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The map label for this gene is phr [H]

Identifier: 17230458

GI number: 17230458

Start: 3607854

End: 3608690

Strand: Direct

Name: phr [H]

Synonym: alr2966

Alternate gene names: 17230458

Gene position: 3607854-3608690 (Clockwise)

Preceding gene: 17230451

Following gene: 17230459

Centisome position: 56.25

GC content: 41.82

Gene sequence:

>837_bases
ATGTTACGTGAATTTGCTAGCCGAGACGAATTAATAGCTTACCTGCGTGAACAATTTCCCCAAGCCGCAGAAAGAAGCGA
TTATGTTAGTGATACCAAAGGTGGAAGGCAAGCCGCTCAGAAAGCTCTGCAAAAAGTTAACCCTGCTACCTATGCAAAAA
CACGTAACTTTTTAACAGGAGATGTAACCAGACTTTCACCCTACATCCGCTATGGAGTTTTGAGCCTGGGAGAAATACGA
AATTATGTATTAGATAACGTCAAACACCCTGATGATGCTAAAAAACTTATTAATGAATTAGGTTGGCGGGATTATTGGCA
GCGATTGTATATCAAGCTTGGCAATGGTATCTGGGAAGACCAGGAAGAATATAAGACAGGTTACACTCCCGCAGAATACG
CATCTGATTTAGCCGCAGATATCAAAGAAGGGAAAACAGGATTAGTTTGTATCGACAGCTTCAGCCGCGAATTGCAGGAA
ACCGGCTACTTACACAACCACATGAGAATGTGGCTAGCTGCCTACATTGTCCATTGGCGACGTATTCGCTGGCAAGAGGG
AGCAAAATGGTTCCTAGAACACCTCTTAGATGGTGATCCTGCTAGTAATAATATGTCCTGGCAATGGGTAGCCAGCACCT
TTAGTCAAAAACCATATTTTTTCAACCGCGAGAACTTAGAACGCTATACCCAAAGCATTTATTGTCAAAAATGCCCTTTA
TATGGTCATTGCAATTTTGAAGGCAGTTACGAAGAATTAGAACAGCAACTTTTTCCCAAAGGAAAATTTACCAAACAACC
CAACAGTCAAAGTTGGCAACGTGGTAAGAAAAAGTAG

Upstream 100 bases:

>100_bases
AACCCTTACCCCCAGTTTCCACAGACAACCTGGGTACATTAGCTATCTAACCCGTTAGCTATATATTGTCATCTGTGTAA
ATGTATAACTGAATTAGCTT

Downstream 100 bases:

>100_bases
TTATGTGATAATTGGTCAAGTCGCTTCTCTACGAGACGCTACGCGAACGCTCCAATTCAAAATTCAAAATTCAAAACAAC
TGCTCCCTACCTTATTCCAA

Product: hypothetical protein

Products: NA

Alternate protein names: DNA photolyase; Photoreactivating enzyme [H]

Number of amino acids: Translated: 278; Mature: 278

Protein sequence:

>278_residues
MLREFASRDELIAYLREQFPQAAERSDYVSDTKGGRQAAQKALQKVNPATYAKTRNFLTGDVTRLSPYIRYGVLSLGEIR
NYVLDNVKHPDDAKKLINELGWRDYWQRLYIKLGNGIWEDQEEYKTGYTPAEYASDLAADIKEGKTGLVCIDSFSRELQE
TGYLHNHMRMWLAAYIVHWRRIRWQEGAKWFLEHLLDGDPASNNMSWQWVASTFSQKPYFFNRENLERYTQSIYCQKCPL
YGHCNFEGSYEELEQQLFPKGKFTKQPNSQSWQRGKKK

Sequences:

>Translated_278_residues
MLREFASRDELIAYLREQFPQAAERSDYVSDTKGGRQAAQKALQKVNPATYAKTRNFLTGDVTRLSPYIRYGVLSLGEIR
NYVLDNVKHPDDAKKLINELGWRDYWQRLYIKLGNGIWEDQEEYKTGYTPAEYASDLAADIKEGKTGLVCIDSFSRELQE
TGYLHNHMRMWLAAYIVHWRRIRWQEGAKWFLEHLLDGDPASNNMSWQWVASTFSQKPYFFNRENLERYTQSIYCQKCPL
YGHCNFEGSYEELEQQLFPKGKFTKQPNSQSWQRGKKK
>Mature_278_residues
MLREFASRDELIAYLREQFPQAAERSDYVSDTKGGRQAAQKALQKVNPATYAKTRNFLTGDVTRLSPYIRYGVLSLGEIR
NYVLDNVKHPDDAKKLINELGWRDYWQRLYIKLGNGIWEDQEEYKTGYTPAEYASDLAADIKEGKTGLVCIDSFSRELQE
TGYLHNHMRMWLAAYIVHWRRIRWQEGAKWFLEHLLDGDPASNNMSWQWVASTFSQKPYFFNRENLERYTQSIYCQKCPL
YGHCNFEGSYEELEQQLFPKGKFTKQPNSQSWQRGKKK

Specific function: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ul

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Escherichia coli, GI1786926, Length=182, Percent_Identity=32.4175824175824, Blast_Score=84, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324962, Length=176, Percent_Identity=28.9772727272727, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17137248, Length=184, Percent_Identity=26.6304347826087, Blast_Score=64, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24585455, Length=184, Percent_Identity=26.6304347826087, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002081
- InterPro:   IPR018394
- InterPro:   IPR006050
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: =4.1.99.3 [H]

Molecular weight: Translated: 32761; Mature: 32761

Theoretical pI: Translated: 8.74; Mature: 8.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHCCCCC
>Mature Secondary Structure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CCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2501760 [H]