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The map label for this gene is luxQ [H]

Identifier: 17229338

GI number: 17229338

Start: 2208314

End: 2210356

Strand: Reverse

Name: luxQ [H]

Synonym: all1846

Alternate gene names: 17229338

Gene position: 2210356-2208314 (Counterclockwise)

Preceding gene: 17229339

Following gene: 17229336

Centisome position: 34.46

GC content: 44.79

Gene sequence:

>2043_bases
ATGCAGCCAGAACCCAAAGTCAACATCCTCTTAGTGGATGATAAAGTGGAAAATTTACTGGCACTAGAGGCAATTTTGGA
GCGTCTAGGCGCTAATTTAGTCAGGGCGACTTCTGGGGAGGAAGCTTTGCGGTGTCTGCTGCACCAAGATTTTGCAGTAA
TTTTGTTAGATGTACAGATGCCAGGGATGGATGGTTTTGAAACTGCCACCCTCATTCGTAATCGTGGGCGATCGCGCCAA
ACTCCGATTATCTTTCTCACGGCTTTCAGTACCAGTGACCAAATGCTGTTCAAGGGTTATGCACTAGGAGCAGTTGATTA
TCTTCTCAAACCCATAGATGCAAATATTCTCACTTCTAAAGTTACAGTATTTGTTGAACTTTTTAAGAAAACTCAAGCAA
TCCAACACCAAGCAGCGCAACTGGCGGCGATTAACGCCGAACTAAGACAAAGTGAAGAACGCTTCCGTTCCTTGAGTACC
TGCTCGCCCATAGGTATTTTTGAAACCGATACCGCAGGATGTTGTAAATATACAAATCCCCGCTATCAAGCAATTTGTGG
CTTGGATGCGACAGAGAGTTTAGATAAAAGATGGCTGGAATCTGTGCATTCAGAAGACCAGGAAAGAGCGATCGCTAGTT
GGTCTACTTATATTTATCAAGGCGGCGACTATTCAGATGAATTCCGCTTTCAAACAGTGGATGGTAGCCTGCGATGGGTG
CAAGTACGCTCCTCACCAATGCTTTCTGGTAATGGTGAATTGCTTGGCTATGTCGGTACACTTGAAGATATTACCGCCCG
TAAGCAATCCGAAGAAATTCGCGCTCAGGTAATCCGCGAACAAACCGCCAGACAAGAAGCAGAGGCGACAAATCGGATGA
AAGATGAATTTTTGGCTGTTCTCTCCCATGAACTCCGCACCCCCCTAACTTCCATGTTGGGCTGGTCAAAAATTCTCCGT
GCCAAAAAACTAGACGAAAAAGCCACAGCCAGAGCCTTGGAAGCAATTGAACGCAATGCTAATTCACAAGTGCAATTAAT
AGAAGATATTTTAGATGTATCCCGGATTATTCGCGGTCAACTGCGGCTAAATTTATCTCCCGTCAATTTGATAACTGTGG
TGGAAGCAGCTCTAGAAGCAGTGCGTCCCCTAGCAGATACAAAAAATATGACCATCAACACTGTACTTGACTACACCTTA
AGTCCCGTCAGTGGCGATTTTGCCAGATTACAGCAAATTGTCTGGAATCTCCTGACTAACGCGATTAAGTTCACACCGAA
AGAAGGTCAAGTAGAAATCCGATTAGAAGGGATAAATGGTGAATTATCTGATGATTTGACTCATGCTCAAATCCAAGTCA
TTGATACAGGTGTTGGCATTGCAAGTGAATTTCTGCCTAAAGTCTTTGAGCGTTTCCGCCAAGCAGATAGTACCACCACG
CGATCGCATAATGGATTAGGGTTAGGGTTGGCAATTGTCCGCCATTTAGTGGAACTGCACAACGGTACGATTTTGGCAGA
AAGTCCAGGTGTGGGCAAAGGAGCTACCTTTACTGTGAGATTTCCCCTCATTCAAGAAAATAGGGAAACTCGACCAACAC
CAACGGAAAAACTTTCTGGGGATGCTGCTAACTCTTCTCCCCTTGCAGGCTTAAAAGTTCTCATTGTTGATGATGAAACC
GATACTCGCAACTTTTTAGGCTTCTTGTTTGAAGAATATGGGGCGATTTCCTCCACCAGTGCATCAGTCGAGACTGCGTT
AGCCGTTATCGAACAGTTAAAACCAGATATCCTAATTAGTGATATTGGCATGGCGGAACAAGACGGTTATAGTCTCATCC
GCAAATTACGCTCCTTACCACCAGAACAAGGTGGTAAGATTCCCGCGATCGCTTTAACCGCATATTCACGAGAAGAAGAC
CGCCAGCAAATTATAGAAGCTGGATTTCAGCATCACCTCTCCAAACCGATTGATCCCAACAAATTAATTTCCGTAGTGGC
CAGTATTTTCCACCTATCCCCAGCACTAAGCGGGTCAGTGTAA

Upstream 100 bases:

>100_bases
ACAGCAGCAATATCTGCCGTTACAGTAGACTGGATTGTGTCACTTTCAGAAATTTCTCCCCTACTAGTAAATCTTGGTTA
CTCTACACGGAAATGAACTC

Downstream 100 bases:

>100_bases
ATACTTAACTGCTTCTCTCAAACAAAGCCCGATAAACTGGTTCTCCCCGATTCTGGGTTGTGGTTTCTCTCTCTGTAGCC
ACTGGGAGGGGATTTTCGGT

Product: two-component hybrid sensor and regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 680; Mature: 680

Protein sequence:

>680_residues
MQPEPKVNILLVDDKVENLLALEAILERLGANLVRATSGEEALRCLLHQDFAVILLDVQMPGMDGFETATLIRNRGRSRQ
TPIIFLTAFSTSDQMLFKGYALGAVDYLLKPIDANILTSKVTVFVELFKKTQAIQHQAAQLAAINAELRQSEERFRSLST
CSPIGIFETDTAGCCKYTNPRYQAICGLDATESLDKRWLESVHSEDQERAIASWSTYIYQGGDYSDEFRFQTVDGSLRWV
QVRSSPMLSGNGELLGYVGTLEDITARKQSEEIRAQVIREQTARQEAEATNRMKDEFLAVLSHELRTPLTSMLGWSKILR
AKKLDEKATARALEAIERNANSQVQLIEDILDVSRIIRGQLRLNLSPVNLITVVEAALEAVRPLADTKNMTINTVLDYTL
SPVSGDFARLQQIVWNLLTNAIKFTPKEGQVEIRLEGINGELSDDLTHAQIQVIDTGVGIASEFLPKVFERFRQADSTTT
RSHNGLGLGLAIVRHLVELHNGTILAESPGVGKGATFTVRFPLIQENRETRPTPTEKLSGDAANSSPLAGLKVLIVDDET
DTRNFLGFLFEEYGAISSTSASVETALAVIEQLKPDILISDIGMAEQDGYSLIRKLRSLPPEQGGKIPAIALTAYSREED
RQQIIEAGFQHHLSKPIDPNKLISVVASIFHLSPALSGSV

Sequences:

>Translated_680_residues
MQPEPKVNILLVDDKVENLLALEAILERLGANLVRATSGEEALRCLLHQDFAVILLDVQMPGMDGFETATLIRNRGRSRQ
TPIIFLTAFSTSDQMLFKGYALGAVDYLLKPIDANILTSKVTVFVELFKKTQAIQHQAAQLAAINAELRQSEERFRSLST
CSPIGIFETDTAGCCKYTNPRYQAICGLDATESLDKRWLESVHSEDQERAIASWSTYIYQGGDYSDEFRFQTVDGSLRWV
QVRSSPMLSGNGELLGYVGTLEDITARKQSEEIRAQVIREQTARQEAEATNRMKDEFLAVLSHELRTPLTSMLGWSKILR
AKKLDEKATARALEAIERNANSQVQLIEDILDVSRIIRGQLRLNLSPVNLITVVEAALEAVRPLADTKNMTINTVLDYTL
SPVSGDFARLQQIVWNLLTNAIKFTPKEGQVEIRLEGINGELSDDLTHAQIQVIDTGVGIASEFLPKVFERFRQADSTTT
RSHNGLGLGLAIVRHLVELHNGTILAESPGVGKGATFTVRFPLIQENRETRPTPTEKLSGDAANSSPLAGLKVLIVDDET
DTRNFLGFLFEEYGAISSTSASVETALAVIEQLKPDILISDIGMAEQDGYSLIRKLRSLPPEQGGKIPAIALTAYSREED
RQQIIEAGFQHHLSKPIDPNKLISVVASIFHLSPALSGSV
>Mature_680_residues
MQPEPKVNILLVDDKVENLLALEAILERLGANLVRATSGEEALRCLLHQDFAVILLDVQMPGMDGFETATLIRNRGRSRQ
TPIIFLTAFSTSDQMLFKGYALGAVDYLLKPIDANILTSKVTVFVELFKKTQAIQHQAAQLAAINAELRQSEERFRSLST
CSPIGIFETDTAGCCKYTNPRYQAICGLDATESLDKRWLESVHSEDQERAIASWSTYIYQGGDYSDEFRFQTVDGSLRWV
QVRSSPMLSGNGELLGYVGTLEDITARKQSEEIRAQVIREQTARQEAEATNRMKDEFLAVLSHELRTPLTSMLGWSKILR
AKKLDEKATARALEAIERNANSQVQLIEDILDVSRIIRGQLRLNLSPVNLITVVEAALEAVRPLADTKNMTINTVLDYTL
SPVSGDFARLQQIVWNLLTNAIKFTPKEGQVEIRLEGINGELSDDLTHAQIQVIDTGVGIASEFLPKVFERFRQADSTTT
RSHNGLGLGLAIVRHLVELHNGTILAESPGVGKGATFTVRFPLIQENRETRPTPTEKLSGDAANSSPLAGLKVLIVDDET
DTRNFLGFLFEEYGAISSTSASVETALAVIEQLKPDILISDIGMAEQDGYSLIRKLRSLPPEQGGKIPAIALTAYSREED
RQQIIEAGFQHHLSKPIDPNKLISVVASIFHLSPALSGSV

Specific function: At low cell density, in absence of AI-2 (autoinducer 2), luxQ has a kinase activity and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is t

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI48994928, Length=447, Percent_Identity=30.8724832214765, Blast_Score=149, Evalue=8e-37,
Organism=Escherichia coli, GI1788713, Length=433, Percent_Identity=28.4064665127021, Blast_Score=144, Evalue=2e-35,
Organism=Escherichia coli, GI1789149, Length=257, Percent_Identity=36.9649805447471, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI145693157, Length=273, Percent_Identity=34.7985347985348, Blast_Score=123, Evalue=4e-29,
Organism=Escherichia coli, GI87081816, Length=411, Percent_Identity=28.2238442822384, Blast_Score=111, Evalue=2e-25,
Organism=Escherichia coli, GI1788393, Length=236, Percent_Identity=30.9322033898305, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1786600, Length=254, Percent_Identity=31.1023622047244, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1788549, Length=367, Percent_Identity=26.7029972752044, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1786912, Length=244, Percent_Identity=30.7377049180328, Blast_Score=96, Evalue=7e-21,
Organism=Escherichia coli, GI1786783, Length=233, Percent_Identity=29.6137339055794, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1790436, Length=225, Percent_Identity=28.4444444444444, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1787894, Length=231, Percent_Identity=28.5714285714286, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1790861, Length=235, Percent_Identity=29.3617021276596, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1788279, Length=295, Percent_Identity=25.7627118644068, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1790437, Length=107, Percent_Identity=36.4485981308411, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1790346, Length=237, Percent_Identity=28.2700421940928, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI87082012, Length=153, Percent_Identity=32.0261437908497, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI87082128, Length=236, Percent_Identity=27.9661016949153, Blast_Score=66, Evalue=8e-12,
Organism=Escherichia coli, GI1788550, Length=138, Percent_Identity=30.4347826086957, Blast_Score=63, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR015387
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789
- ProDom:   PD142495 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09308 LuxQ-periplasm; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 75110; Mature: 75110

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPEPKVNILLVDDKVENLLALEAILERLGANLVRATSGEEALRCLLHQDFAVILLDVQM
CCCCCCEEEEEECCHHHHHHHHHHHHHHHCCHHEECCCHHHHHHHHHHCCCEEEEEEEEC
PGMDGFETATLIRNRGRSRQTPIIFLTAFSTSDQMLFKGYALGAVDYLLKPIDANILTSK
CCCCCHHHHHHHHHCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCHHHHHH
VTVFVELFKKTQAIQHQAAQLAAINAELRQSEERFRSLSTCSPIGIFETDTAGCCKYTNP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCC
RYQAICGLDATESLDKRWLESVHSEDQERAIASWSTYIYQGGDYSDEFRFQTVDGSLRWV
CEEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHEEECCCCCCCCEEEEECCCEEEE
QVRSSPMLSGNGELLGYVGTLEDITARKQSEEIRAQVIREQTARQEAEATNRMKDEFLAV
EEECCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSHELRTPLTSMLGWSKILRAKKLDEKATARALEAIERNANSQVQLIEDILDVSRIIRGQ
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
LRLNLSPVNLITVVEAALEAVRPLADTKNMTINTVLDYTLSPVSGDFARLQQIVWNLLTN
HEEECCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHH
AIKFTPKEGQVEIRLEGINGELSDDLTHAQIQVIDTGVGIASEFLPKVFERFRQADSTTT
HHEECCCCCCEEEEEECCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCC
RSHNGLGLGLAIVRHLVELHNGTILAESPGVGKGATFTVRFPLIQENRETRPTPTEKLSG
CCCCCCHHHHHHHHHHHHHHCCEEEECCCCCCCCCEEEEEECEEECCCCCCCCCHHHCCC
DAANSSPLAGLKVLIVDDETDTRNFLGFLFEEYGAISSTSASVETALAVIEQLKPDILIS
CCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEE
DIGMAEQDGYSLIRKLRSLPPEQGGKIPAIALTAYSREEDRQQIIEAGFQHHLSKPIDPN
CCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCHH
KLISVVASIFHLSPALSGSV
HHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MQPEPKVNILLVDDKVENLLALEAILERLGANLVRATSGEEALRCLLHQDFAVILLDVQM
CCCCCCEEEEEECCHHHHHHHHHHHHHHHCCHHEECCCHHHHHHHHHHCCCEEEEEEEEC
PGMDGFETATLIRNRGRSRQTPIIFLTAFSTSDQMLFKGYALGAVDYLLKPIDANILTSK
CCCCCHHHHHHHHHCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCHHHHHH
VTVFVELFKKTQAIQHQAAQLAAINAELRQSEERFRSLSTCSPIGIFETDTAGCCKYTNP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCC
RYQAICGLDATESLDKRWLESVHSEDQERAIASWSTYIYQGGDYSDEFRFQTVDGSLRWV
CEEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHEEECCCCCCCCEEEEECCCEEEE
QVRSSPMLSGNGELLGYVGTLEDITARKQSEEIRAQVIREQTARQEAEATNRMKDEFLAV
EEECCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSHELRTPLTSMLGWSKILRAKKLDEKATARALEAIERNANSQVQLIEDILDVSRIIRGQ
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
LRLNLSPVNLITVVEAALEAVRPLADTKNMTINTVLDYTLSPVSGDFARLQQIVWNLLTN
HEEECCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHH
AIKFTPKEGQVEIRLEGINGELSDDLTHAQIQVIDTGVGIASEFLPKVFERFRQADSTTT
HHEECCCCCCEEEEEECCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCC
RSHNGLGLGLAIVRHLVELHNGTILAESPGVGKGATFTVRFPLIQENRETRPTPTEKLSG
CCCCCCHHHHHHHHHHHHHHCCEEEECCCCCCCCCEEEEEECEEECCCCCCCCCHHHCCC
DAANSSPLAGLKVLIVDDETDTRNFLGFLFEEYGAISSTSASVETALAVIEQLKPDILIS
CCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEE
DIGMAEQDGYSLIRKLRSLPPEQGGKIPAIALTAYSREEDRQQIIEAGFQHHLSKPIDPN
CCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCHH
KLISVVASIFHLSPALSGSV
HHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301; 12176318 [H]