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The map label for this gene is lysA [H]

Identifier: 17230489

GI number: 17230489

Start: 3639854

End: 3641248

Strand: Reverse

Name: lysA [H]

Synonym: all2997

Alternate gene names: 17230489

Gene position: 3641248-3639854 (Counterclockwise)

Preceding gene: 17230492

Following gene: 17230488

Centisome position: 56.77

GC content: 44.01

Gene sequence:

>1395_bases
ATGGTATCGACTCACCCGGCTGGGGTTCAAGATGCTGGTACTCAGTATCTACCTCAAAGGCGCAACACAAATACAAATAT
TTCTCCCAACCAGGAACTTTTACCTCTAACTGCTAAAGCTAACAGTCAAGGAAACCTGGAAATTGGTGGGTGTGATGTCA
CAACTCTAGTTGAGCAGTTTGGTTCACCTCTATATATATTAGATGAAGAAACCCTACGCACAGCTTGTCAGCAATACCGG
GATGGTTTCCAAAAATATTATCCTGGAGAATCTCAGGTATTGTATGCCTCTAAAGCATGGAATTGTTTAGCTGTTTGTGC
GATCGCAGCCTCAGAAGGTTTAGGAATTGACGTAGTTTCGGGAGGCGAACTCTACACTGCTCTAGCTGCTGGTGTGAGTC
CCGCTAAAATCTACCTCCACGGGAATAATAAATCTCGTGAGGAACTGGTTTTAGCAATTGAATCTGGTGTAACAATCGTT
GCAGATAATTGGTATGAATTGCGTATATTGGCGAGTTTAGCCGACTCAGAAGAGCCAATCCGGCTCATGTTGCGCTTAAC
TCCTGGTATAGAATGTCATACTCACGAATACATTCGCACAGGACACCTGGATAGTAAATTTGGCTTTGACCCCAACGATT
TGGCTGAGGTTTTTGAGTTTGTTAGCCAGCAACCAAATCTCAACTGCGTAGGATTACACGCTCATATTGGCTCGCAAATT
TTTGAGCGCCAACCCCATCGAGATTTAGCTGCTGTCATGGTGCAGTGGTTAAGGGATGCGAATAAATATGGTTTGAATGT
CACCGAATTAAATGTTGGTGGCGGTTTGGGAATTAAATATGTAGAATCAGACGATCCACCAAGCATTGATGAGTGGGTGA
AGGCGATTTGTGAAGTAGTGCAAGCAGCTTGTGCAGCCGAAAACTTGCCTTTACCAAAGCTATTATCTGAACCAGGGCGA
TCGCTCATTGCTACCAGCTGCATCACCGCATACACTGTTGGCTCATCTAAAACAATACCGGAAATCCGTACCTACGTTTC
CATAGACGGGGGTATGTCTGATAATCCACGCCCAATTACTTACCAGTCAGTTTATCGGGCAGTAATTGCCAATAAATTAT
CTGCCCCCCATACAGAAACAGTTACTATTGCGGGTAAGCATTGCGAATCAGGGGATATTCTGATTAAAAATGCCCAACTA
CCAAAAACTGAACCAGGCGATATTCTCGTAGTTATGGCAACTGGTGCGTACAATTACAGTATGGCCTCTAACTATAACCG
CCTACCCCGACCGGCAGCAGTTGTAGTGGCAAATGGCGAAGCAAACTTAATTTTGCAACGCGAAACTTATCAAGACTTAA
TTCGGCAAGATTGTTTACCAGAAAGACTTAAATAG

Upstream 100 bases:

>100_bases
GAGATCACTTTTATTTGGATAAGATTACAAACCCTTTGTAAACTGGGATCGGGACAGTTAATTCACGCCCGTAATTTGAA
CAAGGACAATTTATATAGTT

Downstream 100 bases:

>100_bases
TCAGTGATCAATAGTCAGTAGTCAGTAGCTAAAAAAGACTGACTACTGGCATCTGACAACTGACAACTAACAAATGACTA
TTAGAATCCAGATGTCATGA

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 464; Mature: 464

Protein sequence:

>464_residues
MVSTHPAGVQDAGTQYLPQRRNTNTNISPNQELLPLTAKANSQGNLEIGGCDVTTLVEQFGSPLYILDEETLRTACQQYR
DGFQKYYPGESQVLYASKAWNCLAVCAIAASEGLGIDVVSGGELYTALAAGVSPAKIYLHGNNKSREELVLAIESGVTIV
ADNWYELRILASLADSEEPIRLMLRLTPGIECHTHEYIRTGHLDSKFGFDPNDLAEVFEFVSQQPNLNCVGLHAHIGSQI
FERQPHRDLAAVMVQWLRDANKYGLNVTELNVGGGLGIKYVESDDPPSIDEWVKAICEVVQAACAAENLPLPKLLSEPGR
SLIATSCITAYTVGSSKTIPEIRTYVSIDGGMSDNPRPITYQSVYRAVIANKLSAPHTETVTIAGKHCESGDILIKNAQL
PKTEPGDILVVMATGAYNYSMASNYNRLPRPAAVVVANGEANLILQRETYQDLIRQDCLPERLK

Sequences:

>Translated_464_residues
MVSTHPAGVQDAGTQYLPQRRNTNTNISPNQELLPLTAKANSQGNLEIGGCDVTTLVEQFGSPLYILDEETLRTACQQYR
DGFQKYYPGESQVLYASKAWNCLAVCAIAASEGLGIDVVSGGELYTALAAGVSPAKIYLHGNNKSREELVLAIESGVTIV
ADNWYELRILASLADSEEPIRLMLRLTPGIECHTHEYIRTGHLDSKFGFDPNDLAEVFEFVSQQPNLNCVGLHAHIGSQI
FERQPHRDLAAVMVQWLRDANKYGLNVTELNVGGGLGIKYVESDDPPSIDEWVKAICEVVQAACAAENLPLPKLLSEPGR
SLIATSCITAYTVGSSKTIPEIRTYVSIDGGMSDNPRPITYQSVYRAVIANKLSAPHTETVTIAGKHCESGDILIKNAQL
PKTEPGDILVVMATGAYNYSMASNYNRLPRPAAVVVANGEANLILQRETYQDLIRQDCLPERLK
>Mature_464_residues
MVSTHPAGVQDAGTQYLPQRRNTNTNISPNQELLPLTAKANSQGNLEIGGCDVTTLVEQFGSPLYILDEETLRTACQQYR
DGFQKYYPGESQVLYASKAWNCLAVCAIAASEGLGIDVVSGGELYTALAAGVSPAKIYLHGNNKSREELVLAIESGVTIV
ADNWYELRILASLADSEEPIRLMLRLTPGIECHTHEYIRTGHLDSKFGFDPNDLAEVFEFVSQQPNLNCVGLHAHIGSQI
FERQPHRDLAAVMVQWLRDANKYGLNVTELNVGGGLGIKYVESDDPPSIDEWVKAICEVVQAACAAENLPLPKLLSEPGR
SLIATSCITAYTVGSSKTIPEIRTYVSIDGGMSDNPRPITYQSVYRAVIANKLSAPHTETVTIAGKHCESGDILIKNAQL
PKTEPGDILVVMATGAYNYSMASNYNRLPRPAAVVVANGEANLILQRETYQDLIRQDCLPERLK

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=427, Percent_Identity=29.03981264637, Blast_Score=144, Evalue=2e-35,
Organism=Escherichia coli, GI1789307, Length=284, Percent_Identity=26.4084507042254, Blast_Score=62, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17562780, Length=369, Percent_Identity=24.390243902439, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 50621; Mature: 50621

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSTHPAGVQDAGTQYLPQRRNTNTNISPNQELLPLTAKANSQGNLEIGGCDVTTLVEQF
CCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEECCCCHHHHHHHH
GSPLYILDEETLRTACQQYRDGFQKYYPGESQVLYASKAWNCLAVCAIAASEGLGIDVVS
CCCEEEECHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCCCCEEEEC
GGELYTALAAGVSPAKIYLHGNNKSREELVLAIESGVTIVADNWYELRILASLADSEEPI
CCHHHHHHHCCCCCEEEEEECCCCCCCCEEEEEECCCEEEECCCEEEEEEEECCCCCCCE
RLMLRLTPGIECHTHEYIRTGHLDSKFGFDPNDLAEVFEFVSQQPNLNCVGLHAHIGSQI
EEEEEECCCCEECCHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEHHHHHHHH
FERQPHRDLAAVMVQWLRDANKYGLNVTELNVGGGLGIKYVESDDPPSIDEWVKAICEVV
HHCCCCHHHHHHHHHHHHHHHHHCCEEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHH
QAACAAENLPLPKLLSEPGRSLIATSCITAYTVGSSKTIPEIRTYVSIDGGMSDNPRPIT
HHHHHHCCCCCHHHHHCCCHHHHHHHHHHEEECCCCCCCCCEEEEEEECCCCCCCCCCCC
YQSVYRAVIANKLSAPHTETVTIAGKHCESGDILIKNAQLPKTEPGDILVVMATGAYNYS
HHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCEEEECCCCCCCCCCCEEEEEECCCCCCH
MASNYNRLPRPAAVVVANGEANLILQRETYQDLIRQDCLPERLK
HHCCCCCCCCCEEEEEECCCCEEEEEHHHHHHHHHHCCCHHHCC
>Mature Secondary Structure
MVSTHPAGVQDAGTQYLPQRRNTNTNISPNQELLPLTAKANSQGNLEIGGCDVTTLVEQF
CCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEECCCCHHHHHHHH
GSPLYILDEETLRTACQQYRDGFQKYYPGESQVLYASKAWNCLAVCAIAASEGLGIDVVS
CCCEEEECHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCCCCEEEEC
GGELYTALAAGVSPAKIYLHGNNKSREELVLAIESGVTIVADNWYELRILASLADSEEPI
CCHHHHHHHCCCCCEEEEEECCCCCCCCEEEEEECCCEEEECCCEEEEEEEECCCCCCCE
RLMLRLTPGIECHTHEYIRTGHLDSKFGFDPNDLAEVFEFVSQQPNLNCVGLHAHIGSQI
EEEEEECCCCEECCHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEHHHHHHHH
FERQPHRDLAAVMVQWLRDANKYGLNVTELNVGGGLGIKYVESDDPPSIDEWVKAICEVV
HHCCCCHHHHHHHHHHHHHHHHHCCEEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHH
QAACAAENLPLPKLLSEPGRSLIATSCITAYTVGSSKTIPEIRTYVSIDGGMSDNPRPIT
HHHHHHCCCCCHHHHHCCCHHHHHHHHHHEEECCCCCCCCCEEEEEEECCCCCCCCCCCC
YQSVYRAVIANKLSAPHTETVTIAGKHCESGDILIKNAQLPKTEPGDILVVMATGAYNYS
HHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCEEEECCCCCCCCCCCEEEEEECCCCCCH
MASNYNRLPRPAAVVVANGEANLILQRETYQDLIRQDCLPERLK
HHCCCCCCCCCEEEEEECCCCEEEEEHHHHHHHHHHCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]