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The map label for this gene is srrA [H]

Identifier: 17229228

GI number: 17229228

Start: 2087345

End: 2088040

Strand: Reverse

Name: srrA [H]

Synonym: all1736

Alternate gene names: 17229228

Gene position: 2088040-2087345 (Counterclockwise)

Preceding gene: 17229229

Following gene: 17229227

Centisome position: 32.56

GC content: 45.11

Gene sequence:

>696_bases
ATGTCAGCACAATTGTTACTGGTAGATGATGAACCCGGATTGAGAGAAGCCGTCAAAGACTACTTGCAAGAAAGTGGTTT
TAGCGTTCAAGTCGCCAGTAATGCCCGTGAGGGTTGGGATTTGATGCAGCAAAGCACACCAGACCTCGTAATTTCCGATG
TGATGATGCCTCAGGTAGACGGATATCAATTTCTCAAGCAATTGCGCGAAGACCCCCGCTTTCAATCACTCCCCGTGGTA
TTTTTAACAGCTAAAGGGATGACAAGTGATCGCATCCAGGGATATCAAGCTGGAGTTGATGCTTATCTACCTAAACCCTT
CGACCCAGATGAACTGGTAGCCATTGTCGAAAACTTACTTATCCGTCGCAACAGCAAGCCTCAAAAAACCACCGAAGAAG
GCGAAACACCAGATATAGCCGAACTAGCAAATCAAATTGCTCAAATCAAAGCTTTATTAACTCAAAGGAATGCAATTTCC
CAGTCACCAGCGCCTTTTAAAATTGACCTTACTCCCAGAGAACAGAGTGTTTTAAACTTGGTAGCTGAAGGACTAATGAA
TAAAGAAATCGCCCGCCGCCTCGAAACCAGCGTGCGTAACGTCGAAAAATACGTCAGTCGTTTGTTCAGCAAAACAGGAA
CTAACAGCCGTACTGAGTTAGTGCGTTTTGCCTTGGAACACGGACTAGCCAAATGA

Upstream 100 bases:

>100_bases
TACCCGAAGAAGCGAAGACAATTGAATGGTTGTAGGAAGTTTGAATTTTCGATCCATGATTCGCTACATTGGAACAAGGT
AAACCATAGGAAATTTTTAG

Downstream 100 bases:

>100_bases
ATCAATTCAAAATTCACTCATACCCTACGGGTACTCTGCGAGAACGCCTTTGGCGAACGCGGTAGCGCTCCGCAGGAAAG
GCTACGCCAACAAAATTCAA

Product: two-component response regulator

Products: NA

Alternate protein names: Staphylococcal respiratory response protein A [H]

Number of amino acids: Translated: 231; Mature: 230

Protein sequence:

>231_residues
MSAQLLLVDDEPGLREAVKDYLQESGFSVQVASNAREGWDLMQQSTPDLVISDVMMPQVDGYQFLKQLREDPRFQSLPVV
FLTAKGMTSDRIQGYQAGVDAYLPKPFDPDELVAIVENLLIRRNSKPQKTTEEGETPDIAELANQIAQIKALLTQRNAIS
QSPAPFKIDLTPREQSVLNLVAEGLMNKEIARRLETSVRNVEKYVSRLFSKTGTNSRTELVRFALEHGLAK

Sequences:

>Translated_231_residues
MSAQLLLVDDEPGLREAVKDYLQESGFSVQVASNAREGWDLMQQSTPDLVISDVMMPQVDGYQFLKQLREDPRFQSLPVV
FLTAKGMTSDRIQGYQAGVDAYLPKPFDPDELVAIVENLLIRRNSKPQKTTEEGETPDIAELANQIAQIKALLTQRNAIS
QSPAPFKIDLTPREQSVLNLVAEGLMNKEIARRLETSVRNVEKYVSRLFSKTGTNSRTELVRFALEHGLAK
>Mature_230_residues
SAQLLLVDDEPGLREAVKDYLQESGFSVQVASNAREGWDLMQQSTPDLVISDVMMPQVDGYQFLKQLREDPRFQSLPVVF
LTAKGMTSDRIQGYQAGVDAYLPKPFDPDELVAIVENLLIRRNSKPQKTTEEGETPDIAELANQIAQIKALLTQRNAISQ
SPAPFKIDLTPREQSVLNLVAEGLMNKEIARRLETSVRNVEKYVSRLFSKTGTNSRTELVRFALEHGLAK

Specific function: Member of the two-component regulatory system srrA/srrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels. SrrA binds to the agr, spa and tst promoters and represses their transcript

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788394, Length=142, Percent_Identity=33.8028169014084, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1786599, Length=122, Percent_Identity=36.8852459016393, Blast_Score=91, Evalue=5e-20,
Organism=Escherichia coli, GI1789809, Length=216, Percent_Identity=31.4814814814815, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1786784, Length=175, Percent_Identity=33.1428571428571, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1790299, Length=137, Percent_Identity=34.3065693430657, Blast_Score=85, Evalue=3e-18,
Organism=Escherichia coli, GI1790860, Length=143, Percent_Identity=34.965034965035, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI2367329, Length=217, Percent_Identity=30.8755760368664, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1789402, Length=131, Percent_Identity=32.824427480916, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1787375, Length=211, Percent_Identity=28.9099526066351, Blast_Score=77, Evalue=7e-16,
Organism=Escherichia coli, GI87082012, Length=113, Percent_Identity=36.283185840708, Blast_Score=77, Evalue=8e-16,
Organism=Escherichia coli, GI1788550, Length=130, Percent_Identity=31.5384615384615, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1788521, Length=217, Percent_Identity=29.0322580645161, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI1788905, Length=119, Percent_Identity=37.8151260504202, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1787473, Length=221, Percent_Identity=31.2217194570136, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1786747, Length=225, Percent_Identity=25.3333333333333, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1787229, Length=132, Percent_Identity=29.5454545454545, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788191, Length=105, Percent_Identity=36.1904761904762, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1786911, Length=123, Percent_Identity=35.7723577235772, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1790552, Length=125, Percent_Identity=32, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1790863, Length=121, Percent_Identity=31.404958677686, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI145693157, Length=106, Percent_Identity=30.188679245283, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1790437, Length=154, Percent_Identity=27.9220779220779, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1788222, Length=229, Percent_Identity=24.4541484716157, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25891; Mature: 25760

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAQLLLVDDEPGLREAVKDYLQESGFSVQVASNAREGWDLMQQSTPDLVISDVMMPQVD
CCCEEEEECCCCCHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHCCCCHHHHHHHCCCCC
GYQFLKQLREDPRFQSLPVVFLTAKGMTSDRIQGYQAGVDAYLPKPFDPDELVAIVENLL
HHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHCCHHCCCCCCCHHHHHHHHHHHH
IRRNSKPQKTTEEGETPDIAELANQIAQIKALLTQRNAISQSPAPFKIDLTPREQSVLNL
HHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHH
VAEGLMNKEIARRLETSVRNVEKYVSRLFSKTGTNSRTELVRFALEHGLAK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SAQLLLVDDEPGLREAVKDYLQESGFSVQVASNAREGWDLMQQSTPDLVISDVMMPQVD
CCEEEEECCCCCHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHCCCCHHHHHHHCCCCC
GYQFLKQLREDPRFQSLPVVFLTAKGMTSDRIQGYQAGVDAYLPKPFDPDELVAIVENLL
HHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHCCHHCCCCCCCHHHHHHHHHHHH
IRRNSKPQKTTEEGETPDIAELANQIAQIKALLTQRNAISQSPAPFKIDLTPREQSVLNL
HHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHH
VAEGLMNKEIARRLETSVRNVEKYVSRLFSKTGTNSRTELVRFALEHGLAK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA