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The map label for this gene is mltC [H]

Identifier: 172087662

GI number: 172087662

Start: 449539

End: 450627

Strand: Reverse

Name: mltC [H]

Synonym: VF_0420

Alternate gene names: 172087662

Gene position: 450627-449539 (Counterclockwise)

Preceding gene: 59711028

Following gene: 172087661

Centisome position: 15.55

GC content: 37.83

Gene sequence:

>1089_bases
ATGAAAAAAATTATACTGATCGCCTCGACCTGTCTTCTGCTTACCAGTTGTAGTCGAGAATCAATAGAATCTACTTTTGG
TGTAAATTACGATACAACCAACCGCTTTGCTAAAAATCTAGCCCCACTCCCTGGACAATTCACCAAAGATATTAAAGCAT
TAGATAGTTTAATAAGTAGTTTCAATGGCAATATCGAAAAACGTTGGGGTAAGAAAAACCTTGTTACTGCTGGTAAGCGC
TCCTATGTAAAATACACTGATGGGTATTTAAGCCGCTCTCAAGTGGATTTTACTAATGGTCGAGTTACCGTCGAAACGGT
TGCTGGTACTGACCCTAAAGCGCATTTACGTCAAGCCATCATTACCACCCTTTTGACACCGGAAGACCCTGCCAGTGTTG
ACCTTTATTCTGATGCTGATGTTACCTTAGGTGGCAAACCCTTCTTATATCAACAAGTCTTAGATCAAGATAAAAAACCA
ATTGAATGGTCATGGCGTGCCAGTCGTTACGCAGATTATTTAATTGCACATCATTTAAAACAAAAAAATGTCGATTATAA
AAAAGCATACTACGTCGATATTCCAATGGTAAAAAACCATACTCAACTCCGAGAATACAAGTATGCTGATATCGTACGTA
AAGCATCATTAAAATATGATATTCCTGAAGATCTCATTTATTCAATCATTCGAACTGAAAGTAGTTTTAACCCGTATGCG
GTAAGTTGGGCTAATGCTTATGGTTTAATGCAGGTTGTACCAAAAACAGCTGGTCGTGATGTATTTAAGTTAGTTAAAAA
CAAATCAGGAGATCCAACTCCTGAGTATTTATTTAATCCTTACAATAATATTGATACGGGAACGGCTTACTTTCATATTT
TAAAAACTCGTTATTTAAAAGACATTCGTCACCCAACATCAAAACAATACAGCATGATCTCCGCCTACAATGGTGGCGCT
GGAGGCGTATTTAATACATTTAGTAGCAGCAGAAGTCGTGCAATCAATGACATAAACAGTCTACAACCCAATCAAGTGTA
CTGGGCATTAACCAAAAGCACAAAAATGCAGAGGCCAGACGCTACTTAG

Upstream 100 bases:

>100_bases
ACATTAAAGCAGTCATTTGGCTGCTTTAATTTTATGCTATTAAGTCAAAGTTAAACCTGCCGTTAACCTTATTATCGAGT
TCTCAATCTATATTGCCTTT

Downstream 100 bases:

>100_bases
AAAAAGTTACCGCCTTTAAAAAAGAGTTTAATTCGGGAAAGTTTTAACCATAAAACAGGCCATTCGCTGAATATTCAATC
AAACAATCAAAAAAACGGAC

Product: membrane-bound lytic murein transglycosylase C

Products: N-Acetylmuramic Acid Residues; N-Acetylglucosamine Residues [C]

Alternate protein names: Murein hydrolase C [H]

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MKKIILIASTCLLLTSCSRESIESTFGVNYDTTNRFAKNLAPLPGQFTKDIKALDSLISSFNGNIEKRWGKKNLVTAGKR
SYVKYTDGYLSRSQVDFTNGRVTVETVAGTDPKAHLRQAIITTLLTPEDPASVDLYSDADVTLGGKPFLYQQVLDQDKKP
IEWSWRASRYADYLIAHHLKQKNVDYKKAYYVDIPMVKNHTQLREYKYADIVRKASLKYDIPEDLIYSIIRTESSFNPYA
VSWANAYGLMQVVPKTAGRDVFKLVKNKSGDPTPEYLFNPYNNIDTGTAYFHILKTRYLKDIRHPTSKQYSMISAYNGGA
GGVFNTFSSSRSRAINDINSLQPNQVYWALTKSTKMQRPDAT

Sequences:

>Translated_362_residues
MKKIILIASTCLLLTSCSRESIESTFGVNYDTTNRFAKNLAPLPGQFTKDIKALDSLISSFNGNIEKRWGKKNLVTAGKR
SYVKYTDGYLSRSQVDFTNGRVTVETVAGTDPKAHLRQAIITTLLTPEDPASVDLYSDADVTLGGKPFLYQQVLDQDKKP
IEWSWRASRYADYLIAHHLKQKNVDYKKAYYVDIPMVKNHTQLREYKYADIVRKASLKYDIPEDLIYSIIRTESSFNPYA
VSWANAYGLMQVVPKTAGRDVFKLVKNKSGDPTPEYLFNPYNNIDTGTAYFHILKTRYLKDIRHPTSKQYSMISAYNGGA
GGVFNTFSSSRSRAINDINSLQPNQVYWALTKSTKMQRPDAT
>Mature_362_residues
MKKIILIASTCLLLTSCSRESIESTFGVNYDTTNRFAKNLAPLPGQFTKDIKALDSLISSFNGNIEKRWGKKNLVTAGKR
SYVKYTDGYLSRSQVDFTNGRVTVETVAGTDPKAHLRQAIITTLLTPEDPASVDLYSDADVTLGGKPFLYQQVLDQDKKP
IEWSWRASRYADYLIAHHLKQKNVDYKKAYYVDIPMVKNHTQLREYKYADIVRKASLKYDIPEDLIYSIIRTESSFNPYA
VSWANAYGLMQVVPKTAGRDVFKLVKNKSGDPTPEYLFNPYNNIDTGTAYFHILKTRYLKDIRHPTSKQYSMISAYNGGA
GGVFNTFSSSRSRAINDINSLQPNQVYWALTKSTKMQRPDAT

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division [H]

COG id: COG0741

COG function: function code M; Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains)

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transglycosylase slt family [H]

Homologues:

Organism=Escherichia coli, GI87082191, Length=306, Percent_Identity=51.9607843137255, Blast_Score=318, Evalue=4e-88,
Organism=Escherichia coli, GI87081855, Length=142, Percent_Identity=42.2535211267606, Blast_Score=109, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008258
- InterPro:   IPR000189 [H]

Pfam domain/function: PF01464 SLT [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 41038; Mature: 41038

Theoretical pI: Translated: 9.87; Mature: 9.87

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00922 TRANSGLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKIILIASTCLLLTSCSRESIESTFGVNYDTTNRFAKNLAPLPGQFTKDIKALDSLISS
CCEEEEEHHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHH
FNGNIEKRWGKKNLVTAGKRSYVKYTDGYLSRSQVDFTNGRVTVETVAGTDPKAHLRQAI
HCCCHHHHCCCCCCCCCCCCCEEEECCCCCCCCEEEECCCEEEEEEECCCCHHHHHHHHH
ITTLLTPEDPASVDLYSDADVTLGGKPFLYQQVLDQDKKPIEWSWRASRYADYLIAHHLK
HHHHCCCCCCCCEEEECCCCEEECCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
QKNVDYKKAYYVDIPMVKNHTQLREYKYADIVRKASLKYDIPEDLIYSIIRTESSFNPYA
HCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCEE
VSWANAYGLMQVVPKTAGRDVFKLVKNKSGDPTPEYLFNPYNNIDTGTAYFHILKTRYLK
EEHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHH
DIRHPTSKQYSMISAYNGGAGGVFNTFSSSRSRAINDINSLQPNQVYWALTKSTKMQRPD
HHCCCCCHHEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCC
AT
CC
>Mature Secondary Structure
MKKIILIASTCLLLTSCSRESIESTFGVNYDTTNRFAKNLAPLPGQFTKDIKALDSLISS
CCEEEEEHHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHH
FNGNIEKRWGKKNLVTAGKRSYVKYTDGYLSRSQVDFTNGRVTVETVAGTDPKAHLRQAI
HCCCHHHHCCCCCCCCCCCCCEEEECCCCCCCCEEEECCCEEEEEEECCCCHHHHHHHHH
ITTLLTPEDPASVDLYSDADVTLGGKPFLYQQVLDQDKKPIEWSWRASRYADYLIAHHLK
HHHHCCCCCCCCEEEECCCCEEECCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
QKNVDYKKAYYVDIPMVKNHTQLREYKYADIVRKASLKYDIPEDLIYSIIRTESSFNPYA
HCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCEE
VSWANAYGLMQVVPKTAGRDVFKLVKNKSGDPTPEYLFNPYNNIDTGTAYFHILKTRYLK
EEHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHH
DIRHPTSKQYSMISAYNGGAGGVFNTFSSSRSRAINDINSLQPNQVYWALTKSTKMQRPD
HHCCCCCHHEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCC
AT
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic Bond Between N-Acetylmuramic Acid And N-Acetylglucosamine Residues, Thereby Conserving The Energy In A Newly Synthesized 1,6-Anhydrobond In The Muramic Acid Residue. [C]

General reaction: Cleavage Of The Beta-1,4-Glycosidic Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA