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The map label for this gene is msrA2

Identifier: 17229167

GI number: 17229167

Start: 1998775

End: 1999443

Strand: Direct

Name: msrA2

Synonym: alr1675

Alternate gene names: 17229167

Gene position: 1998775-1999443 (Clockwise)

Preceding gene: 17229166

Following gene: 17229169

Centisome position: 31.16

GC content: 46.19

Gene sequence:

>669_bases
ATGGCACTATTTGGATTTGGTAAAAAATTAGCGTTGCCCACCCCTGAAAAAGCCTTACCTGGAAGGGCGCAAATTATGCC
TGTACCGGCTAACCACTATGTCAACAAGAACCCACTAAAACCTCCTTTTCCTGACGGTTTTGAGAAAGCCTTATTTGGTT
TGGGTTGTTTTTGGGGTGCAGAGCGTAAGTTTTGGCAGCAGCAGGGGGTTTACAGCACAGCTGTTGGTTATGCGGCTGGT
TTTACTCCCAACCCCACCTATGACGAAGTATGTACAGGCTTGACAGGTCACAACGAAGTTGTATTGGTAGTATTTGACCC
CAAGGTAATTAGTTACACTCAGCTACTTAAAGTCTTTTGGGAAAGCCACAACCCTACTCAAGGAATGCGCCAAGGTAATG
ACGTGGGGACTCAGTATCGTTCAGGTATTTACGTCTATTCAGAGGCGCAAAAACAGCTAGCAGAAGCTTCACGCGACGCT
TATCAGCAAGCTCTCAGCAGTGCAGGGTATGAAAAGATTACAACAGAAATCCTAGATGCACCAGAGTTCTACTACGCGGA
AGCTTATCATCAGCAGTACCTAGCGAAAAACCCCAATGGTTATTGTGGTTTAGGTGGGACGAATGTTGCTTGTCCTGTGG
GTGTGTTTGAATCTTCCGCAAATGGGTAG

Upstream 100 bases:

>100_bases
TTTCCTCTTCTTGACTCCCCAGAAAAATGACTGGGGATGGCAGAAGGCTTAAAATATTAAGTAAATTAAAGATGTATGTA
AAAACACAGACTCAAAATCA

Downstream 100 bases:

>100_bases
GAAAGGTAATCAATTCAAAATACCCTATGGGTACGCTTAGGGAACAACAAAAAATAAATTATCCGAAATTGATGGTTTGG
TAGGGTGCGTCAGTACCATA

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase 2; Peptide-methionine (S)-S-oxide reductase 2; Peptide Met(O) reductase 2

Number of amino acids: Translated: 222; Mature: 221

Protein sequence:

>222_residues
MALFGFGKKLALPTPEKALPGRAQIMPVPANHYVNKNPLKPPFPDGFEKALFGLGCFWGAERKFWQQQGVYSTAVGYAAG
FTPNPTYDEVCTGLTGHNEVVLVVFDPKVISYTQLLKVFWESHNPTQGMRQGNDVGTQYRSGIYVYSEAQKQLAEASRDA
YQQALSSAGYEKITTEILDAPEFYYAEAYHQQYLAKNPNGYCGLGGTNVACPVGVFESSANG

Sequences:

>Translated_222_residues
MALFGFGKKLALPTPEKALPGRAQIMPVPANHYVNKNPLKPPFPDGFEKALFGLGCFWGAERKFWQQQGVYSTAVGYAAG
FTPNPTYDEVCTGLTGHNEVVLVVFDPKVISYTQLLKVFWESHNPTQGMRQGNDVGTQYRSGIYVYSEAQKQLAEASRDA
YQQALSSAGYEKITTEILDAPEFYYAEAYHQQYLAKNPNGYCGLGGTNVACPVGVFESSANG
>Mature_221_residues
ALFGFGKKLALPTPEKALPGRAQIMPVPANHYVNKNPLKPPFPDGFEKALFGLGCFWGAERKFWQQQGVYSTAVGYAAGF
TPNPTYDEVCTGLTGHNEVVLVVFDPKVISYTQLLKVFWESHNPTQGMRQGNDVGTQYRSGIYVYSEAQKQLAEASRDAY
QQALSSAGYEKITTEILDAPEFYYAEAYHQQYLAKNPNGYCGLGGTNVACPVGVFESSANG

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family

Homologues:

Organism=Homo sapiens, GI6912516, Length=204, Percent_Identity=61.2745098039216, Blast_Score=271, Evalue=3e-73,
Organism=Homo sapiens, GI208609995, Length=184, Percent_Identity=63.0434782608696, Blast_Score=251, Evalue=3e-67,
Organism=Homo sapiens, GI208609993, Length=202, Percent_Identity=48.019801980198, Blast_Score=185, Evalue=2e-47,
Organism=Escherichia coli, GI1790665, Length=199, Percent_Identity=57.7889447236181, Blast_Score=224, Evalue=3e-60,
Organism=Caenorhabditis elegans, GI17533973, Length=147, Percent_Identity=38.7755102040816, Blast_Score=100, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6320881, Length=172, Percent_Identity=38.953488372093, Blast_Score=100, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24664627, Length=144, Percent_Identity=43.0555555555556, Blast_Score=103, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24664631, Length=144, Percent_Identity=43.0555555555556, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI45553131, Length=140, Percent_Identity=42.1428571428571, Blast_Score=97, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MSRA2_NOSS1 (Q8YWD8)

Other databases:

- EMBL:   BA000019
- PIR:   AE2015
- RefSeq:   NP_485715.1
- ProteinModelPortal:   Q8YWD8
- SMR:   Q8YWD8
- STRING:   Q8YWD8
- GeneID:   1105267
- GenomeReviews:   BA000019_GR
- KEGG:   ana:alr1675
- NMPDR:   fig|103690.1.peg.1982
- eggNOG:   COG0225
- HOGENOM:   HBG748152
- OMA:   QETSFEQ
- PhylomeDB:   Q8YWD8
- ProtClustDB:   PRK00058
- BioCyc:   NSP103690:ALR1675-MONOMER
- HAMAP:   MF_01401
- InterPro:   IPR002569
- Gene3D:   G3DSA:3.30.1060.10
- TIGRFAMs:   TIGR00401

Pfam domain/function: PF01625 PMSR; SSF55068 MsrA

EC number: =1.8.4.11

Molecular weight: Translated: 24359; Mature: 24227

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: ACT_SITE 56-56

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALFGFGKKLALPTPEKALPGRAQIMPVPANHYVNKNPLKPPFPDGFEKALFGLGCFWGA
CCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
ERKFWQQQGVYSTAVGYAAGFTPNPTYDEVCTGLTGHNEVVLVVFDPKVISYTQLLKVFW
HHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHH
ESHNPTQGMRQGNDVGTQYRSGIYVYSEAQKQLAEASRDAYQQALSSAGYEKITTEILDA
HCCCCCCHHHCCCHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCC
PEFYYAEAYHQQYLAKNPNGYCGLGGTNVACPVGVFESSANG
CHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCHHCCCCCCC
>Mature Secondary Structure 
ALFGFGKKLALPTPEKALPGRAQIMPVPANHYVNKNPLKPPFPDGFEKALFGLGCFWGA
CCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
ERKFWQQQGVYSTAVGYAAGFTPNPTYDEVCTGLTGHNEVVLVVFDPKVISYTQLLKVFW
HHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHH
ESHNPTQGMRQGNDVGTQYRSGIYVYSEAQKQLAEASRDAYQQALSSAGYEKITTEILDA
HCCCCCCHHHCCCHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCC
PEFYYAEAYHQQYLAKNPNGYCGLGGTNVACPVGVFESSANG
CHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840