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The map label for this gene is mltA [H]

Identifier: 17228060

GI number: 17228060

Start: 658123

End: 659316

Strand: Direct

Name: mltA [H]

Synonym: alr0564

Alternate gene names: 17228060

Gene position: 658123-659316 (Clockwise)

Preceding gene: 17228055

Following gene: 17228062

Centisome position: 10.26

GC content: 44.22

Gene sequence:

>1194_bases
ATGAGAAAAACGCTGGCTTTGTTTTCCCTGAGTTTAGGAATCACCTTTTTTAACCCACTGCAACTTGCTGTGAGTCAGGT
ACCACCCACAGCACCACCTTTAAAACTTGTTGAGATTGGTACTAACTGCACACCAGTGCGTGCTTGCTTGGGTTGGGATG
AGCAACTTTTTTCAGGACATGGGGGTTTAAAAAGCGATCGCCAAGGTCTATTAAACTCAATAGATAACAGTTTGCGTTAT
TTAGAAACCCCAAAAGCAGTTACAGCTTACGATAATTACCCAATTAAAGAAATTACCCGCGACAGAGTGCGTCGGAGTTT
GCGCCGTTTTCGTCAGTTGGTGGCTACTGCTAAATCTCCAGCACAATTACAAGCGGCTGTGCGGAGGGAGTTCGCTTTTT
ACAAGTCTGTTGGTGATGATGGACAGGGTAGAGTGAAGTTTACAGCCTACTACGCGCCAATTTATCAAGCCAGTCGTGTA
CGCACGGCACAATATAAGTATCCAATTTATCGAGTACCACCGGATTTTGAGCAATGGACTAAACCCCATCCTAAAAGAGC
TGATTTAGAAGGGGTAGACGGTTTGTTGGGAGAAAAAAGCCAGCTACGGGGTTTAGAAATGTTTTGGTTGCGCGATCGCT
TTCAAGCGTACATGATCCATATCCAAGGTTCTGCTAAACTCAACTTAACTGATGGAACTCAAACCAGTGTGGGTTTTGCA
GGCGGAACAGATTACCCTTGGACAGCTGTAGGGCGACTGCTGTTTCAAGACGGTAAATTATCTAAAGAAGAATTAAATAT
GCCGGGAATTATTCGCTATTTCCGCAAAAATCCCCAGTCTATGAGTAATTATTTACCACGTTGGGAACGCTTTATTTTCT
TCAAGGAAACTAAAGGTGAACCAGCTACAGGCAGTATCAGCGTACCTCTTGTACCAGAACGTTCCATTGCCACAGATAAA
TCTCTCATGCCACCAGGAGCATTGGCTGTAATTAACGCGACATTTCCTTATCCTGGTCAACGTAACCAGTTGATTAACCG
CAGAGTCAGCCGTTTTGTCCTTGATCAAGATACAGGTAGCGCCATTAAAGGCCCAGGCAGAGTAGATTATTTCCTTGGCT
ATGGTGACTTAGCAGGCGATCGCGCTGGTATTACCGTTACTACTGGCTCTATATATTACCTACTACTAAAGTAA

Upstream 100 bases:

>100_bases
GATTCAACGCCATGTACCCTACGATCGCTACAGTATATTACTAGCGGAAACTTAAGCCGTGGGTTAATGTCCTAAAGTCT
GAATATATAGAGATACGAAC

Downstream 100 bases:

>100_bases
TTTCTAATTTGTAATTCCTAATTCGTAATTAAGTGTTTAATTACGTAGGACTTACCAATGAAAACGAAAGATTAAGGGTT
TGAACAAGGGTATAGGAAAG

Product: hypothetical protein

Products: Muramic Acid Residue [C]

Alternate protein names: Murein hydrolase A [H]

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MRKTLALFSLSLGITFFNPLQLAVSQVPPTAPPLKLVEIGTNCTPVRACLGWDEQLFSGHGGLKSDRQGLLNSIDNSLRY
LETPKAVTAYDNYPIKEITRDRVRRSLRRFRQLVATAKSPAQLQAAVRREFAFYKSVGDDGQGRVKFTAYYAPIYQASRV
RTAQYKYPIYRVPPDFEQWTKPHPKRADLEGVDGLLGEKSQLRGLEMFWLRDRFQAYMIHIQGSAKLNLTDGTQTSVGFA
GGTDYPWTAVGRLLFQDGKLSKEELNMPGIIRYFRKNPQSMSNYLPRWERFIFFKETKGEPATGSISVPLVPERSIATDK
SLMPPGALAVINATFPYPGQRNQLINRRVSRFVLDQDTGSAIKGPGRVDYFLGYGDLAGDRAGITVTTGSIYYLLLK

Sequences:

>Translated_397_residues
MRKTLALFSLSLGITFFNPLQLAVSQVPPTAPPLKLVEIGTNCTPVRACLGWDEQLFSGHGGLKSDRQGLLNSIDNSLRY
LETPKAVTAYDNYPIKEITRDRVRRSLRRFRQLVATAKSPAQLQAAVRREFAFYKSVGDDGQGRVKFTAYYAPIYQASRV
RTAQYKYPIYRVPPDFEQWTKPHPKRADLEGVDGLLGEKSQLRGLEMFWLRDRFQAYMIHIQGSAKLNLTDGTQTSVGFA
GGTDYPWTAVGRLLFQDGKLSKEELNMPGIIRYFRKNPQSMSNYLPRWERFIFFKETKGEPATGSISVPLVPERSIATDK
SLMPPGALAVINATFPYPGQRNQLINRRVSRFVLDQDTGSAIKGPGRVDYFLGYGDLAGDRAGITVTTGSIYYLLLK
>Mature_397_residues
MRKTLALFSLSLGITFFNPLQLAVSQVPPTAPPLKLVEIGTNCTPVRACLGWDEQLFSGHGGLKSDRQGLLNSIDNSLRY
LETPKAVTAYDNYPIKEITRDRVRRSLRRFRQLVATAKSPAQLQAAVRREFAFYKSVGDDGQGRVKFTAYYAPIYQASRV
RTAQYKYPIYRVPPDFEQWTKPHPKRADLEGVDGLLGEKSQLRGLEMFWLRDRFQAYMIHIQGSAKLNLTDGTQTSVGFA
GGTDYPWTAVGRLLFQDGKLSKEELNMPGIIRYFRKNPQSMSNYLPRWERFIFFKETKGEPATGSISVPLVPERSIATDK
SLMPPGALAVINATFPYPGQRNQLINRRVSRFVLDQDTGSAIKGPGRVDYFLGYGDLAGDRAGITVTTGSIYYLLLK

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division [H]

COG id: COG2821

COG function: function code M; Membrane-bound lytic murein transglycosylase

Gene ontology:

Cell location: Note=In closely related bacteria this protein is attached to the outer membrane by a lipid anchor. This is apparently not the case here [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789179, Length=270, Percent_Identity=29.2592592592593, Blast_Score=114, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010611
- InterPro:   IPR014733
- InterPro:   IPR005300 [H]

Pfam domain/function: PF06725 3D; PF03562 MltA [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 44626; Mature: 44626

Theoretical pI: Translated: 10.26; Mature: 10.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKTLALFSLSLGITFFNPLQLAVSQVPPTAPPLKLVEIGTNCTPVRACLGWDEQLFSGH
CCCCEEEEEEECCCEEECHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHCCCHHHHCCC
GGLKSDRQGLLNSIDNSLRYLETPKAVTAYDNYPIKEITRDRVRRSLRRFRQLVATAKSP
CCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCH
AQLQAAVRREFAFYKSVGDDGQGRVKFTAYYAPIYQASRVRTAQYKYPIYRVPPDFEQWT
HHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCHHHHHHCEEEEECCCEEECCCCHHHHC
KPHPKRADLEGVDGLLGEKSQLRGLEMFWLRDRFQAYMIHIQGSAKLNLTDGTQTSVGFA
CCCCCCCCCCCCHHHCCCHHHHCCHHHHHHHHCCEEEEEEEECCEEEEECCCCCCCEEEC
GGTDYPWTAVGRLLFQDGKLSKEELNMPGIIRYFRKNPQSMSNYLPRWERFIFFKETKGE
CCCCCCHHHHHHHHHCCCCCCHHHCCCCHHHHHHHCCHHHHHHHCCCHHEEEEEEECCCC
PATGSISVPLVPERSIATDKSLMPPGALAVINATFPYPGQRNQLINRRVSRFVLDQDTGS
CCCCEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHEEECCCCC
AIKGPGRVDYFLGYGDLAGDRAGITVTTGSIYYLLLK
CCCCCCCEEEEEECCCCCCCCCCEEEEECCEEEEEEC
>Mature Secondary Structure
MRKTLALFSLSLGITFFNPLQLAVSQVPPTAPPLKLVEIGTNCTPVRACLGWDEQLFSGH
CCCCEEEEEEECCCEEECHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHCCCHHHHCCC
GGLKSDRQGLLNSIDNSLRYLETPKAVTAYDNYPIKEITRDRVRRSLRRFRQLVATAKSP
CCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCH
AQLQAAVRREFAFYKSVGDDGQGRVKFTAYYAPIYQASRVRTAQYKYPIYRVPPDFEQWT
HHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCHHHHHHCEEEEECCCEEECCCCHHHHC
KPHPKRADLEGVDGLLGEKSQLRGLEMFWLRDRFQAYMIHIQGSAKLNLTDGTQTSVGFA
CCCCCCCCCCCCHHHCCCHHHHCCHHHHHHHHCCEEEEEEEECCEEEEECCCCCCCEEEC
GGTDYPWTAVGRLLFQDGKLSKEELNMPGIIRYFRKNPQSMSNYLPRWERFIFFKETKGE
CCCCCCHHHHHHHHHCCCCCCHHHCCCCHHHHHHHCCHHHHHHHCCCHHEEEEEEECCCC
PATGSISVPLVPERSIATDKSLMPPGALAVINATFPYPGQRNQLINRRVSRFVLDQDTGS
CCCCEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHEEECCCCC
AIKGPGRVDYFLGYGDLAGDRAGITVTTGSIYYLLLK
CCCCCCCEEEEEECCCCCCCCCCEEEEECCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic [C]

General reaction: Cleavage Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12089438 [H]