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The map label for this gene is rtcA [H]

Identifier: 17229393

GI number: 17229393

Start: 2270591

End: 2271637

Strand: Direct

Name: rtcA [H]

Synonym: alr1901

Alternate gene names: 17229393

Gene position: 2270591-2271637 (Clockwise)

Preceding gene: 17229392

Following gene: 17229395

Centisome position: 35.4

GC content: 48.14

Gene sequence:

>1047_bases
ATGATTAACATTGACGGTTCCTACGGCGAGGGAGGCGGGCAAGTCCTCCGCACTTCCCTGAGTTTAGCCGCCATCACTGG
TGAACCCATACGTATTGCCGGCATTCGCGCCGGACGCAGGAAGCCAGGATTAGCAGCACAACACTTAACAGCAGTGCGTG
CGGCGGCGAGAATTTGTCATGGGGAATTGCAAGGTGATGCTTTAGGTTCCACGATGCTGGAATTTATACCTGGTGGTGGG
GTAAAAGCAGGAAATTATATTTTTGATGTCAGCGAAGTACAGCAAGGTGGTTCGGCTGGGGCGATTACTCTGGTTTTGCA
GACAATTCTCTTACCTTTAGCTTTAGCAGATGGTGATTCTCATATCACCTTACGGGGTGGAACTCATGTCATTTTCAGCC
CCACAGTCACCTACATTGAGCGAGTATATCTGCCAATGTTATGTCGCATGGGAATCAAGGCACAAGTTAAGTTAGGTGCT
TGGGGATGGTATCCCAGGGGTGGGGGAGAAGTCAATTTACAGGTGAAGGGAGGCTGTCAACTCTGCGGTCTTAACTTGCT
GGAAAGGGGAGAATTAAAGCGGGTACAAGGACTAGCTGTGGCGACAGAATTACCTGCACATATACCCCAGCGCATGGCAA
ATCGGGCTGAGAATTTGTTACGTACAGCAGGTTTGCGGGTATCTATGCAGGCGTTACGTGAAAAAGGTGTTGCACCAGGG
GCGGGGATTTTTTTAACGGCTGAGTATTGTAATAGTTTGACGGGTTTTGGTGGCTTTGGACGTTTGCGATTGTCTTCTGA
AAAAGTAGCAGAGATTGCTTGCGGACAACTATTACAATTCCATGAAACTGGCGCACCAGTTGATGAACACCTAGCAGATC
AATTATTATTACCGGCGGTTCTGGCTTCCGAGTCCAGTCAGTATAAAGTGGCTGAGGTGAGTACACACTTAACAACTAAC
GCCGCAGTCATTGAAAAGTTTGGCTTAGGAAAGATTACCGTCAATCAAGCAGAAAGGGTAGTGGCGATCGCCTCTAGTAA
AGTTTAA

Upstream 100 bases:

>100_bases
ATCCCCAGTCCCCAATCCCCAGTCCCCAGTCCCCAATCCCCAATCCCCAGTCCCCAATCCCCAAAAATTTTGAATTGATT
CATCGCCCAGACTACTGAGT

Downstream 100 bases:

>100_bases
TCCTACTTCCAAATAATAGGAGCGATCGCCGCCATGAACAAGAGAAAAGCTATTTCTAAAACGTAGCTGATAAAGACACT
GCGATTTAAAAGACCATCCC

Product: RNA 3'-terminal-phosphate cyclase

Products: NA

Alternate protein names: RNA cyclase; RNA-3'-phosphate cyclase [H]

Number of amino acids: Translated: 348; Mature: 348

Protein sequence:

>348_residues
MINIDGSYGEGGGQVLRTSLSLAAITGEPIRIAGIRAGRRKPGLAAQHLTAVRAAARICHGELQGDALGSTMLEFIPGGG
VKAGNYIFDVSEVQQGGSAGAITLVLQTILLPLALADGDSHITLRGGTHVIFSPTVTYIERVYLPMLCRMGIKAQVKLGA
WGWYPRGGGEVNLQVKGGCQLCGLNLLERGELKRVQGLAVATELPAHIPQRMANRAENLLRTAGLRVSMQALREKGVAPG
AGIFLTAEYCNSLTGFGGFGRLRLSSEKVAEIACGQLLQFHETGAPVDEHLADQLLLPAVLASESSQYKVAEVSTHLTTN
AAVIEKFGLGKITVNQAERVVAIASSKV

Sequences:

>Translated_348_residues
MINIDGSYGEGGGQVLRTSLSLAAITGEPIRIAGIRAGRRKPGLAAQHLTAVRAAARICHGELQGDALGSTMLEFIPGGG
VKAGNYIFDVSEVQQGGSAGAITLVLQTILLPLALADGDSHITLRGGTHVIFSPTVTYIERVYLPMLCRMGIKAQVKLGA
WGWYPRGGGEVNLQVKGGCQLCGLNLLERGELKRVQGLAVATELPAHIPQRMANRAENLLRTAGLRVSMQALREKGVAPG
AGIFLTAEYCNSLTGFGGFGRLRLSSEKVAEIACGQLLQFHETGAPVDEHLADQLLLPAVLASESSQYKVAEVSTHLTTN
AAVIEKFGLGKITVNQAERVVAIASSKV
>Mature_348_residues
MINIDGSYGEGGGQVLRTSLSLAAITGEPIRIAGIRAGRRKPGLAAQHLTAVRAAARICHGELQGDALGSTMLEFIPGGG
VKAGNYIFDVSEVQQGGSAGAITLVLQTILLPLALADGDSHITLRGGTHVIFSPTVTYIERVYLPMLCRMGIKAQVKLGA
WGWYPRGGGEVNLQVKGGCQLCGLNLLERGELKRVQGLAVATELPAHIPQRMANRAENLLRTAGLRVSMQALREKGVAPG
AGIFLTAEYCNSLTGFGGFGRLRLSSEKVAEIACGQLLQFHETGAPVDEHLADQLLLPAVLASESSQYKVAEVSTHLTTN
AAVIEKFGLGKITVNQAERVVAIASSKV

Specific function: Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps:(A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA- N3'PP5'A;

COG id: COG0430

COG function: function code A; RNA 3'-terminal phosphate cyclase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI4506589, Length=344, Percent_Identity=32.8488372093023, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI195927044, Length=357, Percent_Identity=31.6526610644258, Blast_Score=159, Evalue=3e-39,
Organism=Escherichia coli, GI48994937, Length=331, Percent_Identity=41.0876132930514, Blast_Score=209, Evalue=3e-55,
Organism=Drosophila melanogaster, GI18543269, Length=334, Percent_Identity=32.6347305389222, Blast_Score=163, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013791
- InterPro:   IPR000228
- InterPro:   IPR013796
- InterPro:   IPR020723
- InterPro:   IPR017770
- InterPro:   IPR013792 [H]

Pfam domain/function: PF01137 RTC; PF05189 RTC_insert [H]

EC number: =6.5.1.4 [H]

Molecular weight: Translated: 36638; Mature: 36638

Theoretical pI: Translated: 8.79; Mature: 8.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINIDGSYGEGGGQVLRTSLSLAAITGEPIRIAGIRAGRRKPGLAAQHLTAVRAAARICH
CEECCCCCCCCCHHHHHHHHEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHH
GELQGDALGSTMLEFIPGGGVKAGNYIFDVSEVQQGGSAGAITLVLQTILLPLALADGDS
CCCCCCHHHHHHHHHCCCCCCCCCCEEEEHHHHHCCCCCCHHHHHHHHHHHHHEEECCCC
HITLRGGTHVIFSPTVTYIERVYLPMLCRMGIKAQVKLGAWGWYPRGGGEVNLQVKGGCQ
EEEEECCCEEEECCHHHHHHHHHHHHHHHCCCCEEEEECCEECCCCCCCEEEEEECCCCE
LCGLNLLERGELKRVQGLAVATELPAHIPQRMANRAENLLRTAGLRVSMQALREKGVAPG
EECCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCC
AGIFLTAEYCNSLTGFGGFGRLRLSSEKVAEIACGQLLQFHETGAPVDEHLADQLLLPAV
CCEEEEHHHHCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
LASESSQYKVAEVSTHLTTNAAVIEKFGLGKITVNQAERVVAIASSKV
HHCCCCCEEEEEHHHHHCCCHHHHHHCCCCEEEECCCCEEEEEECCCC
>Mature Secondary Structure
MINIDGSYGEGGGQVLRTSLSLAAITGEPIRIAGIRAGRRKPGLAAQHLTAVRAAARICH
CEECCCCCCCCCHHHHHHHHEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHH
GELQGDALGSTMLEFIPGGGVKAGNYIFDVSEVQQGGSAGAITLVLQTILLPLALADGDS
CCCCCCHHHHHHHHHCCCCCCCCCCEEEEHHHHHCCCCCCHHHHHHHHHHHHHEEECCCC
HITLRGGTHVIFSPTVTYIERVYLPMLCRMGIKAQVKLGAWGWYPRGGGEVNLQVKGGCQ
EEEEECCCEEEECCHHHHHHHHHHHHHHHCCCCEEEEECCEECCCCCCCEEEEEECCCCE
LCGLNLLERGELKRVQGLAVATELPAHIPQRMANRAENLLRTAGLRVSMQALREKGVAPG
EECCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCC
AGIFLTAEYCNSLTGFGGFGRLRLSSEKVAEIACGQLLQFHETGAPVDEHLADQLLLPAV
CCEEEEHHHHCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
LASESSQYKVAEVSTHLTTNAAVIEKFGLGKITVNQAERVVAIASSKV
HHCCCCCEEEEEHHHHHCCCHHHHHHCCCCEEEECCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA