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The map label for this gene is pepA [H]

Identifier: 17227733

GI number: 17227733

Start: 254248

End: 255723

Strand: Direct

Name: pepA [H]

Synonym: alr0237

Alternate gene names: 17227733

Gene position: 254248-255723 (Clockwise)

Preceding gene: 17227732

Following gene: 17227734

Centisome position: 3.96

GC content: 45.05

Gene sequence:

>1476_bases
ATGGCAATTCAACTGAGTGATAAGCCTCTGCTAGAATGGGCAGGCGATACTTTGGCGATCGCATTATTTGAAGATGCAGT
CGAGTTAACTGGTGAACTAGGAAGTTTAGATGAAAAGTTTGCCGGCATCTTAAAAGAGCTAATTACTGAAGAAGAGTTTA
CAGGCAAAGCCAACAGCACGGTTTTTACTCGTGTGAGTTCTAATATCCCAGTACGGAAAATAATTTTGGTGGGTTTAGGC
AAAACTGAAGCCTTCAAAATAGAAACCTTAAGACGTGCGGCGGCGGCTGTAGGTAAAGTAGGCAAAAAACAAAAAAGCAA
AGTTATCGGACTGAGTTTTCCTTTGTGGAATAATGACCCTACGGCCTCAGCTCAAGCAATTGCTGAAGGCTTGCAGTTAG
CACTCTATCAAGATAATCGCTTTAAATCAGACCCAGAAGACAAAGGTTCTCAAGTCGAAACAGTAGAATTACTTGGTTTT
GCCGGACAAGAAGCGGCAATTAACCGAGCAAATCAAATCGTTTCTGGGGTAATCTTGGCTCGCCAGTTGGTAGCAGCACC
AGCAAATAGTGTCACACCAATTACAATGGCAGAAACGGCTCAACAGATTGCCCAAGATTATGGTTTACAAATAGAAATTT
TAGAGCAGGAAGATTGCGAAAAACTAGGCATGGGTGCATTTTTAGGAGTTGCCCTCGCCTCAGATTTACCACCTAAATTT
ATTCACTTAACTTACAAACCAGAAGGCACACCCAAGCGCAAACTAGCAATTGTGGGTAAAGGTCTAACCTTCGATTCCGG
TGGACTCAACATTAAAGGCGCTGGTAGTGGTATCGAAACCATGAAAATTGATATGGGAGGTGCAGCAGCTACCTTAGGCG
CAGCCAAAGCCATTGCCCAAATCAAACCAAATGTAGAAGTTCACTTCATCTCAGCCGTGACCGAAAACATGATTAGCGGT
AAGGCTATGCACCCAGGAGACATCCTGACTGCATCCAATGGCAAAACCATCGAAGTAAACAACACCGATGCCGAAGGGCG
TTTAACCCTAGCAGATGCCCTAGTCTATACCGATAAATTGGGATTAGATGCGATCGTAGATCTAGCAACCCTCACCGGTG
CCAATGTCATTGCTTTAGGTGATGACATTGCTGGTTTGTATACTCCCGATGATGCCTTAGCAGGGCAACTAGAGCAAGCC
GCTAGTGAATCAGGGGAAAAGATTTGGCGGATGCCATTAGAAGAAAAATATTTTGAAGGACTAAAATCTGGCATTGCCGA
CATGAAAAACACCGGGCCTCGTCCTGGTGGTTCCATCACTGCTGCTTTGTTTCTCAAGCAGTTTGTCAAAGATACCGCGT
GGGCGCACTTAGATATTGCCGGGCCAGTTTGGGCGGACAAAGAAAACGGCTACAACGGCCCAGGTGCTACTGGTTATGGT
GTCAGGCTGTTAGTAGATTGGGTATTGAGTGAGTAG

Upstream 100 bases:

>100_bases
ACCTTCCCCAGTCCCCAGTCCCCAATCCCCCCTATCCTGAAACAAAAATTTTGAGCAATACTGGTACAGGAAAGCATATA
TACATAGACAAGACCCCAAC

Downstream 100 bases:

>100_bases
GGGGGGTAGGGGTATAGGGGTGTAGGGGTATAGGGGAAGGAATAATAAATTTCTTTTCCCTCACACCCTTACACCCTTAC
ACCCTCACACCCTCATACAC

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 491; Mature: 490

Protein sequence:

>491_residues
MAIQLSDKPLLEWAGDTLAIALFEDAVELTGELGSLDEKFAGILKELITEEEFTGKANSTVFTRVSSNIPVRKIILVGLG
KTEAFKIETLRRAAAAVGKVGKKQKSKVIGLSFPLWNNDPTASAQAIAEGLQLALYQDNRFKSDPEDKGSQVETVELLGF
AGQEAAINRANQIVSGVILARQLVAAPANSVTPITMAETAQQIAQDYGLQIEILEQEDCEKLGMGAFLGVALASDLPPKF
IHLTYKPEGTPKRKLAIVGKGLTFDSGGLNIKGAGSGIETMKIDMGGAAATLGAAKAIAQIKPNVEVHFISAVTENMISG
KAMHPGDILTASNGKTIEVNNTDAEGRLTLADALVYTDKLGLDAIVDLATLTGANVIALGDDIAGLYTPDDALAGQLEQA
ASESGEKIWRMPLEEKYFEGLKSGIADMKNTGPRPGGSITAALFLKQFVKDTAWAHLDIAGPVWADKENGYNGPGATGYG
VRLLVDWVLSE

Sequences:

>Translated_491_residues
MAIQLSDKPLLEWAGDTLAIALFEDAVELTGELGSLDEKFAGILKELITEEEFTGKANSTVFTRVSSNIPVRKIILVGLG
KTEAFKIETLRRAAAAVGKVGKKQKSKVIGLSFPLWNNDPTASAQAIAEGLQLALYQDNRFKSDPEDKGSQVETVELLGF
AGQEAAINRANQIVSGVILARQLVAAPANSVTPITMAETAQQIAQDYGLQIEILEQEDCEKLGMGAFLGVALASDLPPKF
IHLTYKPEGTPKRKLAIVGKGLTFDSGGLNIKGAGSGIETMKIDMGGAAATLGAAKAIAQIKPNVEVHFISAVTENMISG
KAMHPGDILTASNGKTIEVNNTDAEGRLTLADALVYTDKLGLDAIVDLATLTGANVIALGDDIAGLYTPDDALAGQLEQA
ASESGEKIWRMPLEEKYFEGLKSGIADMKNTGPRPGGSITAALFLKQFVKDTAWAHLDIAGPVWADKENGYNGPGATGYG
VRLLVDWVLSE
>Mature_490_residues
AIQLSDKPLLEWAGDTLAIALFEDAVELTGELGSLDEKFAGILKELITEEEFTGKANSTVFTRVSSNIPVRKIILVGLGK
TEAFKIETLRRAAAAVGKVGKKQKSKVIGLSFPLWNNDPTASAQAIAEGLQLALYQDNRFKSDPEDKGSQVETVELLGFA
GQEAAINRANQIVSGVILARQLVAAPANSVTPITMAETAQQIAQDYGLQIEILEQEDCEKLGMGAFLGVALASDLPPKFI
HLTYKPEGTPKRKLAIVGKGLTFDSGGLNIKGAGSGIETMKIDMGGAAATLGAAKAIAQIKPNVEVHFISAVTENMISGK
AMHPGDILTASNGKTIEVNNTDAEGRLTLADALVYTDKLGLDAIVDLATLTGANVIALGDDIAGLYTPDDALAGQLEQAA
SESGEKIWRMPLEEKYFEGLKSGIADMKNTGPRPGGSITAALFLKQFVKDTAWAHLDIAGPVWADKENGYNGPGATGYGV
RLLVDWVLSE

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=483, Percent_Identity=37.888198757764, Blast_Score=257, Evalue=1e-68,
Organism=Homo sapiens, GI47155554, Length=321, Percent_Identity=38.6292834890966, Blast_Score=170, Evalue=3e-42,
Organism=Escherichia coli, GI1790710, Length=468, Percent_Identity=34.1880341880342, Blast_Score=240, Evalue=1e-64,
Organism=Escherichia coli, GI87082123, Length=315, Percent_Identity=38.0952380952381, Blast_Score=184, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17556903, Length=305, Percent_Identity=37.3770491803279, Blast_Score=158, Evalue=7e-39,
Organism=Caenorhabditis elegans, GI17565172, Length=308, Percent_Identity=27.2727272727273, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI21355725, Length=415, Percent_Identity=30.1204819277108, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24661038, Length=376, Percent_Identity=31.6489361702128, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI221379063, Length=328, Percent_Identity=34.4512195121951, Blast_Score=171, Evalue=2e-42,
Organism=Drosophila melanogaster, GI221379062, Length=328, Percent_Identity=34.4512195121951, Blast_Score=171, Evalue=2e-42,
Organism=Drosophila melanogaster, GI21357381, Length=328, Percent_Identity=34.4512195121951, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI20129969, Length=444, Percent_Identity=30.4054054054054, Blast_Score=169, Evalue=5e-42,
Organism=Drosophila melanogaster, GI24662227, Length=439, Percent_Identity=28.4738041002278, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI21355645, Length=440, Percent_Identity=29.5454545454545, Blast_Score=155, Evalue=7e-38,
Organism=Drosophila melanogaster, GI24662223, Length=440, Percent_Identity=29.5454545454545, Blast_Score=155, Evalue=7e-38,
Organism=Drosophila melanogaster, GI20129963, Length=448, Percent_Identity=30.1339285714286, Blast_Score=148, Evalue=8e-36,
Organism=Drosophila melanogaster, GI161077148, Length=339, Percent_Identity=30.9734513274336, Blast_Score=148, Evalue=1e-35,
Organism=Drosophila melanogaster, GI20130057, Length=339, Percent_Identity=30.9734513274336, Blast_Score=148, Evalue=1e-35,
Organism=Drosophila melanogaster, GI19922386, Length=443, Percent_Identity=29.1196388261851, Blast_Score=142, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24646701, Length=151, Percent_Identity=33.112582781457, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24646703, Length=151, Percent_Identity=33.112582781457, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI21358201, Length=151, Percent_Identity=33.112582781457, Blast_Score=86, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 51919; Mature: 51788

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIQLSDKPLLEWAGDTLAIALFEDAVELTGELGSLDEKFAGILKELITEEEFTGKANST
CEEECCCCCHHHHCCCEEEEEEHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHCCCCCCCE
VFTRVSSNIPVRKIILVGLGKTEAFKIETLRRAAAAVGKVGKKQKSKVIGLSFPLWNNDP
EEEEECCCCCEEEEEEEECCCCCEEHHHHHHHHHHHHHHHCCHHHCCEEEEECCCCCCCC
TASAQAIAEGLQLALYQDNRFKSDPEDKGSQVETVELLGFAGQEAAINRANQIVSGVILA
CHHHHHHHHHHEEEEEECCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHH
RQLVAAPANSVTPITMAETAQQIAQDYGLQIEILEQEDCEKLGMGAFLGVALASDLPPKF
HHHHHCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCHHHHCCHHHHHHHHHCCCCCCE
IHLTYKPEGTPKRKLAIVGKGLTFDSGGLNIKGAGSGIETMKIDMGGAAATLGAAKAIAQ
EEEEECCCCCCCCEEEEEECCEEECCCCCEEEECCCCCEEEEEECCCCHHHHHHHHHHHH
IKPNVEVHFISAVTENMISGKAMHPGDILTASNGKTIEVNNTDAEGRLTLADALVYTDKL
CCCCCEEEEHHHHHHHHHCCCCCCCCCEEECCCCCEEEECCCCCCCEEEEEHHHHHHHCC
GLDAIVDLATLTGANVIALGDDIAGLYTPDDALAGQLEQAASESGEKIWRMPLEEKYFEG
CHHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCEECCCHHHHHHHH
LKSGIADMKNTGPRPGGSITAALFLKQFVKDTAWAHLDIAGPVWADKENGYNGPGATGYG
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCCCCCCCCCCCH
VRLLVDWVLSE
HHHHHHHHHCC
>Mature Secondary Structure 
AIQLSDKPLLEWAGDTLAIALFEDAVELTGELGSLDEKFAGILKELITEEEFTGKANST
EEECCCCCHHHHCCCEEEEEEHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHCCCCCCCE
VFTRVSSNIPVRKIILVGLGKTEAFKIETLRRAAAAVGKVGKKQKSKVIGLSFPLWNNDP
EEEEECCCCCEEEEEEEECCCCCEEHHHHHHHHHHHHHHHCCHHHCCEEEEECCCCCCCC
TASAQAIAEGLQLALYQDNRFKSDPEDKGSQVETVELLGFAGQEAAINRANQIVSGVILA
CHHHHHHHHHHEEEEEECCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHH
RQLVAAPANSVTPITMAETAQQIAQDYGLQIEILEQEDCEKLGMGAFLGVALASDLPPKF
HHHHHCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCHHHHCCHHHHHHHHHCCCCCCE
IHLTYKPEGTPKRKLAIVGKGLTFDSGGLNIKGAGSGIETMKIDMGGAAATLGAAKAIAQ
EEEEECCCCCCCCEEEEEECCEEECCCCCEEEECCCCCEEEEEECCCCHHHHHHHHHHHH
IKPNVEVHFISAVTENMISGKAMHPGDILTASNGKTIEVNNTDAEGRLTLADALVYTDKL
CCCCCEEEEHHHHHHHHHCCCCCCCCCEEECCCCCEEEECCCCCCCEEEEEHHHHHHHCC
GLDAIVDLATLTGANVIALGDDIAGLYTPDDALAGQLEQAASESGEKIWRMPLEEKYFEG
CHHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCEECCCHHHHHHHH
LKSGIADMKNTGPRPGGSITAALFLKQFVKDTAWAHLDIAGPVWADKENGYNGPGATGYG
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCCCCCCCCCCCH
VRLLVDWVLSE
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA