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The map label for this gene is trxC [C]

Identifier: 17229385

GI number: 17229385

Start: 2262788

End: 2263105

Strand: Reverse

Name: trxC [C]

Synonym: all1893

Alternate gene names: 17229385

Gene position: 2263105-2262788 (Counterclockwise)

Preceding gene: 17229387

Following gene: 17229381

Centisome position: 35.29

GC content: 38.36

Gene sequence:

>318_bases
ATGACTGAGAAAAAACAATTCAACAGCTTTGAAGAGATGCTATCTGGTTCTGATTTACCTGTTTTAGTAGACTTTTATGC
TGACTGGTGTGGCCCCTGTCAGATGATGGGGACAATTTTACAACAAGTAAACAATCAACTTAAAGACCGCATACGAATTG
TCAAAATTGACACAGAAAAATACACAGAGTTGGCAACTCAGTATCAAATTGCAGCTCTACCAACACTGGTATTATTCAAA
CAAGGTAAACCAGTAGATCGAATTGAAGGTGTATTGCAAACGCCCGATTTAGTACGGCGTTTGCAAAGTTTCGTTTAG

Upstream 100 bases:

>100_bases
GATGCAAAGTTTAGCAACAATAAAAACAAAATAACGTTACACCATTTCTAGAAAGCAGACATTAATATTAGATTCAATCA
ATAAAAATGGTGTGTGTCAC

Downstream 100 bases:

>100_bases
TCAAGATTAAGTTAGAGATGCAAATTTTTGCATCTCTACATATTAATTATTATTAGGTAGAGAGATTGAATGTTCAAATC
AATCTAAGCTATCAGGCATT

Product: thioredoxin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 105; Mature: 104

Protein sequence:

>105_residues
MTEKKQFNSFEEMLSGSDLPVLVDFYADWCGPCQMMGTILQQVNNQLKDRIRIVKIDTEKYTELATQYQIAALPTLVLFK
QGKPVDRIEGVLQTPDLVRRLQSFV

Sequences:

>Translated_105_residues
MTEKKQFNSFEEMLSGSDLPVLVDFYADWCGPCQMMGTILQQVNNQLKDRIRIVKIDTEKYTELATQYQIAALPTLVLFK
QGKPVDRIEGVLQTPDLVRRLQSFV
>Mature_104_residues
TEKKQFNSFEEMLSGSDLPVLVDFYADWCGPCQMMGTILQQVNNQLKDRIRIVKIDTEKYTELATQYQIAALPTLVLFKQ
GKPVDRIEGVLQTPDLVRRLQSFV

Specific function: Efficient Electron Donor For The Essential Enzyme Ribonucleotide Reductase. Is Also Able To Reduce The Interchain Disulfide Bridges Of Insulin. [C]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=82, Percent_Identity=35.3658536585366, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1788936, Length=75, Percent_Identity=40, Blast_Score=79, Evalue=9e-17,
Organism=Escherichia coli, GI87082331, Length=96, Percent_Identity=32.2916666666667, Blast_Score=70, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI212646193, Length=83, Percent_Identity=40.9638554216867, Blast_Score=79, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17509965, Length=75, Percent_Identity=36, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI193209454, Length=80, Percent_Identity=33.75, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI32566189, Length=80, Percent_Identity=33.75, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17569137, Length=80, Percent_Identity=33.75, Blast_Score=62, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=91, Percent_Identity=31.8681318681319, Blast_Score=72, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323072, Length=91, Percent_Identity=34.0659340659341, Blast_Score=67, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6319925, Length=94, Percent_Identity=32.9787234042553, Blast_Score=62, Evalue=1e-11,
Organism=Drosophila melanogaster, GI28573567, Length=91, Percent_Identity=38.4615384615385, Blast_Score=83, Evalue=4e-17,
Organism=Drosophila melanogaster, GI17648013, Length=70, Percent_Identity=35.7142857142857, Blast_Score=69, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24583090, Length=70, Percent_Identity=35.7142857142857, Blast_Score=69, Evalue=7e-13,
Organism=Drosophila melanogaster, GI17530795, Length=92, Percent_Identity=28.2608695652174, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24664269, Length=67, Percent_Identity=38.8059701492537, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24639826, Length=73, Percent_Identity=31.5068493150685, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21358065, Length=90, Percent_Identity=36.6666666666667, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: 1.8.1.8 [C]

Molecular weight: Translated: 12083; Mature: 11952

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEKKQFNSFEEMLSGSDLPVLVDFYADWCGPCQMMGTILQQVNNQLKDRIRIVKIDTEK
CCCHHHHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHEEEEEECHHH
YTELATQYQIAALPTLVLFKQGKPVDRIEGVLQTPDLVRRLQSFV
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHCC
>Mature Secondary Structure 
TEKKQFNSFEEMLSGSDLPVLVDFYADWCGPCQMMGTILQQVNNQLKDRIRIVKIDTEK
CCHHHHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHEEEEEECHHH
YTELATQYQIAALPTLVLFKQGKPVDRIEGVLQTPDLVRRLQSFV
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]