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The map label for this gene is rfbF [H]

Identifier: 17230317

GI number: 17230317

Start: 3441147

End: 3441920

Strand: Direct

Name: rfbF [H]

Synonym: alr2825

Alternate gene names: 17230317

Gene position: 3441147-3441920 (Clockwise)

Preceding gene: 17230316

Following gene: 17230318

Centisome position: 53.65

GC content: 39.41

Gene sequence:

>774_bases
ATGAAAGCGGTGATTTTGGCTGGAGGGCTTGGTACACGCCTCAGTGAAGAAACCAGTATCAAGCCTAAGCCGATGGTAGA
AATTGGTGGTAAACCAATTCTTTGGCACATCATGAAAACTTATTCTAGCCACGGCATTAATGATTTTATTATTTGTTGTG
GTTACAAAGGTTACGTGATTAAGGAGTATTTTGCTAACTACTTCTTACATATGTCTGATGTAACTTTTGATATGCGTTTT
AACCAGATGAATATCCATTCTGGTTACGCTGAACCTTGGCGAGTAACTTTGGTCAACACAGGCGATAATACTATGACTGG
TGGACGCTTAAAACGTGTCCGCGAACATCTTGGGAATGATACTTTTTGTTTTACTTATGGTGACGGTGTATGTGATATTA
ATATCACCGAATTAATTAAGTTTCATCGAGAACAAAAGAGTTTAGCAACCCTGACAGCAGTCCAACCAGCAGGACGTTTC
GGGGCAATTTCCCTGGGATACGAACAAACTAAAATAACCAGTTTCCGGGAAAAGCCCGAAGGTGATGGTGCTTGGATTAA
CGGTGGTTATTTTATCTTAGAACCAGAAGTCATAGATTTAATTGCTGATGATGCTACCGTTTGGGAAAAAGAACCACTAG
AAAAGCTAGCAGATATGGAGGAATTATCTGCTTTTAAACACAATGGTTTTTGGCAACCAATGGATACATTGCGTGATAAA
AACTATCTAGAGGAGTTATGGAAAAATAACCAAGCTCCTTGGAAAGTGTGGTAA

Upstream 100 bases:

>100_bases
AGAAAAATAAAAGAGAAGTGAATTTTTCTCCCATCCATGTGCATCCTCTTCATCCCGATATTCAAAAATTAATCTAACTG
CAAATCCCCAAGGTAATTGT

Downstream 100 bases:

>100_bases
TTAACAGTACACGGAATTCAAAAAACATTTTGGCATTTTGTCCTATCTTATTTTGACTTCCGTTGTAAGGTATTCTTTAC
TGATTTAGTGTAATTTTTGC

Product: glucose-1-P cytidylyltransferase

Products: NA

Alternate protein names: CDP-glucose pyrophosphorylase [H]

Number of amino acids: Translated: 257; Mature: 257

Protein sequence:

>257_residues
MKAVILAGGLGTRLSEETSIKPKPMVEIGGKPILWHIMKTYSSHGINDFIICCGYKGYVIKEYFANYFLHMSDVTFDMRF
NQMNIHSGYAEPWRVTLVNTGDNTMTGGRLKRVREHLGNDTFCFTYGDGVCDINITELIKFHREQKSLATLTAVQPAGRF
GAISLGYEQTKITSFREKPEGDGAWINGGYFILEPEVIDLIADDATVWEKEPLEKLADMEELSAFKHNGFWQPMDTLRDK
NYLEELWKNNQAPWKVW

Sequences:

>Translated_257_residues
MKAVILAGGLGTRLSEETSIKPKPMVEIGGKPILWHIMKTYSSHGINDFIICCGYKGYVIKEYFANYFLHMSDVTFDMRF
NQMNIHSGYAEPWRVTLVNTGDNTMTGGRLKRVREHLGNDTFCFTYGDGVCDINITELIKFHREQKSLATLTAVQPAGRF
GAISLGYEQTKITSFREKPEGDGAWINGGYFILEPEVIDLIADDATVWEKEPLEKLADMEELSAFKHNGFWQPMDTLRDK
NYLEELWKNNQAPWKVW
>Mature_257_residues
MKAVILAGGLGTRLSEETSIKPKPMVEIGGKPILWHIMKTYSSHGINDFIICCGYKGYVIKEYFANYFLHMSDVTFDMRF
NQMNIHSGYAEPWRVTLVNTGDNTMTGGRLKRVREHLGNDTFCFTYGDGVCDINITELIKFHREQKSLATLTAVQPAGRF
GAISLGYEQTKITSFREKPEGDGAWINGGYFILEPEVIDLIADDATVWEKEPLEKLADMEELSAFKHNGFWQPMDTLRDK
NYLEELWKNNQAPWKVW

Specific function: Involved in the biosynthesis of the tyvelose, a 3,6- dideoxyhexose found in the O-antigen of the surface lipopolysaccharides. It catalyzes the transfer of a CMP moiety from CTP to glucose 1-phosphate. This enzyme can utilize either CTP or UTP as the nucle

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate cytidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=248, Percent_Identity=28.6290322580645, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI11761619, Length=248, Percent_Identity=28.6290322580645, Blast_Score=98, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI133931050, Length=250, Percent_Identity=29.6, Blast_Score=105, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6320148, Length=250, Percent_Identity=32, Blast_Score=104, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013446
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.33 [H]

Molecular weight: Translated: 29392; Mature: 29392

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVILAGGLGTRLSEETSIKPKPMVEIGGKPILWHIMKTYSSHGINDFIICCGYKGYVI
CCEEEEECCCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHCCCCCEEEEEECCCCHHH
KEYFANYFLHMSDVTFDMRFNQMNIHSGYAEPWRVTLVNTGDNTMTGGRLKRVREHLGND
HHHHHHHEEEECCEEEEEEECEEEECCCCCCCEEEEEEECCCCCCCCHHHHHHHHHCCCC
TFCFTYGDGVCDINITELIKFHREQKSLATLTAVQPAGRFGAISLGYEQTKITSFREKPE
EEEEEECCCEEECCHHHHHHHHHHHHHHHHHEEECCCCCCCEEEECCCHHHHHHHHCCCC
GDGAWINGGYFILEPEVIDLIADDATVWEKEPLEKLADMEELSAFKHNGFWQPMDTLRDK
CCCCEEECCEEEECCCEEEEECCCCHHCCHHHHHHHHCHHHHHHHHHCCCCCCHHHHCCH
NYLEELWKNNQAPWKVW
HHHHHHHCCCCCCEECC
>Mature Secondary Structure
MKAVILAGGLGTRLSEETSIKPKPMVEIGGKPILWHIMKTYSSHGINDFIICCGYKGYVI
CCEEEEECCCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHCCCCCEEEEEECCCCHHH
KEYFANYFLHMSDVTFDMRFNQMNIHSGYAEPWRVTLVNTGDNTMTGGRLKRVREHLGND
HHHHHHHEEEECCEEEEEEECEEEECCCCCCCEEEEEEECCCCCCCCHHHHHHHHHCCCC
TFCFTYGDGVCDINITELIKFHREQKSLATLTAVQPAGRFGAISLGYEQTKITSFREKPE
EEEEEECCCEEECCHHHHHHHHHHHHHHHHHEEECCCCCCCEEEECCCHHHHHHHHCCCC
GDGAWINGGYFILEPEVIDLIADDATVWEKEPLEKLADMEELSAFKHNGFWQPMDTLRDK
CCCCEEECCEEEECCCEEEEECCCCHHCCHHHHHHHHCHHHHHHHHHCCCCCCHHHHCCH
NYLEELWKNNQAPWKVW
HHHHHHHCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]