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The map label for this gene is uppS1

Identifier: 17230487

GI number: 17230487

Start: 3638046

End: 3638795

Strand: Reverse

Name: uppS1

Synonym: all2995

Alternate gene names: 17230487

Gene position: 3638795-3638046 (Counterclockwise)

Preceding gene: 17230488

Following gene: 17230484

Centisome position: 56.73

GC content: 44.27

Gene sequence:

>750_bases
ATGACAATACAACAAACTGAACTGCAAGAATTGCCCCTGGATTTAAAACGAGAACTACTGCCCAAACACGTTGCAGTAAT
TATGGATGGCAATGGTCGATGGGCTAAACGTCAAGGTCTACCCCGAATTATGGGTCATAAGCGAGGAGTAGATGCCCTCA
AGGATTTACTACGTTGCTGTAGAGACTGGGGGATTCAGGCGCTGACTGCTTATGCTTTTTCCACAGAGAACTGGAAAAGA
CCACAGGAAGAAGTAGAGTTTCTGATGACTCTGTTTCAAAGAGTTTTACGTCAAGAACTGCGGGAAATGGTCGAAGAGAA
TGTGCAGATTCAGTTTGTAGGAAATTTAACAGCTTTGCCGCGATCGCTGCAAGCGGAAATTTCCCGCTCTATGGAAGAAA
CTAAAAATAATCGCGGTATTCGGTTTTCTGTCGCCACCAATTATGGAGGAAGGCAGGAGATTTTACAAGCTTGCCGGGCG
ATCGCCCAAAAAGTTCAGCAAGGTCTACTACAACCAGATGAAATTAACGAAGAAGTATTTGAACGCCACTTATACACAGC
CGGAATTTCCGACCCAGACTTATTAATCCGTACCAGTGGCGAAATGCGCCTCTCAAATTTCTTACTATGGCAAATGGCTT
ATGGGGAAATCTATATTACTGATACTCTCTGGCCAGATTTTGACCGTACAGAGTTTCATCGCGCCTTATGTGCATATCAG
CAAAGAGAACGGCGATTTGGGAAAGTTTAG

Upstream 100 bases:

>100_bases
CACTAGCACTGGTTTCACGTTTACCCGGTTTACCACGTCTTCGACGTGCCACGCGTAGTTTACTTCCCCGTAGGGATAAG
ACCGCTTCTCAAGATAAAAA

Downstream 100 bases:

>100_bases
GGATTGGGGATTGGGAATTGGGGACTGGCGATTGGGGACTGGGGACTGGGGATTTATCCCTCCACTTCCCCTGCTTCCTC
TACTCCCCCTGCTTCCCCAT

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase 1; Di-trans,poly-cis-decaprenylcistransferase 1; Undecaprenyl diphosphate synthase 1; UDS 1

Number of amino acids: Translated: 249; Mature: 248

Protein sequence:

>249_residues
MTIQQTELQELPLDLKRELLPKHVAVIMDGNGRWAKRQGLPRIMGHKRGVDALKDLLRCCRDWGIQALTAYAFSTENWKR
PQEEVEFLMTLFQRVLRQELREMVEENVQIQFVGNLTALPRSLQAEISRSMEETKNNRGIRFSVATNYGGRQEILQACRA
IAQKVQQGLLQPDEINEEVFERHLYTAGISDPDLLIRTSGEMRLSNFLLWQMAYGEIYITDTLWPDFDRTEFHRALCAYQ
QRERRFGKV

Sequences:

>Translated_249_residues
MTIQQTELQELPLDLKRELLPKHVAVIMDGNGRWAKRQGLPRIMGHKRGVDALKDLLRCCRDWGIQALTAYAFSTENWKR
PQEEVEFLMTLFQRVLRQELREMVEENVQIQFVGNLTALPRSLQAEISRSMEETKNNRGIRFSVATNYGGRQEILQACRA
IAQKVQQGLLQPDEINEEVFERHLYTAGISDPDLLIRTSGEMRLSNFLLWQMAYGEIYITDTLWPDFDRTEFHRALCAYQ
QRERRFGKV
>Mature_248_residues
TIQQTELQELPLDLKRELLPKHVAVIMDGNGRWAKRQGLPRIMGHKRGVDALKDLLRCCRDWGIQALTAYAFSTENWKRP
QEEVEFLMTLFQRVLRQELREMVEENVQIQFVGNLTALPRSLQAEISRSMEETKNNRGIRFSVATNYGGRQEILQACRAI
AQKVQQGLLQPDEINEEVFERHLYTAGISDPDLLIRTSGEMRLSNFLLWQMAYGEIYITDTLWPDFDRTEFHRALCAYQQ
RERRFGKV

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family

Homologues:

Organism=Homo sapiens, GI45580742, Length=225, Percent_Identity=40.8888888888889, Blast_Score=171, Evalue=6e-43,
Organism=Homo sapiens, GI45580738, Length=225, Percent_Identity=40.8888888888889, Blast_Score=171, Evalue=7e-43,
Organism=Escherichia coli, GI1786371, Length=226, Percent_Identity=49.5575221238938, Blast_Score=238, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI71993029, Length=227, Percent_Identity=39.647577092511, Blast_Score=159, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6319474, Length=213, Percent_Identity=39.906103286385, Blast_Score=142, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6323748, Length=216, Percent_Identity=34.2592592592593, Blast_Score=114, Evalue=1e-26,
Organism=Drosophila melanogaster, GI18857969, Length=226, Percent_Identity=40.7079646017699, Blast_Score=171, Evalue=6e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UPPS1_NOSS1 (P58563)

Other databases:

- EMBL:   BA000019
- PIR:   AD2180
- RefSeq:   NP_487035.1
- ProteinModelPortal:   P58563
- SMR:   P58563
- STRING:   P58563
- GeneID:   1106593
- GenomeReviews:   BA000019_GR
- KEGG:   ana:all2995
- NMPDR:   fig|103690.1.peg.3302
- eggNOG:   COG0020
- HOGENOM:   HBG627837
- OMA:   RVRWAGR
- PhylomeDB:   P58563
- ProtClustDB:   PRK14831
- BioCyc:   NSP103690:ALL2995-MONOMER
- HAMAP:   MF_01139
- InterPro:   IPR001441
- InterPro:   IPR018520
- Gene3D:   G3DSA:3.40.1180.10
- PANTHER:   PTHR10291
- TIGRFAMs:   TIGR00055

Pfam domain/function: PF01255 Prenyltransf; SSF64005 UPP_synth

EC number: =2.5.1.31

Molecular weight: Translated: 29131; Mature: 29000

Theoretical pI: Translated: 7.45; Mature: 7.45

Prosite motif: PS01066 UPP_SYNTHASE

Important sites: ACT_SITE 29-29

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIQQTELQELPLDLKRELLPKHVAVIMDGNGRWAKRQGLPRIMGHKRGVDALKDLLRCC
CCCCHHHHHHCCHHHHHHHCHHHEEEEECCCCCCHHHCCCHHHHCCCCCHHHHHHHHHHH
RDWGIQALTAYAFSTENWKRPQEEVEFLMTLFQRVLRQELREMVEENVQIQFVGNLTALP
HHHCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHH
RSLQAEISRSMEETKNNRGIRFSVATNYGGRQEILQACRAIAQKVQQGLLQPDEINEEVF
HHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
ERHLYTAGISDPDLLIRTSGEMRLSNFLLWQMAYGEIYITDTLWPDFDRTEFHRALCAYQ
HHHHHHCCCCCCCEEEECCCCHHHHHHHHHHEECCCEEEEECCCCCCCHHHHHHHHHHHH
QRERRFGKV
HHHHHCCCC
>Mature Secondary Structure 
TIQQTELQELPLDLKRELLPKHVAVIMDGNGRWAKRQGLPRIMGHKRGVDALKDLLRCC
CCCHHHHHHCCHHHHHHHCHHHEEEEECCCCCCHHHCCCHHHHCCCCCHHHHHHHHHHH
RDWGIQALTAYAFSTENWKRPQEEVEFLMTLFQRVLRQELREMVEENVQIQFVGNLTALP
HHHCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHH
RSLQAEISRSMEETKNNRGIRFSVATNYGGRQEILQACRAIAQKVQQGLLQPDEINEEVF
HHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
ERHLYTAGISDPDLLIRTSGEMRLSNFLLWQMAYGEIYITDTLWPDFDRTEFHRALCAYQ
HHHHHHCCCCCCCEEEECCCCHHHHHHHHHHEECCCEEEEECCCCCCCHHHHHHHHHHHH
QRERRFGKV
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840