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The map label for this gene is arsB [C]

Identifier: 17230525

GI number: 17230525

Start: 3673118

End: 3674503

Strand: Reverse

Name: arsB [C]

Synonym: all3033

Alternate gene names: 17230525

Gene position: 3674503-3673118 (Counterclockwise)

Preceding gene: 17230526

Following gene: 17230524

Centisome position: 57.29

GC content: 39.47

Gene sequence:

>1386_bases
GTGACTTTTTTCGCTATTACGCAACAATATAAGCTACAAGAGGTAGGCGTGGAAAACTGGCAAGCACTCCTAAGTGTCAT
CGTATTTATCAGTGTCATCTTTCTAGTTATGACGGAATGGGTGCATTTGACTATTGCAGCCTTATTAGGAGCATTATTAT
TAGTATTTACTAATGTGATGACTTTACAGGAAGCTGTTGCTTACATTGGTAATAGTTATGGCACACTGGGATTATTTTTT
GGTGTAATGGTTTTAGTTAGAGCATTTGAGCCTACTAAGATATTTGATTATTTGGCAACCCAAATAGTGATATTAGCTAA
AGGCGATGGTAAGCGTCTTTTACTCGGTATTGTTGCTATTGTTACTCCTATTTGTGCAGTTTTACCAAATGCAACAACAG
TGATGTTGTTAGCGCCACTAATTCCACCAATGGCACAAGAAATAGGGATAAATTTTGTACCTTTATTGATATTGATGGTT
TTGATTGCCAATAGTGCTGGATTGCTGACATTAGTAGGTGACCCAGCAACATTTATTGTAGGTGATGCTGTCAATATAAG
TTTTATAGATTATCTATGGAAACTGAGTTTAGGTGGTGTCATTGCAGTCGCTGTGGTAACTCTCACTTTGCCATTTTTAT
TCCGCAAAATTTGGCATACAAAATTAGAGAATCTGGAAGAATTACCACACCCAGAAATTAATCATCCACGGGTTTTGAGT
CTGGGTGCAGTAATTGTCGCTTTTGTCCTGCTATTTTTTGTGATTGGAGAATCCCTGCCAATACCGATTTCCCCGGCGGC
TGTGGCTCTGTTAGGCGCAGCTTTGGCTTTACTACTATCTCACCATAGCAAAATTGATACAGTCAACAATATTTTGCGCG
ATGTAGACTGGAGTACATTAATATTTTTTATGAGTATTTTTGTGCTGATTGGAGGATTAGAAAAAACAGGCGTAATTGGT
GGTCTATCAGGGATATTGGCAGCTATTTTAGGAAAAAATATTATCTTGGGTTCTCTGGTGTTGTTGTTTCTTGTAGGAAT
TTTATCGAGTGTCGTACCTAATATTCCCTTGGTAGTGGCGATGGTTCCCCTGCTCAAGCAATACCTTGTCACTGTAGGAT
TAGCACCCGCAGAAGTCTTAGCACGCGACTTTCAAGGACAATTTCCCCCAGAAGTTTTACCATTGTTTTACGCCATGATG
TTTGGTGCAACCTTAGGCGGGAATGGTACGTTAGTTGGTGCATCGTCTAACATCGTAGCGGCGGGAATTTCCGAACAGCA
CGGACGACGGATTTCTTTTAAAACTTTTCTTCACTATGGTATTCCAGTCACAATATTACAACTAATTGCCTCAGCATTGT
ATGTGTTAATCCGGTTTCTGATTTAG

Upstream 100 bases:

>100_bases
GTCTTAGGGATTCCTGAATGTATAGATGAATAATTCTGACCCCGACTTTCAGAAGTTATTTATCTAAATGAAAATACAGA
AAAAAGTCACCATATTTTAG

Downstream 100 bases:

>100_bases
AAAGATTTATTTATATTCAGTGAAAATTAGATATGTTTATACTGGTAGAGAGTGTAATCATACACTCTTGCCTAGAATGG
TATTATTGAGTGTAATATGC

Product: hypothetical protein

Products: ADP; phosphate; arsenite [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MTFFAITQQYKLQEVGVENWQALLSVIVFISVIFLVMTEWVHLTIAALLGALLLVFTNVMTLQEAVAYIGNSYGTLGLFF
GVMVLVRAFEPTKIFDYLATQIVILAKGDGKRLLLGIVAIVTPICAVLPNATTVMLLAPLIPPMAQEIGINFVPLLILMV
LIANSAGLLTLVGDPATFIVGDAVNISFIDYLWKLSLGGVIAVAVVTLTLPFLFRKIWHTKLENLEELPHPEINHPRVLS
LGAVIVAFVLLFFVIGESLPIPISPAAVALLGAALALLLSHHSKIDTVNNILRDVDWSTLIFFMSIFVLIGGLEKTGVIG
GLSGILAAILGKNIILGSLVLLFLVGILSSVVPNIPLVVAMVPLLKQYLVTVGLAPAEVLARDFQGQFPPEVLPLFYAMM
FGATLGGNGTLVGASSNIVAAGISEQHGRRISFKTFLHYGIPVTILQLIASALYVLIRFLI

Sequences:

>Translated_461_residues
MTFFAITQQYKLQEVGVENWQALLSVIVFISVIFLVMTEWVHLTIAALLGALLLVFTNVMTLQEAVAYIGNSYGTLGLFF
GVMVLVRAFEPTKIFDYLATQIVILAKGDGKRLLLGIVAIVTPICAVLPNATTVMLLAPLIPPMAQEIGINFVPLLILMV
LIANSAGLLTLVGDPATFIVGDAVNISFIDYLWKLSLGGVIAVAVVTLTLPFLFRKIWHTKLENLEELPHPEINHPRVLS
LGAVIVAFVLLFFVIGESLPIPISPAAVALLGAALALLLSHHSKIDTVNNILRDVDWSTLIFFMSIFVLIGGLEKTGVIG
GLSGILAAILGKNIILGSLVLLFLVGILSSVVPNIPLVVAMVPLLKQYLVTVGLAPAEVLARDFQGQFPPEVLPLFYAMM
FGATLGGNGTLVGASSNIVAAGISEQHGRRISFKTFLHYGIPVTILQLIASALYVLIRFLI
>Mature_460_residues
TFFAITQQYKLQEVGVENWQALLSVIVFISVIFLVMTEWVHLTIAALLGALLLVFTNVMTLQEAVAYIGNSYGTLGLFFG
VMVLVRAFEPTKIFDYLATQIVILAKGDGKRLLLGIVAIVTPICAVLPNATTVMLLAPLIPPMAQEIGINFVPLLILMVL
IANSAGLLTLVGDPATFIVGDAVNISFIDYLWKLSLGGVIAVAVVTLTLPFLFRKIWHTKLENLEELPHPEINHPRVLSL
GAVIVAFVLLFFVIGESLPIPISPAAVALLGAALALLLSHHSKIDTVNNILRDVDWSTLIFFMSIFVLIGGLEKTGVIGG
LSGILAAILGKNIILGSLVLLFLVGILSSVVPNIPLVVAMVPLLKQYLVTVGLAPAEVLARDFQGQFPPEVLPLFYAMMF
GATLGGNGTLVGASSNIVAAGISEQHGRRISFKTFLHYGIPVTILQLIASALYVLIRFLI

Specific function: Involved In Arsenical Resistance. Thought To Form The Channel Of An Arsenite Pump (By Similarity). [C]

COG id: COG1055

COG function: function code P; Na+/H+ antiporter NhaD and related arsenite permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CitM (TC 2.A.11) transporter family [H]

Homologues:

Organism=Homo sapiens, GI157266326, Length=248, Percent_Identity=32.6612903225806, Blast_Score=107, Evalue=3e-23,
Organism=Escherichia coli, GI87082277, Length=443, Percent_Identity=23.7020316027088, Blast_Score=73, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24581759, Length=461, Percent_Identity=28.1995661605206, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI19920704, Length=461, Percent_Identity=28.1995661605206, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI28574683, Length=247, Percent_Identity=33.1983805668016, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI28574681, Length=247, Percent_Identity=33.1983805668016, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI28574685, Length=247, Percent_Identity=33.1983805668016, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI28574678, Length=247, Percent_Identity=33.1983805668016, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI45550608, Length=498, Percent_Identity=26.9076305220884, Blast_Score=110, Evalue=3e-24,
Organism=Drosophila melanogaster, GI221472711, Length=177, Percent_Identity=29.9435028248588, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24581764, Length=177, Percent_Identity=29.9435028248588, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI62484377, Length=470, Percent_Identity=23.1914893617021, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI85724998, Length=470, Percent_Identity=22.9787234042553, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24656008, Length=472, Percent_Identity=23.9406779661017, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000802
- InterPro:   IPR004680 [H]

Pfam domain/function: PF03600 CitMHS [H]

EC number: NA

Molecular weight: Translated: 49535; Mature: 49403

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFFAITQQYKLQEVGVENWQALLSVIVFISVIFLVMTEWVHLTIAALLGALLLVFTNVM
CCEEEEHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLQEAVAYIGNSYGTLGLFFGVMVLVRAFEPTKIFDYLATQIVILAKGDGKRLLLGIVAI
HHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHEEEEECCCCCHHHHHHHHH
VTPICAVLPNATTVMLLAPLIPPMAQEIGINFVPLLILMVLIANSAGLLTLVGDPATFIV
HHHHHHHCCCCHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHCCCCEEEEECCCCEEEE
GDAVNISFIDYLWKLSLGGVIAVAVVTLTLPFLFRKIWHTKLENLEELPHPEINHPRVLS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
LGAVIVAFVLLFFVIGESLPIPISPAAVALLGAALALLLSHHSKIDTVNNILRDVDWSTL
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHH
IFFMSIFVLIGGLEKTGVIGGLSGILAAILGKNIILGSLVLLFLVGILSSVVPNIPLVVA
HHHHHHHHHHCCCHHHCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCHHHHH
MVPLLKQYLVTVGLAPAEVLARDFQGQFPPEVLPLFYAMMFGATLGGNGTLVGASSNIVA
HHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCEEEECCCCEEE
AGISEQHGRRISFKTFLHYGIPVTILQLIASALYVLIRFLI
ECCCHHCCCEEHHHHHHHHCCHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
TFFAITQQYKLQEVGVENWQALLSVIVFISVIFLVMTEWVHLTIAALLGALLLVFTNVM
CEEEEHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLQEAVAYIGNSYGTLGLFFGVMVLVRAFEPTKIFDYLATQIVILAKGDGKRLLLGIVAI
HHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHEEEEECCCCCHHHHHHHHH
VTPICAVLPNATTVMLLAPLIPPMAQEIGINFVPLLILMVLIANSAGLLTLVGDPATFIV
HHHHHHHCCCCHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHCCCCEEEEECCCCEEEE
GDAVNISFIDYLWKLSLGGVIAVAVVTLTLPFLFRKIWHTKLENLEELPHPEINHPRVLS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
LGAVIVAFVLLFFVIGESLPIPISPAAVALLGAALALLLSHHSKIDTVNNILRDVDWSTL
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHH
IFFMSIFVLIGGLEKTGVIGGLSGILAAILGKNIILGSLVLLFLVGILSSVVPNIPLVVA
HHHHHHHHHHCCCHHHCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCHHHHH
MVPLLKQYLVTVGLAPAEVLARDFQGQFPPEVLPLFYAMMFGATLGGNGTLVGASSNIVA
HHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCEEEECCCCEEE
AGISEQHGRRISFKTFLHYGIPVTILQLIASALYVLIRFLI
ECCCHHCCCEEHHHHHHHHCCHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; arsenite [Cytoplasm]; H2O [C]

Specific reaction: ATP + arsenite [Cytoplasm] + H2O = ADP + phosphate + arsenite [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]