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The map label for this gene is hemK [C]

Identifier: 17227611

GI number: 17227611

Start: 117428

End: 118342

Strand: Direct

Name: hemK [C]

Synonym: alr0115

Alternate gene names: 17227611

Gene position: 117428-118342 (Clockwise)

Preceding gene: 17227610

Following gene: 17227612

Centisome position: 1.83

GC content: 47.32

Gene sequence:

>915_bases
ATGACAAATCGACAGGCAAATGTAGTTTCTGGTTTACAACTTTGGCAGTGGCGCATCAAAGCAAATCAAGCCGCGATCGC
TCATAATATTCCCATAGCAGAAGTGGATTGGCTGTTGCAAGAGATAGCTGATTTAGACCGCTTGGCACTGCGTTTAGAGT
CGTTTAAAGACTGGTCTGAAGTGCCGATGGGTTTATCTCTGGACAAGTTAGACCAACTTTGGCAGAGGCGATTAGGCGAT
CGCTTACCCGTACAGTACATCGCCGGAGTTACACCTTGGCGCAAGTTCAAACTTACGGTGTCGAGCGCTGTTTTGATTCC
TAGACCGGAAACTGAGTGCTTGATTGATTTAGCTGTAGCTGCTGTTGCTAACAGCGAATCGGCTATGCACTTACAACAAG
GACATTGGGTAGACTTGGGAACGGGTAGTGGGGCGATCGCCTTGGGGTTAGCTGATGCTTTCCCTGAAGCCACAATTCAT
GCTGTAGATTGCAGTGTGGAAGCTTTGGCGATCGCCCAGCAAAACGCCTGGAACGCAGGTTTATTTGATAGGATGCGATT
TTATCAGGGTCGCTGGTGGGAGCCTTTAAGTTTGCTGAAAGGTCAATTTAATGGCATGGTATCTAACCCTCCTTATATTC
CCAGCGACATTGTGCCTACGCTACAACCAGAAGTAGTAAACCATGAACCACATTTAGCCTTAGATGGCGGTGCGGATGGC
TTAGATGCCATCCGCCATCTAATAGAAGTTGCCCCCAGTTATTTACGACCTGGGGGTATATGGTTAATTGAAATGATGGC
GGGTCAAGCGGACGCGGTACAAGCTCTTCTGCTGCAACAGGGCAGTTATAGTAATATTCAAATTCACTCTGATTTAGCTG
GTATTGAGCGTTTCGCTTTAGCACAGATTCAGTGA

Upstream 100 bases:

>100_bases
AATATATTAGGACTCTACCCAAACCACCTAACACTCCTGCTGCCCCTAATCGTAACAATAATAACTCCCGACCTGGGGCA
AAATAGAATTCACCTTAGGC

Downstream 100 bases:

>100_bases
TGAGTTTTAAGTAGTATTCTTGAGTAAGAATTGCTTAAGTGTTAATTTGTAATTGATAATTACAAGTTATTTATGACTAG
GGTTTCCTTAGAAACATTAA

Product: protoporphyrinogen oxidase

Products: NA

Alternate protein names: M.Ssp6803HemKP [H]

Number of amino acids: Translated: 304; Mature: 303

Protein sequence:

>304_residues
MTNRQANVVSGLQLWQWRIKANQAAIAHNIPIAEVDWLLQEIADLDRLALRLESFKDWSEVPMGLSLDKLDQLWQRRLGD
RLPVQYIAGVTPWRKFKLTVSSAVLIPRPETECLIDLAVAAVANSESAMHLQQGHWVDLGTGSGAIALGLADAFPEATIH
AVDCSVEALAIAQQNAWNAGLFDRMRFYQGRWWEPLSLLKGQFNGMVSNPPYIPSDIVPTLQPEVVNHEPHLALDGGADG
LDAIRHLIEVAPSYLRPGGIWLIEMMAGQADAVQALLLQQGSYSNIQIHSDLAGIERFALAQIQ

Sequences:

>Translated_304_residues
MTNRQANVVSGLQLWQWRIKANQAAIAHNIPIAEVDWLLQEIADLDRLALRLESFKDWSEVPMGLSLDKLDQLWQRRLGD
RLPVQYIAGVTPWRKFKLTVSSAVLIPRPETECLIDLAVAAVANSESAMHLQQGHWVDLGTGSGAIALGLADAFPEATIH
AVDCSVEALAIAQQNAWNAGLFDRMRFYQGRWWEPLSLLKGQFNGMVSNPPYIPSDIVPTLQPEVVNHEPHLALDGGADG
LDAIRHLIEVAPSYLRPGGIWLIEMMAGQADAVQALLLQQGSYSNIQIHSDLAGIERFALAQIQ
>Mature_303_residues
TNRQANVVSGLQLWQWRIKANQAAIAHNIPIAEVDWLLQEIADLDRLALRLESFKDWSEVPMGLSLDKLDQLWQRRLGDR
LPVQYIAGVTPWRKFKLTVSSAVLIPRPETECLIDLAVAAVANSESAMHLQQGHWVDLGTGSGAIALGLADAFPEATIHA
VDCSVEALAIAQQNAWNAGLFDRMRFYQGRWWEPLSLLKGQFNGMVSNPPYIPSDIVPTLQPEVVNHEPHLALDGGADGL
DAIRHLIEVAPSYLRPGGIWLIEMMAGQADAVQALLLQQGSYSNIQIHSDLAGIERFALAQIQ

Specific function: Probable protein methyltransferase. May methylate a Gln residue in target proteins [H]

COG id: COG2890

COG function: function code J; Methylase of polypeptide chain release factors

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hemK family [H]

Homologues:

Organism=Homo sapiens, GI7705409, Length=249, Percent_Identity=32.1285140562249, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI1787463, Length=235, Percent_Identity=37.4468085106383, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI87082085, Length=190, Percent_Identity=34.2105263157895, Blast_Score=102, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24582226, Length=224, Percent_Identity=32.5892857142857, Blast_Score=114, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002052
- InterPro:   IPR004556
- InterPro:   IPR019874
- InterPro:   IPR007848 [H]

Pfam domain/function: PF05175 MTS [H]

EC number: 2.1.1.-

Molecular weight: Translated: 33572; Mature: 33441

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS00092 N6_MTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNRQANVVSGLQLWQWRIKANQAAIAHNIPIAEVDWLLQEIADLDRLALRLESFKDWSE
CCCCCHHHHHHHHHHHEEECCCCEEHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
VPMGLSLDKLDQLWQRRLGDRLPVQYIAGVTPWRKFKLTVSSAVLIPRPETECLIDLAVA
CCCCCCHHHHHHHHHHHCCCCCCHHHHHCCCCCCEEEEEEEEEEEECCCCHHHHHHHHHH
AVANSESAMHLQQGHWVDLGTGSGAIALGLADAFPEATIHAVDCSVEALAIAQQNAWNAG
HHCCCCCCEEECCCCEEEECCCCCEEEEEEHHCCCCCEEEEECCCHHHHHHHHCCCCCCC
LFDRMRFYQGRWWEPLSLLKGQFNGMVSNPPYIPSDIVPTLQPEVVNHEPHLALDGGADG
HHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHCCCCCCEEECCCCCH
LDAIRHLIEVAPSYLRPGGIWLIEMMAGQADAVQALLLQQGSYSNIQIHSDLAGIERFAL
HHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHCCCCCCCEEEECHHHHHHHHHH
AQIQ
HCCC
>Mature Secondary Structure 
TNRQANVVSGLQLWQWRIKANQAAIAHNIPIAEVDWLLQEIADLDRLALRLESFKDWSE
CCCCHHHHHHHHHHHEEECCCCEEHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
VPMGLSLDKLDQLWQRRLGDRLPVQYIAGVTPWRKFKLTVSSAVLIPRPETECLIDLAVA
CCCCCCHHHHHHHHHHHCCCCCCHHHHHCCCCCCEEEEEEEEEEEECCCCHHHHHHHHHH
AVANSESAMHLQQGHWVDLGTGSGAIALGLADAFPEATIHAVDCSVEALAIAQQNAWNAG
HHCCCCCCEEECCCCEEEECCCCCEEEEEEHHCCCCCEEEEECCCHHHHHHHHCCCCCCC
LFDRMRFYQGRWWEPLSLLKGQFNGMVSNPPYIPSDIVPTLQPEVVNHEPHLALDGGADG
HHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHCCCCCCEEECCCCCH
LDAIRHLIEVAPSYLRPGGIWLIEMMAGQADAVQALLLQQGSYSNIQIHSDLAGIERFAL
HHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHCCCCCCCEEEECHHHHHHHHHH
AQIQ
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]