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The map label for this gene is macB [H]

Identifier: 17227948

GI number: 17227948

Start: 534272

End: 535489

Strand: Direct

Name: macB [H]

Synonym: alr0452

Alternate gene names: 17227948

Gene position: 534272-535489 (Clockwise)

Preceding gene: 17227947

Following gene: 17227956

Centisome position: 8.33

GC content: 45.4

Gene sequence:

>1218_bases
ATGAACTTCTTAGAAAGTATGCAAATGGCAGGGAAAACCCTGCTGTCCAATAAGCTGCGTAGCGCCCTAACTATGTTGGG
CATTGTTATTGGTAATGCCTCAGTCATTGCCATGATTGGGATTGGGGAAGGAGGACAGAGGTTTGTTCAGCAACAGTTAG
AGTCACTAGGCCCAAACGTGCTGTTTGTGATTCCAGGGAACCAAGCCACTCAACGCATCTCTAACGAATTACCCAAAACT
TTGGTATTAGCAGACGCAGAAGCGATCGCCACCCAAGTACCAACCATCGCCGCCGTGACGGTAGAGTTAAATAGTCGGCA
AGTAGTCACCTACAGTAACAGAAATACCAACGTCAATATTATTGGTACAAATCCCAACTTCTTAAGAGTGCGAGATTTTG
ATGTTGATAGAGGGCGATTTTTTACCGATATAGATATGAAACGCAGCAATCAAGTTGCGGTACTCGGTGCAAAATTAGCC
GAAAGACTTTTTGGTAATACAAACCCAGTGGGGCAACAATTACGCATCAAAAATGCCAGCTTTCAAGTTATTGGTGTATT
GGAAGCCAAAGGCTCAAATCTTGGTGTCGATTATGATGATGCGGCAATGGTACCAATCATTACCACAGCTAACCGGATTG
TGGGGCGTACTTCTCCTTATGGATTAGAGGTAACCTTTATTGTCGCCTCAGCGAAAAATGCCGAGAGTGTAGACGCAGCA
GTATTCCAAATTACCAACTTGCTACGACAACGGCACAAAATCACCGATGAAGATGACTTCACCATCCGCACCCAAAAAGA
TGCCTTGCAGACAGTTGGACAAATCTCCAGTGCATTGACAATTATGTTAGCGGCGATCGCTGGTATATCATTGTTTGTTG
GTGGCATTGGCATCATGAATATTATGCTTGTTTCCGTCACTGAGCGCACCCAAGAAATTGGACTCCGCAAAGCCATTGGC
GCGACAGAACAAGATATTTTATTGCAATTTATTATTGAATCTGTGATTGTGTCTGCCATTGGTGGCTTAGTGGGGACTGG
TGTTGGTGTTGGTGGCATTATGTTAGTGGCAGCCTTAACACCCCTAGAAGCCGCCATTTCTCCTGTAGCCATTGCCACAG
CCGTGGGTATTTCTGGGGCGATCGGTTTATTTTTTGGCGTGGTTCCTGCCCGTCGTGCAGCTAAACTTGATCCTATTGTG
GCTTTGAGAAGTGCTTAG

Upstream 100 bases:

>100_bases
ACCAAACTCAAGTTTTATCTGGCTTGAAAACAGGCGATCGCGTGTTTGTTGACTTACCCCAAGATTACAGAATCCAACAG
GCCAAAGAAAAAGCAAATCA

Downstream 100 bases:

>100_bases
TATTGGATCAGTTAATCTACAGTTTTCGGCAATAAAAAATGCCTGCATATGCAGACATTTATGAGGCTTTCTGTCACTGT
AATCGGCTACAATCATGTTT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MNFLESMQMAGKTLLSNKLRSALTMLGIVIGNASVIAMIGIGEGGQRFVQQQLESLGPNVLFVIPGNQATQRISNELPKT
LVLADAEAIATQVPTIAAVTVELNSRQVVTYSNRNTNVNIIGTNPNFLRVRDFDVDRGRFFTDIDMKRSNQVAVLGAKLA
ERLFGNTNPVGQQLRIKNASFQVIGVLEAKGSNLGVDYDDAAMVPIITTANRIVGRTSPYGLEVTFIVASAKNAESVDAA
VFQITNLLRQRHKITDEDDFTIRTQKDALQTVGQISSALTIMLAAIAGISLFVGGIGIMNIMLVSVTERTQEIGLRKAIG
ATEQDILLQFIIESVIVSAIGGLVGTGVGVGGIMLVAALTPLEAAISPVAIATAVGISGAIGLFFGVVPARRAAKLDPIV
ALRSA

Sequences:

>Translated_405_residues
MNFLESMQMAGKTLLSNKLRSALTMLGIVIGNASVIAMIGIGEGGQRFVQQQLESLGPNVLFVIPGNQATQRISNELPKT
LVLADAEAIATQVPTIAAVTVELNSRQVVTYSNRNTNVNIIGTNPNFLRVRDFDVDRGRFFTDIDMKRSNQVAVLGAKLA
ERLFGNTNPVGQQLRIKNASFQVIGVLEAKGSNLGVDYDDAAMVPIITTANRIVGRTSPYGLEVTFIVASAKNAESVDAA
VFQITNLLRQRHKITDEDDFTIRTQKDALQTVGQISSALTIMLAAIAGISLFVGGIGIMNIMLVSVTERTQEIGLRKAIG
ATEQDILLQFIIESVIVSAIGGLVGTGVGVGGIMLVAALTPLEAAISPVAIATAVGISGAIGLFFGVVPARRAAKLDPIV
ALRSA
>Mature_405_residues
MNFLESMQMAGKTLLSNKLRSALTMLGIVIGNASVIAMIGIGEGGQRFVQQQLESLGPNVLFVIPGNQATQRISNELPKT
LVLADAEAIATQVPTIAAVTVELNSRQVVTYSNRNTNVNIIGTNPNFLRVRDFDVDRGRFFTDIDMKRSNQVAVLGAKLA
ERLFGNTNPVGQQLRIKNASFQVIGVLEAKGSNLGVDYDDAAMVPIITTANRIVGRTSPYGLEVTFIVASAKNAESVDAA
VFQITNLLRQRHKITDEDDFTIRTQKDALQTVGQISSALTIMLAAIAGISLFVGGIGIMNIMLVSVTERTQEIGLRKAIG
ATEQDILLQFIIESVIVSAIGGLVGTGVGVGGIMLVAALTPLEAAISPVAIATAVGISGAIGLFFGVVPARRAAKLDPIV
ALRSA

Specific function: Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation [H]

COG id: COG0577

COG function: function code V; ABC-type antimicrobial peptide transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Escherichia coli, GI1787105, Length=402, Percent_Identity=34.0796019900498, Blast_Score=186, Evalue=2e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR017911
- InterPro:   IPR003593
- InterPro:   IPR003838 [H]

Pfam domain/function: PF00005 ABC_tran; PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 42838; Mature: 42838

Theoretical pI: Translated: 9.47; Mature: 9.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFLESMQMAGKTLLSNKLRSALTMLGIVIGNASVIAMIGIGEGGQRFVQQQLESLGPNV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHCCCCE
LFVIPGNQATQRISNELPKTLVLADAEAIATQVPTIAAVTVELNSRQVVTYSNRNTNVNI
EEEECCCHHHHHHHHHCCCEEEEECHHHHHHCCCEEEEEEEEECCCEEEEEECCCCEEEE
IGTNPNFLRVRDFDVDRGRFFTDIDMKRSNQVAVLGAKLAERLFGNTNPVGQQLRIKNAS
EECCCCEEEEEECCCCCCCEEEEECCCCCCCEEEEHHHHHHHHCCCCCCCCCEEEEECCC
FQVIGVLEAKGSNLGVDYDDAAMVPIITTANRIVGRTSPYGLEVTFIVASAKNAESVDAA
EEEEEEEEECCCCCCCCCCCCCEEEEEECCHHHHCCCCCCCEEEEEEEEECCCCCHHHHH
VFQITNLLRQRHKITDEDDFTIRTQKDALQTVGQISSALTIMLAAIAGISLFVGGIGIMN
HHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IMLVSVTERTQEIGLRKAIGATEQDILLQFIIESVIVSAIGGLVGTGVGVGGIMLVAALT
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
PLEAAISPVAIATAVGISGAIGLFFGVVPARRAAKLDPIVALRSA
HHHHHHCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCEEECCC
>Mature Secondary Structure
MNFLESMQMAGKTLLSNKLRSALTMLGIVIGNASVIAMIGIGEGGQRFVQQQLESLGPNV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHCCCCE
LFVIPGNQATQRISNELPKTLVLADAEAIATQVPTIAAVTVELNSRQVVTYSNRNTNVNI
EEEECCCHHHHHHHHHCCCEEEEECHHHHHHCCCEEEEEEEEECCCEEEEEECCCCEEEE
IGTNPNFLRVRDFDVDRGRFFTDIDMKRSNQVAVLGAKLAERLFGNTNPVGQQLRIKNAS
EECCCCEEEEEECCCCCCCEEEEECCCCCCCEEEEHHHHHHHHCCCCCCCCCEEEEECCC
FQVIGVLEAKGSNLGVDYDDAAMVPIITTANRIVGRTSPYGLEVTFIVASAKNAESVDAA
EEEEEEEEECCCCCCCCCCCCCEEEEEECCHHHHCCCCCCCEEEEEEEEECCCCCHHHHH
VFQITNLLRQRHKITDEDDFTIRTQKDALQTVGQISSALTIMLAAIAGISLFVGGIGIMN
HHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IMLVSVTERTQEIGLRKAIGATEQDILLQFIIESVIVSAIGGLVGTGVGVGGIMLVAALT
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
PLEAAISPVAIATAVGISGAIGLFFGVVPARRAAKLDPIVALRSA
HHHHHHCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA