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The map label for this gene is fbp [H]

Identifier: 17228073

GI number: 17228073

Start: 670707

End: 671204

Strand: Direct

Name: fbp [H]

Synonym: alr0577

Alternate gene names: 17228073

Gene position: 670707-671204 (Clockwise)

Preceding gene: 17228072

Following gene: 17228077

Centisome position: 10.46

GC content: 45.58

Gene sequence:

>498_bases
ATGCTGGCCTGTGTTGTGGTTTTGGTATTGGCACAAGTGGGGAATAAACAGGACTCTGCTATTGCTGCTAATTTACCTCA
AACTCCACTAGCCACCATTAGCGTTACTGAAAACAATACTCCAATCAAGAAAAATATCATGTCTGAAGCCTCTAAGCCGC
CTGTTACTACCGATTCTGGACTCAAATATGTGGAAATAGAAGAGGGAACTGGCGCGACTCCTAAAAGTGGACAAACCGTC
GTAGTTCACTACACAGGTACTCTAGAAGATGGTACCAAGTTTGATAGCTCACGCGATCGCAATCGTCCCTTCAGCTTTAC
CATCGGCGTTGGACAAGTAATTAAAGGTTGGGATGAAGGACTTAGCACTATGAAAGTAGGTGGTCGTCGTCAATTAATCA
TCCCTTCAGAATTGGGTTATGGCGCTCGTGGTGCTGGTGGGGTGATTCCACCTTACGCAACCCTGCTGTTTGATGTGGAA
TTGTTGGAAGTGAAGTAG

Upstream 100 bases:

>100_bases
TCTGATTTAAACTAATTGTGTCCTATTGGTAATTTTCATTGCCAAACTACCTCAGTGGGGAGGGCTAATTTTGAAAGCAA
TTTTACTCAGCATAGGTTTG

Downstream 100 bases:

>100_bases
GGGAATAGTCCATAGTCAATAGTCCACAGTCAAAGGTAAAAACTCATGACTGTTGACTGTTGACTGTCTTAATCATCATT
TAATAGCCTGATCTGGCTAA

Product: FKBP-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: Peptidyl-prolyl cis-trans isomerase; PPIase; Rotamase [H]

Number of amino acids: Translated: 165; Mature: 165

Protein sequence:

>165_residues
MLACVVVLVLAQVGNKQDSAIAANLPQTPLATISVTENNTPIKKNIMSEASKPPVTTDSGLKYVEIEEGTGATPKSGQTV
VVHYTGTLEDGTKFDSSRDRNRPFSFTIGVGQVIKGWDEGLSTMKVGGRRQLIIPSELGYGARGAGGVIPPYATLLFDVE
LLEVK

Sequences:

>Translated_165_residues
MLACVVVLVLAQVGNKQDSAIAANLPQTPLATISVTENNTPIKKNIMSEASKPPVTTDSGLKYVEIEEGTGATPKSGQTV
VVHYTGTLEDGTKFDSSRDRNRPFSFTIGVGQVIKGWDEGLSTMKVGGRRQLIIPSELGYGARGAGGVIPPYATLLFDVE
LLEVK
>Mature_165_residues
MLACVVVLVLAQVGNKQDSAIAANLPQTPLATISVTENNTPIKKNIMSEASKPPVTTDSGLKYVEIEEGTGATPKSGQTV
VVHYTGTLEDGTKFDSSRDRNRPFSFTIGVGQVIKGWDEGLSTMKVGGRRQLIIPSELGYGARGAGGVIPPYATLLFDVE
LLEVK

Specific function: PPIases accelerate the folding of proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Cytoplasm And Periplasmic Protein [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI17149836, Length=107, Percent_Identity=57.9439252336449, Blast_Score=128, Evalue=2e-30,
Organism=Homo sapiens, GI4503725, Length=107, Percent_Identity=57.9439252336449, Blast_Score=128, Evalue=2e-30,
Organism=Homo sapiens, GI4758380, Length=107, Percent_Identity=56.0747663551402, Blast_Score=119, Evalue=9e-28,
Organism=Homo sapiens, GI206725530, Length=91, Percent_Identity=59.3406593406593, Blast_Score=114, Evalue=4e-26,
Organism=Homo sapiens, GI17149844, Length=91, Percent_Identity=59.3406593406593, Blast_Score=114, Evalue=4e-26,
Organism=Homo sapiens, GI17149842, Length=91, Percent_Identity=59.3406593406593, Blast_Score=114, Evalue=4e-26,
Organism=Homo sapiens, GI4503729, Length=109, Percent_Identity=52.2935779816514, Blast_Score=104, Evalue=3e-23,
Organism=Homo sapiens, GI224809329, Length=145, Percent_Identity=41.3793103448276, Blast_Score=102, Evalue=1e-22,
Organism=Homo sapiens, GI224809327, Length=145, Percent_Identity=41.3793103448276, Blast_Score=102, Evalue=1e-22,
Organism=Homo sapiens, GI4758384, Length=145, Percent_Identity=41.3793103448276, Blast_Score=102, Evalue=1e-22,
Organism=Homo sapiens, GI224809331, Length=145, Percent_Identity=41.3793103448276, Blast_Score=101, Evalue=3e-22,
Organism=Homo sapiens, GI192448443, Length=90, Percent_Identity=55.5555555555556, Blast_Score=99, Evalue=1e-21,
Organism=Homo sapiens, GI8923659, Length=94, Percent_Identity=48.936170212766, Blast_Score=93, Evalue=1e-19,
Organism=Homo sapiens, GI33469985, Length=92, Percent_Identity=48.9130434782609, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI4503727, Length=99, Percent_Identity=46.4646464646465, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI206725547, Length=100, Percent_Identity=45, Blast_Score=84, Evalue=7e-17,
Organism=Homo sapiens, GI31317231, Length=101, Percent_Identity=45.5445544554455, Blast_Score=81, Evalue=5e-16,
Organism=Homo sapiens, GI17149839, Length=66, Percent_Identity=57.5757575757576, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI7706131, Length=109, Percent_Identity=40.3669724770642, Blast_Score=74, Evalue=6e-14,
Organism=Escherichia coli, GI87082390, Length=109, Percent_Identity=53.2110091743119, Blast_Score=111, Evalue=3e-26,
Organism=Escherichia coli, GI1789745, Length=110, Percent_Identity=52.7272727272727, Blast_Score=99, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71993519, Length=98, Percent_Identity=58.1632653061224, Blast_Score=111, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17540882, Length=90, Percent_Identity=58.8888888888889, Blast_Score=110, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17561782, Length=107, Percent_Identity=53.2710280373832, Blast_Score=105, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17506169, Length=109, Percent_Identity=44.0366972477064, Blast_Score=85, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17506167, Length=109, Percent_Identity=44.0366972477064, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17561778, Length=107, Percent_Identity=44.8598130841121, Blast_Score=82, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI71993555, Length=66, Percent_Identity=54.5454545454545, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17561780, Length=97, Percent_Identity=39.1752577319588, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324194, Length=106, Percent_Identity=57.5471698113208, Blast_Score=119, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6320727, Length=90, Percent_Identity=61.1111111111111, Blast_Score=110, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6323482, Length=121, Percent_Identity=39.6694214876033, Blast_Score=81, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6323566, Length=97, Percent_Identity=43.298969072165, Blast_Score=80, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24655568, Length=107, Percent_Identity=62.6168224299065, Blast_Score=138, Evalue=2e-33,
Organism=Drosophila melanogaster, GI281363946, Length=91, Percent_Identity=63.7362637362637, Blast_Score=129, Evalue=7e-31,
Organism=Drosophila melanogaster, GI17352457, Length=91, Percent_Identity=63.7362637362637, Blast_Score=129, Evalue=7e-31,
Organism=Drosophila melanogaster, GI24583150, Length=117, Percent_Identity=49.5726495726496, Blast_Score=109, Evalue=8e-25,
Organism=Drosophila melanogaster, GI24647110, Length=115, Percent_Identity=46.0869565217391, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI21356629, Length=92, Percent_Identity=59.7826086956522, Blast_Score=92, Evalue=1e-19,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179 [H]

Pfam domain/function: PF00254 FKBP_C [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 17504; Mature: 17504

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLACVVVLVLAQVGNKQDSAIAANLPQTPLATISVTENNTPIKKNIMSEASKPPVTTDSG
CHHHHHHHHHHHHCCCCCCEEECCCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCC
LKYVEIEEGTGATPKSGQTVVVHYTGTLEDGTKFDSSRDRNRPFSFTIGVGQVIKGWDEG
CEEEEEECCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHHC
LSTMKVGGRRQLIIPSELGYGARGAGGVIPPYATLLFDVELLEVK
CCEEECCCCEEEEEECCCCCCCCCCCCCCCCHHHHEEEEEEEEEC
>Mature Secondary Structure
MLACVVVLVLAQVGNKQDSAIAANLPQTPLATISVTENNTPIKKNIMSEASKPPVTTDSG
CHHHHHHHHHHHHCCCCCCEEECCCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCC
LKYVEIEEGTGATPKSGQTVVVHYTGTLEDGTKFDSSRDRNRPFSFTIGVGQVIKGWDEG
CEEEEEECCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHHC
LSTMKVGGRRQLIIPSELGYGARGAGGVIPPYATLLFDVELLEVK
CCEEECCCCEEEEEECCCCCCCCCCCCCCCCHHHHEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]