Click here to switch to the map view.

The map label for this gene is hemN [H]

Identifier: 17230618

GI number: 17230618

Start: 3785366

End: 3786748

Strand: Direct

Name: hemN [H]

Synonym: alr3126

Alternate gene names: 17230618

Gene position: 3785366-3786748 (Clockwise)

Preceding gene: 17230617

Following gene: 17230625

Centisome position: 59.02

GC content: 39.84

Gene sequence:

>1383_bases
ATGGTTTTTGTCTTACCTGGTGTCAAGTTTGATCTAGACATGATCAAAAAATATGACACTCCTGCACCTAGATATACCAG
TTATCCACCCGCTACACAGTTAACTGAAGGATTCAGCGCCGCCGATTATCAAAGTGCGATCGCCGCCTCAAATCACAGAA
AATCGCCCATATCGTTGTATTTCCACATTCCCTTTTGTCAGAGTTCCTGTTATTTTTGCGGTTGTAATACGGTCATTTCC
AACAACAAAAATATTGCTAAACCATACTTAGAGCATCTGGTGAGAGAAATCAAGCATACAAGTAACTTGATTGATCCAGA
TAGAAAAGTATTGCAAGTTCACTGGGGTGGTGGGACACCTAATTACTTAGATTGTGACCAAGTAGAATTTTTGTGGAAAC
ATATTCATCGCCACTTCAATATTGATCCACAGGCAGAAATATCTGTTGAGATTAACCCCCGCTACGTTGATCAAAATTAC
ATCTCCTTTTTGCGTGAGATTGGTTTTAATCGGATTAGTTTTGGTATTCAGGATTTTAATAGCCAAGTACAAAAAGCTGT
CAACCGCATCCAACCGGAAGAACTGCTAGTGAATGTCATGAGTTGGATTAAAGCTGCTAAATTTGATAGTGTAAATGTAG
ACCTAATTTATGGTTTACCCCATCAAACCTTGCAAACATTTCGGGAGACGGTGAAAAAAACCGTTGCATTAGACCCCGAT
CGCATTGTAGTTTTTAACTTTGCCTACGTTCCTTGGTTGAAGCCAGCCCAGAAAAATATTCCCCTGGAGGCGTTACCCCA
ACCGCAGGAAAAGCTGGAAATTTTAAAAATGACTATTGAGGAACTGACTAATAGCCAGTACCTATTTATCGGGATGGATC
ATTTTGCCAAACATAACGATGAGTTAGCGATCGCCCAACGTAACCACACCCTCCAGCGCAACTTCCAAGGTTACACCACC
CACGCCGGTACAGAACTTTTCGGCTTTGGTGCGACATCTATTAGTATGCTGCATGATGCTTATGTGCAGAATCACAAGCA
GTTAAAAGAATATTATCAAGCCGTTGCTGGTGATGCTTTACCTGTGAGCAAGGGTATCAAACTCACAACCGATGATATTC
TCAGACGGGATGTGATTATGTGTATCATGTCTAACTTTTATCTGCATAAACAAGAGATTGAGGACAAATATCACATTAAT
TTTGATGAATATTTCTCTCAAGAAATTGCAGCTTTAAAACCATTAGCGGCTGATGGATTAGTTAGTCTTTCCAGCAAACA
CATCCAAGTAACAGAAATCGGTAGATTACTAGTAAGGAATATCGCTGTTGTCTTTGATATTTATCACCACAATCAAGACA
AACAATTCTCTCGGACTATTTAA

Upstream 100 bases:

>100_bases
TCGATAGGTGTTGTTGAATTTTGTAGCGCTTGCGCTTCCCATAGGGTATTTTGACTTCCACGTAGCGGCATGGTGTGGTT
GCAGTACCTTGGAGGTTTTG

Downstream 100 bases:

>100_bases
TTCAGAGGGGCGCGGGGTGAGACAGCGCGGTCTTGGGGGTTTCCCCCATAAGCGACTGCGAACCCGAAGGGCTGAGGTAT
GGGAGAAAAATTTACCTAGT

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MVFVLPGVKFDLDMIKKYDTPAPRYTSYPPATQLTEGFSAADYQSAIAASNHRKSPISLYFHIPFCQSSCYFCGCNTVIS
NNKNIAKPYLEHLVREIKHTSNLIDPDRKVLQVHWGGGTPNYLDCDQVEFLWKHIHRHFNIDPQAEISVEINPRYVDQNY
ISFLREIGFNRISFGIQDFNSQVQKAVNRIQPEELLVNVMSWIKAAKFDSVNVDLIYGLPHQTLQTFRETVKKTVALDPD
RIVVFNFAYVPWLKPAQKNIPLEALPQPQEKLEILKMTIEELTNSQYLFIGMDHFAKHNDELAIAQRNHTLQRNFQGYTT
HAGTELFGFGATSISMLHDAYVQNHKQLKEYYQAVAGDALPVSKGIKLTTDDILRRDVIMCIMSNFYLHKQEIEDKYHIN
FDEYFSQEIAALKPLAADGLVSLSSKHIQVTEIGRLLVRNIAVVFDIYHHNQDKQFSRTI

Sequences:

>Translated_460_residues
MVFVLPGVKFDLDMIKKYDTPAPRYTSYPPATQLTEGFSAADYQSAIAASNHRKSPISLYFHIPFCQSSCYFCGCNTVIS
NNKNIAKPYLEHLVREIKHTSNLIDPDRKVLQVHWGGGTPNYLDCDQVEFLWKHIHRHFNIDPQAEISVEINPRYVDQNY
ISFLREIGFNRISFGIQDFNSQVQKAVNRIQPEELLVNVMSWIKAAKFDSVNVDLIYGLPHQTLQTFRETVKKTVALDPD
RIVVFNFAYVPWLKPAQKNIPLEALPQPQEKLEILKMTIEELTNSQYLFIGMDHFAKHNDELAIAQRNHTLQRNFQGYTT
HAGTELFGFGATSISMLHDAYVQNHKQLKEYYQAVAGDALPVSKGIKLTTDDILRRDVIMCIMSNFYLHKQEIEDKYHIN
FDEYFSQEIAALKPLAADGLVSLSSKHIQVTEIGRLLVRNIAVVFDIYHHNQDKQFSRTI
>Mature_460_residues
MVFVLPGVKFDLDMIKKYDTPAPRYTSYPPATQLTEGFSAADYQSAIAASNHRKSPISLYFHIPFCQSSCYFCGCNTVIS
NNKNIAKPYLEHLVREIKHTSNLIDPDRKVLQVHWGGGTPNYLDCDQVEFLWKHIHRHFNIDPQAEISVEINPRYVDQNY
ISFLREIGFNRISFGIQDFNSQVQKAVNRIQPEELLVNVMSWIKAAKFDSVNVDLIYGLPHQTLQTFRETVKKTVALDPD
RIVVFNFAYVPWLKPAQKNIPLEALPQPQEKLEILKMTIEELTNSQYLFIGMDHFAKHNDELAIAQRNHTLQRNFQGYTT
HAGTELFGFGATSISMLHDAYVQNHKQLKEYYQAVAGDALPVSKGIKLTTDDILRRDVIMCIMSNFYLHKQEIEDKYHIN
FDEYFSQEIAALKPLAADGLVSLSSKHIQVTEIGRLLVRNIAVVFDIYHHNQDKQFSRTI

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Escherichia coli, GI87082341, Length=455, Percent_Identity=47.2527472527472, Blast_Score=437, Evalue=1e-124,
Organism=Escherichia coli, GI1789325, Length=196, Percent_Identity=27.0408163265306, Blast_Score=97, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 52931; Mature: 52931

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVFVLPGVKFDLDMIKKYDTPAPRYTSYPPATQLTEGFSAADYQSAIAASNHRKSPISLY
CEEEECCCCCCHHHHHHCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHCCCCCCCEEEE
FHIPFCQSSCYFCGCNTVISNNKNIAKPYLEHLVREIKHTSNLIDPDRKVLQVHWGGGTP
EEEEECCCCCEEEECCCEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCC
NYLDCDQVEFLWKHIHRHFNIDPQAEISVEINPRYVDQNYISFLREIGFNRISFGIQDFN
CCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCEECCHHHHHHHHHHCCCHHHHHHHHHH
SQVQKAVNRIQPEELLVNVMSWIKAAKFDSVNVDLIYGLPHQTLQTFRETVKKTVALDPD
HHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCC
RIVVFNFAYVPWLKPAQKNIPLEALPQPQEKLEILKMTIEELTNSQYLFIGMDHFAKHND
CEEEEEEEECCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECHHHHCCCC
ELAIAQRNHTLQRNFQGYTTHAGTELFGFGATSISMLHDAYVQNHKQLKEYYQAVAGDAL
CEEEEECCCHHHHCCCCCEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PVSKGIKLTTDDILRRDVIMCIMSNFYLHKQEIEDKYHINFDEYFSQEIAALKPLAADGL
CCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHCCCCCCCH
VSLSSKHIQVTEIGRLLVRNIAVVFDIYHHNQDKQFSRTI
HHHCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCC
>Mature Secondary Structure
MVFVLPGVKFDLDMIKKYDTPAPRYTSYPPATQLTEGFSAADYQSAIAASNHRKSPISLY
CEEEECCCCCCHHHHHHCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHCCCCCCCEEEE
FHIPFCQSSCYFCGCNTVISNNKNIAKPYLEHLVREIKHTSNLIDPDRKVLQVHWGGGTP
EEEEECCCCCEEEECCCEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCC
NYLDCDQVEFLWKHIHRHFNIDPQAEISVEINPRYVDQNYISFLREIGFNRISFGIQDFN
CCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCEECCHHHHHHHHHHCCCHHHHHHHHHH
SQVQKAVNRIQPEELLVNVMSWIKAAKFDSVNVDLIYGLPHQTLQTFRETVKKTVALDPD
HHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCC
RIVVFNFAYVPWLKPAQKNIPLEALPQPQEKLEILKMTIEELTNSQYLFIGMDHFAKHND
CEEEEEEEECCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECHHHHCCCC
ELAIAQRNHTLQRNFQGYTTHAGTELFGFGATSISMLHDAYVQNHKQLKEYYQAVAGDAL
CEEEEECCCHHHHCCCCCEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PVSKGIKLTTDDILRRDVIMCIMSNFYLHKQEIEDKYHINFDEYFSQEIAALKPLAADGL
CCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHCCCCCCCH
VSLSSKHIQVTEIGRLLVRNIAVVFDIYHHNQDKQFSRTI
HHHCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]