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The map label for this gene is proC [H]

Identifier: 17227984

GI number: 17227984

Start: 582738

End: 583550

Strand: Direct

Name: proC [H]

Synonym: alr0488

Alternate gene names: 17227984

Gene position: 582738-583550 (Clockwise)

Preceding gene: 17227983

Following gene: 17227985

Centisome position: 9.09

GC content: 48.71

Gene sequence:

>813_bases
ATGACTATAAAATTTGGTTTAATTGGTGGCGGGGTAATGGGAGAAGCGCTCTTATCCCGCCTTATTGCGCGGGGAATTTA
TCAACCATCAGAAGTCATAGTCAGCGAACCGCAAACAGCGCGACAAGCTTTTTTACAACAAAAATATCATGTGGGTGTGA
CCACAGATAACAGTTTGGTATTCACACAAGCTCAAGACGTTGTATTCTTGGCGGTGAAACCACAAGTGTTTAGTGCGATC
GCTCAAGAATTAGCAGATACAGTATTCACAGACCATTCCCCCCTTGTCGTCTCCATTCTTGCAGGGGTGTCTCTAAGCCA
GCTAGAAGCGGCGTTTCCCCAATCACCAGTCATTAGAGCCATGCCCAATACCCCAGCCACTGTAGGCTCAGGGATGACCG
CTATCTGCTCTGGTGCCTACACTTATGCCCAACACCAAAAATTGGCGCAACAAATTTTTTCCGCAGTAGGGGAAGTAGTC
GAAGTTTCCGAAAGTTTGATGGATGCAGTCACCGGGCTTTCTGGCAGTGGCCCGGCTTACGTAGCTTTATTGGTAGAAGC
CCTCGCTGATGGGGGAGTGGCATCGGGTTTACCCAGAGGAATAGCCAATCAACTAGCATTACAAACTGTGCTAGGAACAG
CCCAACTATTACACGAAAGTAAACTCCACCCAGCCGAACTCAAAGACCGAGTTACTAGCCCTGGCGGTACTACCATCGCG
GGGATTGCCCAACTAGAAAAAGCGGGATTCCGTTCAGCCTTAATCGAAGCCGTCAAAGCAGCTACATGGCGATCGCAAGA
ACTAGGAAAATAG

Upstream 100 bases:

>100_bases
AAAGTTAAATTAGTCATTAGTCCATAGTCAAGAGTCCAAATGAGAAAATTTTTGACTATTGACTATTGATTAACGAATAA
CGACTAACGACTAACGACTA

Downstream 100 bases:

>100_bases
TTATTAATCGATGTTTTGCCTGTTGACTGTTGACAGTTAAATAATGACTAATGTCGAAGTTGACAAAAGACTCGTTAATA
TAGTAAACAGTCTGGTTGAA

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 270; Mature: 269

Protein sequence:

>270_residues
MTIKFGLIGGGVMGEALLSRLIARGIYQPSEVIVSEPQTARQAFLQQKYHVGVTTDNSLVFTQAQDVVFLAVKPQVFSAI
AQELADTVFTDHSPLVVSILAGVSLSQLEAAFPQSPVIRAMPNTPATVGSGMTAICSGAYTYAQHQKLAQQIFSAVGEVV
EVSESLMDAVTGLSGSGPAYVALLVEALADGGVASGLPRGIANQLALQTVLGTAQLLHESKLHPAELKDRVTSPGGTTIA
GIAQLEKAGFRSALIEAVKAATWRSQELGK

Sequences:

>Translated_270_residues
MTIKFGLIGGGVMGEALLSRLIARGIYQPSEVIVSEPQTARQAFLQQKYHVGVTTDNSLVFTQAQDVVFLAVKPQVFSAI
AQELADTVFTDHSPLVVSILAGVSLSQLEAAFPQSPVIRAMPNTPATVGSGMTAICSGAYTYAQHQKLAQQIFSAVGEVV
EVSESLMDAVTGLSGSGPAYVALLVEALADGGVASGLPRGIANQLALQTVLGTAQLLHESKLHPAELKDRVTSPGGTTIA
GIAQLEKAGFRSALIEAVKAATWRSQELGK
>Mature_269_residues
TIKFGLIGGGVMGEALLSRLIARGIYQPSEVIVSEPQTARQAFLQQKYHVGVTTDNSLVFTQAQDVVFLAVKPQVFSAIA
QELADTVFTDHSPLVVSILAGVSLSQLEAAFPQSPVIRAMPNTPATVGSGMTAICSGAYTYAQHQKLAQQIFSAVGEVVE
VSESLMDAVTGLSGSGPAYVALLVEALADGGVASGLPRGIANQLALQTVLGTAQLLHESKLHPAELKDRVTSPGGTTIAG
IAQLEKAGFRSALIEAVKAATWRSQELGK

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI21361454, Length=271, Percent_Identity=43.5424354243542, Blast_Score=192, Evalue=2e-49,
Organism=Homo sapiens, GI24797097, Length=271, Percent_Identity=42.4354243542435, Blast_Score=187, Evalue=9e-48,
Organism=Homo sapiens, GI24797095, Length=271, Percent_Identity=42.4354243542435, Blast_Score=186, Evalue=1e-47,
Organism=Homo sapiens, GI198041662, Length=269, Percent_Identity=40.8921933085502, Blast_Score=176, Evalue=2e-44,
Organism=Escherichia coli, GI1786585, Length=271, Percent_Identity=39.8523985239852, Blast_Score=188, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI17569021, Length=270, Percent_Identity=43.3333333333333, Blast_Score=200, Evalue=5e-52,
Organism=Caenorhabditis elegans, GI17540664, Length=287, Percent_Identity=34.1463414634146, Blast_Score=147, Evalue=5e-36,
Organism=Saccharomyces cerevisiae, GI6320861, Length=289, Percent_Identity=32.1799307958478, Blast_Score=134, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24648116, Length=276, Percent_Identity=43.4782608695652, Blast_Score=197, Evalue=8e-51,
Organism=Drosophila melanogaster, GI21358587, Length=268, Percent_Identity=42.1641791044776, Blast_Score=190, Evalue=7e-49,
Organism=Drosophila melanogaster, GI24647700, Length=168, Percent_Identity=47.0238095238095, Blast_Score=153, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 28140; Mature: 28008

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIKFGLIGGGVMGEALLSRLIARGIYQPSEVIVSEPQTARQAFLQQKYHVGVTTDNSLV
CEEEEEECCCHHHHHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHHHHEEEECCCCEE
FTQAQDVVFLAVKPQVFSAIAQELADTVFTDHSPLVVSILAGVSLSQLEAAFPQSPVIRA
EEECCCEEEEEECHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHCCCCCCEEE
MPNTPATVGSGMTAICSGAYTYAQHQKLAQQIFSAVGEVVEVSESLMDAVTGLSGSGPAY
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
VALLVEALADGGVASGLPRGIANQLALQTVLGTAQLLHESKLHPAELKDRVTSPGGTTIA
HHHHHHHHHCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHH
GIAQLEKAGFRSALIEAVKAATWRSQELGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TIKFGLIGGGVMGEALLSRLIARGIYQPSEVIVSEPQTARQAFLQQKYHVGVTTDNSLV
EEEEEECCCHHHHHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHHHHEEEECCCCEE
FTQAQDVVFLAVKPQVFSAIAQELADTVFTDHSPLVVSILAGVSLSQLEAAFPQSPVIRA
EEECCCEEEEEECHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHCCCCCCEEE
MPNTPATVGSGMTAICSGAYTYAQHQKLAQQIFSAVGEVVEVSESLMDAVTGLSGSGPAY
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
VALLVEALADGGVASGLPRGIANQLALQTVLGTAQLLHESKLHPAELKDRVTSPGGTTIA
HHHHHHHHHCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHH
GIAQLEKAGFRSALIEAVKAATWRSQELGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]