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The map label for this gene is folK [H]

Identifier: 17230445

GI number: 17230445

Start: 3595614

End: 3595853

Strand: Direct

Name: folK [H]

Synonym: asr2953

Alternate gene names: 17230445

Gene position: 3595614-3595853 (Clockwise)

Preceding gene: 17230441

Following gene: 17230446

Centisome position: 56.06

GC content: 44.17

Gene sequence:

>240_bases
GTGCGTCAAGAGCGCTGGGGGCCGCGATCGCTAGACTTGGATTTGTTATTGTATGATGACTTAATTATTGATACACCAAC
TCTCCAAATACCCCATCCGCGAATGCAAGAGCGAGCCTTTGTTTTAGTACCTCTAGCGGAGATTGCGCCCGACTGGTTAG
AACCAATTTCCGGATATGTAATTAGAGAACTGGTAAAAAAGGTAGACTGTTCTGATGTACATTTGTTAAAGGGCAGTTAA

Upstream 100 bases:

>100_bases
ACAGCCAGATTATTTAAATGGTTGCATCATACTACAAGTAGAACTTGACCCCCCAAAATTGCTAGAAGTATTGCTAACAA
TAGAACAGAAGTTTGGGCGG

Downstream 100 bases:

>100_bases
AACCATTACCCAGAGCAGAAAACGCTGATAGAATGATCAACTCCAGTGTTTATCTGTGCTATTTAAGACAAAACAAGCTT
AAATTATGCCATTAGGTAGA

Product: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokin ase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 79; Mature: 79

Protein sequence:

>79_residues
MRQERWGPRSLDLDLLLYDDLIIDTPTLQIPHPRMQERAFVLVPLAEIAPDWLEPISGYVIRELVKKVDCSDVHLLKGS

Sequences:

>Translated_79_residues
MRQERWGPRSLDLDLLLYDDLIIDTPTLQIPHPRMQERAFVLVPLAEIAPDWLEPISGYVIRELVKKVDCSDVHLLKGS
>Mature_79_residues
MRQERWGPRSLDLDLLLYDDLIIDTPTLQIPHPRMQERAFVLVPLAEIAPDWLEPISGYVIRELVKKVDCSDVHLLKGS

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=64, Percent_Identity=45.3125, Blast_Score=64, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 9136; Mature: 9136

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQERWGPRSLDLDLLLYDDLIIDTPTLQIPHPRMQERAFVLVPLAEIAPDWLEPISGYV
CCCCCCCCCCCCEEEEEECCEEECCCCCCCCCCCCCCCEEEEEEHHHCCCHHHHHHHHHH
IRELVKKVDCSDVHLLKGS
HHHHHHHCCCCCEEEEECC
>Mature Secondary Structure
MRQERWGPRSLDLDLLLYDDLIIDTPTLQIPHPRMQERAFVLVPLAEIAPDWLEPISGYV
CCCCCCCCCCCCEEEEEECCEEECCCCCCCCCCCCCCCEEEEEEHHHCCCHHHHHHHHHH
IRELVKKVDCSDVHLLKGS
HHHHHHHCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]