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The map label for this gene is clpB [H]

Identifier: 17230491

GI number: 17230491

Start: 3642344

End: 3644863

Strand: Direct

Name: clpB [H]

Synonym: alr2999

Alternate gene names: 17230491

Gene position: 3642344-3644863 (Clockwise)

Preceding gene: 17230490

Following gene: 17230493

Centisome position: 56.79

GC content: 49.56

Gene sequence:

>2520_bases
GTGCTAAAATCAGCGTACCGGCACGACGCAGGTGATGGGAAAAATGCCATGTTTGAACGCTTCACAGAAAAAGCCATTAA
GGTAATCATGCTGGCCCAAGAAGAGGCCCGCCGTTTAGGTCACAACTTCGTCGGAACCGAACAGATCCTCTTGGGTCTGA
TCGGGGAAGGTACGGGAGTTGCGGCCAAGGTGCTGAAATCGATGGGTGTCAATCTCAAAGATGCCCGCATTGAGGTAGAA
AAAATCATAGGCCGGGGTTCAGGCTTTGTGGCCGTGGAAATTCCGTTTACGCCACGGGCAAAGCGGGTTCTGGAACTATC
CCTAGAAGAAGCGCGCCAATTAGGCCATAACTACATTGGCACCGAGCATCTGCTGTTGGGCCTGATCCGGGAAGGGGAAG
GTGTGGCAGCCAGGGTGCTAGAAAACCTGGGGGTGGATCTATCTAAAGTTAGAACTCAAGTCATCCGAATGCTGGGAGAA
ACAGCAGAGGTTTCGGCGACCGGGCAATCGGGACGCACCAAAACACCTACTTTGGATGAATTCGGATCGAACCTGACCCA
AATGGCAACTGATAACAAGCTTGATCCTGTGGTGGGACGCGCCAAGGAAATCGAGCGAGTGATTCAGATTTTGGGTCGCC
GGACAAAAAATAACCCCGTATTGATTGGTGAACCTGGGGTTGGTAAAACCGCGATCGCCGAAGGTCTAGCATCACGCATT
GCTAACAAAGATGTCCCCGACATCCTTGAAGATAAGCGTGTTGTCACTCTAGATATCGGTCTACTGGTCGCAGGCACCAA
GTACCGGGGTGAATTTGAAGAACGCTTGAAGAAAATCATGGATGAGATTCGTCAAGCGGGTAATGTAATACTTGTAATAG
ACGAAGTACACACCCTCATCGGTGCAGGTGCTGCCGAAGGTGCGATTGATGCGGCAAATATCCTCAAGCCAGCCTTGGCA
AGAGGTGAATTGCAATGTATCGGTGCGACAACCTTAGATGAGTACCGCAAGCACATCGAACGGGACGCAGCGCTAGAACG
CCGCTTCCAGCCAGTGATGGTCGGTGAACCCTCCGTCGATGAAACAATAGAAATTTTATATGGTTTGCGCGATCGCTACG
AGCAACACCACAAGCTGAAAATCTCCGATGAAGCTTTAGTCGCGGCGGCGAAATTATCTGATCGTTATATTAGCGATCGC
TATCTGCCAGACAAAGCCATCGACTTGGTTGACGAAGCTGGTTCGCGCGTGCGGTTGATGAACTCTCAGCTGCCCCCCGC
AGCCAAAGAGTTAGATAAAGAACTGCGCCAAATCTTAAAAGAAAAAGATGATGCAGTCCGTTCCCAAGACTTTGACAGAG
CTGGGGAACTGCGCGATCGGGAAATGGAAATCAAAGCCGAAATCCGCGCGATCGCCCAAAGCAAGACCAATGCTTCTGGT
ACCGAAGGTCAAGAACCTGTAGTTACAGAAGAAGACATTGCTCACATCGTGGCTTCGTGGACAGGCGTTCCCGTCAACAA
GCTCACCGAATCTGAATCCGAAAAGCTGCTGCACATGGAAGATACCTTGCACCAGCGCTTAATCGGACAAGAAGATGCGG
TAAAAGCAGTTTCACGGGCAATTCGTCGCGCTCGTGTCGGTTTGAAAAATCCCAACCGACCCATTGCTAGCTTTGTCTTC
TCTGGGCCGACTGGTGTTGGTAAAACCGAGTTGGCGAAATCCTTGGCTTCCTACTTCTTCGGTTCCGAAGAAGCAATGAT
TCGCTTGGATATGTCCGAGTACATGGAACGCCACACCGTCAGCAAGTTGATTGGTTCACCTCCTGGTTATGTTGGTTATA
ACGAAGGTGGTCAATTAACCGAAGCTGTGCGCCGTCGTCCTTACACAGTGGTGCTGTTCGACGAAATCGAAAAAGCCCAC
CCCGATGTCTTCAATATGCTGCTGCAAATTTTAGAAGATGGTCGGTTAACAGATGCGAAAGGACGCACCGTAGACTTCAA
GAACACCTTGCTGATTTTGACATCCAACATCGGTTCCAAGGTAATTGAAAAAGGTGGTGGTGGTATCGGCTTCGAGTTCT
CCGAAGATCAAACCGAAACACAATACAACCGCATTCGCTCCTTGGTGAACGAAGAACTGAAGCAATACTTCCGTCCTGAG
TTCCTCAACCGTCTAGACGAGATTATCGTCTTCCGTCAGTTGAGCAAGCTAGAAGTTACCGAAATTGCGGACATTATGCT
CAAAGAAGTGTTTGGTCGCCTCACCGAAAAAGGTATCACTTTAGAAGTAAGCGATCGCTTCAAAGGACGACTCATCGAAG
AAGGTTACAGTCCGAGCTACGGTGCAAGACCGTTACGTCGGGCAATTATGCGCTTGTTAGAAGATAGCCTAGCAGAAGAA
ATTCTGTCAGGTCGCATCAAAGATGGCGATGTCGCCCTCATTGATATTGATGAAAACGGCAATGTGCAAGTTACTTCTCA
ACAACGCCGGGAATTATTACCCCAAGGTGTTGAGTCATAG

Upstream 100 bases:

>100_bases
AGGGCGACAGTAATAAACAAATAATAATCAAGCCATCAACTTGTGTGATAGCTGTTGGATGCTGATTATCTTTGGATACA
GACATCCAAACTCTTAGCCT

Downstream 100 bases:

>100_bases
TTAAAGTTTGGGATTTGATTCTCAAATAAAAATTAGCAAGCGGTAGAGCAATTAACGTTCTACCGTTTTTCTTTTTTTGA
TCAGCCACTATGACTCATAT

Product: endopeptidase Clp ATP-binding chain

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 839; Mature: 839

Protein sequence:

>839_residues
MLKSAYRHDAGDGKNAMFERFTEKAIKVIMLAQEEARRLGHNFVGTEQILLGLIGEGTGVAAKVLKSMGVNLKDARIEVE
KIIGRGSGFVAVEIPFTPRAKRVLELSLEEARQLGHNYIGTEHLLLGLIREGEGVAARVLENLGVDLSKVRTQVIRMLGE
TAEVSATGQSGRTKTPTLDEFGSNLTQMATDNKLDPVVGRAKEIERVIQILGRRTKNNPVLIGEPGVGKTAIAEGLASRI
ANKDVPDILEDKRVVTLDIGLLVAGTKYRGEFEERLKKIMDEIRQAGNVILVIDEVHTLIGAGAAEGAIDAANILKPALA
RGELQCIGATTLDEYRKHIERDAALERRFQPVMVGEPSVDETIEILYGLRDRYEQHHKLKISDEALVAAAKLSDRYISDR
YLPDKAIDLVDEAGSRVRLMNSQLPPAAKELDKELRQILKEKDDAVRSQDFDRAGELRDREMEIKAEIRAIAQSKTNASG
TEGQEPVVTEEDIAHIVASWTGVPVNKLTESESEKLLHMEDTLHQRLIGQEDAVKAVSRAIRRARVGLKNPNRPIASFVF
SGPTGVGKTELAKSLASYFFGSEEAMIRLDMSEYMERHTVSKLIGSPPGYVGYNEGGQLTEAVRRRPYTVVLFDEIEKAH
PDVFNMLLQILEDGRLTDAKGRTVDFKNTLLILTSNIGSKVIEKGGGGIGFEFSEDQTETQYNRIRSLVNEELKQYFRPE
FLNRLDEIIVFRQLSKLEVTEIADIMLKEVFGRLTEKGITLEVSDRFKGRLIEEGYSPSYGARPLRRAIMRLLEDSLAEE
ILSGRIKDGDVALIDIDENGNVQVTSQQRRELLPQGVES

Sequences:

>Translated_839_residues
MLKSAYRHDAGDGKNAMFERFTEKAIKVIMLAQEEARRLGHNFVGTEQILLGLIGEGTGVAAKVLKSMGVNLKDARIEVE
KIIGRGSGFVAVEIPFTPRAKRVLELSLEEARQLGHNYIGTEHLLLGLIREGEGVAARVLENLGVDLSKVRTQVIRMLGE
TAEVSATGQSGRTKTPTLDEFGSNLTQMATDNKLDPVVGRAKEIERVIQILGRRTKNNPVLIGEPGVGKTAIAEGLASRI
ANKDVPDILEDKRVVTLDIGLLVAGTKYRGEFEERLKKIMDEIRQAGNVILVIDEVHTLIGAGAAEGAIDAANILKPALA
RGELQCIGATTLDEYRKHIERDAALERRFQPVMVGEPSVDETIEILYGLRDRYEQHHKLKISDEALVAAAKLSDRYISDR
YLPDKAIDLVDEAGSRVRLMNSQLPPAAKELDKELRQILKEKDDAVRSQDFDRAGELRDREMEIKAEIRAIAQSKTNASG
TEGQEPVVTEEDIAHIVASWTGVPVNKLTESESEKLLHMEDTLHQRLIGQEDAVKAVSRAIRRARVGLKNPNRPIASFVF
SGPTGVGKTELAKSLASYFFGSEEAMIRLDMSEYMERHTVSKLIGSPPGYVGYNEGGQLTEAVRRRPYTVVLFDEIEKAH
PDVFNMLLQILEDGRLTDAKGRTVDFKNTLLILTSNIGSKVIEKGGGGIGFEFSEDQTETQYNRIRSLVNEELKQYFRPE
FLNRLDEIIVFRQLSKLEVTEIADIMLKEVFGRLTEKGITLEVSDRFKGRLIEEGYSPSYGARPLRRAIMRLLEDSLAEE
ILSGRIKDGDVALIDIDENGNVQVTSQQRRELLPQGVES
>Mature_839_residues
MLKSAYRHDAGDGKNAMFERFTEKAIKVIMLAQEEARRLGHNFVGTEQILLGLIGEGTGVAAKVLKSMGVNLKDARIEVE
KIIGRGSGFVAVEIPFTPRAKRVLELSLEEARQLGHNYIGTEHLLLGLIREGEGVAARVLENLGVDLSKVRTQVIRMLGE
TAEVSATGQSGRTKTPTLDEFGSNLTQMATDNKLDPVVGRAKEIERVIQILGRRTKNNPVLIGEPGVGKTAIAEGLASRI
ANKDVPDILEDKRVVTLDIGLLVAGTKYRGEFEERLKKIMDEIRQAGNVILVIDEVHTLIGAGAAEGAIDAANILKPALA
RGELQCIGATTLDEYRKHIERDAALERRFQPVMVGEPSVDETIEILYGLRDRYEQHHKLKISDEALVAAAKLSDRYISDR
YLPDKAIDLVDEAGSRVRLMNSQLPPAAKELDKELRQILKEKDDAVRSQDFDRAGELRDREMEIKAEIRAIAQSKTNASG
TEGQEPVVTEEDIAHIVASWTGVPVNKLTESESEKLLHMEDTLHQRLIGQEDAVKAVSRAIRRARVGLKNPNRPIASFVF
SGPTGVGKTELAKSLASYFFGSEEAMIRLDMSEYMERHTVSKLIGSPPGYVGYNEGGQLTEAVRRRPYTVVLFDEIEKAH
PDVFNMLLQILEDGRLTDAKGRTVDFKNTLLILTSNIGSKVIEKGGGGIGFEFSEDQTETQYNRIRSLVNEELKQYFRPE
FLNRLDEIIVFRQLSKLEVTEIADIMLKEVFGRLTEKGITLEVSDRFKGRLIEEGYSPSYGARPLRRAIMRLLEDSLAEE
ILSGRIKDGDVALIDIDENGNVQVTSQQRRELLPQGVES

Specific function: Competence gene repressor; required for cell growth at high temperature. Negative regulator of comK expression. May interact with MecA to negatively regulate comK [H]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=349, Percent_Identity=35.5300859598854, Blast_Score=205, Evalue=2e-52,
Organism=Escherichia coli, GI1788943, Length=874, Percent_Identity=46.7963386727689, Blast_Score=743, Evalue=0.0,
Organism=Escherichia coli, GI1787109, Length=808, Percent_Identity=38.6138613861386, Blast_Score=529, Evalue=1e-151,
Organism=Saccharomyces cerevisiae, GI6320464, Length=699, Percent_Identity=47.4964234620887, Blast_Score=620, Evalue=1e-178,
Organism=Saccharomyces cerevisiae, GI6323002, Length=898, Percent_Identity=37.3051224944321, Blast_Score=535, Evalue=1e-153,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150
- InterPro:   IPR001943 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 93142; Mature: 93142

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS50151 UVR ; PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKSAYRHDAGDGKNAMFERFTEKAIKVIMLAQEEARRLGHNFVGTEQILLGLIGEGTGV
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCH
AAKVLKSMGVNLKDARIEVEKIIGRGSGFVAVEIPFTPRAKRVLELSLEEARQLGHNYIG
HHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCC
TEHLLLGLIREGEGVAARVLENLGVDLSKVRTQVIRMLGETAEVSATGQSGRTKTPTLDE
HHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCHHEEECCCCCCCCCCCHHH
FGSNLTQMATDNKLDPVVGRAKEIERVIQILGRRTKNNPVLIGEPGVGKTAIAEGLASRI
HCCHHHHHHCCCCCCHHHCCHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHH
ANKDVPDILEDKRVVTLDIGLLVAGTKYRGEFEERLKKIMDEIRQAGNVILVIDEVHTLI
CCCCCCHHHHCCEEEEEEECEEEECCCCCCHHHHHHHHHHHHHHHHCCEEEEEHHHHHHH
GAGAAEGAIDAANILKPALARGELQCIGATTLDEYRKHIERDAALERRFQPVMVGEPSVD
CCCCCCCCCHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCEECCCCCHH
ETIEILYGLRDRYEQHHKLKISDEALVAAAKLSDRYISDRYLPDKAIDLVDEAGSRVRLM
HHHHHHHHHHHHHHHHCCEEECHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEEC
NSQLPPAAKELDKELRQILKEKDDAVRSQDFDRAGELRDREMEIKAEIRAIAQSKTNASG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHHHHHCCCCCC
TEGQEPVVTEEDIAHIVASWTGVPVNKLTESESEKLLHMEDTLHQRLIGQEDAVKAVSRA
CCCCCCCCCHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
IRRARVGLKNPNRPIASFVFSGPTGVGKTELAKSLASYFFGSEEAMIRLDMSEYMERHTV
HHHHHCCCCCCCCHHHHHEECCCCCCCHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHH
SKLIGSPPGYVGYNEGGQLTEAVRRRPYTVVLFDEIEKAHPDVFNMLLQILEDGRLTDAK
HHHHCCCCCCCCCCCCCHHHHHHHHCCCEEEEEHHHHHCCHHHHHHHHHHHHCCCEECCC
GRTVDFKNTLLILTSNIGSKVIEKGGGGIGFEFSEDQTETQYNRIRSLVNEELKQYFRPE
CCEEECCCEEEEEECCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHH
FLNRLDEIIVFRQLSKLEVTEIADIMLKEVFGRLTEKGITLEVSDRFKGRLIEEGYSPSY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHCCCCCCC
GARPLRRAIMRLLEDSLAEEILSGRIKDGDVALIDIDENGNVQVTSQQRRELLPQGVES
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCEEEECHHHHHHCCCCCCC
>Mature Secondary Structure
MLKSAYRHDAGDGKNAMFERFTEKAIKVIMLAQEEARRLGHNFVGTEQILLGLIGEGTGV
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCH
AAKVLKSMGVNLKDARIEVEKIIGRGSGFVAVEIPFTPRAKRVLELSLEEARQLGHNYIG
HHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCC
TEHLLLGLIREGEGVAARVLENLGVDLSKVRTQVIRMLGETAEVSATGQSGRTKTPTLDE
HHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCHHEEECCCCCCCCCCCHHH
FGSNLTQMATDNKLDPVVGRAKEIERVIQILGRRTKNNPVLIGEPGVGKTAIAEGLASRI
HCCHHHHHHCCCCCCHHHCCHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHH
ANKDVPDILEDKRVVTLDIGLLVAGTKYRGEFEERLKKIMDEIRQAGNVILVIDEVHTLI
CCCCCCHHHHCCEEEEEEECEEEECCCCCCHHHHHHHHHHHHHHHHCCEEEEEHHHHHHH
GAGAAEGAIDAANILKPALARGELQCIGATTLDEYRKHIERDAALERRFQPVMVGEPSVD
CCCCCCCCCHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCEECCCCCHH
ETIEILYGLRDRYEQHHKLKISDEALVAAAKLSDRYISDRYLPDKAIDLVDEAGSRVRLM
HHHHHHHHHHHHHHHHCCEEECHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEEC
NSQLPPAAKELDKELRQILKEKDDAVRSQDFDRAGELRDREMEIKAEIRAIAQSKTNASG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHHHHHCCCCCC
TEGQEPVVTEEDIAHIVASWTGVPVNKLTESESEKLLHMEDTLHQRLIGQEDAVKAVSRA
CCCCCCCCCHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
IRRARVGLKNPNRPIASFVFSGPTGVGKTELAKSLASYFFGSEEAMIRLDMSEYMERHTV
HHHHHCCCCCCCCHHHHHEECCCCCCCHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHH
SKLIGSPPGYVGYNEGGQLTEAVRRRPYTVVLFDEIEKAHPDVFNMLLQILEDGRLTDAK
HHHHCCCCCCCCCCCCCHHHHHHHHCCCEEEEEHHHHHCCHHHHHHHHHHHHCCCEECCC
GRTVDFKNTLLILTSNIGSKVIEKGGGGIGFEFSEDQTETQYNRIRSLVNEELKQYFRPE
CCEEECCCEEEEEECCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHH
FLNRLDEIIVFRQLSKLEVTEIADIMLKEVFGRLTEKGITLEVSDRFKGRLIEEGYSPSY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHCCCCCCC
GARPLRRAIMRLLEDSLAEEILSGRIKDGDVALIDIDENGNVQVTSQQRRELLPQGVES
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCEEEECHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8016066; 7584024; 9384377; 8195092 [H]