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The map label for this gene is clpC

Identifier: 170757820

GI number: 170757820

Start: 3809259

End: 3811694

Strand: Reverse

Name: clpC

Synonym: CLD_0992

Alternate gene names: 170757820

Gene position: 3811694-3809259 (Counterclockwise)

Preceding gene: 170754684

Following gene: 170757152

Centisome position: 96.3

GC content: 31.28

Gene sequence:

>2436_bases
ATGATGTTTGGAAGATTTACGGAAAGAGCTCAGAAAGTACTTATGAATGCTCAGGAAGAAGCAGAAAAATTTAAACATGG
ATATGTAGGTACAGAACATATTCTTTTAGGAATTTTAATAGAAGATGGAGTAGCCAAAGAATTATTAAATAATTTTAGTA
TAACAGAAGATAAAGTTAGACAGTTAATAGAGAGATATGAAGGAAAAGGGGAAATGGATCTTTATAAAAATGAGATTCCA
CTTACACCAAGAACAAAAAGGTTACTTGAAATGAGTTTATTAGAAGCTAGAAATTTAAATCATAATTATATAACTCCAGA
ACATATATTATTGGGATTAATAAGAGAAGCTGAAGGGGTAGCCTTTACCATTCTTTCTAATTTAGGCTTAGATGCTGAAA
GATTAAGAAAAGAGTTAATAAAGAATTTATCTGGGCAAGAAACTCCTAAAGATGAAGGCAGTAAAAAAAGTTCTAAAAGC
TCTACCCCTACATTAGACCAATTTGGAAGAGATTTAACTGAAATGGCAGAAGAGGGGAAGGTTGACCCTGTTATTGGAAG
AGATAAAGAAACCCAAAGAGTTTTAGAAATATTATGTAGAAGAACTAAGAACAATCCTTGCTTAATAGGTGAACCAGGAG
TTGGGAAAACAGCAATAGCCGAAGGCTTAGCTCAAAATATAATTGATGGAAATATACCAGAAATATTAAAAAACAAAAGA
GTAGTTACATTAGACTTAACATCTATGATAGCAGGGGCCAAGTATAGGGGTGAATTTGAGGATAGATTAAAGAAAATAAT
GGAGGAAGTAAGAAGTTCTAAGGATACAATATTGTTTATAGATGAAATTCATACAATAGTTGGAGCTGGGGCAGCAGAAG
GGGCTATAGATGCAGCAAACATATTAAAACCAGCATTAGCAAGAGGAGAAATTCAATGTATAGGTGCAACTACACTAGAT
GAATATAGAAAGTATATAGAAAAAGATTCTGCTTTAGAGAGAAGATTCCAGCCTATAAACGTAGGAGAACCTACAAAAGA
AGAAACAATAGAAATTTTAAAGGGATTAAGAGATAAGTATGAAGCACATCATAGAGTTAAATTTACAGATGATGCTATAT
ATGCAGCAGTTAATTTATCTGATAGATATATAAGAGATAGATTTTTGCCAGATAAAGCGATAGATCTGATGGATGAAGCT
GGTTCCAAGGTTAGAATACAAAATTTAATTGCACCACCAGATCTGAAGAATATAGAAGAACAACTAGATAAAGTTGTTAA
AGAAAAAGAAGATGCAATAAGAGTGCAGGATTTTGAAAAAGCCGCTAATTTAAGAGATAAAGAAAAAGAATTAAAAGAAA
AGTTAGAAGGGTTGAAAAAGGATTGGAATGCAGAAAAAGAAGGCTCTAATTTAATTGTATCAGAACAACAAATAGCAGCA
GTAGTTTCAAATTGGACTAATATACCAGTTAATAAGCTTACTGAGAAGGAATCTGAAAGACTCTTAAAATTAGAAGATAT
TCTTCATAACAGGGTAATTGGCCAAGAAGAAGCTATTAAATCAGTATCAAGATCTGTAAGAAGAGCAAGAGTAGGCTTGA
AAGATCCAAAGAGACCAATAGGTTCATTTATATTTTTGGGACCAACAGGTGTAGGGAAAACTGAATTGACTAAAGCCTTA
GCAGAAGCTATGTTTGGAAATGAAAATAATATGATTAGGGTTGACATGTCAGAATATATGGAAAAACATTCAGTATCTAG
ATTAATAGGATCACCTCCAGGATATGTAGGGCACGATGAAGGTGGTCAATTAACAGACAAGGTAAGGACAAATCCATATT
CAGTTGTTTTATTTGATGAAATAGAAAAAGCTCATCCAGAAGTGTTTAATATATTACTTCAAATATTAGAAGATGGAAGG
CTTACAGATGGAAAAGGAAAAACAGTAGATTTTAGGAATACTATAATCATAATGACATCTAATGTGGGAGCATCAACTAT
AAGTAGGCAAAAGACATTAGGTTTTAATACCTCCATAGAGGAAGAAAGAGAAACAGAATATGAAAAAATGAAGGATAACA
TTATGAATGAATTAAAACATTCATTTAGGCCAGAATTCTTAAATAGAATAGATGATATAATAGTTTTCCATCAATTAAGA
GAAGAGCATATTAGAGAAATAGTTAAACTTATGCTAAAAACTGTATCAAATAGAGTTAAAGATCAAGGAATAAAATTAGA
GTTTACAGAAGAAGCAGAAAAAATATTGGCAAAAGAAGGATACGATACTAATTATGGAGCGAGGCCTTTAAGAAGAGCTA
TAACTAAAATTGTAGAAGATAAATTGTCAGAAGAAATATTAAAGGGAAATATTAAAAAAGGTGATTCAGTTAAAGTTAAT
ACAATTGAAGATAAATTAAATTTTTGTAAGATGTAA

Upstream 100 bases:

>100_bases
ATTTATGATAAAGAAATGACTGAAAAAGAAAGCAAGTATTATAGGGCTATGTTAGTTAAAGAAAGATTAAAAAAACAAAA
GTTTAAGGAGGGTGATTAAT

Downstream 100 bases:

>100_bases
ATTTTGAATTTAATTTTAAGCCAATAATTAAATTTATTTAATTATTGGTTTTTTTAAAATTATTTTTACTAATTGATGTT
ATAATAATATTATTGTAATT

Product: negative regulator of genetic competence MecB/ClpC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 811; Mature: 811

Protein sequence:

>811_residues
MMFGRFTERAQKVLMNAQEEAEKFKHGYVGTEHILLGILIEDGVAKELLNNFSITEDKVRQLIERYEGKGEMDLYKNEIP
LTPRTKRLLEMSLLEARNLNHNYITPEHILLGLIREAEGVAFTILSNLGLDAERLRKELIKNLSGQETPKDEGSKKSSKS
STPTLDQFGRDLTEMAEEGKVDPVIGRDKETQRVLEILCRRTKNNPCLIGEPGVGKTAIAEGLAQNIIDGNIPEILKNKR
VVTLDLTSMIAGAKYRGEFEDRLKKIMEEVRSSKDTILFIDEIHTIVGAGAAEGAIDAANILKPALARGEIQCIGATTLD
EYRKYIEKDSALERRFQPINVGEPTKEETIEILKGLRDKYEAHHRVKFTDDAIYAAVNLSDRYIRDRFLPDKAIDLMDEA
GSKVRIQNLIAPPDLKNIEEQLDKVVKEKEDAIRVQDFEKAANLRDKEKELKEKLEGLKKDWNAEKEGSNLIVSEQQIAA
VVSNWTNIPVNKLTEKESERLLKLEDILHNRVIGQEEAIKSVSRSVRRARVGLKDPKRPIGSFIFLGPTGVGKTELTKAL
AEAMFGNENNMIRVDMSEYMEKHSVSRLIGSPPGYVGHDEGGQLTDKVRTNPYSVVLFDEIEKAHPEVFNILLQILEDGR
LTDGKGKTVDFRNTIIIMTSNVGASTISRQKTLGFNTSIEEERETEYEKMKDNIMNELKHSFRPEFLNRIDDIIVFHQLR
EEHIREIVKLMLKTVSNRVKDQGIKLEFTEEAEKILAKEGYDTNYGARPLRRAITKIVEDKLSEEILKGNIKKGDSVKVN
TIEDKLNFCKM

Sequences:

>Translated_811_residues
MMFGRFTERAQKVLMNAQEEAEKFKHGYVGTEHILLGILIEDGVAKELLNNFSITEDKVRQLIERYEGKGEMDLYKNEIP
LTPRTKRLLEMSLLEARNLNHNYITPEHILLGLIREAEGVAFTILSNLGLDAERLRKELIKNLSGQETPKDEGSKKSSKS
STPTLDQFGRDLTEMAEEGKVDPVIGRDKETQRVLEILCRRTKNNPCLIGEPGVGKTAIAEGLAQNIIDGNIPEILKNKR
VVTLDLTSMIAGAKYRGEFEDRLKKIMEEVRSSKDTILFIDEIHTIVGAGAAEGAIDAANILKPALARGEIQCIGATTLD
EYRKYIEKDSALERRFQPINVGEPTKEETIEILKGLRDKYEAHHRVKFTDDAIYAAVNLSDRYIRDRFLPDKAIDLMDEA
GSKVRIQNLIAPPDLKNIEEQLDKVVKEKEDAIRVQDFEKAANLRDKEKELKEKLEGLKKDWNAEKEGSNLIVSEQQIAA
VVSNWTNIPVNKLTEKESERLLKLEDILHNRVIGQEEAIKSVSRSVRRARVGLKDPKRPIGSFIFLGPTGVGKTELTKAL
AEAMFGNENNMIRVDMSEYMEKHSVSRLIGSPPGYVGHDEGGQLTDKVRTNPYSVVLFDEIEKAHPEVFNILLQILEDGR
LTDGKGKTVDFRNTIIIMTSNVGASTISRQKTLGFNTSIEEERETEYEKMKDNIMNELKHSFRPEFLNRIDDIIVFHQLR
EEHIREIVKLMLKTVSNRVKDQGIKLEFTEEAEKILAKEGYDTNYGARPLRRAITKIVEDKLSEEILKGNIKKGDSVKVN
TIEDKLNFCKM
>Mature_811_residues
MMFGRFTERAQKVLMNAQEEAEKFKHGYVGTEHILLGILIEDGVAKELLNNFSITEDKVRQLIERYEGKGEMDLYKNEIP
LTPRTKRLLEMSLLEARNLNHNYITPEHILLGLIREAEGVAFTILSNLGLDAERLRKELIKNLSGQETPKDEGSKKSSKS
STPTLDQFGRDLTEMAEEGKVDPVIGRDKETQRVLEILCRRTKNNPCLIGEPGVGKTAIAEGLAQNIIDGNIPEILKNKR
VVTLDLTSMIAGAKYRGEFEDRLKKIMEEVRSSKDTILFIDEIHTIVGAGAAEGAIDAANILKPALARGEIQCIGATTLD
EYRKYIEKDSALERRFQPINVGEPTKEETIEILKGLRDKYEAHHRVKFTDDAIYAAVNLSDRYIRDRFLPDKAIDLMDEA
GSKVRIQNLIAPPDLKNIEEQLDKVVKEKEDAIRVQDFEKAANLRDKEKELKEKLEGLKKDWNAEKEGSNLIVSEQQIAA
VVSNWTNIPVNKLTEKESERLLKLEDILHNRVIGQEEAIKSVSRSVRRARVGLKDPKRPIGSFIFLGPTGVGKTELTKAL
AEAMFGNENNMIRVDMSEYMEKHSVSRLIGSPPGYVGHDEGGQLTDKVRTNPYSVVLFDEIEKAHPEVFNILLQILEDGR
LTDGKGKTVDFRNTIIIMTSNVGASTISRQKTLGFNTSIEEERETEYEKMKDNIMNELKHSFRPEFLNRIDDIIVFHQLR
EEHIREIVKLMLKTVSNRVKDQGIKLEFTEEAEKILAKEGYDTNYGARPLRRAITKIVEDKLSEEILKGNIKKGDSVKVN
TIEDKLNFCKM

Specific function: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=322, Percent_Identity=37.888198757764, Blast_Score=215, Evalue=2e-55,
Organism=Escherichia coli, GI1788943, Length=880, Percent_Identity=44.2045454545455, Blast_Score=713, Evalue=0.0,
Organism=Escherichia coli, GI1787109, Length=802, Percent_Identity=38.2793017456359, Blast_Score=552, Evalue=1e-158,
Organism=Saccharomyces cerevisiae, GI6320464, Length=710, Percent_Identity=45.0704225352113, Blast_Score=582, Evalue=1e-167,
Organism=Saccharomyces cerevisiae, GI6323002, Length=889, Percent_Identity=37.2328458942632, Blast_Score=502, Evalue=1e-142,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150
- InterPro:   IPR001943 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 91973; Mature: 91973

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS50151 UVR ; PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMFGRFTERAQKVLMNAQEEAEKFKHGYVGTEHILLGILIEDGVAKELLNNFSITEDKVR
CCCCHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHCCCCCHHHHH
QLIERYEGKGEMDLYKNEIPLTPRTKRLLEMSLLEARNLNHNYITPEHILLGLIREAEGV
HHHHHHCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCC
AFTILSNLGLDAERLRKELIKNLSGQETPKDEGSKKSSKSSTPTLDQFGRDLTEMAEEGK
EEEHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHCHHHHHHHHCCC
VDPVIGRDKETQRVLEILCRRTKNNPCLIGEPGVGKTAIAEGLAQNIIDGNIPEILKNKR
CCCCCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHCCCCCHHHHHCCC
VVTLDLTSMIAGAKYRGEFEDRLKKIMEEVRSSKDTILFIDEIHTIVGAGAAEGAIDAAN
EEEEEHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEEHHHHHHHHCCCCCCCCCHHHH
ILKPALARGEIQCIGATTLDEYRKYIEKDSALERRFQPINVGEPTKEETIEILKGLRDKY
HHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
EAHHRVKFTDDAIYAAVNLSDRYIRDRFLPDKAIDLMDEAGSKVRIQNLIAPPDLKNIEE
HHHCCEEECCCCEEEEECCHHHHHHHHCCCHHHHHHHHHCCCEEEEHHCCCCCCHHHHHH
QLDKVVKEKEDAIRVQDFEKAANLRDKEKELKEKLEGLKKDWNAEKEGSNLIVSEQQIAA
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEECHHHHHH
VVSNWTNIPVNKLTEKESERLLKLEDILHNRVIGQEEAIKSVSRSVRRARVGLKDPKRPI
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCC
GSFIFLGPTGVGKTELTKALAEAMFGNENNMIRVDMSEYMEKHSVSRLIGSPPGYVGHDE
CCEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHCCCCCCCCCCC
GGQLTDKVRTNPYSVVLFDEIEKAHPEVFNILLQILEDGRLTDGKGKTVDFRNTIIIMTS
CCCCHHHHCCCCEEEEEEHHHHHHCHHHHHHHHHHHHCCCCCCCCCCEEEECCEEEEEEC
NVGASTISRQKTLGFNTSIEEERETEYEKMKDNIMNELKHSFRPEFLNRIDDIIVFHQLR
CCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
EEHIREIVKLMLKTVSNRVKDQGIKLEFTEEAEKILAKEGYDTNYGARPLRRAITKIVED
HHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
KLSEEILKGNIKKGDSVKVNTIEDKLNFCKM
HHHHHHHHCCCCCCCCEEEEEHHHHHHHHCC
>Mature Secondary Structure
MMFGRFTERAQKVLMNAQEEAEKFKHGYVGTEHILLGILIEDGVAKELLNNFSITEDKVR
CCCCHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHCCCCCHHHHH
QLIERYEGKGEMDLYKNEIPLTPRTKRLLEMSLLEARNLNHNYITPEHILLGLIREAEGV
HHHHHHCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCC
AFTILSNLGLDAERLRKELIKNLSGQETPKDEGSKKSSKSSTPTLDQFGRDLTEMAEEGK
EEEHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHCHHHHHHHHCCC
VDPVIGRDKETQRVLEILCRRTKNNPCLIGEPGVGKTAIAEGLAQNIIDGNIPEILKNKR
CCCCCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHCCCCCHHHHHCCC
VVTLDLTSMIAGAKYRGEFEDRLKKIMEEVRSSKDTILFIDEIHTIVGAGAAEGAIDAAN
EEEEEHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEEHHHHHHHHCCCCCCCCCHHHH
ILKPALARGEIQCIGATTLDEYRKYIEKDSALERRFQPINVGEPTKEETIEILKGLRDKY
HHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
EAHHRVKFTDDAIYAAVNLSDRYIRDRFLPDKAIDLMDEAGSKVRIQNLIAPPDLKNIEE
HHHCCEEECCCCEEEEECCHHHHHHHHCCCHHHHHHHHHCCCEEEEHHCCCCCCHHHHHH
QLDKVVKEKEDAIRVQDFEKAANLRDKEKELKEKLEGLKKDWNAEKEGSNLIVSEQQIAA
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEECHHHHHH
VVSNWTNIPVNKLTEKESERLLKLEDILHNRVIGQEEAIKSVSRSVRRARVGLKDPKRPI
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCC
GSFIFLGPTGVGKTELTKALAEAMFGNENNMIRVDMSEYMEKHSVSRLIGSPPGYVGHDE
CCEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHCCCCCCCCCCC
GGQLTDKVRTNPYSVVLFDEIEKAHPEVFNILLQILEDGRLTDGKGKTVDFRNTIIIMTS
CCCCHHHHCCCCEEEEEEHHHHHHCHHHHHHHHHHHHCCCCCCCCCCEEEECCEEEEEEC
NVGASTISRQKTLGFNTSIEEERETEYEKMKDNIMNELKHSFRPEFLNRIDDIIVFHQLR
CCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
EEHIREIVKLMLKTVSNRVKDQGIKLEFTEEAEKILAKEGYDTNYGARPLRRAITKIVED
HHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
KLSEEILKGNIKKGDSVKVNTIEDKLNFCKM
HHHHHHHHCCCCCCCCEEEEEHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12235376 [H]