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The map label for this gene is htrA [H]

Identifier: 17228197

GI number: 17228197

Start: 807721

End: 809010

Strand: Direct

Name: htrA [H]

Synonym: alr0702

Alternate gene names: 17228197

Gene position: 807721-809010 (Clockwise)

Preceding gene: 17228196

Following gene: 17228199

Centisome position: 12.59

GC content: 45.5

Gene sequence:

>1290_bases
ATGCTATCTAAAGTAGTAATAAACATAGTTTCCTTGCTCACGGCCATGCAAAACCAAGTACACGATGAATCTCAACCGTT
AAATCCTAAAAACCATAATCATGCACCTTGGAAAAAAGCGGCTGCATCTCTATCACTAGTACTGCTGGGATCTGGTATGA
CTTTAGCTGGTGGATATTTAGCAGGAAACCAGCAGCAATTGGCACAAAAAGCATCTGACTTGGCGGTGAGCCGAGTAGAT
GCAGCACCACCATTAGGAAATAACACAGACCCCAACTTTGTGACTCAAGTGGTGCAAAGAGTTGGGCCGGCTGTGGTGCG
GATTGAAGCGTCTCGGACTGTCACATCTCGATTACCAGCCGAGTTTAACGACCCATTTTTCCGCCGCTTCTTCGGTTCTC
AACTACCTCAACAACAAGAAAGAGTACAACGGGGTACTGGTTCCGGCTTTCTTATTAGTGCTGATGGCAGTATTCTTACC
AATGCTCACGTTGTTGATGGTGCAGATACAGTGCGGGTCATCCTCAAAGATGGGCGCAGTTTTCAGGGTAAAGTATTAGG
TACAGATAATTTAACAGATGTAGCTGTTGTCAAAATTCAGGCAAATAACTTGCCAACCTTAACGGTGGGTAATTCTGACC
AATTACAACCAGGACAATGGGCGATCGCTATTGGTAATCCTTTAGGTTTAGATAACACCGTCACCACAGGTATAATTAGT
GCGACTGGACGTACCAGCAATCAAATTGGCGCACCTGATAAGCGCGTAGAATATATTCAAACTGACGCGGCAATTAATCC
AGGTAACTCTGGTGGCCCCTTGCTGAATTATCGTGGTGAAGTGATTGGGATGAATACCGCCATTATTCAAGGCGCACAGG
GTCTAGGTTTTGCCATCCCTATCAAAACAGCACAACGTATTTCTAATCAACTTATAGCTACCGGTAAAGTACAGCATCCT
TACCTTGGTATTCAAATGGTAGGGTTAACACCGCAAATCAAGCAAAACATTAACTCTGACCCCAATAGCGGTTTAACTGT
AGATAGAGACAAGGGTGTTTTAGTGGTCAGAGTCCTGCCAAACTCGCCAGCCGCAAGAGCAGGGCTACGCGCTGGTGATG
TCATTCAAAAGCTGAATGGCCAAGCTGTTACAGATGCTAGCAATGTACAGAGAGCCGTTGAGAACGCTCAAGTTGGTGGA
CAATTGCAGCTAGAATTATGGCGCAATGGTCGAAATCTCAACTTAGCCGTACAAGCAGGCGCTTTCCCGACCCAACAACA
GGTGAAATAA

Upstream 100 bases:

>100_bases
TTAGCCCCTAGCCTTTATCATGTAAGTTGAGCGTCGCCAAACCGAGAAATATTGCAACTCTTCACAAAAAAGCAATAACA
AAGCAACAAAACTGTCATAA

Downstream 100 bases:

>100_bases
GGGTGTAAGTAGGGATGTAGGGGTGTAGGGGTGTAGAAGAAGAAAAAATTCTTACTCAGCACTCATTACTACCCACTCCC
TACTCCCTCAATTAACGTAC

Product: serine proteinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MLSKVVINIVSLLTAMQNQVHDESQPLNPKNHNHAPWKKAAASLSLVLLGSGMTLAGGYLAGNQQQLAQKASDLAVSRVD
AAPPLGNNTDPNFVTQVVQRVGPAVVRIEASRTVTSRLPAEFNDPFFRRFFGSQLPQQQERVQRGTGSGFLISADGSILT
NAHVVDGADTVRVILKDGRSFQGKVLGTDNLTDVAVVKIQANNLPTLTVGNSDQLQPGQWAIAIGNPLGLDNTVTTGIIS
ATGRTSNQIGAPDKRVEYIQTDAAINPGNSGGPLLNYRGEVIGMNTAIIQGAQGLGFAIPIKTAQRISNQLIATGKVQHP
YLGIQMVGLTPQIKQNINSDPNSGLTVDRDKGVLVVRVLPNSPAARAGLRAGDVIQKLNGQAVTDASNVQRAVENAQVGG
QLQLELWRNGRNLNLAVQAGAFPTQQQVK

Sequences:

>Translated_429_residues
MLSKVVINIVSLLTAMQNQVHDESQPLNPKNHNHAPWKKAAASLSLVLLGSGMTLAGGYLAGNQQQLAQKASDLAVSRVD
AAPPLGNNTDPNFVTQVVQRVGPAVVRIEASRTVTSRLPAEFNDPFFRRFFGSQLPQQQERVQRGTGSGFLISADGSILT
NAHVVDGADTVRVILKDGRSFQGKVLGTDNLTDVAVVKIQANNLPTLTVGNSDQLQPGQWAIAIGNPLGLDNTVTTGIIS
ATGRTSNQIGAPDKRVEYIQTDAAINPGNSGGPLLNYRGEVIGMNTAIIQGAQGLGFAIPIKTAQRISNQLIATGKVQHP
YLGIQMVGLTPQIKQNINSDPNSGLTVDRDKGVLVVRVLPNSPAARAGLRAGDVIQKLNGQAVTDASNVQRAVENAQVGG
QLQLELWRNGRNLNLAVQAGAFPTQQQVK
>Mature_429_residues
MLSKVVINIVSLLTAMQNQVHDESQPLNPKNHNHAPWKKAAASLSLVLLGSGMTLAGGYLAGNQQQLAQKASDLAVSRVD
AAPPLGNNTDPNFVTQVVQRVGPAVVRIEASRTVTSRLPAEFNDPFFRRFFGSQLPQQQERVQRGTGSGFLISADGSILT
NAHVVDGADTVRVILKDGRSFQGKVLGTDNLTDVAVVKIQANNLPTLTVGNSDQLQPGQWAIAIGNPLGLDNTVTTGIIS
ATGRTSNQIGAPDKRVEYIQTDAAINPGNSGGPLLNYRGEVIGMNTAIIQGAQGLGFAIPIKTAQRISNQLIATGKVQHP
YLGIQMVGLTPQIKQNINSDPNSGLTVDRDKGVLVVRVLPNSPAARAGLRAGDVIQKLNGQAVTDASNVQRAVENAQVGG
QLQLELWRNGRNLNLAVQAGAFPTQQQVK

Specific function: A putative protease, its function overlaps that of the related putative proteases HhoA and HhoB [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential). Cell outer membrane (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=309, Percent_Identity=39.4822006472492, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI22129776, Length=339, Percent_Identity=36.8731563421829, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI7019477, Length=334, Percent_Identity=38.3233532934132, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI24308541, Length=347, Percent_Identity=34.5821325648415, Blast_Score=179, Evalue=5e-45,
Organism=Escherichia coli, GI1789629, Length=328, Percent_Identity=38.4146341463415, Blast_Score=220, Evalue=1e-58,
Organism=Escherichia coli, GI1786356, Length=355, Percent_Identity=39.7183098591549, Blast_Score=214, Evalue=8e-57,
Organism=Escherichia coli, GI1789630, Length=288, Percent_Identity=37.5, Blast_Score=164, Evalue=7e-42,
Organism=Drosophila melanogaster, GI24646839, Length=328, Percent_Identity=36.280487804878, Blast_Score=187, Evalue=1e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 45423; Mature: 45423

Theoretical pI: Translated: 10.49; Mature: 10.49

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSKVVINIVSLLTAMQNQVHDESQPLNPKNHNHAPWKKAAASLSLVLLGSGMTLAGGYL
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHCEEEEEEECCCEEECCEE
AGNQQQLAQKASDLAVSRVDAAPPLGNNTDPNFVTQVVQRVGPAVVRIEASRTVTSRLPA
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCHHHHHCCC
EFNDPFFRRFFGSQLPQQQERVQRGTGSGFLISADGSILTNAHVVDGADTVRVILKDGRS
CCCCHHHHHHHHHCCCHHHHHHHHCCCCEEEEECCCCEEECCEEECCCHHEEEEECCCCC
FQGKVLGTDNLTDVAVVKIQANNLPTLTVGNSDQLQPGQWAIAIGNPLGLDNTVTTGIIS
CCCEEECCCCCCEEEEEEEECCCCCEEEECCCCCCCCCCEEEEECCCCCCCCCHHEEEEE
ATGRTSNQIGAPDKRVEYIQTDAAINPGNSGGPLLNYRGEVIGMNTAIIQGAQGLGFAIP
ECCCCCCCCCCCHHHHHEEEECCCCCCCCCCCCEEEECCCEEECCHHEEECCCCCEEEEE
IKTAQRISNQLIATGKVQHPYLGIQMVGLTPQIKQNINSDPNSGLTVDRDKGVLVVRVLP
HHHHHHHHHHEEECCCCCCCEECEEEECCCHHHHHCCCCCCCCCEEEECCCCEEEEEECC
NSPAARAGLRAGDVIQKLNGQAVTDASNVQRAVENAQVGGQLQLELWRNGRNLNLAVQAG
CCCHHHHCCCHHHHHHHHCCCEECCHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEEECC
AFPTQQQVK
CCCCHHCCC
>Mature Secondary Structure
MLSKVVINIVSLLTAMQNQVHDESQPLNPKNHNHAPWKKAAASLSLVLLGSGMTLAGGYL
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHCEEEEEEECCCEEECCEE
AGNQQQLAQKASDLAVSRVDAAPPLGNNTDPNFVTQVVQRVGPAVVRIEASRTVTSRLPA
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCHHHHHCCC
EFNDPFFRRFFGSQLPQQQERVQRGTGSGFLISADGSILTNAHVVDGADTVRVILKDGRS
CCCCHHHHHHHHHCCCHHHHHHHHCCCCEEEEECCCCEEECCEEECCCHHEEEEECCCCC
FQGKVLGTDNLTDVAVVKIQANNLPTLTVGNSDQLQPGQWAIAIGNPLGLDNTVTTGIIS
CCCEEECCCCCCEEEEEEEECCCCCEEEECCCCCCCCCCEEEEECCCCCCCCCHHEEEEE
ATGRTSNQIGAPDKRVEYIQTDAAINPGNSGGPLLNYRGEVIGMNTAIIQGAQGLGFAIP
ECCCCCCCCCCCHHHHHEEEECCCCCCCCCCCCEEEECCCEEECCHHEEECCCCCEEEEE
IKTAQRISNQLIATGKVQHPYLGIQMVGLTPQIKQNINSDPNSGLTVDRDKGVLVVRVLP
HHHHHHHHHHEEECCCCCCCEECEEEECCCHHHHHCCCCCCCCCEEEECCCCEEEEEECC
NSPAARAGLRAGDVIQKLNGQAVTDASNVQRAVENAQVGGQLQLELWRNGRNLNLAVQAG
CCCHHHHCCCHHHHHHHHCCCEECCHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEEECC
AFPTQQQVK
CCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]