Click here to switch to the map view.

The map label for this gene is mrdB [H]

Identifier: 17228149

GI number: 17228149

Start: 756086

End: 757402

Strand: Direct

Name: mrdB [H]

Synonym: alr0653

Alternate gene names: 17228149

Gene position: 756086-757402 (Clockwise)

Preceding gene: 17228148

Following gene: 17228150

Centisome position: 11.79

GC content: 43.2

Gene sequence:

>1317_bases
ATGTTATTAAAACGATCGCTTCCCAAAATGCGTTGGAAATCTTGGGTTAAGCCGTGGCAACAATTAGACTGGCCATTATT
TTGCTTGCCTGTAGGGGTCAGCATCTTTGGCGGTCTGATGATCCTCAGCACAGAACTCAAGCAGCCAGTAACAGATTGGT
GGTGGCACTGGCTAATTGCTGGTATTGGTGTTTTTATTGCCTTATTTCTGGCTCGTTGCCGTTACGACAACCTGTTGCAA
TGGCATTGGATCACCTACGTATTGACTAATATCAGTCTGATTACTGTGATGGCTGCGGGTACAAGTGCCAAAGGCGCACA
ACGTTGGCTGACGATTGGTGGTTTTAACGTACAACCTTCAGAGTTCGCCAAAATTGGTGTAATCATCACCCTAGCAGCTT
TGCTGCATAAACACACAGCCACCAGAATTGAAGATGTTTTTCGCGCTCTGGCGATTACGGCTATACCTTGGCTATTAGTA
TTTGTCCAGCCAGATTTAGCCACATCTTTAGTGTTTGGGGCGATCGTTTTAGGAATGCTTTACTGGGCAAACGCTAACCC
TGGTTGGTTGTTATTAATGATTTCACCAATCATCGCTGCCATACTGTTTACGATGTCTTGGCCTTTATCGACACCAATAA
TTTTATTTAAAGAAATTTTTATTACTCCTTTTGGTGTTGCTTGGGCAATAGGCATGGCTATTTTAGGTTGGCTGACTCTT
CCCTGGCGACGCTTCAATATGGGTACTATCGGCGCATTTAGCCTGAATTTGCTCGGTGGTGAATTAGGTATTTTTGCTTG
GAATCATGTACTAAAAGAGTATCAAAAGAATAGATTGACCGCATTTATCAATCCCGAACAAGACCCCCTTGGTTCTGGAT
ATCACCTCATTCAATCACGCATTGCCATTGGTGCTGGGGAAATGTGGGGTTGGGGTCTGTTTAAGGGGCCAATGACTCAA
CTAAATTTTGTGCCTGAACAACACACTGATTTTATTTTCTCCGCCATCGGTGAAGAGTTTGGTCTTTTCGGCTGTTTAAT
TGTTTTGTTTGTTTTCTGCTTGATTTGCTGGCGACTGCTGCACGTAGCGCAAACAGCCAAAGATAATTTTGGTTCTTTGT
TAGCGATCGGCGTTTTATCGATGATTATATTTCAGTTAGTGGTGAATGTGGGCATGAACGTAGGTTTAGCACCTGTAGCG
GGTATTCCCTTACCGTGGATGAGTTATGGACGTTCTGCCATGCTGACCAATTTTATTGCTTTAGGAATAGTAGAATCGGT
GGCAAACTTTCGACAACGACAGAAATATTATTTTTGA

Upstream 100 bases:

>100_bases
GTCCTAATTTTAAATTTTTGTCTAATTTCTAGACCAAAACCCAGTCAGACAAAGTTATTAATAGTCAATAAATCTCATAG
CTAAACCCTCAACTCATACG

Downstream 100 bases:

>100_bases
GTTAAGGGTTAGTAGTTAGTGGAAAACAACTGACCACCAACCACTAACAACTGTCATCTCACAAGTATTAAGCTAAGAAC
AGGAAGTAAGCGAGAAAAGA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MLLKRSLPKMRWKSWVKPWQQLDWPLFCLPVGVSIFGGLMILSTELKQPVTDWWWHWLIAGIGVFIALFLARCRYDNLLQ
WHWITYVLTNISLITVMAAGTSAKGAQRWLTIGGFNVQPSEFAKIGVIITLAALLHKHTATRIEDVFRALAITAIPWLLV
FVQPDLATSLVFGAIVLGMLYWANANPGWLLLMISPIIAAILFTMSWPLSTPIILFKEIFITPFGVAWAIGMAILGWLTL
PWRRFNMGTIGAFSLNLLGGELGIFAWNHVLKEYQKNRLTAFINPEQDPLGSGYHLIQSRIAIGAGEMWGWGLFKGPMTQ
LNFVPEQHTDFIFSAIGEEFGLFGCLIVLFVFCLICWRLLHVAQTAKDNFGSLLAIGVLSMIIFQLVVNVGMNVGLAPVA
GIPLPWMSYGRSAMLTNFIALGIVESVANFRQRQKYYF

Sequences:

>Translated_438_residues
MLLKRSLPKMRWKSWVKPWQQLDWPLFCLPVGVSIFGGLMILSTELKQPVTDWWWHWLIAGIGVFIALFLARCRYDNLLQ
WHWITYVLTNISLITVMAAGTSAKGAQRWLTIGGFNVQPSEFAKIGVIITLAALLHKHTATRIEDVFRALAITAIPWLLV
FVQPDLATSLVFGAIVLGMLYWANANPGWLLLMISPIIAAILFTMSWPLSTPIILFKEIFITPFGVAWAIGMAILGWLTL
PWRRFNMGTIGAFSLNLLGGELGIFAWNHVLKEYQKNRLTAFINPEQDPLGSGYHLIQSRIAIGAGEMWGWGLFKGPMTQ
LNFVPEQHTDFIFSAIGEEFGLFGCLIVLFVFCLICWRLLHVAQTAKDNFGSLLAIGVLSMIIFQLVVNVGMNVGLAPVA
GIPLPWMSYGRSAMLTNFIALGIVESVANFRQRQKYYF
>Mature_438_residues
MLLKRSLPKMRWKSWVKPWQQLDWPLFCLPVGVSIFGGLMILSTELKQPVTDWWWHWLIAGIGVFIALFLARCRYDNLLQ
WHWITYVLTNISLITVMAAGTSAKGAQRWLTIGGFNVQPSEFAKIGVIITLAALLHKHTATRIEDVFRALAITAIPWLLV
FVQPDLATSLVFGAIVLGMLYWANANPGWLLLMISPIIAAILFTMSWPLSTPIILFKEIFITPFGVAWAIGMAILGWLTL
PWRRFNMGTIGAFSLNLLGGELGIFAWNHVLKEYQKNRLTAFINPEQDPLGSGYHLIQSRIAIGAGEMWGWGLFKGPMTQ
LNFVPEQHTDFIFSAIGEEFGLFGCLIVLFVFCLICWRLLHVAQTAKDNFGSLLAIGVLSMIIFQLVVNVGMNVGLAPVA
GIPLPWMSYGRSAMLTNFIALGIVESVANFRQRQKYYF

Specific function: This is one of the proteins responsible for the rod shape of the cell. It is required for the expression of the enzymatic activity of PBP2, which is thought to synthesize peptidoglycan in the step of initiation of cell elongation [H]

COG id: COG0772

COG function: function code D; Bacterial cell division membrane protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ftsW/rodA/spoVE family [H]

Homologues:

Organism=Escherichia coli, GI1786853, Length=371, Percent_Identity=32.8840970350404, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1786277, Length=147, Percent_Identity=41.4965986394558, Blast_Score=117, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001182
- InterPro:   IPR018365
- InterPro:   IPR011923 [H]

Pfam domain/function: PF01098 FTSW_RODA_SPOVE [H]

EC number: NA

Molecular weight: Translated: 49207; Mature: 49207

Theoretical pI: Translated: 9.71; Mature: 9.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLKRSLPKMRWKSWVKPWQQLDWPLFCLPVGVSIFGGLMILSTELKQPVTDWWWHWLIA
CCCCCCCHHHHHHHHHCHHHHCCCCEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
GIGVFIALFLARCRYDNLLQWHWITYVLTNISLITVMAAGTSAKGAQRWLTIGGFNVQPS
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHEECCCCCCCCHHEEEECCCCCCHH
EFAKIGVIITLAALLHKHTATRIEDVFRALAITAIPWLLVFVQPDLATSLVFGAIVLGML
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
YWANANPGWLLLMISPIIAAILFTMSWPLSTPIILFKEIFITPFGVAWAIGMAILGWLTL
HHCCCCCCEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHC
PWRRFNMGTIGAFSLNLLGGELGIFAWNHVLKEYQKNRLTAFINPEQDPLGSGYHLIQSR
CHHHCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCHHHHHHH
IAIGAGEMWGWGLFKGPMTQLNFVPEQHTDFIFSAIGEEFGLFGCLIVLFVFCLICWRLL
HHHCCCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HVAQTAKDNFGSLLAIGVLSMIIFQLVVNVGMNVGLAPVAGIPLPWMSYGRSAMLTNFIA
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHH
LGIVESVANFRQRQKYYF
HHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLLKRSLPKMRWKSWVKPWQQLDWPLFCLPVGVSIFGGLMILSTELKQPVTDWWWHWLIA
CCCCCCCHHHHHHHHHCHHHHCCCCEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
GIGVFIALFLARCRYDNLLQWHWITYVLTNISLITVMAAGTSAKGAQRWLTIGGFNVQPS
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHEECCCCCCCCHHEEEECCCCCCHH
EFAKIGVIITLAALLHKHTATRIEDVFRALAITAIPWLLVFVQPDLATSLVFGAIVLGML
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
YWANANPGWLLLMISPIIAAILFTMSWPLSTPIILFKEIFITPFGVAWAIGMAILGWLTL
HHCCCCCCEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHC
PWRRFNMGTIGAFSLNLLGGELGIFAWNHVLKEYQKNRLTAFINPEQDPLGSGYHLIQSR
CHHHCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCHHHHHHH
IAIGAGEMWGWGLFKGPMTQLNFVPEQHTDFIFSAIGEEFGLFGCLIVLFVFCLICWRLL
HHHCCCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HVAQTAKDNFGSLLAIGVLSMIIFQLVVNVGMNVGLAPVAGIPLPWMSYGRSAMLTNFIA
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHH
LGIVESVANFRQRQKYYF
HHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]