAVLEAIIAALETQAQLTETA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
AQDIIKQVVKGQNVKKGLVMRSLRVALTGDVHGPDLIQSWLLLNQIGLDKPRLNQAIAVS
HHHHHHHHHCCCCCHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA