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The map label for this gene is patB [H]

Identifier: 170757605

GI number: 170757605

Start: 2101615

End: 2102784

Strand: Reverse

Name: patB [H]

Synonym: CLD_2661

Alternate gene names: 170757605

Gene position: 2102784-2101615 (Counterclockwise)

Preceding gene: 170757074

Following gene: 170755826

Centisome position: 53.12

GC content: 39.91

Gene sequence:

>1170_bases
ATGAAATATGATTTTGATGAAATCATTGACCGCAGCAATAATCGTGCAGCAAAGTATGATGAACGGGTGAAAAAATTCGG
TACCAGTGAAGTGATTCCTTTGTGGATTGCGGATATGGATTTCAGAACTGCTCAACCAATCATCGATGCTTGCAAAAGAA
AAGCAGAGGAAGGCGTCTGGGGTTATACTTCTAGGCCGGACAGCTACTTTAAGGCCGTACAGGAATGGGAAAAAAGGCGG
AATCAATGGGATGTTGATGTATCCCTGATGAGCTGGAGCTTAGGGGTTGTTCCTGCATTATCGGCTATTGTCAAAATTTT
CAGCCACACTGGCGACAAAATTTTGATTCAGACTCCGGTTTATTCAGAGTTTTATGATATCACAGAGGCTTGGGGACGAG
TAGTGATAGAAAACCAGTTTATAGAAAAAAATGGAAAATGGTATATTGATTTTGAGGATTTTGAAAAAAAGGCAAAAGAG
TGTAAGATTTTTCTTCTATGTAATCCCCACAATCCACTGGGCATTGTATGGGAGCCGGAGGAATTAAAACGGATGGCGGA
AATATGCATTGCAAATGATGTACTTCTGGTGTCAGATGAGATACACTCAGATTTAATTTTCCATGGAAAGAAGCATACGC
CTACAGCAACACTTTCAAAAGAAGTTGCAAAAAAAATTATTACCTGTGTATCTGCAACTAAAACTTTCAACCTAGCAGGT
CTTCAAGCTTCTACGACTATCTTTCCAAATGAACAGATAAAGCAGAAGTTCGATGGCCTCTGGATGAATATGGATATTCA
AAGAAACAATGCCTTTAGCTCAGTGGCCATGGAAGTAGCTTACAATGAAGGCGAGGAGTGGCTAACACAGTTGCTTGCTT
ACGTATCAGAAAACTTTGATTTTATTAAAAAATATTTTGATGAAAACATTCCAAAAATCAAGCCTAATGTTCCAGATGCT
ACATATCTGGTCTGGCTGGACTGCCGAGAATTAGGCATGAGCAATGAAGAGCTCCGTGACTTCATGGTTCATAAGGCTGG
TTTAGGCTTAAATGAAGGATGTAGTTTTGGACGCAGTCTTTCCGGATACATGAGACTTAATGCAGCATGCCCGCGCTCTG
TACTGGAACAGGCATTGAAACAGTTAAAAGAAGCAATCGATAAATTATAA

Upstream 100 bases:

>100_bases
TTTTGTTTAAAAATGCAAAAAAATTTTTTGGCATGGTTTTTGCTCATTATATTAGTATCAACTGTAAACAACAAGGACAG
TGAGGAAAGGAAGATTTATT

Downstream 100 bases:

>100_bases
AATACAAAAGCTAGGGTTTTTATGAAATGCTGGAAAGGAGAAAATATGGGGAAGAAGAAAATATGGGAGAGTTATCGATC
TCCACTCATTTTACTTGGGG

Product: aminotransferase, classes I and II

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MKYDFDEIIDRSNNRAAKYDERVKKFGTSEVIPLWIADMDFRTAQPIIDACKRKAEEGVWGYTSRPDSYFKAVQEWEKRR
NQWDVDVSLMSWSLGVVPALSAIVKIFSHTGDKILIQTPVYSEFYDITEAWGRVVIENQFIEKNGKWYIDFEDFEKKAKE
CKIFLLCNPHNPLGIVWEPEELKRMAEICIANDVLLVSDEIHSDLIFHGKKHTPTATLSKEVAKKIITCVSATKTFNLAG
LQASTTIFPNEQIKQKFDGLWMNMDIQRNNAFSSVAMEVAYNEGEEWLTQLLAYVSENFDFIKKYFDENIPKIKPNVPDA
TYLVWLDCRELGMSNEELRDFMVHKAGLGLNEGCSFGRSLSGYMRLNAACPRSVLEQALKQLKEAIDKL

Sequences:

>Translated_389_residues
MKYDFDEIIDRSNNRAAKYDERVKKFGTSEVIPLWIADMDFRTAQPIIDACKRKAEEGVWGYTSRPDSYFKAVQEWEKRR
NQWDVDVSLMSWSLGVVPALSAIVKIFSHTGDKILIQTPVYSEFYDITEAWGRVVIENQFIEKNGKWYIDFEDFEKKAKE
CKIFLLCNPHNPLGIVWEPEELKRMAEICIANDVLLVSDEIHSDLIFHGKKHTPTATLSKEVAKKIITCVSATKTFNLAG
LQASTTIFPNEQIKQKFDGLWMNMDIQRNNAFSSVAMEVAYNEGEEWLTQLLAYVSENFDFIKKYFDENIPKIKPNVPDA
TYLVWLDCRELGMSNEELRDFMVHKAGLGLNEGCSFGRSLSGYMRLNAACPRSVLEQALKQLKEAIDKL
>Mature_389_residues
MKYDFDEIIDRSNNRAAKYDERVKKFGTSEVIPLWIADMDFRTAQPIIDACKRKAEEGVWGYTSRPDSYFKAVQEWEKRR
NQWDVDVSLMSWSLGVVPALSAIVKIFSHTGDKILIQTPVYSEFYDITEAWGRVVIENQFIEKNGKWYIDFEDFEKKAKE
CKIFLLCNPHNPLGIVWEPEELKRMAEICIANDVLLVSDEIHSDLIFHGKKHTPTATLSKEVAKKIITCVSATKTFNLAG
LQASTTIFPNEQIKQKFDGLWMNMDIQRNNAFSSVAMEVAYNEGEEWLTQLLAYVSENFDFIKKYFDENIPKIKPNVPDA
TYLVWLDCRELGMSNEELRDFMVHKAGLGLNEGCSFGRSLSGYMRLNAACPRSVLEQALKQLKEAIDKL

Specific function: Catalyzes the transformation of cystathionine to homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI56713256, Length=283, Percent_Identity=26.5017667844523, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI56713254, Length=284, Percent_Identity=27.4647887323944, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI95147551, Length=259, Percent_Identity=23.1660231660232, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI169881279, Length=259, Percent_Identity=23.1660231660232, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1787909, Length=388, Percent_Identity=29.8969072164948, Blast_Score=224, Evalue=8e-60,
Organism=Escherichia coli, GI1788627, Length=196, Percent_Identity=23.469387755102, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322401, Length=142, Percent_Identity=31.6901408450704, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI28573069, Length=253, Percent_Identity=25.6916996047431, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24646114, Length=253, Percent_Identity=25.6916996047431, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI28573067, Length=253, Percent_Identity=25.6916996047431, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI28573065, Length=253, Percent_Identity=25.6916996047431, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI18859735, Length=392, Percent_Identity=20.9183673469388, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 44781; Mature: 44781

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYDFDEIIDRSNNRAAKYDERVKKFGTSEVIPLWIADMDFRTAQPIIDACKRKAEEGVW
CCCCHHHHHCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCC
GYTSRPDSYFKAVQEWEKRRNQWDVDVSLMSWSLGVVPALSAIVKIFSHTGDKILIQTPV
CCCCCCHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCEEEEECCC
YSEFYDITEAWGRVVIENQFIEKNGKWYIDFEDFEKKAKECKIFLLCNPHNPLGIVWEPE
HHHHHHHHHHHCCEEEEHHHCCCCCCEEEEHHHHHHHHHHCEEEEEECCCCCEEEEECHH
ELKRMAEICIANDVLLVSDEIHSDLIFHGKKHTPTATLSKEVAKKIITCVSATKTFNLAG
HHHHHHHHHHHCCEEEEECHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCEEEEEC
LQASTTIFPNEQIKQKFDGLWMNMDIQRNNAFSSVAMEVAYNEGEEWLTQLLAYVSENFD
CCCCCEECCCHHHHHHHCCEEEEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCHH
FIKKYFDENIPKIKPNVPDATYLVWLDCRELGMSNEELRDFMVHKAGLGLNEGCSFGRSL
HHHHHHHCCCCCCCCCCCCCEEEEEEEHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCC
SGYMRLNAACPRSVLEQALKQLKEAIDKL
CHHEEECCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKYDFDEIIDRSNNRAAKYDERVKKFGTSEVIPLWIADMDFRTAQPIIDACKRKAEEGVW
CCCCHHHHHCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCC
GYTSRPDSYFKAVQEWEKRRNQWDVDVSLMSWSLGVVPALSAIVKIFSHTGDKILIQTPV
CCCCCCHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCEEEEECCC
YSEFYDITEAWGRVVIENQFIEKNGKWYIDFEDFEKKAKECKIFLLCNPHNPLGIVWEPE
HHHHHHHHHHHCCEEEEHHHCCCCCCEEEEHHHHHHHHHHCEEEEEECCCCCEEEEECHH
ELKRMAEICIANDVLLVSDEIHSDLIFHGKKHTPTATLSKEVAKKIITCVSATKTFNLAG
HHHHHHHHHHHCCEEEEECHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCEEEEEC
LQASTTIFPNEQIKQKFDGLWMNMDIQRNNAFSSVAMEVAYNEGEEWLTQLLAYVSENFD
CCCCCEECCCHHHHHHHCCEEEEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCHH
FIKKYFDENIPKIKPNVPDATYLVWLDCRELGMSNEELRDFMVHKAGLGLNEGCSFGRSL
HHHHHHHCCCCCCCCCCCCCEEEEEEEHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCC
SGYMRLNAACPRSVLEQALKQLKEAIDKL
CHHEEECCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8497199; 9274030; 9384377 [H]