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The map label for this gene is ecaA

Identifier: 17230421

GI number: 17230421

Start: 3566296

End: 3567090

Strand: Reverse

Name: ecaA

Synonym: all2929

Alternate gene names: 17230421

Gene position: 3567090-3566296 (Counterclockwise)

Preceding gene: 17230422

Following gene: 17230420

Centisome position: 55.62

GC content: 43.27

Gene sequence:

>795_bases
ATGAGTAGTACTTTATATCGAAGGCAACTACTGAAATTATTGGGTATGAGTGTCTTGGGAACCTCATTTTCTAGTTGTGT
CACATCTCCAGCTAGGGCAAAAACGGTAAACTGGGGATATATCGGCAAAGTAGGCCCAGAGCATTGGGGTGAGCTTTCCC
CTGACTTTGCCCTTTGCCAAATAGGCAGAAAACAAACGCCGATTGATTTGCAGATTGCAGATGTGAAAGATGTCCACAGC
AGCAGTCAAGATTTGTTAGTTACCAATTATCAGCCAACGGCATTACACCTAATCAACAACGGTAAAACAGTCCAAGTCAA
CTATCAACCAGGCAGTTATCTCAAGTATGCTCACCAAAAATTTGAGCTGCTTCAGTTTCACTTTCATCACTTCAGCGAAC
ATCGGGTTGATGGGAAATTATATGATATGGAACTCCATTTAGTTCACCGGAGTAAATCTGGCGACTTAGCCGTTATGGGT
ATTTTCTTGCAAGCAGGAGCATTTAACCCGACGCTGCAAATTATCTGGGATGCCACACCTCAAAACCAAGGAACAGACAA
AAGAATAGAGGATATAAATATAGACGCTTCCCAATTTCTCCCAGCACAACACAGATTTTTTACTTATTCTGGCTCTCTGA
CAACCCCACCCTGTTCAGAAAATGTTCTCTGGTGCGTAATGGCGACACCTATCGAAGCCTCTCCTGCACAGATAGCTAAG
TTTAGTCAAATGTTTCCCCAAAACGCACGTCCAGTGCAACCTCTCAACGATCGCCTAGTTATCGAAGCCATTTAA

Upstream 100 bases:

>100_bases
ACACCAATGTTTGCTCTCAATGTCTTGAGAAATTACTCAGAACGTCTCAGCCGTTTGCAACGTTTAGTTTAATATCGCAG
TATGTTTCAACCGCAGGGAA

Downstream 100 bases:

>100_bases
AATTTTTCTGTCAACTTCCCCGGATTTTGTGTTGCTATGTCATACTAAGAGATGAGAATTAATTCGGCGACCGCGTTTGT
TTTGAGTATTGACAGGCTTT

Product: carbonic anhydrase

Products: NA

Alternate protein names: Carbonate dehydratase

Number of amino acids: Translated: 264; Mature: 263

Protein sequence:

>264_residues
MSSTLYRRQLLKLLGMSVLGTSFSSCVTSPARAKTVNWGYIGKVGPEHWGELSPDFALCQIGRKQTPIDLQIADVKDVHS
SSQDLLVTNYQPTALHLINNGKTVQVNYQPGSYLKYAHQKFELLQFHFHHFSEHRVDGKLYDMELHLVHRSKSGDLAVMG
IFLQAGAFNPTLQIIWDATPQNQGTDKRIEDINIDASQFLPAQHRFFTYSGSLTTPPCSENVLWCVMATPIEASPAQIAK
FSQMFPQNARPVQPLNDRLVIEAI

Sequences:

>Translated_264_residues
MSSTLYRRQLLKLLGMSVLGTSFSSCVTSPARAKTVNWGYIGKVGPEHWGELSPDFALCQIGRKQTPIDLQIADVKDVHS
SSQDLLVTNYQPTALHLINNGKTVQVNYQPGSYLKYAHQKFELLQFHFHHFSEHRVDGKLYDMELHLVHRSKSGDLAVMG
IFLQAGAFNPTLQIIWDATPQNQGTDKRIEDINIDASQFLPAQHRFFTYSGSLTTPPCSENVLWCVMATPIEASPAQIAK
FSQMFPQNARPVQPLNDRLVIEAI
>Mature_263_residues
SSTLYRRQLLKLLGMSVLGTSFSSCVTSPARAKTVNWGYIGKVGPEHWGELSPDFALCQIGRKQTPIDLQIADVKDVHSS
SQDLLVTNYQPTALHLINNGKTVQVNYQPGSYLKYAHQKFELLQFHFHHFSEHRVDGKLYDMELHLVHRSKSGDLAVMGI
FLQAGAFNPTLQIIWDATPQNQGTDKRIEDINIDASQFLPAQHRFFTYSGSLTTPPCSENVLWCVMATPIEASPAQIAKF
SQMFPQNARPVQPLNDRLVIEAI

Specific function: Reversible hydration of carbon dioxide

COG id: COG3338

COG function: function code P; Carbonic anhydrase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alpha-carbonic anhydrase family

Homologues:

Organism=Homo sapiens, GI258679498, Length=259, Percent_Identity=35.5212355212355, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI192447434, Length=259, Percent_Identity=35.5212355212355, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI192447432, Length=259, Percent_Identity=35.5212355212355, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI192447430, Length=259, Percent_Identity=35.5212355212355, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI4502517, Length=259, Percent_Identity=35.5212355212355, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI4557395, Length=262, Percent_Identity=35.8778625954198, Blast_Score=132, Evalue=2e-31,
Organism=Homo sapiens, GI4885099, Length=265, Percent_Identity=33.5849056603774, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI38348436, Length=260, Percent_Identity=33.8461538461538, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI4885101, Length=259, Percent_Identity=33.976833976834, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI4502521, Length=234, Percent_Identity=33.3333333333333, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI6005723, Length=234, Percent_Identity=33.3333333333333, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI4502515, Length=271, Percent_Identity=28.7822878228782, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI45935383, Length=271, Percent_Identity=28.7822878228782, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI62240989, Length=201, Percent_Identity=33.8308457711443, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI6912284, Length=266, Percent_Identity=30.0751879699248, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI169636420, Length=262, Percent_Identity=30.9160305343511, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI70167127, Length=259, Percent_Identity=30.5019305019305, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI22027500, Length=259, Percent_Identity=28.957528957529, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI130979954, Length=292, Percent_Identity=24.3150684931507, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI130979679, Length=292, Percent_Identity=24.3150684931507, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI9910366, Length=292, Percent_Identity=24.3150684931507, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI194097398, Length=269, Percent_Identity=27.8810408921933, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI4502519, Length=265, Percent_Identity=26.4150943396226, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI9951923, Length=256, Percent_Identity=28.125, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17568715, Length=258, Percent_Identity=33.7209302325581, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI71995280, Length=264, Percent_Identity=31.4393939393939, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17569165, Length=225, Percent_Identity=31.1111111111111, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17569163, Length=226, Percent_Identity=30.9734513274336, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI17737413, Length=248, Percent_Identity=31.8548387096774, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI21358169, Length=272, Percent_Identity=30.5147058823529, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24650523, Length=251, Percent_Identity=29.8804780876494, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24645604, Length=241, Percent_Identity=26.5560165975104, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI161079350, Length=281, Percent_Identity=27.4021352313167, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI18858185, Length=268, Percent_Identity=24.6268656716418, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24649809, Length=232, Percent_Identity=28.8793103448276, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI28573346, Length=269, Percent_Identity=24.907063197026, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CAH_NOSS1 (P94170)

Other databases:

- EMBL:   U72708
- EMBL:   BA000019
- PIR:   AB2172
- RefSeq:   NP_486969.1
- ProteinModelPortal:   P94170
- SMR:   P94170
- STRING:   P94170
- GeneID:   1106527
- GenomeReviews:   BA000019_GR
- KEGG:   ana:all2929
- NMPDR:   fig|103690.1.peg.3236
- eggNOG:   COG3338
- HOGENOM:   HBG717384
- OMA:   QFHFHAP
- ProtClustDB:   CLSK895842
- BioCyc:   NSP103690:ALL2929-MONOMER
- InterPro:   IPR001148
- InterPro:   IPR018338
- InterPro:   IPR018340
- InterPro:   IPR006311
- Gene3D:   G3DSA:3.10.200.10
- PANTHER:   PTHR18952:SF2
- PANTHER:   PTHR18952
- TIGRFAMs:   TIGR01409

Pfam domain/function: PF00194 Carb_anhydrase; SSF51069 Euk_COanhd

EC number: =4.2.1.1

Molecular weight: Translated: 29639; Mature: 29508

Theoretical pI: Translated: 7.68; Mature: 7.68

Prosite motif: PS00162 ALPHA_CA_1; PS51144 ALPHA_CA_2; PS51318 TAT; PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSTLYRRQLLKLLGMSVLGTSFSSCVTSPARAKTVNWGYIGKVGPEHWGELSPDFALCQ
CCCHHHHHHHHHHHCHHHHHCCHHHHHCCCCCCEEECCCCCCCCCCHHHCCCCCCHHHHH
IGRKQTPIDLQIADVKDVHSSSQDLLVTNYQPTALHLINNGKTVQVNYQPGSYLKYAHQK
CCCCCCCCEEEEECCHHHCCCCCCEEEECCCCEEEEEECCCEEEEEEECCCHHHHHHHHH
FELLQFHFHHFSEHRVDGKLYDMELHLVHRSKSGDLAVMGIFLQAGAFNPTLQIIWDATP
HHHHHHHHHHHHHHCCCCEEEEEEEEEEEECCCCCEEEEEEEEECCCCCCEEEEEEECCC
QNQGTDKRIEDINIDASQFLPAQHRFFTYSGSLTTPPCSENVLWCVMATPIEASPAQIAK
CCCCCCCEEEECCCCHHHCCCCCCEEEEEECCCCCCCCCCCEEEEEEECCCCCCHHHHHH
FSQMFPQNARPVQPLNDRLVIEAI
HHHHCCCCCCCCCCCCCEEEEEEC
>Mature Secondary Structure 
SSTLYRRQLLKLLGMSVLGTSFSSCVTSPARAKTVNWGYIGKVGPEHWGELSPDFALCQ
CCHHHHHHHHHHHCHHHHHCCHHHHHCCCCCCEEECCCCCCCCCCHHHCCCCCCHHHHH
IGRKQTPIDLQIADVKDVHSSSQDLLVTNYQPTALHLINNGKTVQVNYQPGSYLKYAHQK
CCCCCCCCEEEEECCHHHCCCCCCEEEECCCCEEEEEECCCEEEEEEECCCHHHHHHHHH
FELLQFHFHHFSEHRVDGKLYDMELHLVHRSKSGDLAVMGIFLQAGAFNPTLQIIWDATP
HHHHHHHHHHHHHHCCCCEEEEEEEEEEEECCCCCEEEEEEEEECCCCCCEEEEEEECCC
QNQGTDKRIEDINIDASQFLPAQHRFFTYSGSLTTPPCSENVLWCVMATPIEASPAQIAK
CCCCCCCEEEECCCCHHHCCCCCCEEEEEECCCCCCCCCCCEEEEEEECCCCCCHHHHHH
FSQMFPQNARPVQPLNDRLVIEAI
HHHHCCCCCCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9006032; 11759840