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The map label for this gene is pyrF [H]

Identifier: 17230475

GI number: 17230475

Start: 3625025

End: 3625741

Strand: Direct

Name: pyrF [H]

Synonym: alr2983

Alternate gene names: 17230475

Gene position: 3625025-3625741 (Clockwise)

Preceding gene: 17230474

Following gene: 17230476

Centisome position: 56.52

GC content: 48.81

Gene sequence:

>717_bases
ATGAGTAATGACAAAATAATTGTGGCTTTGGATGTGCCAGATACGGAGAGTGCGATCGCTCTCATTGATAAGCTAGAGTC
GGTGACTTTTTGGAAGGTTGGGTTGGAATTGTTTACTAGTTCCGGCCCCAGAATTCTAGAAGTACTGAAATCTAGACAAA
AGCGCATCTTTCTCGATTTGAAGTTTCACGACATCCCCAATACGGTGGCTGGGGCTTGTCGTGCGGCGGCTGGTTACGGG
GTGGATTTGATGACAATCCATGCTACCTCTGGTAGAGATGCCCTGAAGGCTGCAAAAGAGGCGGTAGAGGAAGGGGCTGC
ACAAGCTGGTGTGAAACCGCCCAAGTTAATCGCTGTGACGGTGTTAACCAGTATTTCTGCCAGACAGTTGGCGTTAGATT
TGAAAATTCCTTCAGAATTGCCAGAATATGCTTTAGATATGGCTCTAATGGCGCAGGAGATGGGGTTAGATGGGGCAGTG
TGTTCACCCCAAGAAGTGGCACATTTACGCCAAATTTGCGGGGATGATTTCGTGTTGGTTTGTCCGGGGGTACGCCCAAC
ATGGGCAGAAGCGGGAGATCAAAAGCGATCGCTCACCCCCTCCCAAGCCATCCAAGCAGGGGCTGATTATTTAGTGATTG
GTCGTCCAATTACTGCTGCTGCTGAACCTGAGTTAGCCTGGAAACGCATTTCTCAAGAGTTAACAACAGTGGTATGA

Upstream 100 bases:

>100_bases
CTCCAAGGGCGAGTGTTACAAGTAGGGAAAAATAAGTTTATGCGCTTAGTACCTTAGAGGAGATAGGGGTATAAGGGTGT
AAGGGTGTAGGGGGAAATTA

Downstream 100 bases:

>100_bases
GGGTAAAAATGGGAGGGCATAAAGGGAGCAGGGGGGGCAGAGGAGCAGGGGGGGCAGGGGAAGGATTTATTACTCAGTAC
GCTGCTCAAATCCCGTTAAC

Product: orotidine 5'-phosphate decarboxylase

Products: NA

Alternate protein names: OMP decarboxylase; OMPDCase; OMPdecase [H]

Number of amino acids: Translated: 238; Mature: 237

Protein sequence:

>238_residues
MSNDKIIVALDVPDTESAIALIDKLESVTFWKVGLELFTSSGPRILEVLKSRQKRIFLDLKFHDIPNTVAGACRAAAGYG
VDLMTIHATSGRDALKAAKEAVEEGAAQAGVKPPKLIAVTVLTSISARQLALDLKIPSELPEYALDMALMAQEMGLDGAV
CSPQEVAHLRQICGDDFVLVCPGVRPTWAEAGDQKRSLTPSQAIQAGADYLVIGRPITAAAEPELAWKRISQELTTVV

Sequences:

>Translated_238_residues
MSNDKIIVALDVPDTESAIALIDKLESVTFWKVGLELFTSSGPRILEVLKSRQKRIFLDLKFHDIPNTVAGACRAAAGYG
VDLMTIHATSGRDALKAAKEAVEEGAAQAGVKPPKLIAVTVLTSISARQLALDLKIPSELPEYALDMALMAQEMGLDGAV
CSPQEVAHLRQICGDDFVLVCPGVRPTWAEAGDQKRSLTPSQAIQAGADYLVIGRPITAAAEPELAWKRISQELTTVV
>Mature_237_residues
SNDKIIVALDVPDTESAIALIDKLESVTFWKVGLELFTSSGPRILEVLKSRQKRIFLDLKFHDIPNTVAGACRAAAGYGV
DLMTIHATSGRDALKAAKEAVEEGAAQAGVKPPKLIAVTVLTSISARQLALDLKIPSELPEYALDMALMAQEMGLDGAVC
SPQEVAHLRQICGDDFVLVCPGVRPTWAEAGDQKRSLTPSQAIQAGADYLVIGRPITAAAEPELAWKRISQELTTVV

Specific function: Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) [H]

COG id: COG0284

COG function: function code F; Orotidine-5'-phosphate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the OMP decarboxylase family. Type 1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787537, Length=235, Percent_Identity=45.531914893617, Blast_Score=187, Evalue=5e-49,

Paralogues:

None

Copy number: 6,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR014732
- InterPro:   IPR018089
- InterPro:   IPR001754
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00215 OMPdecase [H]

EC number: =4.1.1.23 [H]

Molecular weight: Translated: 25473; Mature: 25342

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS00156 OMPDECASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNDKIIVALDVPDTESAIALIDKLESVTFWKVGLELFTSSGPRILEVLKSRQKRIFLDL
CCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCEEEEEE
KFHDIPNTVAGACRAAAGYGVDLMTIHATSGRDALKAAKEAVEEGAAQAGVKPPKLIAVT
EECCCCHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCEEEHH
VLTSISARQLALDLKIPSELPEYALDMALMAQEMGLDGAVCSPQEVAHLRQICGDDFVLV
HHHHCCHHHEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCEEEE
CPGVRPTWAEAGDQKRSLTPSQAIQAGADYLVIGRPITAAAEPELAWKRISQELTTVV
ECCCCCCHHHCCCCCCCCCHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SNDKIIVALDVPDTESAIALIDKLESVTFWKVGLELFTSSGPRILEVLKSRQKRIFLDL
CCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCEEEEEE
KFHDIPNTVAGACRAAAGYGVDLMTIHATSGRDALKAAKEAVEEGAAQAGVKPPKLIAVT
EECCCCHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCEEEHH
VLTSISARQLALDLKIPSELPEYALDMALMAQEMGLDGAVCSPQEVAHLRQICGDDFVLV
HHHHCCHHHEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCEEEE
CPGVRPTWAEAGDQKRSLTPSQAIQAGADYLVIGRPITAAAEPELAWKRISQELTTVV
ECCCCCCHHHCCCCCCCCCHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA