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The map label for this gene is irlR [H]

Identifier: 17229456

GI number: 17229456

Start: 2346940

End: 2347650

Strand: Reverse

Name: irlR [H]

Synonym: all1964

Alternate gene names: 17229456

Gene position: 2347650-2346940 (Counterclockwise)

Preceding gene: 17229461

Following gene: 17229454

Centisome position: 36.6

GC content: 44.16

Gene sequence:

>711_bases
ATGCTTACCTCAAGCAGCATGAGAATTTTATTGGTTGATGATGAAGTAGAACTCACTGTCCCCTTGAGCCGTGTGTTAAC
TCGTGAAGGTTACACCGTAGAAGCAGCTTATGAGGGGAAAAGTGGTAGTGAAATGGCGACAGTAGGCAATTATGACCTAC
TGATTTTAGACTGGATGCTACCAGGGAAAACGGGCTTAGAGATATGCCAAGAACTACGCCGCCAAGGAAAAATTACACCA
GTTCTTTTCCTCACCGCCAAAGATACCCTAGATGACCGTGTACAAGGTTTAGATGCTGGTGCTGATGACTATTTAGTCAA
ACCCTTTGAACTGCGAGAGTTGTTGGCCAGAGTCCGTGCTTTATTACGGCGTTCTAGTTCCCAAACCTATGAAGCTACAC
CAGGAAGATTAACTGTAGCCGACCTAGAACTTGACTGTGAAAATCAAGTCGCCTACCGTCAAGGACGAGTCATTGAACTA
TCGCAGAAAGAAAGCCAATTGCTGCAATACTTTATGGAACACACGGGACAACTATTAACTCACGCCCAAATTCTGCAACA
TCTGTGGGAAGATAACGAGCCACCAAATAGTAATGTTATCGCCGCATTAATCAGATTGCTACGCCGTAAAATCGAGGTAG
GCAAAGAACTTCCCTTAATCCACACAGTCTACGGTAAAGGCTATCGCTTCGGTACAAATTTAGTTGAATAA

Upstream 100 bases:

>100_bases
GGCAACGCAACAGTTAACATTCGTTTTCTTGGTATCCTTGGCTAGAGACACTTTATCGTGTCCTTGTCTTAGCAGTTCAT
TAATATTGAGAATATCTCTA

Downstream 100 bases:

>100_bases
AAAAAGACCCTAGTTTTTATACTAGGGTCTAACCTAAATTTTATTGATAAGGAAATTATGTGTTGTCAAGCTTGGAATAT
CTGAGAATTAGCCTACATTG

Product: two-component system response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 236; Mature: 236

Protein sequence:

>236_residues
MLTSSSMRILLVDDEVELTVPLSRVLTREGYTVEAAYEGKSGSEMATVGNYDLLILDWMLPGKTGLEICQELRRQGKITP
VLFLTAKDTLDDRVQGLDAGADDYLVKPFELRELLARVRALLRRSSSQTYEATPGRLTVADLELDCENQVAYRQGRVIEL
SQKESQLLQYFMEHTGQLLTHAQILQHLWEDNEPPNSNVIAALIRLLRRKIEVGKELPLIHTVYGKGYRFGTNLVE

Sequences:

>Translated_236_residues
MLTSSSMRILLVDDEVELTVPLSRVLTREGYTVEAAYEGKSGSEMATVGNYDLLILDWMLPGKTGLEICQELRRQGKITP
VLFLTAKDTLDDRVQGLDAGADDYLVKPFELRELLARVRALLRRSSSQTYEATPGRLTVADLELDCENQVAYRQGRVIEL
SQKESQLLQYFMEHTGQLLTHAQILQHLWEDNEPPNSNVIAALIRLLRRKIEVGKELPLIHTVYGKGYRFGTNLVE
>Mature_236_residues
MLTSSSMRILLVDDEVELTVPLSRVLTREGYTVEAAYEGKSGSEMATVGNYDLLILDWMLPGKTGLEICQELRRQGKITP
VLFLTAKDTLDDRVQGLDAGADDYLVKPFELRELLARVRALLRRSSSQTYEATPGRLTVADLELDCENQVAYRQGRVIEL
SQKESQLLQYFMEHTGQLLTHAQILQHLWEDNEPPNSNVIAALIRLLRRKIEVGKELPLIHTVYGKGYRFGTNLVE

Specific function: Member of the two-component regulatory system irlR/irlS. May be involved in invasion of eukaryotic cells and heavy-metal resistance [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=222, Percent_Identity=42.7927927927928, Blast_Score=170, Evalue=7e-44,
Organism=Escherichia coli, GI87082012, Length=224, Percent_Identity=39.7321428571429, Blast_Score=154, Evalue=4e-39,
Organism=Escherichia coli, GI1786599, Length=229, Percent_Identity=34.4978165938865, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1789402, Length=225, Percent_Identity=37.7777777777778, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1790552, Length=227, Percent_Identity=36.5638766519824, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=33.4801762114537, Blast_Score=124, Evalue=4e-30,
Organism=Escherichia coli, GI1788394, Length=237, Percent_Identity=34.1772151898734, Blast_Score=118, Evalue=4e-28,
Organism=Escherichia coli, GI1790863, Length=236, Percent_Identity=32.2033898305085, Blast_Score=117, Evalue=7e-28,
Organism=Escherichia coli, GI2367329, Length=226, Percent_Identity=39.3805309734513, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1787375, Length=227, Percent_Identity=31.2775330396476, Blast_Score=111, Evalue=4e-26,
Organism=Escherichia coli, GI1786911, Length=223, Percent_Identity=34.9775784753363, Blast_Score=110, Evalue=8e-26,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=32.8828828828829, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1787229, Length=233, Percent_Identity=30.9012875536481, Blast_Score=100, Evalue=7e-23,
Organism=Escherichia coli, GI145693140, Length=237, Percent_Identity=27.8481012658228, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI48994928, Length=120, Percent_Identity=39.1666666666667, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=32.7102803738318, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1790437, Length=134, Percent_Identity=29.8507462686567, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1790299, Length=110, Percent_Identity=31.8181818181818, Blast_Score=61, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26718; Mature: 26718

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTSSSMRILLVDDEVELTVPLSRVLTREGYTVEAAYEGKSGSEMATVGNYDLLILDWML
CCCCCCCEEEEECCCEEEEECHHHHHHCCCCEEEEEECCCCCCCEEEECCCEEEEEEEEC
PGKTGLEICQELRRQGKITPVLFLTAKDTLDDRVQGLDAGADDYLVKPFELRELLARVRA
CCCHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHCCCCCCCCCEECCHHHHHHHHHHHH
LLRRSSSQTYEATPGRLTVADLELDCENQVAYRQGRVIELSQKESQLLQYFMEHTGQLLT
HHHCCCCCCEECCCCEEEEEEEEECCCCCHHHHCCCEEEECHHHHHHHHHHHHHHHHHHH
HAQILQHLWEDNEPPNSNVIAALIRLLRRKIEVGKELPLIHTVYGKGYRFGTNLVE
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCEECCCCCCC
>Mature Secondary Structure
MLTSSSMRILLVDDEVELTVPLSRVLTREGYTVEAAYEGKSGSEMATVGNYDLLILDWML
CCCCCCCEEEEECCCEEEEECHHHHHHCCCCEEEEEECCCCCCCEEEECCCEEEEEEEEC
PGKTGLEICQELRRQGKITPVLFLTAKDTLDDRVQGLDAGADDYLVKPFELRELLARVRA
CCCHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHCCCCCCCCCEECCHHHHHHHHHHHH
LLRRSSSQTYEATPGRLTVADLELDCENQVAYRQGRVIELSQKESQLLQYFMEHTGQLLT
HHHCCCCCCEECCCCEEEEEEEEECCCCCHHHHCCCEEEECHHHHHHHHHHHHHHHHHHH
HAQILQHLWEDNEPPNSNVIAALIRLLRRKIEVGKELPLIHTVYGKGYRFGTNLVE
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9393784 [H]