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The map label for this gene is ispA [C]

Identifier: 17227709

GI number: 17227709

Start: 229783

End: 230712

Strand: Direct

Name: ispA [C]

Synonym: alr0213

Alternate gene names: 17227709

Gene position: 229783-230712 (Clockwise)

Preceding gene: 17227708

Following gene: 17227710

Centisome position: 3.58

GC content: 43.66

Gene sequence:

>930_bases
ATGGTAGCAGCTGATAACCTCCGGAAGATGTCAGAGGAAGCCAAATTTAATCTAGTAGCTTATCTTAAAGAGCGGCAAAA
ACTTTGTGAAGCTGCTTTGGATGCAGCCATACCTATTATTTATCCAGAAAAAATTTATGAATCAATGCGCTACTCTCTAT
TAGCTGGAGGTAAGCGCCTGCGTCCGATTCTTTGTCTGGCTACCTCGGAAATGATGGGTGGGACAATCGAAATAGCTATG
CCAACAGCTTGTGCTGTAGAAATGATCCACACCATGTCTTTGATTCACGACGACTTGCCAGCAATGGATAACGACGATTA
TCGTCGCGGTATGCTGACGAATCACAAGGTATATGGTGAAGATATTGCGATTTTGGCGGGAGATGGCTTATTAGCCTACG
CTTTTGAGTTCGTAGCTATCCGTACTCCTGAAAGCGTACCTAGAGACCGAGTATTGCAGGTAGTAGCCCGTTTAGGACGA
GCATTGGGAGCTGCTGGCTTGGTTGGGGGTCAAGTGGTTGACTTAGACTCAGAAGGAAAATCAGATACTTCCTTAGAAAC
ACTCAATTTTATTCATAATCACAAAACAGCAGCTCTTTTAGAAGCTTGTGTAGTCTGTGGCGGCATTTTAGCTGGGGCAT
CATCAGAAAATGTACAAAGACTCTCACGATATTCTCAAAATATTGGGCTAGCATTTCAAATCATTGATGATATTCTTGAT
ATCACTTCTACTCAAGAGCAATTAGGCAAGACTGCGGGTAAAGACCTTTTAGCGAAGAAAGTTACCTATCCTAGCCTGTG
GGGAATTGAACAATCGCGCGTCAAAGCCCAACAGCTAATTGAGGCAGCTTGTACAGAACTAGAACCATTTGGAGAAGATG
CACAGCCCCTGAAAGCGATCGCTCACTTCATCACTAGTCGTAATCACTAA

Upstream 100 bases:

>100_bases
GATTACTGAAGTATGAGTTAATCTTTCAGCTCCAGAGCATCTTAAAATTGTGACGTGTATGACAAACAGCCAAAAACAAA
AAATTTAAGGAAATCCAAGA

Downstream 100 bases:

>100_bases
TCAAACATCCAGTTGTTGTGTTGACTCCCAAGTATATACAGGCGGAATACAGTAAAAATAATTACCACTGACAACCGACA
ACTAACAACTAATAACTACT

Product: geranylgeranyl diphosphate synthase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MVAADNLRKMSEEAKFNLVAYLKERQKLCEAALDAAIPIIYPEKIYESMRYSLLAGGKRLRPILCLATSEMMGGTIEIAM
PTACAVEMIHTMSLIHDDLPAMDNDDYRRGMLTNHKVYGEDIAILAGDGLLAYAFEFVAIRTPESVPRDRVLQVVARLGR
ALGAAGLVGGQVVDLDSEGKSDTSLETLNFIHNHKTAALLEACVVCGGILAGASSENVQRLSRYSQNIGLAFQIIDDILD
ITSTQEQLGKTAGKDLLAKKVTYPSLWGIEQSRVKAQQLIEAACTELEPFGEDAQPLKAIAHFITSRNH

Sequences:

>Translated_309_residues
MVAADNLRKMSEEAKFNLVAYLKERQKLCEAALDAAIPIIYPEKIYESMRYSLLAGGKRLRPILCLATSEMMGGTIEIAM
PTACAVEMIHTMSLIHDDLPAMDNDDYRRGMLTNHKVYGEDIAILAGDGLLAYAFEFVAIRTPESVPRDRVLQVVARLGR
ALGAAGLVGGQVVDLDSEGKSDTSLETLNFIHNHKTAALLEACVVCGGILAGASSENVQRLSRYSQNIGLAFQIIDDILD
ITSTQEQLGKTAGKDLLAKKVTYPSLWGIEQSRVKAQQLIEAACTELEPFGEDAQPLKAIAHFITSRNH
>Mature_309_residues
MVAADNLRKMSEEAKFNLVAYLKERQKLCEAALDAAIPIIYPEKIYESMRYSLLAGGKRLRPILCLATSEMMGGTIEIAM
PTACAVEMIHTMSLIHDDLPAMDNDDYRRGMLTNHKVYGEDIAILAGDGLLAYAFEFVAIRTPESVPRDRVLQVVARLGR
ALGAAGLVGGQVVDLDSEGKSDTSLETLNFIHNHKTAALLEACVVCGGILAGASSENVQRLSRYSQNIGLAFQIIDDILD
ITSTQEQLGKTAGKDLLAKKVTYPSLWGIEQSRVKAQQLIEAACTELEPFGEDAQPLKAIAHFITSRNH

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=241, Percent_Identity=29.4605809128631, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI1786623, Length=269, Percent_Identity=46.4684014869888, Blast_Score=188, Evalue=3e-49,
Organism=Escherichia coli, GI1789578, Length=248, Percent_Identity=32.6612903225806, Blast_Score=120, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17505681, Length=189, Percent_Identity=30.6878306878307, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24651612, Length=229, Percent_Identity=28.3842794759825, Blast_Score=86, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 33707; Mature: 33707

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAADNLRKMSEEAKFNLVAYLKERQKLCEAALDAAIPIIYPEKIYESMRYSLLAGGKRL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCC
RPILCLATSEMMGGTIEIAMPTACAVEMIHTMSLIHDDLPAMDNDDYRRGMLTNHKVYGE
CHHHEEEHHHHCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCEECCC
DIAILAGDGLLAYAFEFVAIRTPESVPRDRVLQVVARLGRALGAAGLVGGQVVDLDSEGK
CEEEEECCCHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCC
SDTSLETLNFIHNHKTAALLEACVVCGGILAGASSENVQRLSRYSQNIGLAFQIIDDILD
CCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHH
ITSTQEQLGKTAGKDLLAKKVTYPSLWGIEQSRVKAQQLIEAACTELEPFGEDAQPLKAI
HCCHHHHHHHHHHHHHHHHHCCCCHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
AHFITSRNH
HHHHHCCCC
>Mature Secondary Structure
MVAADNLRKMSEEAKFNLVAYLKERQKLCEAALDAAIPIIYPEKIYESMRYSLLAGGKRL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCC
RPILCLATSEMMGGTIEIAMPTACAVEMIHTMSLIHDDLPAMDNDDYRRGMLTNHKVYGE
CHHHEEEHHHHCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCEECCC
DIAILAGDGLLAYAFEFVAIRTPESVPRDRVLQVVARLGRALGAAGLVGGQVVDLDSEGK
CEEEEECCCHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCC
SDTSLETLNFIHNHKTAALLEACVVCGGILAGASSENVQRLSRYSQNIGLAFQIIDDILD
CCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHH
ITSTQEQLGKTAGKDLLAKKVTYPSLWGIEQSRVKAQQLIEAACTELEPFGEDAQPLKAI
HCCHHHHHHHHHHHHHHHHHCCCCHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
AHFITSRNH
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8486607; 7918490 [H]