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The map label for this gene is ampC [C]

Identifier: 17230148

GI number: 17230148

Start: 3223052

End: 3224296

Strand: Reverse

Name: ampC [C]

Synonym: all2656

Alternate gene names: 17230148

Gene position: 3224296-3223052 (Counterclockwise)

Preceding gene: 17230149

Following gene: 17230147

Centisome position: 50.27

GC content: 46.02

Gene sequence:

>1245_bases
ATGCTGTTGAAAATTTTTCGCACAACAATTCTGACTTCAGCCCTGTTATGTACTCCAGCGATCGCCCAAGCTGCAACCTT
AACAACTGAATCAAGCCAGTCCATTACCTTCAGAAATACAGTCAATAGAGACTTAGGACAACAGCTACAAACAGCCTTAG
ATCAAGCACGGGGAGACATCCCAGGCGCGGCTGTAGCAATTATCAGCCCGAAAGGAAATTGGTTTGGGGCTAGTGGAGTA
GCAGACATAGCCACAGGTAGACAATTGCAATCGAGCGATCGCTTTCAAATTGGCAGTATTACTAAAACATTTGTCGCAAC
AACTACATTACAGCTAGTAGAAGAAGACATCCTGAATTTAGACGATAAGCTAACAGACAGACTACCAATATCTGTCACTG
ATTGGATTCCCAACGCTAATCAAATTACCCTCCGCCAACTCCTAAACCATACAAGCGGCGTGCCTGATTATACAGATGTA
TTATTTAGATGGGCTGCCGTAAATCCAGGGGTATTTTTCAACAATTGGCAACCAGAACTACTAGTGAGTTTTATTGATGG
CTTAGAGGCAAGTTTTCAACCGGGAGATGCTTGGCAATATTCCAACACCAATTATTTACTGTTGGGTATGGTGGTAGAAG
CAGCGACAAATAATAGTATTGCACAAGAAATACGCGATCGCATTCTTGAACCCTTAGCCCTCAGCAACACCTTCTTTGCC
GAAGAAGAAACCATTCCCGGTGGTTACGTCAGAGGTTATTGGGACTTCGACCAAAACGGCACACTCAACGATATTTCCAC
CGCTAACCTATCTTGGGCTTGGGCTAGCGGCGCAATGGTTTCCAACACCAGCGATTTAGCCACCTTCATTCATGCTCTCA
TAGGTGGGAAACTACTAGAACCCGACACCCTCCAACAAATGCTCACCACCATCAGTCCCATCACCTCCCAAAACTATACC
ACCTACGGTCTAGGCATCGGCACTCTAGAATCCCCCAATCGCTTTTGGTACATCCATCGGGGACAAACTCTAGGTTATCG
CTCCAATATGTGGTACTCACCCTTAGAAAACATCACCTATATCGAATTAATTAACGCCCGTTCCAGTCGTAACTTAGCCG
GTGCAACACTCACCACCCTACGACGCTATGAACCCCCCGCCGCAGTTCCCGAACCAAGAACGCTCCTTAGTGTGCTGTTA
ATAACAGTCGGTATGCTGACAGTTAGAGCAAGACCAGGTGTGTAA

Upstream 100 bases:

>100_bases
TTAGATTTACTCTCACAACACATAGCTTTTCAAGAAAATCGGGCTAATATCCTTTTCTTGATTACTTTTGCCTTTTAACT
TTTACCTTTCTTCTACTTAT

Downstream 100 bases:

>100_bases
GGGTGCAGGGGTGCAGGGGAAGTAAATTCGCCCTTTCTTTCCCCAGTCCCCCATTCGTGCAAAATTTGCACAAACAATTT
ATATCTACGAAAATATATTG

Product: serine-type D-Ala-D-Ala carboxypeptidase

Products: NA

Alternate protein names: DD-carboxypeptidase; DD-peptidase [H]

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MLLKIFRTTILTSALLCTPAIAQAATLTTESSQSITFRNTVNRDLGQQLQTALDQARGDIPGAAVAIISPKGNWFGASGV
ADIATGRQLQSSDRFQIGSITKTFVATTTLQLVEEDILNLDDKLTDRLPISVTDWIPNANQITLRQLLNHTSGVPDYTDV
LFRWAAVNPGVFFNNWQPELLVSFIDGLEASFQPGDAWQYSNTNYLLLGMVVEAATNNSIAQEIRDRILEPLALSNTFFA
EEETIPGGYVRGYWDFDQNGTLNDISTANLSWAWASGAMVSNTSDLATFIHALIGGKLLEPDTLQQMLTTISPITSQNYT
TYGLGIGTLESPNRFWYIHRGQTLGYRSNMWYSPLENITYIELINARSSRNLAGATLTTLRRYEPPAAVPEPRTLLSVLL
ITVGMLTVRARPGV

Sequences:

>Translated_414_residues
MLLKIFRTTILTSALLCTPAIAQAATLTTESSQSITFRNTVNRDLGQQLQTALDQARGDIPGAAVAIISPKGNWFGASGV
ADIATGRQLQSSDRFQIGSITKTFVATTTLQLVEEDILNLDDKLTDRLPISVTDWIPNANQITLRQLLNHTSGVPDYTDV
LFRWAAVNPGVFFNNWQPELLVSFIDGLEASFQPGDAWQYSNTNYLLLGMVVEAATNNSIAQEIRDRILEPLALSNTFFA
EEETIPGGYVRGYWDFDQNGTLNDISTANLSWAWASGAMVSNTSDLATFIHALIGGKLLEPDTLQQMLTTISPITSQNYT
TYGLGIGTLESPNRFWYIHRGQTLGYRSNMWYSPLENITYIELINARSSRNLAGATLTTLRRYEPPAAVPEPRTLLSVLL
ITVGMLTVRARPGV
>Mature_414_residues
MLLKIFRTTILTSALLCTPAIAQAATLTTESSQSITFRNTVNRDLGQQLQTALDQARGDIPGAAVAIISPKGNWFGASGV
ADIATGRQLQSSDRFQIGSITKTFVATTTLQLVEEDILNLDDKLTDRLPISVTDWIPNANQITLRQLLNHTSGVPDYTDV
LFRWAAVNPGVFFNNWQPELLVSFIDGLEASFQPGDAWQYSNTNYLLLGMVVEAATNNSIAQEIRDRILEPLALSNTFFA
EEETIPGGYVRGYWDFDQNGTLNDISTANLSWAWASGAMVSNTSDLATFIHALIGGKLLEPDTLQQMLTTISPITSQNYT
TYGLGIGTLESPNRFWYIHRGQTLGYRSNMWYSPLENITYIELINARSSRNLAGATLTTLRRYEPPAAVPEPRTLLSVLL
ITVGMLTVRARPGV

Specific function: Catalyzes distinct carboxypeptidation and transpeptidation reactions during the last stages of wall peptidoglycan synthesis. Mistaking a beta-lactam antibiotic molecule for a normal substrate (i.e., a D-alanyl-D-alanine- terminated peptide), it becomes im

COG id: COG1680

COG function: function code V; Beta-lactamase class C and other penicillin binding proteins

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S12 family [H]

Homologues:

Organism=Escherichia coli, GI1790593, Length=242, Percent_Identity=26.8595041322314, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87082101, Length=386, Percent_Identity=25.6476683937824, Blast_Score=69, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI115533026, Length=306, Percent_Identity=25.8169934640523, Blast_Score=85, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17550934, Length=180, Percent_Identity=27.7777777777778, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466 [H]

Pfam domain/function: PF00144 Beta-lactamase [H]

EC number: =3.4.16.4 [H]

Molecular weight: Translated: 45573; Mature: 45573

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLKIFRTTILTSALLCTPAIAQAATLTTESSQSITFRNTVNRDLGQQLQTALDQARGDI
CHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCEEEHHHHCHHHHHHHHHHHHHHCCCC
PGAAVAIISPKGNWFGASGVADIATGRQLQSSDRFQIGSITKTFVATTTLQLVEEDILNL
CCCEEEEECCCCCCCCCCCCHHHHCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHCC
DDKLTDRLPISVTDWIPNANQITLRQLLNHTSGVPDYTDVLFRWAAVNPGVFFNNWQPEL
CHHHHCCCCCEEECCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCEEECCCCHHH
LVSFIDGLEASFQPGDAWQYSNTNYLLLGMVVEAATNNSIAQEIRDRILEPLALSNTFFA
HHHHHHCCCCCCCCCCCEEECCCCEEEEEEHHHHHCCCHHHHHHHHHHHCCHHHCCCEEC
EEETIPGGYVRGYWDFDQNGTLNDISTANLSWAWASGAMVSNTSDLATFIHALIGGKLLE
CCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEECCCEECCHHHHHHHHHHHHCCCCCC
PDTLQQMLTTISPITSQNYTTYGLGIGTLESPNRFWYIHRGQTLGYRSNMWYSPLENITY
HHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCEE
IELINARSSRNLAGATLTTLRRYEPPAAVPEPRTLLSVLLITVGMLTVRARPGV
EEEECCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHEEECCCCC
>Mature Secondary Structure
MLLKIFRTTILTSALLCTPAIAQAATLTTESSQSITFRNTVNRDLGQQLQTALDQARGDI
CHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCEEEHHHHCHHHHHHHHHHHHHHCCCC
PGAAVAIISPKGNWFGASGVADIATGRQLQSSDRFQIGSITKTFVATTTLQLVEEDILNL
CCCEEEEECCCCCCCCCCCCHHHHCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHCC
DDKLTDRLPISVTDWIPNANQITLRQLLNHTSGVPDYTDVLFRWAAVNPGVFFNNWQPEL
CHHHHCCCCCEEECCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCEEECCCCHHH
LVSFIDGLEASFQPGDAWQYSNTNYLLLGMVVEAATNNSIAQEIRDRILEPLALSNTFFA
HHHHHHCCCCCCCCCCCEEECCCCEEEEEEHHHHHCCCHHHHHHHHHHHCCHHHCCCEEC
EEETIPGGYVRGYWDFDQNGTLNDISTANLSWAWASGAMVSNTSDLATFIHALIGGKLLE
CCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEECCCEECCHHHHHHHHHHHHCCCCCC
PDTLQQMLTTISPITSQNYTTYGLGIGTLESPNRFWYIHRGQTLGYRSNMWYSPLENITY
HHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCEE
IELINARSSRNLAGATLTTLRRYEPPAAVPEPRTLLSVLLITVGMLTVRARPGV
EEEECCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3830154; 7925404; 3030739; 2175384; 2386365; 3997832; 7490745 [H]