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The map label for this gene is aroE [H]

Identifier: 17229549

GI number: 17229549

Start: 2465228

End: 2466097

Strand: Direct

Name: aroE [H]

Synonym: alr2057

Alternate gene names: 17229549

Gene position: 2465228-2466097 (Clockwise)

Preceding gene: 17229547

Following gene: 17229552

Centisome position: 38.44

GC content: 43.1

Gene sequence:

>870_bases
ATGATTACAGGCAAAACTAAACTATTAGGGGTAATTGGACATCCGGTGGAACATTCGCTCTCACCAGTGATGCACAATGC
AGCGATCGCTCAATTAGGATTAGATTATGTATATCTGCCTTTTCCTATAGCACCAGATAATTTAGAAGCAGCGATCGCTC
TTTTGGCTACTATTGGTGTTGTTGGTTTTAGTGTGACCATTCCTCACAAACAAGCAATCATCCCCCTGCTTTCCGAAATT
AGCCCAGTTGCTCAAGCTATAGGCGCGGTAAATACTGTCACCCGTCAAAATAATCAATGGGTGGGGACAAACACAGATAT
AGAAGGGTTTATTGCCCCTTTGCAGACAACATATAAACGAGATTGGAGTCAGCAAATCGCCGTAATTTTAGGTAATGGTG
GCGCTGCGAGAGCTGTTGTTGCTGGTTGTTATCAACTGGGTTTTGCGGAAATTCATGTGGTGGGGCGCAATGTGCAACGC
TTAGAAGAATTTCGCCACAGTTGGGAAAATTCCCCCATTGCTGAGAATTTACAAGTGCATACCTGGGATTATCTAGCAAA
GCTCATCCCTCAAGCTAACTTACTGGTGAACACAACCCCGATAGGGATGTATCCGCAGGTTGATGAGTCGCCTTTGAGTG
CAGAGGAACTGGTGAATTTACAAACTGGTACTATTGCCTATGATTTGATATATATTCCCAAACCAACGCAATTTCTCCAA
AAAGCCCAACAACAAGGCGCAATTATTATCGACGGCTTAGAAATGTTAGTTCAGCAAGGTGTAGCTGCTTTAAAAATTTG
GTTGCAGCAGGACGATATTCCTGTAGATGTCATGCGTCAAGCTTTAATTAAGCACTTAGGTCTAAAGTGA

Upstream 100 bases:

>100_bases
AATTGTAGAGCTAGGAATGGGGAGTAGGGGAAGCAGGGAAAAGACAACTGTACAGACGCGATTAATCGCGTCTCTGACAA
CTGACTAATGATTAAAAACA

Downstream 100 bases:

>100_bases
GATTACCAATTAATTATCTGCACCATCAAGCTTGTTTAAAATAATCTGAATAGCATTGATGATTAATTCTGGTTGATCAA
TCCAAACAAAATGTCCGCTT

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MITGKTKLLGVIGHPVEHSLSPVMHNAAIAQLGLDYVYLPFPIAPDNLEAAIALLATIGVVGFSVTIPHKQAIIPLLSEI
SPVAQAIGAVNTVTRQNNQWVGTNTDIEGFIAPLQTTYKRDWSQQIAVILGNGGAARAVVAGCYQLGFAEIHVVGRNVQR
LEEFRHSWENSPIAENLQVHTWDYLAKLIPQANLLVNTTPIGMYPQVDESPLSAEELVNLQTGTIAYDLIYIPKPTQFLQ
KAQQQGAIIIDGLEMLVQQGVAALKIWLQQDDIPVDVMRQALIKHLGLK

Sequences:

>Translated_289_residues
MITGKTKLLGVIGHPVEHSLSPVMHNAAIAQLGLDYVYLPFPIAPDNLEAAIALLATIGVVGFSVTIPHKQAIIPLLSEI
SPVAQAIGAVNTVTRQNNQWVGTNTDIEGFIAPLQTTYKRDWSQQIAVILGNGGAARAVVAGCYQLGFAEIHVVGRNVQR
LEEFRHSWENSPIAENLQVHTWDYLAKLIPQANLLVNTTPIGMYPQVDESPLSAEELVNLQTGTIAYDLIYIPKPTQFLQ
KAQQQGAIIIDGLEMLVQQGVAALKIWLQQDDIPVDVMRQALIKHLGLK
>Mature_289_residues
MITGKTKLLGVIGHPVEHSLSPVMHNAAIAQLGLDYVYLPFPIAPDNLEAAIALLATIGVVGFSVTIPHKQAIIPLLSEI
SPVAQAIGAVNTVTRQNNQWVGTNTDIEGFIAPLQTTYKRDWSQQIAVILGNGGAARAVVAGCYQLGFAEIHVVGRNVQR
LEEFRHSWENSPIAENLQVHTWDYLAKLIPQANLLVNTTPIGMYPQVDESPLSAEELVNLQTGTIAYDLIYIPKPTQFLQ
KAQQQGAIIIDGLEMLVQQGVAALKIWLQQDDIPVDVMRQALIKHLGLK

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1787983, Length=290, Percent_Identity=30.3448275862069, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1789675, Length=264, Percent_Identity=28.030303030303, Blast_Score=87, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320332, Length=270, Percent_Identity=27.4074074074074, Blast_Score=82, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151 [H]

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N [H]

EC number: =1.1.1.25 [H]

Molecular weight: Translated: 31539; Mature: 31539

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITGKTKLLGVIGHPVEHSLSPVMHNAAIAQLGLDYVYLPFPIAPDNLEAAIALLATIGV
CCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHH
VGFSVTIPHKQAIIPLLSEISPVAQAIGAVNTVTRQNNQWVGTNTDIEGFIAPLQTTYKR
HHEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHH
DWSQQIAVILGNGGAARAVVAGCYQLGFAEIHVVGRNVQRLEEFRHSWENSPIAENLQVH
CCCCEEEEEEECCCHHHHHHHHHHHHCHHEEEEECCCHHHHHHHHHHHCCCCCCCCCEEE
TWDYLAKLIPQANLLVNTTPIGMYPQVDESPLSAEELVNLQTGTIAYDLIYIPKPTQFLQ
HHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCHHHHHCCCCCEEEEEEEECCCCHHHHH
KAQQQGAIIIDGLEMLVQQGVAALKIWLQQDDIPVDVMRQALIKHLGLK
HHHHCCCEEEHHHHHHHHCCHHHEEEECCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MITGKTKLLGVIGHPVEHSLSPVMHNAAIAQLGLDYVYLPFPIAPDNLEAAIALLATIGV
CCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHH
VGFSVTIPHKQAIIPLLSEISPVAQAIGAVNTVTRQNNQWVGTNTDIEGFIAPLQTTYKR
HHEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHH
DWSQQIAVILGNGGAARAVVAGCYQLGFAEIHVVGRNVQRLEEFRHSWENSPIAENLQVH
CCCCEEEEEEECCCHHHHHHHHHHHHCHHEEEEECCCHHHHHHHHHHHCCCCCCCCCEEE
TWDYLAKLIPQANLLVNTTPIGMYPQVDESPLSAEELVNLQTGTIAYDLIYIPKPTQFLQ
HHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCHHHHHCCCCCEEEEEEEECCCCHHHHH
KAQQQGAIIIDGLEMLVQQGVAALKIWLQQDDIPVDVMRQALIKHLGLK
HHHHCCCEEEHHHHHHHHCCHHHEEEECCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA