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The map label for this gene is menB [H]

Identifier: 17229839

GI number: 17229839

Start: 2829448

End: 2830281

Strand: Reverse

Name: menB [H]

Synonym: all2347

Alternate gene names: 17229839

Gene position: 2830281-2829448 (Counterclockwise)

Preceding gene: 17229841

Following gene: 17229836

Centisome position: 44.13

GC content: 44.24

Gene sequence:

>834_bases
ATGCAAATCGATTGGCAATCTACCAAAACCTACGAAGACATCCTTTATGACAAAGCTGATGGTATGGCTAAAATTACCAT
CAACCGTCCTCACAAACGCAATGCTTTTCGTCCCAAAACTGTTTTTGAACTGTATGACGCTTTCTGTGATGCTCGTGAAG
ATACGAGTATTGGCGTAGTTCTCTTTACTGGTGCTGGCCCCCATACTGATGGTAAATATGCCTTCTGTTCAGGTGGAGAC
CAAAGCGTGCGGGGGCAAGCTGGCTATGTAGATGATGCTGGCATTCCCCGATTAAATGTGCTGGATTTACAACGCCTGAT
TCGTTCCATGCCAAAAGTGGTAATTGCCTTAGTAGCTGGATATGCGATCGGTGGTGGACACGTCCTACACTTAATTTGTG
ACCTCACGATCGCTGCTGATAATGCTATTTTTGGGCAGACTGGCCCCAAAGTGGGCAGTTTTGATGGTGGTTTTGGCGCT
AGCTATCTCGCCCGGATTGTCGGACAGAAAAAAGCACGAGAAATTTGGTTTCTCTGTCGTCAATATGATGCTCAACAAGC
TTTAGAAATGGGTTTAGTAAATTGCGTTGTGCCGATAGAGCAACTAGAAGCAGAAGGAATTAAATGGGCTGGAGAAATTT
TAGAAAAAAGCCCTATTGCCATTCGCTGTCTCAAAGCAGCCTTTAATGCTGATTGTGATGGACAAGCAGGTTTACAAGAA
CTAGCTGGTAATGCCACCTTACTTTATTACATGACAGAAGAAGGTGCTGAAGGTAAACAAGCTTTTTTGGAAAAACGTCC
ACCAAATTTTCGAGACTTTCCTTGGCTACCGTGA

Upstream 100 bases:

>100_bases
GGATGTCTACCTGCTGTTGCTGGACTGGGGTGCTAAATATTAGCGATCGCAACTCCCCACCTCTGCGATAAAATTCTCAA
GCACAACAGCTATAATTCCC

Downstream 100 bases:

>100_bases
TCGGGTATTAAAGATTAGGTATTGGGTATTGGAAAAATTAATTAGTCACCAGTCCCCAACTCCTAATCTCCAGACCCCAA
CTATAAATCTTAAAAGGCAA

Product: naphthoate synthase

Products: NA

Alternate protein names: DHNA-CoA synthase [H]

Number of amino acids: Translated: 277; Mature: 277

Protein sequence:

>277_residues
MQIDWQSTKTYEDILYDKADGMAKITINRPHKRNAFRPKTVFELYDAFCDAREDTSIGVVLFTGAGPHTDGKYAFCSGGD
QSVRGQAGYVDDAGIPRLNVLDLQRLIRSMPKVVIALVAGYAIGGGHVLHLICDLTIAADNAIFGQTGPKVGSFDGGFGA
SYLARIVGQKKAREIWFLCRQYDAQQALEMGLVNCVVPIEQLEAEGIKWAGEILEKSPIAIRCLKAAFNADCDGQAGLQE
LAGNATLLYYMTEEGAEGKQAFLEKRPPNFRDFPWLP

Sequences:

>Translated_277_residues
MQIDWQSTKTYEDILYDKADGMAKITINRPHKRNAFRPKTVFELYDAFCDAREDTSIGVVLFTGAGPHTDGKYAFCSGGD
QSVRGQAGYVDDAGIPRLNVLDLQRLIRSMPKVVIALVAGYAIGGGHVLHLICDLTIAADNAIFGQTGPKVGSFDGGFGA
SYLARIVGQKKAREIWFLCRQYDAQQALEMGLVNCVVPIEQLEAEGIKWAGEILEKSPIAIRCLKAAFNADCDGQAGLQE
LAGNATLLYYMTEEGAEGKQAFLEKRPPNFRDFPWLP
>Mature_277_residues
MQIDWQSTKTYEDILYDKADGMAKITINRPHKRNAFRPKTVFELYDAFCDAREDTSIGVVLFTGAGPHTDGKYAFCSGGD
QSVRGQAGYVDDAGIPRLNVLDLQRLIRSMPKVVIALVAGYAIGGGHVLHLICDLTIAADNAIFGQTGPKVGSFDGGFGA
SYLARIVGQKKAREIWFLCRQYDAQQALEMGLVNCVVPIEQLEAEGIKWAGEILEKSPIAIRCLKAAFNADCDGQAGLQE
LAGNATLLYYMTEEGAEGKQAFLEKRPPNFRDFPWLP

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) [H]

COG id: COG0447

COG function: function code H; Dihydroxynaphthoic acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=274, Percent_Identity=31.3868613138686, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI31542718, Length=256, Percent_Identity=29.296875, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI4502327, Length=264, Percent_Identity=28.4090909090909, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI213417737, Length=226, Percent_Identity=24.7787610619469, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI157694516, Length=226, Percent_Identity=24.7787610619469, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI1788597, Length=278, Percent_Identity=67.9856115107914, Blast_Score=384, Evalue=1e-108,
Organism=Escherichia coli, GI1787659, Length=266, Percent_Identity=31.5789473684211, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI221142681, Length=267, Percent_Identity=29.9625468164794, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI87082183, Length=175, Percent_Identity=33.7142857142857, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1787660, Length=270, Percent_Identity=30, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1788682, Length=212, Percent_Identity=27.8301886792453, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI25145438, Length=254, Percent_Identity=31.8897637795276, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17554946, Length=278, Percent_Identity=30.5755395683453, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17540714, Length=226, Percent_Identity=27.8761061946903, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17549921, Length=212, Percent_Identity=29.2452830188679, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17560910, Length=200, Percent_Identity=29.5, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17534483, Length=264, Percent_Identity=27.2727272727273, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17535521, Length=212, Percent_Identity=27.3584905660377, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17536985, Length=224, Percent_Identity=26.7857142857143, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI20129971, Length=273, Percent_Identity=31.5018315018315, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24653477, Length=273, Percent_Identity=31.5018315018315, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24653139, Length=272, Percent_Identity=27.9411764705882, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI21357171, Length=191, Percent_Identity=30.3664921465969, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI19922422, Length=281, Percent_Identity=25.2669039145907, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24654903, Length=199, Percent_Identity=27.1356783919598, Blast_Score=68, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376
- InterPro:   IPR010198 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.3.36 [H]

Molecular weight: Translated: 30359; Mature: 30359

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIDWQSTKTYEDILYDKADGMAKITINRPHKRNAFRPKTVFELYDAFCDAREDTSIGVV
CCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEE
LFTGAGPHTDGKYAFCSGGDQSVRGQAGYVDDAGIPRLNVLDLQRLIRSMPKVVIALVAG
EEECCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
YAIGGGHVLHLICDLTIAADNAIFGQTGPKVGSFDGGFGASYLARIVGQKKAREIWFLCR
HCCCCHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHH
QYDAQQALEMGLVNCVVPIEQLEAEGIKWAGEILEKSPIAIRCLKAAFNADCDGQAGLQE
HHCHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHH
LAGNATLLYYMTEEGAEGKQAFLEKRPPNFRDFPWLP
HCCCCEEEEEEECCCCCHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MQIDWQSTKTYEDILYDKADGMAKITINRPHKRNAFRPKTVFELYDAFCDAREDTSIGVV
CCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEE
LFTGAGPHTDGKYAFCSGGDQSVRGQAGYVDDAGIPRLNVLDLQRLIRSMPKVVIALVAG
EEECCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
YAIGGGHVLHLICDLTIAADNAIFGQTGPKVGSFDGGFGASYLARIVGQKKAREIWFLCR
HCCCCHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHH
QYDAQQALEMGLVNCVVPIEQLEAEGIKWAGEILEKSPIAIRCLKAAFNADCDGQAGLQE
HHCHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHH
LAGNATLLYYMTEEGAEGKQAFLEKRPPNFRDFPWLP
HCCCCEEEEEEECCCCCHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629163; 8566759; 9387221; 9384377 [H]