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The map label for this gene is groEL [H]

Identifier: 17229388

GI number: 17229388

Start: 2265567

End: 2267249

Strand: Direct

Name: groEL [H]

Synonym: alr1896

Alternate gene names: 17229388

Gene position: 2265567-2267249 (Clockwise)

Preceding gene: 17229386

Following gene: 17229391

Centisome position: 35.32

GC content: 45.87

Gene sequence:

>1683_bases
ATGGCAAAAATTATTTCGTTTGATGAAGAATCACGGCGTGCTTTAGAGCGGGGTGTCAATGCCCTGGCTGATGCTGTAAA
AATTACCTTAGGCCCCAAGGGTCGCAACGTGCTTTTAGAAAAAAAATATGGCACACCCCAAATTGTGAACGATGGTATTA
CCGTCGCTAAAGAAATTGAATTAGAAGATCCTTTAGAAAATACTGGTGCCAGATTAATTCAAGAGGTAGCATCCAAAACC
AAGGATGTAGCTGGCGATGGCACAACTACGGCTACCGTTTTAGTACAAGCCCTAATTAGAGAAGGTTTGAAGAACGTCGC
GGCTGGTACTAACCCAGTTAGTCTCAAGCGCGGTATAGATAAAACTACCGAGGCTTTGGTAGCGGAAATTGCTAAGGTCG
CCAAGCCTGTAGAAGGTAGTGCGATCGCTCAAGTTGCCACTGTCTCATCTGGTAATGATGAAGAAGTTGGTGCCATGATT
GCCCAAGCGGTGGAAAAAGTCACCAAAGACGGTGTAATCACTGTAGAAGAATCTAAATCCCTGACAACTGAACTAGAAGT
AGTCGAAGGGATGCAGATTGACAGAGGTTATATTTCCCCCTACTTCATCACCAACAACGAGCGCCAAACGGTGGAGTTGG
AAAATGTGCGGATTTTGATTACTGACAAAAAAATCAGCAGTATTCAAGAATTAGTCCCCGTTCTAGAAAAAGTAGCTCGT
TTGGGTCAACCCTTACTGATCATTGCTGAAGATGTAGAAGGAGATGCCCTAGCAACTTTGGTGGTGAACAAAGCACGGGG
TGTACTTTCTGTGGCGGCAATTAAAGCCCCAGGATTTGGCGAACGCCGCAAAGCATTGTTGCAAGATATCGCTATCCTCA
CAGACGGTCAACTAATTTCGGAAGAAATTGGCTTAAGCTTAGATACCGCTTCTCTAGAAGCTTTGGGTACGGCGCAGAAA
ATCACAATTGAAAAAGACAACACCACAATTGTTGCTGGTAATACTACTAAGCCAGAAATCCAAAAGCGGATTGCACAAAT
TCGCCGACAGTTGGAAGAGACTGACTCTGAGTACGATAGCGAGAAATTGCAAGAACGTATTGCCAAGTTAGCTGGTGGTA
TTGCAGTGATCAAAGTCGGTGCAGCAACTGAAACCGAACTCAAAGACCGCAAACTGAGAATCGAAGACGCACTCAACGCC
ACCAAAGCTGCTGTTGCTGAAGGTATCGTTCCTGGTGGCGGCAAAACTCTGATTTACTTGGCGAGTAAGGTAGACGAGAT
TAAGAAAAACTTTGACGAAGAAGAAAAAATCGGTGCTGACATCGTTAAACGGGCTTTAGAAGCTCCTTTACGTCAGATTG
CCGATAATGCTGGTGCAGAAGGTTCTGTCATCGTCTCCAGAGTCAAAGACAGCGATTTCAACATCGGTTACAACGCTGCT
ACTGGGGAATTTGAAGACCTGATTGCGGCTGGTATTATTGACCCTGCAAAAGTTGTGCGTTCAGCATTGCAAAATGCCGC
TTCCATTGCCGGTCTAGTTTTAACCACCGAAGCGATCGTTGTGGAAAAACCAGAGAAAAAATCTGCTGCTCCTGCTGATG
CCGGTATGGGTGGCATGGGCGGCATGGGTGGTATGGGCGGTATGGGTGGCATGGGCGGTATGGGTGGTATGGGTATGTTC
TAA

Upstream 100 bases:

>100_bases
TTTTTTTTACTTCCACACATGATCTAAAGTTTTTGATGTTCTTAGCACTCTGAGCCTGTGAGTGCTAAATTGTCTAATGG
AAGCGCAAGAGAAAGGAAAC

Downstream 100 bases:

>100_bases
GAAGAGGCAGGGAGCAGGGGGCAGGGAGCAAGGGGGAAGAAGTGACTGCAAGATTTTCGCCCAGTACCCAATCCCCAATC
CCCAGTACCCAATAGCCAAA

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 2; Protein Cpn60 2 [H]

Number of amino acids: Translated: 560; Mature: 559

Protein sequence:

>560_residues
MAKIISFDEESRRALERGVNALADAVKITLGPKGRNVLLEKKYGTPQIVNDGITVAKEIELEDPLENTGARLIQEVASKT
KDVAGDGTTTATVLVQALIREGLKNVAAGTNPVSLKRGIDKTTEALVAEIAKVAKPVEGSAIAQVATVSSGNDEEVGAMI
AQAVEKVTKDGVITVEESKSLTTELEVVEGMQIDRGYISPYFITNNERQTVELENVRILITDKKISSIQELVPVLEKVAR
LGQPLLIIAEDVEGDALATLVVNKARGVLSVAAIKAPGFGERRKALLQDIAILTDGQLISEEIGLSLDTASLEALGTAQK
ITIEKDNTTIVAGNTTKPEIQKRIAQIRRQLEETDSEYDSEKLQERIAKLAGGIAVIKVGAATETELKDRKLRIEDALNA
TKAAVAEGIVPGGGKTLIYLASKVDEIKKNFDEEEKIGADIVKRALEAPLRQIADNAGAEGSVIVSRVKDSDFNIGYNAA
TGEFEDLIAAGIIDPAKVVRSALQNAASIAGLVLTTEAIVVEKPEKKSAAPADAGMGGMGGMGGMGGMGGMGGMGGMGMF

Sequences:

>Translated_560_residues
MAKIISFDEESRRALERGVNALADAVKITLGPKGRNVLLEKKYGTPQIVNDGITVAKEIELEDPLENTGARLIQEVASKT
KDVAGDGTTTATVLVQALIREGLKNVAAGTNPVSLKRGIDKTTEALVAEIAKVAKPVEGSAIAQVATVSSGNDEEVGAMI
AQAVEKVTKDGVITVEESKSLTTELEVVEGMQIDRGYISPYFITNNERQTVELENVRILITDKKISSIQELVPVLEKVAR
LGQPLLIIAEDVEGDALATLVVNKARGVLSVAAIKAPGFGERRKALLQDIAILTDGQLISEEIGLSLDTASLEALGTAQK
ITIEKDNTTIVAGNTTKPEIQKRIAQIRRQLEETDSEYDSEKLQERIAKLAGGIAVIKVGAATETELKDRKLRIEDALNA
TKAAVAEGIVPGGGKTLIYLASKVDEIKKNFDEEEKIGADIVKRALEAPLRQIADNAGAEGSVIVSRVKDSDFNIGYNAA
TGEFEDLIAAGIIDPAKVVRSALQNAASIAGLVLTTEAIVVEKPEKKSAAPADAGMGGMGGMGGMGGMGGMGGMGGMGMF
>Mature_559_residues
AKIISFDEESRRALERGVNALADAVKITLGPKGRNVLLEKKYGTPQIVNDGITVAKEIELEDPLENTGARLIQEVASKTK
DVAGDGTTTATVLVQALIREGLKNVAAGTNPVSLKRGIDKTTEALVAEIAKVAKPVEGSAIAQVATVSSGNDEEVGAMIA
QAVEKVTKDGVITVEESKSLTTELEVVEGMQIDRGYISPYFITNNERQTVELENVRILITDKKISSIQELVPVLEKVARL
GQPLLIIAEDVEGDALATLVVNKARGVLSVAAIKAPGFGERRKALLQDIAILTDGQLISEEIGLSLDTASLEALGTAQKI
TIEKDNTTIVAGNTTKPEIQKRIAQIRRQLEETDSEYDSEKLQERIAKLAGGIAVIKVGAATETELKDRKLRIEDALNAT
KAAVAEGIVPGGGKTLIYLASKVDEIKKNFDEEEKIGADIVKRALEAPLRQIADNAGAEGSVIVSRVKDSDFNIGYNAAT
GEFEDLIAAGIIDPAKVVRSALQNAASIAGLVLTTEAIVVEKPEKKSAAPADAGMGGMGGMGGMGGMGGMGGMGGMGMF

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=526, Percent_Identity=47.148288973384, Blast_Score=479, Evalue=1e-135,
Organism=Homo sapiens, GI31542947, Length=526, Percent_Identity=47.148288973384, Blast_Score=479, Evalue=1e-135,
Organism=Escherichia coli, GI1790586, Length=529, Percent_Identity=60.1134215500945, Blast_Score=613, Evalue=1e-177,
Organism=Caenorhabditis elegans, GI17555558, Length=534, Percent_Identity=47.1910112359551, Blast_Score=470, Evalue=1e-133,
Organism=Caenorhabditis elegans, GI193210679, Length=215, Percent_Identity=45.5813953488372, Blast_Score=182, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=50.3802281368821, Blast_Score=498, Evalue=1e-142,
Organism=Drosophila melanogaster, GI24641193, Length=528, Percent_Identity=46.5909090909091, Blast_Score=487, Evalue=1e-138,
Organism=Drosophila melanogaster, GI24641191, Length=528, Percent_Identity=46.5909090909091, Blast_Score=487, Evalue=1e-138,
Organism=Drosophila melanogaster, GI45550936, Length=525, Percent_Identity=44.5714285714286, Blast_Score=464, Evalue=1e-131,
Organism=Drosophila melanogaster, GI45550132, Length=525, Percent_Identity=44.5714285714286, Blast_Score=464, Evalue=1e-131,
Organism=Drosophila melanogaster, GI45550935, Length=525, Percent_Identity=44.5714285714286, Blast_Score=464, Evalue=1e-131,
Organism=Drosophila melanogaster, GI17864606, Length=552, Percent_Identity=39.1304347826087, Blast_Score=394, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24584129, Length=530, Percent_Identity=37.1698113207547, Blast_Score=308, Evalue=5e-84,
Organism=Drosophila melanogaster, GI19921262, Length=530, Percent_Identity=37.1698113207547, Blast_Score=308, Evalue=5e-84,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 58970; Mature: 58839

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIISFDEESRRALERGVNALADAVKITLGPKGRNVLLEKKYGTPQIVNDGITVAKEIE
CCCEECCCHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCEECCCCCEEEECC
LEDPLENTGARLIQEVASKTKDVAGDGTTTATVLVQALIREGLKNVAAGTNPVSLKRGID
CCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCC
KTTEALVAEIAKVAKPVEGSAIAQVATVSSGNDEEVGAMIAQAVEKVTKDGVITVEESKS
HHHHHHHHHHHHHHCCCCCCHHHHEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCC
LTTELEVVEGMQIDRGYISPYFITNNERQTVELENVRILITDKKISSIQELVPVLEKVAR
HHHHHHHHHCCEECCCCCCCEEEECCCCCEEEECCEEEEEECHHHHHHHHHHHHHHHHHH
LGQPLLIIAEDVEGDALATLVVNKARGVLSVAAIKAPGFGERRKALLQDIAILTDGQLIS
CCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCHHHH
EEIGLSLDTASLEALGTAQKITIEKDNTTIVAGNTTKPEIQKRIAQIRRQLEETDSEYDS
HHHCCEECHHHHHHHCCCEEEEEECCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCH
EKLQERIAKLAGGIAVIKVGAATETELKDRKLRIEDALNATKAAVAEGIVPGGGKTLIYL
HHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEH
ASKVDEIKKNFDEEEKIGADIVKRALEAPLRQIADNAGAEGSVIVSRVKDSDFNIGYNAA
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCC
TGEFEDLIAAGIIDPAKVVRSALQNAASIAGLVLTTEAIVVEKPEKKSAAPADAGMGGMG
CCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHEEECEEEEECCCCCCCCCCCCCCCCCC
GMGGMGGMGGMGGMGGMGMF
CCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AKIISFDEESRRALERGVNALADAVKITLGPKGRNVLLEKKYGTPQIVNDGITVAKEIE
CCEECCCHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCEECCCCCEEEECC
LEDPLENTGARLIQEVASKTKDVAGDGTTTATVLVQALIREGLKNVAAGTNPVSLKRGID
CCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCC
KTTEALVAEIAKVAKPVEGSAIAQVATVSSGNDEEVGAMIAQAVEKVTKDGVITVEESKS
HHHHHHHHHHHHHHCCCCCCHHHHEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCC
LTTELEVVEGMQIDRGYISPYFITNNERQTVELENVRILITDKKISSIQELVPVLEKVAR
HHHHHHHHHCCEECCCCCCCEEEECCCCCEEEECCEEEEEECHHHHHHHHHHHHHHHHHH
LGQPLLIIAEDVEGDALATLVVNKARGVLSVAAIKAPGFGERRKALLQDIAILTDGQLIS
CCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCHHHH
EEIGLSLDTASLEALGTAQKITIEKDNTTIVAGNTTKPEIQKRIAQIRRQLEETDSEYDS
HHHCCEECHHHHHHHCCCEEEEEECCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCH
EKLQERIAKLAGGIAVIKVGAATETELKDRKLRIEDALNATKAAVAEGIVPGGGKTLIYL
HHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEH
ASKVDEIKKNFDEEEKIGADIVKRALEAPLRQIADNAGAEGSVIVSRVKDSDFNIGYNAA
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCC
TGEFEDLIAAGIIDPAKVVRSALQNAASIAGLVLTTEAIVVEKPEKKSAAPADAGMGGMG
CCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHEEECEEEEECCCCCCCCCCCCCCCCCC
GMGGMGGMGGMGGMGGMGMF
CCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA