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The map label for this gene is phoR [H]

Identifier: 17230659

GI number: 17230659

Start: 3832498

End: 3833760

Strand: Reverse

Name: phoR [H]

Synonym: all3167

Alternate gene names: 17230659

Gene position: 3833760-3832498 (Counterclockwise)

Preceding gene: 17230661

Following gene: 17230656

Centisome position: 59.77

GC content: 42.12

Gene sequence:

>1263_bases
ATGTTTAATCGCAGTCGTCGCAATCTTGCCAGTTGGTTCACCCTCGCAATGGGGGGTATTTTAGTTGTGTTTGCGGCGGC
GGTCTATTATGTGAAGGTCATAGATGAGTTAGAAGAACTAGATCAATTACTGTATAAAAAAACTACCGTGATGGCGGCGA
GTGTGAGGACAGATCTGGACAATCGTCAACGCAGGGTAGATTTGGACAAAGTACCTCTGTTGGGAACGAAGGTAGAGCCA
CTGTCAGATAGTCAATTAGTGTATGCAGGTTGGTATGATGAGCAGAAGCGACTAGTGCAGTTTTTTGGTGAAACTCCGAG
CGATCGCCTGTTAGTTGCTAGTGGATTTAATACTATTAAAATTCATAGGGAGTTATGGTTACGTCGGGTAACTTTGCCTG
TTTACCAGGATGGCTTATTAATTGGCTATATGCAGGCTGCAATGCCATTGACAGAGACGGAAGGTGCTTTAGCGGAGTTT
CGGCTTGTTTTGGCTATTTCAGTCCCCATTACTTTAGGAATTATTGCTTTGACTGGTTGGTGGCTGGGGGGAGTGGCGAT
GCAACCAATTCGCCAAAGTTACGATTATCTCCAAAGGTTTACGGCTGATGCTTCCCATGAATTGCGATCGCCTCTATCTG
CTATTGTCAGTAATGCCCAGTATGGCTTACTAACAAAGTCTACTGACCCAGAAACCCAACGTCAGCGCCTACAAAAGATT
TTTGATATTGCCCAGTCAATGAGTATCCTGGTCAATGATTTGTTATTTTTAGCACGTTATCAAGGGCGCATACCCATCGA
ATCTTTGCAAACCGTTGACCTAAAAATTTTACTTTTGCAAATCCAAGATGATTTTCTTCCCCATCCAGAAACGCAACACA
TCAAGTTACTTTTCACACTACCAAATCATCATGTCAGCGTTCTTGGTGATGCTAATCTACTCCGTCAAGCAGTCATCAAT
TTACTGAGTAATGCTTGTAAATATACTCCTGAAGGTGGTCAGGTGGAGTTACAGTTATTTACTCAGTCAAATTGGGCTGT
AATTCAAGTTGTAGATAATGGTATTGGCATTCCTCAAGATGATGTACCATACATTTTTGAACGATTTTATCGGGTAGATA
AAAAGCGTTCTCGTAAGACTGGTGGGTTTGGGTTGGGATTAGCTATTACCCAACAAATCATCCAATCTCATGGCGGTAAG
ATTAATGTTCACAGTGCAGTAAATCAAGGTGCAACTTTTCAAGTGTTATTACCTCTGAAATAG

Upstream 100 bases:

>100_bases
CAGGTGAAGGTAGGGAATGGGGGAAGAGTGTAGATAATGGTGGTGGTTCTATAGTGGGGAGAGGAACCAATGACAACTGA
CAACTAACAACTGACCAATT

Downstream 100 bases:

>100_bases
AGTTATCAAGTATTAGCGTAAGCAATAGTACTAAGCAGGGCATTTTCCGCTTGTCGTGAGTCTAGGCGAGTGTGTTGAAC
AACAATCGGCACATTTGATT

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MFNRSRRNLASWFTLAMGGILVVFAAAVYYVKVIDELEELDQLLYKKTTVMAASVRTDLDNRQRRVDLDKVPLLGTKVEP
LSDSQLVYAGWYDEQKRLVQFFGETPSDRLLVASGFNTIKIHRELWLRRVTLPVYQDGLLIGYMQAAMPLTETEGALAEF
RLVLAISVPITLGIIALTGWWLGGVAMQPIRQSYDYLQRFTADASHELRSPLSAIVSNAQYGLLTKSTDPETQRQRLQKI
FDIAQSMSILVNDLLFLARYQGRIPIESLQTVDLKILLLQIQDDFLPHPETQHIKLLFTLPNHHVSVLGDANLLRQAVIN
LLSNACKYTPEGGQVELQLFTQSNWAVIQVVDNGIGIPQDDVPYIFERFYRVDKKRSRKTGGFGLGLAITQQIIQSHGGK
INVHSAVNQGATFQVLLPLK

Sequences:

>Translated_420_residues
MFNRSRRNLASWFTLAMGGILVVFAAAVYYVKVIDELEELDQLLYKKTTVMAASVRTDLDNRQRRVDLDKVPLLGTKVEP
LSDSQLVYAGWYDEQKRLVQFFGETPSDRLLVASGFNTIKIHRELWLRRVTLPVYQDGLLIGYMQAAMPLTETEGALAEF
RLVLAISVPITLGIIALTGWWLGGVAMQPIRQSYDYLQRFTADASHELRSPLSAIVSNAQYGLLTKSTDPETQRQRLQKI
FDIAQSMSILVNDLLFLARYQGRIPIESLQTVDLKILLLQIQDDFLPHPETQHIKLLFTLPNHHVSVLGDANLLRQAVIN
LLSNACKYTPEGGQVELQLFTQSNWAVIQVVDNGIGIPQDDVPYIFERFYRVDKKRSRKTGGFGLGLAITQQIIQSHGGK
INVHSAVNQGATFQVLLPLK
>Mature_420_residues
MFNRSRRNLASWFTLAMGGILVVFAAAVYYVKVIDELEELDQLLYKKTTVMAASVRTDLDNRQRRVDLDKVPLLGTKVEP
LSDSQLVYAGWYDEQKRLVQFFGETPSDRLLVASGFNTIKIHRELWLRRVTLPVYQDGLLIGYMQAAMPLTETEGALAEF
RLVLAISVPITLGIIALTGWWLGGVAMQPIRQSYDYLQRFTADASHELRSPLSAIVSNAQYGLLTKSTDPETQRQRLQKI
FDIAQSMSILVNDLLFLARYQGRIPIESLQTVDLKILLLQIQDDFLPHPETQHIKLLFTLPNHHVSVLGDANLLRQAVIN
LLSNACKYTPEGGQVELQLFTQSNWAVIQVVDNGIGIPQDDVPYIFERFYRVDKKRSRKTGGFGLGLAITQQIIQSHGGK
INVHSAVNQGATFQVLLPLK

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=226, Percent_Identity=33.1858407079646, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1786783, Length=252, Percent_Identity=29.7619047619048, Blast_Score=111, Evalue=7e-26,
Organism=Escherichia coli, GI1789149, Length=225, Percent_Identity=35.1111111111111, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1790346, Length=224, Percent_Identity=31.25, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1788393, Length=224, Percent_Identity=32.1428571428571, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI48994928, Length=220, Percent_Identity=33.6363636363636, Blast_Score=98, Evalue=8e-22,
Organism=Escherichia coli, GI145693157, Length=238, Percent_Identity=31.0924369747899, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1790861, Length=225, Percent_Identity=30.2222222222222, Blast_Score=92, Evalue=9e-20,
Organism=Escherichia coli, GI87081816, Length=224, Percent_Identity=31.25, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1789403, Length=218, Percent_Identity=32.1100917431193, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1786912, Length=217, Percent_Identity=29.4930875576037, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1787894, Length=215, Percent_Identity=31.6279069767442, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1790436, Length=225, Percent_Identity=28.8888888888889, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1788279, Length=230, Percent_Identity=26.9565217391304, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1790551, Length=202, Percent_Identity=31.1881188118812, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1788549, Length=226, Percent_Identity=29.646017699115, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788713, Length=230, Percent_Identity=29.1304347826087, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI87082128, Length=224, Percent_Identity=27.2321428571429, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1789808, Length=238, Percent_Identity=26.4705882352941, Blast_Score=68, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 47334; Mature: 47334

Theoretical pI: Translated: 8.77; Mature: 8.77

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNRSRRNLASWFTLAMGGILVVFAAAVYYVKVIDELEELDQLLYKKTTVMAASVRTDLD
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
NRQRRVDLDKVPLLGTKVEPLSDSQLVYAGWYDEQKRLVQFFGETPSDRLLVASGFNTIK
CHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHCCCCCCCEEEECCCCEEE
IHRELWLRRVTLPVYQDGLLIGYMQAAMPLTETEGALAEFRLVLAISVPITLGIIALTGW
EHHHHHHHHHCCCCCCCCHHEEHHHHHCCCCCCCCHHHHEEEEEEEECHHHHHHHHHHHH
WLGGVAMQPIRQSYDYLQRFTADASHELRSPLSAIVSNAQYGLLTKSTDPETQRQRLQKI
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHH
FDIAQSMSILVNDLLFLARYQGRIPIESLQTVDLKILLLQIQDDFLPHPETQHIKLLFTL
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCEEEEEEEECCCCCCCCCCCEEEEEEEE
PNHHVSVLGDANLLRQAVINLLSNACKYTPEGGQVELQLFTQSNWAVIQVVDNGIGIPQD
CCCCEEEECCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCEEEEEEECCCCCCCC
DVPYIFERFYRVDKKRSRKTGGFGLGLAITQQIIQSHGGKINVHSAVNQGATFQVLLPLK
CHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCEEEEEHHCCCCCEEEEEEECC
>Mature Secondary Structure
MFNRSRRNLASWFTLAMGGILVVFAAAVYYVKVIDELEELDQLLYKKTTVMAASVRTDLD
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
NRQRRVDLDKVPLLGTKVEPLSDSQLVYAGWYDEQKRLVQFFGETPSDRLLVASGFNTIK
CHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHCCCCCCCEEEECCCCEEE
IHRELWLRRVTLPVYQDGLLIGYMQAAMPLTETEGALAEFRLVLAISVPITLGIIALTGW
EHHHHHHHHHCCCCCCCCHHEEHHHHHCCCCCCCCHHHHEEEEEEEECHHHHHHHHHHHH
WLGGVAMQPIRQSYDYLQRFTADASHELRSPLSAIVSNAQYGLLTKSTDPETQRQRLQKI
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHH
FDIAQSMSILVNDLLFLARYQGRIPIESLQTVDLKILLLQIQDDFLPHPETQHIKLLFTL
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCEEEEEEEECCCCCCCCCCCEEEEEEEE
PNHHVSVLGDANLLRQAVINLLSNACKYTPEGGQVELQLFTQSNWAVIQVVDNGIGIPQD
CCCCEEEECCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCEEEEEEECCCCCCCC
DVPYIFERFYRVDKKRSRKTGGFGLGLAITQQIIQSHGGKINVHSAVNQGATFQVLLPLK
CHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCEEEEEHHCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]