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The map label for this gene is hoxU [H]

Identifier: 17228257

GI number: 17228257

Start: 883817

End: 884533

Strand: Direct

Name: hoxU [H]

Synonym: alr0762

Alternate gene names: 17228257

Gene position: 883817-884533 (Clockwise)

Preceding gene: 17228256

Following gene: 17228258

Centisome position: 13.78

GC content: 46.3

Gene sequence:

>717_bases
ATGTCAGTCAAAACTTTAACAATTAACGACCAACTCATTAGCGCTCAAGAGGAGGAAACCTTACTACAGGCGGCGCAAGA
GGCGGGGATTCATATTCCGACACTGTGCCATTTAGAAGGGGTTGGTGATGTGGGTGCTTGTCGGCTGTGTTTGGTGGAAA
TTACTGGTAGTAACAAATTGTTACCGGCTTGTGTCACGAAAGTTGCCGAAGGGATGGAAGTTCGCACAAATAGCGATCGC
CTACAAAAATACCGTCGTACAATTGTCGAAATGCTTTTTGCTGAGGGCAATCACATTTGTTCTGTTTGCGTGGCTAATAA
TAATTGCGAACTGCAAGACCTAGCCATTGAAATGGGCATGGATCATGTGCGTCTAGAATACCATTTCCCAAATCGCAAAG
TTGATATTTCTCACGATCGCTTTGGTGTTGACCATAACCGTTGTGTACTTTGTACTCGCTGCATCCGTGTTTGTGATGAA
ATCGAAGGCGCACACACTTGGGATATGGCAGGTAGGGGAACAAACTCTCACGTAATTACCGACCTCAGCCAACCTTGGGG
AACCTCTGACACTTGTACTTCCTGCGGTAAATGCGTCAATGCTTGCCCCACAGGAGCTATATTCTACCAGGGTTCCAGCG
TTGGAGAAATGAAACGCGATCGCGCCAAACTCGATTTTTTAGTCACAGCACGGGAAAAACAGCAATGGAACCTTTAG

Upstream 100 bases:

>100_bases
AACCTTCACAAGTTCCTCAAACTCTTCACCTATAACTCAAGGTGTGAGTGATGAATTATGACACCAACCAAAGGCTAATT
CTCAACCAGGGCTAAGAGCA

Downstream 100 bases:

>100_bases
AGAGAGATGGGGAAGGAGAAGAGGCAAGGGAGCAGGGGGCGGGGAGCGGAGGGGAGACGTTACTTAAAGTCCCTTCTCTT
CCCTCGTCCCTAAGAAAACC

Product: bidirectional hydrogenase complex protein HoxU

Products: NA

Alternate protein names: NADH dehydrogenase I subunit G 2; NDH-1 subunit G 2 [H]

Number of amino acids: Translated: 238; Mature: 237

Protein sequence:

>238_residues
MSVKTLTINDQLISAQEEETLLQAAQEAGIHIPTLCHLEGVGDVGACRLCLVEITGSNKLLPACVTKVAEGMEVRTNSDR
LQKYRRTIVEMLFAEGNHICSVCVANNNCELQDLAIEMGMDHVRLEYHFPNRKVDISHDRFGVDHNRCVLCTRCIRVCDE
IEGAHTWDMAGRGTNSHVITDLSQPWGTSDTCTSCGKCVNACPTGAIFYQGSSVGEMKRDRAKLDFLVTAREKQQWNL

Sequences:

>Translated_238_residues
MSVKTLTINDQLISAQEEETLLQAAQEAGIHIPTLCHLEGVGDVGACRLCLVEITGSNKLLPACVTKVAEGMEVRTNSDR
LQKYRRTIVEMLFAEGNHICSVCVANNNCELQDLAIEMGMDHVRLEYHFPNRKVDISHDRFGVDHNRCVLCTRCIRVCDE
IEGAHTWDMAGRGTNSHVITDLSQPWGTSDTCTSCGKCVNACPTGAIFYQGSSVGEMKRDRAKLDFLVTAREKQQWNL
>Mature_237_residues
SVKTLTINDQLISAQEEETLLQAAQEAGIHIPTLCHLEGVGDVGACRLCLVEITGSNKLLPACVTKVAEGMEVRTNSDRL
QKYRRTIVEMLFAEGNHICSVCVANNNCELQDLAIEMGMDHVRLEYHFPNRKVDISHDRFGVDHNRCVLCTRCIRVCDEI
EGAHTWDMAGRGTNSHVITDLSQPWGTSDTCTSCGKCVNACPTGAIFYQGSSVGEMKRDRAKLDFLVTAREKQQWNL

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1034

COG function: function code C; NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Homo sapiens, GI33519475, Length=204, Percent_Identity=31.3725490196078, Blast_Score=107, Evalue=7e-24,
Organism=Escherichia coli, GI145693161, Length=217, Percent_Identity=27.1889400921659, Blast_Score=84, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI193209088, Length=204, Percent_Identity=29.9019607843137, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI32566231, Length=204, Percent_Identity=29.9019607843137, Blast_Score=110, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17565758, Length=204, Percent_Identity=29.9019607843137, Blast_Score=110, Evalue=9e-25,
Organism=Drosophila melanogaster, GI24640559, Length=204, Percent_Identity=30.8823529411765, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24640557, Length=204, Percent_Identity=30.8823529411765, Blast_Score=108, Evalue=4e-24,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR009010
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655
- InterPro:   IPR000283
- InterPro:   IPR019574 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding; PF10588 NADH-G_4Fe-4S_3 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 26429; Mature: 26298

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS51085 2FE2S_FER_2 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

6.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
9.2 %Cys+Met (Translated Protein)
6.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
8.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVKTLTINDQLISAQEEETLLQAAQEAGIHIPTLCHLEGVGDVGACRLCLVEITGSNKL
CCEEEEEECHHHHCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCEEEEEEEEECCCCCC
LPACVTKVAEGMEVRTNSDRLQKYRRTIVEMLFAEGNHICSVCVANNNCELQDLAIEMGM
HHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHCC
DHVRLEYHFPNRKVDISHDRFGVDHNRCVLCTRCIRVCDEIEGAHTWDMAGRGTNSHVIT
CEEEEEEECCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCCCCEEE
DLSQPWGTSDTCTSCGKCVNACPTGAIFYQGSSVGEMKRDRAKLDFLVTAREKQQWNL
ECCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHEEEEEEECCCCCCCC
>Mature Secondary Structure 
SVKTLTINDQLISAQEEETLLQAAQEAGIHIPTLCHLEGVGDVGACRLCLVEITGSNKL
CEEEEEECHHHHCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCEEEEEEEEECCCCCC
LPACVTKVAEGMEVRTNSDRLQKYRRTIVEMLFAEGNHICSVCVANNNCELQDLAIEMGM
HHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHCC
DHVRLEYHFPNRKVDISHDRFGVDHNRCVLCTRCIRVCDEIEGAHTWDMAGRGTNSHVIT
CEEEEEEECCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCCCCEEE
DLSQPWGTSDTCTSCGKCVNACPTGAIFYQGSSVGEMKRDRAKLDFLVTAREKQQWNL
ECCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481432 [H]