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The map label for this gene is cysK [H]

Identifier: 17230013

GI number: 17230013

Start: 3027261

End: 3028220

Strand: Reverse

Name: cysK [H]

Synonym: all2521

Alternate gene names: 17230013

Gene position: 3028220-3027261 (Counterclockwise)

Preceding gene: 17230020

Following gene: 17230011

Centisome position: 47.21

GC content: 47.6

Gene sequence:

>960_bases
ATGCGAATTGCTAATGATGTAACAGAACTTATTGGAGGTACACCTTTAGTTAAGCTTAATAAGATTCCGCAAGCGGAAGG
AGTAGTTGCCAGAATAGTTGTCAAACTAGAAGGAATGAATCCAGCCTCTTCCGTAAAAGACCGGATTGGGGTGAGTATGA
TTAACGCAGCAGAAGCGGAAGGTTTAATCATACCGGGAAAAACTATTTTAGTAGAACCAACTTCCGGTAACACAGGAATT
GCCCTGGCGATGGTAGCCGCCGCCCGTGGCTATCGGTTAATTTTGACTATGCCAGAGACTATGAGCCAAGAAAGACGGGC
TATGTTGCGGGCTTATGGTGCAACTCTAGAGTTGACTCCAGGTACAGAAGGTATGCGGGGAGCCATTCGCAAAGCCGAAG
AAATTGTGGCTAGTACCCCTGATACTCATATGCTGCAACAGTTTCGCAACCCAGCTAACCCCAAAATCCACCGTGAAACT
ACCGCCGAAGAAATTTGGAATGATACCGATGGTGAAGTTGATATTGTGATTGCTGGGGTGGGTACTGGAGGAACAATTAC
TGGGATTGCAGAGGTATTGAAACAACGCAAACCTAGCTTTCAGGCGATCGCAGTTGAACCTAGCAATAGTCCTATCCTTT
CCGGTGGACAAGCCGGGCCACACAAAATCCAAGGTATCGGTGCAGGCTTTGTTCCCGATGTCCTCCGTCTAGAATTGGTG
GATGAAGTCATCAGAGTTAGCGATGATCAAGCGATGAGCTACGGGCGGCGTTTAGCCAGAGAAGAAGGTTTGCTATCTGG
TATTTCCTCTGGTGCGGCTTTGTGTGCAGCTTTACAGGTGGGGAAACGTCCAGAAAATGCCGGCAAGTTAATTGTGATGA
TTCAACCTTCCTTCGGCGAACGCTACCTCAGCACCCCTTTGTTTCAGGATTTGACGAATGAAACTGCTGGTGTCAGTTAG

Upstream 100 bases:

>100_bases
CAAGCTGATTTGTAAATTTAATACGTCTAAGGTAATTGTTATAAGCTAATTGTTATAAGTAAACAATTCACTCTGAATTG
AGAATTTTAGGAGTAAAATA

Downstream 100 bases:

>100_bases
TTGGGGTGCTTTATCCATAAACCTTTGTTGGAGACGTAGCGGTGCTACGTCTCTACGGTTAGGTTAATTCGGTCTGTGTT
TAATGATTACACCCTTGTCT

Product: cysteine synthase

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MRIANDVTELIGGTPLVKLNKIPQAEGVVARIVVKLEGMNPASSVKDRIGVSMINAAEAEGLIIPGKTILVEPTSGNTGI
ALAMVAAARGYRLILTMPETMSQERRAMLRAYGATLELTPGTEGMRGAIRKAEEIVASTPDTHMLQQFRNPANPKIHRET
TAEEIWNDTDGEVDIVIAGVGTGGTITGIAEVLKQRKPSFQAIAVEPSNSPILSGGQAGPHKIQGIGAGFVPDVLRLELV
DEVIRVSDDQAMSYGRRLAREEGLLSGISSGAALCAALQVGKRPENAGKLIVMIQPSFGERYLSTPLFQDLTNETAGVS

Sequences:

>Translated_319_residues
MRIANDVTELIGGTPLVKLNKIPQAEGVVARIVVKLEGMNPASSVKDRIGVSMINAAEAEGLIIPGKTILVEPTSGNTGI
ALAMVAAARGYRLILTMPETMSQERRAMLRAYGATLELTPGTEGMRGAIRKAEEIVASTPDTHMLQQFRNPANPKIHRET
TAEEIWNDTDGEVDIVIAGVGTGGTITGIAEVLKQRKPSFQAIAVEPSNSPILSGGQAGPHKIQGIGAGFVPDVLRLELV
DEVIRVSDDQAMSYGRRLAREEGLLSGISSGAALCAALQVGKRPENAGKLIVMIQPSFGERYLSTPLFQDLTNETAGVS
>Mature_319_residues
MRIANDVTELIGGTPLVKLNKIPQAEGVVARIVVKLEGMNPASSVKDRIGVSMINAAEAEGLIIPGKTILVEPTSGNTGI
ALAMVAAARGYRLILTMPETMSQERRAMLRAYGATLELTPGTEGMRGAIRKAEEIVASTPDTHMLQQFRNPANPKIHRET
TAEEIWNDTDGEVDIVIAGVGTGGTITGIAEVLKQRKPSFQAIAVEPSNSPILSGGQAGPHKIQGIGAGFVPDVLRLELV
DEVIRVSDDQAMSYGRRLAREEGLLSGISSGAALCAALQVGKRPENAGKLIVMIQPSFGERYLSTPLFQDLTNETAGVS

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=314, Percent_Identity=39.8089171974522, Blast_Score=226, Evalue=3e-59,
Organism=Homo sapiens, GI295821200, Length=314, Percent_Identity=39.8089171974522, Blast_Score=226, Evalue=3e-59,
Organism=Homo sapiens, GI4557415, Length=314, Percent_Identity=39.8089171974522, Blast_Score=226, Evalue=3e-59,
Organism=Escherichia coli, GI1788754, Length=322, Percent_Identity=57.1428571428571, Blast_Score=314, Evalue=4e-87,
Organism=Escherichia coli, GI2367138, Length=300, Percent_Identity=42.6666666666667, Blast_Score=217, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI17535051, Length=310, Percent_Identity=54.8387096774194, Blast_Score=343, Evalue=6e-95,
Organism=Caenorhabditis elegans, GI17562970, Length=314, Percent_Identity=52.8662420382166, Blast_Score=325, Evalue=2e-89,
Organism=Caenorhabditis elegans, GI115535073, Length=309, Percent_Identity=55.0161812297735, Blast_Score=315, Evalue=2e-86,
Organism=Caenorhabditis elegans, GI32566674, Length=301, Percent_Identity=53.8205980066445, Blast_Score=313, Evalue=7e-86,
Organism=Caenorhabditis elegans, GI17561720, Length=314, Percent_Identity=50.6369426751592, Blast_Score=284, Evalue=4e-77,
Organism=Caenorhabditis elegans, GI32566672, Length=220, Percent_Identity=52.2727272727273, Blast_Score=232, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI17534315, Length=326, Percent_Identity=39.8773006134969, Blast_Score=195, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI25147552, Length=325, Percent_Identity=38.4615384615385, Blast_Score=181, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17561716, Length=124, Percent_Identity=48.3870967741936, Blast_Score=113, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6321594, Length=315, Percent_Identity=38.0952380952381, Blast_Score=203, Evalue=4e-53,
Organism=Saccharomyces cerevisiae, GI6321449, Length=327, Percent_Identity=35.7798165137615, Blast_Score=143, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24643623, Length=311, Percent_Identity=40.5144694533762, Blast_Score=207, Evalue=5e-54,
Organism=Drosophila melanogaster, GI20129101, Length=311, Percent_Identity=40.5144694533762, Blast_Score=207, Evalue=5e-54,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 33784; Mature: 33784

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIANDVTELIGGTPLVKLNKIPQAEGVVARIVVKLEGMNPASSVKDRIGVSMINAAEAE
CCCHHHHHHHHCCCCEEEECCCCCCCCCEEEEEEEECCCCCHHHHHHHHCHHHCCCCCCC
GLIIPGKTILVEPTSGNTGIALAMVAAARGYRLILTMPETMSQERRAMLRAYGATLELTP
CEEECCCEEEEECCCCCCCHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHCCEEEECC
GTEGMRGAIRKAEEIVASTPDTHMLQQFRNPANPKIHRETTAEEIWNDTDGEVDIVIAGV
CCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCEECHHHHHHHCCCCCCCEEEEEEEC
GTGGTITGIAEVLKQRKPSFQAIAVEPSNSPILSGGQAGPHKIQGIGAGFVPDVLRLELV
CCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHH
DEVIRVSDDQAMSYGRRLAREEGLLSGISSGAALCAALQVGKRPENAGKLIVMIQPSFGE
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCC
RYLSTPLFQDLTNETAGVS
HHHCCHHHHHHHHHCCCCC
>Mature Secondary Structure
MRIANDVTELIGGTPLVKLNKIPQAEGVVARIVVKLEGMNPASSVKDRIGVSMINAAEAE
CCCHHHHHHHHCCCCEEEECCCCCCCCCEEEEEEEECCCCCHHHHHHHHCHHHCCCCCCC
GLIIPGKTILVEPTSGNTGIALAMVAAARGYRLILTMPETMSQERRAMLRAYGATLELTP
CEEECCCEEEEECCCCCCCHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHCCEEEECC
GTEGMRGAIRKAEEIVASTPDTHMLQQFRNPANPKIHRETTAEEIWNDTDGEVDIVIAGV
CCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCEECHHHHHHHCCCCCCCEEEEEEEC
GTGGTITGIAEVLKQRKPSFQAIAVEPSNSPILSGGQAGPHKIQGIGAGFVPDVLRLELV
CCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHH
DEVIRVSDDQAMSYGRRLAREEGLLSGISSGAALCAALQVGKRPENAGKLIVMIQPSFGE
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCC
RYLSTPLFQDLTNETAGVS
HHHCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]