Click here to switch to the map view.

The map label for this gene is hoxH [H]

Identifier: 17228261

GI number: 17228261

Start: 886799

End: 888250

Strand: Direct

Name: hoxH [H]

Synonym: alr0766

Alternate gene names: 17228261

Gene position: 886799-888250 (Clockwise)

Preceding gene: 17228260

Following gene: 17228268

Centisome position: 13.83

GC content: 44.9

Gene sequence:

>1452_bases
ATGTCTAAACGAATCGTCATCGACCCCGTTACCCGCATTGAAGGTCACGCCAAGATTAGTATCTACTTGGACGATACTGG
ACAGGTAAACGATGCGCGCTTTCATGTCACAGAATTTCGTGGGTTTGAAAAGTTTTGCGAAGGTCGTCCTTTGTGGGAAA
TGCCGGGGATTACAGCGCGGATTTGTGGTATTTGTCCGGTGAGTCACTTGTTGGCTTCTGCAAAAGCAGGCGATCGCATT
TTATCTGTTACCATACCCCCAACAGCCACTAAACTCCGCCGGCTGATGAATTTGGGACAAATCCTCCAATCCCATGCACT
CAGTTTCTTTCACCTCAGCGCCCCAGATTTTTTGCTGGGAATGGATAGTGACCCCCAAAAGCGCAATATTTTCGGATTAA
TTGCAGCTCAACCAGAACTCGCCCGTGGTGGTATTCGTCTGCGCCAATTTGGGCAAGAAATAATTGAAGTGTTGGGAGGA
GCAAAGATTCACCCGGCTTGGGCTGTTCCTGGCGGTGTGCGAGAACCCCTTTCTGCTGAAGGACGCACTCACATACAAGA
ACGCATCCCTGAAGCCCGGACTATTGCCTTGGATGCTTTGGATAGATTCAAGAAACTGCTCAAAGATTATGAAAAGGAGG
CGCAGACTTTTGGTAACTTCCCCAGCTTGTTTATGGGTTTAGTAACACCTGATGGCTTGTGGGAAACTTACGACGGATAT
ATTCGTTTTGTGGATAGTGCAGGTAATATTATTGCTGATAAACTAGACCCCACACGTTATCAAGAATTTATTGGCGAAGC
CGTCCAACCAGACTCTTATTTAAAATCGCCTTATTATCGACCTTTGGGTTATCCTGACCAACATGACCAATGTCGCATAG
ATAGCGGAATGTATCGAGTAGGGCCACTAGCGCGTCTCAATATTTGCAGTCATATTGGGACAACTTTAGCAGACCGTGAA
TTGCGAGAATTCCGCGAACTGACTTCAGGTACAGCCAAATCATCGTTTTTCTACCACTATGCGCGTTTAATCGAAATTTT
GGCTTGTATAGAACACATTGAAATCTTACTTAACGACCCAGATATTCTGTCAACTCGATTGCGTTCCGAAGCCGGTGTTA
ACCAATTAGAAGGTGTTGGTGTGAGTGAAGCACCAAGGGGTACATTATTTCATCATTATCAAGTCGATGAAAATGGCTTA
CTGCAAAAAGTGAATTTAATTATCGCTACTGGTCAAAACAATCTAGCAATGAATCGCACGGTAGCCCAAATTGCTCGACA
TTTCATTCAAGGTACAGAAATTCTTGAAGGAATGCTCAATCGTGTAGAAGCAGGAATCCGGGCTTTTGACCCCTGTTTAA
GTTGTTCCACCCATGCAGCCGGACAAATGCCATTGCACATTCAATTAGTCGCAGCAGATGGAAATATTGTTAATCAAGTT
TGGCGAGAGTAA

Upstream 100 bases:

>100_bases
TCGCAGGGAAGGGGTTGGGGGTTAGGTTTGAGAGAAAGTTGCACACGGCGTTAGTTATTCTTCTTTGCCTCCCCTGCTTC
CCTTGCACCCCCTGCGCCCT

Downstream 100 bases:

>100_bases
AAAATTAAGGGTATAGGGGTATGGGAATGTAGAAGTTAAGTTTTCAAAACCCTCACACCCCTACACCCTTGTATATTAAT
TAACGATTTTCTGGAATCAC

Product: hydrogenase large subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 483; Mature: 482

Protein sequence:

>483_residues
MSKRIVIDPVTRIEGHAKISIYLDDTGQVNDARFHVTEFRGFEKFCEGRPLWEMPGITARICGICPVSHLLASAKAGDRI
LSVTIPPTATKLRRLMNLGQILQSHALSFFHLSAPDFLLGMDSDPQKRNIFGLIAAQPELARGGIRLRQFGQEIIEVLGG
AKIHPAWAVPGGVREPLSAEGRTHIQERIPEARTIALDALDRFKKLLKDYEKEAQTFGNFPSLFMGLVTPDGLWETYDGY
IRFVDSAGNIIADKLDPTRYQEFIGEAVQPDSYLKSPYYRPLGYPDQHDQCRIDSGMYRVGPLARLNICSHIGTTLADRE
LREFRELTSGTAKSSFFYHYARLIEILACIEHIEILLNDPDILSTRLRSEAGVNQLEGVGVSEAPRGTLFHHYQVDENGL
LQKVNLIIATGQNNLAMNRTVAQIARHFIQGTEILEGMLNRVEAGIRAFDPCLSCSTHAAGQMPLHIQLVAADGNIVNQV
WRE

Sequences:

>Translated_483_residues
MSKRIVIDPVTRIEGHAKISIYLDDTGQVNDARFHVTEFRGFEKFCEGRPLWEMPGITARICGICPVSHLLASAKAGDRI
LSVTIPPTATKLRRLMNLGQILQSHALSFFHLSAPDFLLGMDSDPQKRNIFGLIAAQPELARGGIRLRQFGQEIIEVLGG
AKIHPAWAVPGGVREPLSAEGRTHIQERIPEARTIALDALDRFKKLLKDYEKEAQTFGNFPSLFMGLVTPDGLWETYDGY
IRFVDSAGNIIADKLDPTRYQEFIGEAVQPDSYLKSPYYRPLGYPDQHDQCRIDSGMYRVGPLARLNICSHIGTTLADRE
LREFRELTSGTAKSSFFYHYARLIEILACIEHIEILLNDPDILSTRLRSEAGVNQLEGVGVSEAPRGTLFHHYQVDENGL
LQKVNLIIATGQNNLAMNRTVAQIARHFIQGTEILEGMLNRVEAGIRAFDPCLSCSTHAAGQMPLHIQLVAADGNIVNQV
WRE
>Mature_482_residues
SKRIVIDPVTRIEGHAKISIYLDDTGQVNDARFHVTEFRGFEKFCEGRPLWEMPGITARICGICPVSHLLASAKAGDRIL
SVTIPPTATKLRRLMNLGQILQSHALSFFHLSAPDFLLGMDSDPQKRNIFGLIAAQPELARGGIRLRQFGQEIIEVLGGA
KIHPAWAVPGGVREPLSAEGRTHIQERIPEARTIALDALDRFKKLLKDYEKEAQTFGNFPSLFMGLVTPDGLWETYDGYI
RFVDSAGNIIADKLDPTRYQEFIGEAVQPDSYLKSPYYRPLGYPDQHDQCRIDSGMYRVGPLARLNICSHIGTTLADREL
REFRELTSGTAKSSFFYHYARLIEILACIEHIEILLNDPDILSTRLRSEAGVNQLEGVGVSEAPRGTLFHHYQVDENGLL
QKVNLIIATGQNNLAMNRTVAQIARHFIQGTEILEGMLNRVEAGIRAFDPCLSCSTHAAGQMPLHIQLVAADGNIVNQVW
RE

Specific function: This Is One Of Three E.Coli Hydrogenases Synthesized In Response To Different Physiological Conditions. Hyd1 Is Believed To Have A Role In Hydrogen Cycling During Fermentative Growth. [C]

COG id: COG3259

COG function: function code C; Coenzyme F420-reducing hydrogenase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family [H]

Homologues:

Organism=Escherichia coli, GI1787207, Length=592, Percent_Identity=23.6486486486486, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1789368, Length=130, Percent_Identity=35.3846153846154, Blast_Score=87, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001501
- InterPro:   IPR018194 [H]

Pfam domain/function: PF00374 NiFeSe_Hases [H]

EC number: =1.12.1.2 [H]

Molecular weight: Translated: 53907; Mature: 53775

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00508 NI_HGENASE_L_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKRIVIDPVTRIEGHAKISIYLDDTGQVNDARFHVTEFRGFEKFCEGRPLWEMPGITAR
CCCCEEECCHHHCCCCEEEEEEECCCCCCCCCEEEHHHHHHHHHHHCCCCCCCCCCCHHH
ICGICPVSHLLASAKAGDRILSVTIPPTATKLRRLMNLGQILQSHALSFFHLSAPDFLLG
HHHHCHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEE
MDSDPQKRNIFGLIAAQPELARGGIRLRQFGQEIIEVLGGAKIHPAWAVPGGVREPLSAE
CCCCCCCCCEEEEEECCCHHHHCCHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCC
GRTHIQERIPEARTIALDALDRFKKLLKDYEKEAQTFGNFPSLFMGLVTPDGLWETYDGY
CHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHCCCCC
IRFVDSAGNIIADKLDPTRYQEFIGEAVQPDSYLKSPYYRPLGYPDQHDQCRIDSGMYRV
EEEECCCCCEEECCCCHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCCCCCEECCCCCEEC
GPLARLNICSHIGTTLADRELREFRELTSGTAKSSFFYHYARLIEILACIEHIEILLNDP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DILSTRLRSEAGVNQLEGVGVSEAPRGTLFHHYQVDENGLLQKVNLIIATGQNNLAMNRT
HHHHHHHHHHCCCHHHCCCCCCCCCCCCEEEEEEECCCCCEEEEEEEEEECCCCCHHHHH
VAQIARHFIQGTEILEGMLNRVEAGIRAFDPCLSCSTHAAGQMPLHIQLVAADGNIVNQV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCHHHHHH
WRE
HCC
>Mature Secondary Structure 
SKRIVIDPVTRIEGHAKISIYLDDTGQVNDARFHVTEFRGFEKFCEGRPLWEMPGITAR
CCCEEECCHHHCCCCEEEEEEECCCCCCCCCEEEHHHHHHHHHHHCCCCCCCCCCCHHH
ICGICPVSHLLASAKAGDRILSVTIPPTATKLRRLMNLGQILQSHALSFFHLSAPDFLLG
HHHHCHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEE
MDSDPQKRNIFGLIAAQPELARGGIRLRQFGQEIIEVLGGAKIHPAWAVPGGVREPLSAE
CCCCCCCCCEEEEEECCCHHHHCCHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCC
GRTHIQERIPEARTIALDALDRFKKLLKDYEKEAQTFGNFPSLFMGLVTPDGLWETYDGY
CHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHCCCCC
IRFVDSAGNIIADKLDPTRYQEFIGEAVQPDSYLKSPYYRPLGYPDQHDQCRIDSGMYRV
EEEECCCCCEEECCCCHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCCCCCEECCCCCEEC
GPLARLNICSHIGTTLADRELREFRELTSGTAKSSFFYHYARLIEILACIEHIEILLNDP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DILSTRLRSEAGVNQLEGVGVSEAPRGTLFHHYQVDENGLLQKVNLIIATGQNNLAMNRT
HHHHHHHHHHCCCHHHCCCCCCCCCCCCEEEEEEECCCCCEEEEEEEEEECCCCCHHHHH
VAQIARHFIQGTEILEGMLNRVEAGIRAFDPCLSCSTHAAGQMPLHIQLVAADGNIVNQV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCHHHHHH
WRE
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2188945; 12948488; 2496982 [H]