Click here to switch to the map view.

The map label for this gene is mltA [H]

Identifier: 17230425

GI number: 17230425

Start: 3569181

End: 3570413

Strand: Direct

Name: mltA [H]

Synonym: alr2933

Alternate gene names: 17230425

Gene position: 3569181-3570413 (Clockwise)

Preceding gene: 17230424

Following gene: 17230427

Centisome position: 55.65

GC content: 44.85

Gene sequence:

>1233_bases
ATGATAAGAAAAACCCTTGCTTTGTTTTCCTTAAGTCTGGGAATTGCTTTGGTAAATCCGATCGCAGTAGCCCAGGTGAT
TGATGTCCCGTCACCACTCCCTAGCAATCCTCAACTACCGTCGCCTGTAACTCGAACTCCCCTTAAACTTGTAGAAATTG
GTAACAACTGTGTTACCCAAAATCCTTGTTTGGGTTTCGATGAGCAAATTTTTGGTGTAGGTAGAGCCAGTGACCGCAAA
GCGCTATTAGCAGCCATAGACAACAGTTTGCGTTACTTACAAACGAATACCGCCAAACGAATTTATCAGAATTATCCAGT
CAGAGGAATTACCCTGAGTCGGGTACGGCGGAGTTTGTTACGTTTCCGTCAACTAGTTGTCAATTCTAGAACTCCCGCCC
AGTTGCAAGCTGCGGTGCGACGAGAGTTTGCTTTTTACCAGTCTGTAGGTAATGACGGCAAGGGTACTGTTAAGTTTACT
TCTTACTATCAACCAGTTTATAGAGCTAGTCGTGTAAGAACTTCCGTATATAAATATCCTCTATATCGATTACCATCTAA
TTTCCAGCAATGGTCTAAACCACACCCAACAAGGCTGGAACTGGAAGGTGAAGACGGTTTACAAGGGCATACAGGCCCAT
TGCGTGGCTCAGAATTGCTGTGGTTTAGCGATCGCCTAGATGCGTACATGGTACAAATTCAAGGTTCTGCCCAAATTCAA
TTAACTAATGGACAGCGAACCGCGATCGGCTATGCAGGTGGAACCGATTATCCTTGGACTAGTATTGGGCGAGAACTGGC
CAAAGATGGCAAACTTCCCTTATCTGGGATGACTATGCCAAAAATGATCAGTTTCTTCCGCCAACAACCAGAGGAATTAA
ATAACTACTTACCACGTTGGGAAAGATTTGTTTTCTTCCAAGAAACTGGTAGTAGGCCAGCTACTGGTAGTATCAACGTA
CCAGTAACCCCAGAACGTTCTATTGCCACAGATAAATCTTTAATGCCTCCGGGCGCACTAGCACTTGTTCATACTTCTAT
TCCCTTTCCCGTCGCTGGTGGAAGAATGGAGTATCGCACTGTCAGCCGCTATGTATTAGATCAAGATACTGGTAATGCGA
TCAAAGGCCCAGGAAGAGTAGATTACTTCATGGGAACTGGGAAACAAGCAGGCGATCGCGCAGGTGTTACAGGTGGCCAT
GGTTCACTCTATTATTTGTTGTTGAGGAAATAG

Upstream 100 bases:

>100_bases
CAAGAATATTCAAGGGGAGTATATGGTTGTGCGCCCTTCCCGGATTGTAGCGATCCGAGTAGAACCTGTTTTTAGTTCTA
GTGTTGAAAGATTCAACTAA

Downstream 100 bases:

>100_bases
GCCAGGAAACAGGGAGCAGGGGAGAATAACAACTCAACACTCACAATTCCCCACTCCCCATTCTCCATTTCCCACTTTCA
TACATTCAAATAGATGTAAG

Product: membrane-bound lytic transglycosylase A

Products: Muramic Acid Residue [C]

Alternate protein names: Murein hydrolase A [H]

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MIRKTLALFSLSLGIALVNPIAVAQVIDVPSPLPSNPQLPSPVTRTPLKLVEIGNNCVTQNPCLGFDEQIFGVGRASDRK
ALLAAIDNSLRYLQTNTAKRIYQNYPVRGITLSRVRRSLLRFRQLVVNSRTPAQLQAAVRREFAFYQSVGNDGKGTVKFT
SYYQPVYRASRVRTSVYKYPLYRLPSNFQQWSKPHPTRLELEGEDGLQGHTGPLRGSELLWFSDRLDAYMVQIQGSAQIQ
LTNGQRTAIGYAGGTDYPWTSIGRELAKDGKLPLSGMTMPKMISFFRQQPEELNNYLPRWERFVFFQETGSRPATGSINV
PVTPERSIATDKSLMPPGALALVHTSIPFPVAGGRMEYRTVSRYVLDQDTGNAIKGPGRVDYFMGTGKQAGDRAGVTGGH
GSLYYLLLRK

Sequences:

>Translated_410_residues
MIRKTLALFSLSLGIALVNPIAVAQVIDVPSPLPSNPQLPSPVTRTPLKLVEIGNNCVTQNPCLGFDEQIFGVGRASDRK
ALLAAIDNSLRYLQTNTAKRIYQNYPVRGITLSRVRRSLLRFRQLVVNSRTPAQLQAAVRREFAFYQSVGNDGKGTVKFT
SYYQPVYRASRVRTSVYKYPLYRLPSNFQQWSKPHPTRLELEGEDGLQGHTGPLRGSELLWFSDRLDAYMVQIQGSAQIQ
LTNGQRTAIGYAGGTDYPWTSIGRELAKDGKLPLSGMTMPKMISFFRQQPEELNNYLPRWERFVFFQETGSRPATGSINV
PVTPERSIATDKSLMPPGALALVHTSIPFPVAGGRMEYRTVSRYVLDQDTGNAIKGPGRVDYFMGTGKQAGDRAGVTGGH
GSLYYLLLRK
>Mature_410_residues
MIRKTLALFSLSLGIALVNPIAVAQVIDVPSPLPSNPQLPSPVTRTPLKLVEIGNNCVTQNPCLGFDEQIFGVGRASDRK
ALLAAIDNSLRYLQTNTAKRIYQNYPVRGITLSRVRRSLLRFRQLVVNSRTPAQLQAAVRREFAFYQSVGNDGKGTVKFT
SYYQPVYRASRVRTSVYKYPLYRLPSNFQQWSKPHPTRLELEGEDGLQGHTGPLRGSELLWFSDRLDAYMVQIQGSAQIQ
LTNGQRTAIGYAGGTDYPWTSIGRELAKDGKLPLSGMTMPKMISFFRQQPEELNNYLPRWERFVFFQETGSRPATGSINV
PVTPERSIATDKSLMPPGALALVHTSIPFPVAGGRMEYRTVSRYVLDQDTGNAIKGPGRVDYFMGTGKQAGDRAGVTGGH
GSLYYLLLRK

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division [H]

COG id: COG2821

COG function: function code M; Membrane-bound lytic murein transglycosylase

Gene ontology:

Cell location: Note=In closely related bacteria this protein is attached to the outer membrane by a lipid anchor. This is apparently not the case here [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789179, Length=271, Percent_Identity=30.2583025830258, Blast_Score=112, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010611
- InterPro:   IPR014733
- InterPro:   IPR005300 [H]

Pfam domain/function: PF06725 3D; PF03562 MltA [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 45611; Mature: 45611

Theoretical pI: Translated: 10.45; Mature: 10.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRKTLALFSLSLGIALVNPIAVAQVIDVPSPLPSNPQLPSPVTRTPLKLVEIGNNCVTQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCC
NPCLGFDEQIFGVGRASDRKALLAAIDNSLRYLQTNTAKRIYQNYPVRGITLSRVRRSLL
CCCCCCCHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHH
RFRQLVVNSRTPAQLQAAVRREFAFYQSVGNDGKGTVKFTSYYQPVYRASRVRTSVYKYP
HHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCC
LYRLPSNFQQWSKPHPTRLELEGEDGLQGHTGPLRGSELLWFSDRLDAYMVQIQGSAQIQ
HHHCCCCHHHHCCCCCCEEEECCCCCCCCCCCCCCCCEEEEEECCCCEEEEEECCCEEEE
LTNGQRTAIGYAGGTDYPWTSIGRELAKDGKLPLSGMTMPKMISFFRQQPEELNNYLPRW
EECCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCHHHHHHHCCCH
ERFVFFQETGSRPATGSINVPVTPERSIATDKSLMPPGALALVHTSIPFPVAGGRMEYRT
HEEEEEECCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHH
VSRYVLDQDTGNAIKGPGRVDYFMGTGKQAGDRAGVTGGHGSLYYLLLRK
HHHHHEECCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEEEC
>Mature Secondary Structure
MIRKTLALFSLSLGIALVNPIAVAQVIDVPSPLPSNPQLPSPVTRTPLKLVEIGNNCVTQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCC
NPCLGFDEQIFGVGRASDRKALLAAIDNSLRYLQTNTAKRIYQNYPVRGITLSRVRRSLL
CCCCCCCHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHH
RFRQLVVNSRTPAQLQAAVRREFAFYQSVGNDGKGTVKFTSYYQPVYRASRVRTSVYKYP
HHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCC
LYRLPSNFQQWSKPHPTRLELEGEDGLQGHTGPLRGSELLWFSDRLDAYMVQIQGSAQIQ
HHHCCCCHHHHCCCCCCEEEECCCCCCCCCCCCCCCCEEEEEECCCCEEEEEECCCEEEE
LTNGQRTAIGYAGGTDYPWTSIGRELAKDGKLPLSGMTMPKMISFFRQQPEELNNYLPRW
EECCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCHHHHHHHCCCH
ERFVFFQETGSRPATGSINVPVTPERSIATDKSLMPPGALALVHTSIPFPVAGGRMEYRT
HEEEEEECCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHH
VSRYVLDQDTGNAIKGPGRVDYFMGTGKQAGDRAGVTGGHGSLYYLLLRK
HHHHHEECCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic [C]

General reaction: Cleavage Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12089438 [H]