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The map label for this gene is walR [H]

Identifier: 170757493

GI number: 170757493

Start: 1445514

End: 1446038

Strand: Direct

Name: walR [H]

Synonym: CLD_3258

Alternate gene names: 170757493

Gene position: 1445514-1446038 (Clockwise)

Preceding gene: 170754742

Following gene: 170757451

Centisome position: 36.52

GC content: 25.71

Gene sequence:

>525_bases
ATGAAAAGTACATTGCTTGTAGAGGATAATATGTCATTAAATAGAGGAATACAATTTTCTCTTATGAAGGAAGGATATAA
TGTTATAGCTACAGATAGTATAAAAGAATCCCAGCAAAAGCTTAATAAAGAAAAAGTAGATTTAATAATATTGGATATTA
ATTTACCAGATGGAAATGGGTTCGATTATTGCTTAGATATTAGAAAAACTAGTAATATTCCCATAATATTTTTAACAGCT
CTTGATTCTGAAATAGATGTGGTAAATAGTTTGGATATGGGAGCAGATGATTATATAACTAAACCTTTTAGATTAAGAGA
GCTTATTTCAAGAGTTAATGCCATAATAAGGAGGGCATCAAATGATTGCGACTTTAATATAATTCAGTCAAAGGATATAG
TTTTTTATATTAATGAAATGAAGATTGAAAAGCATGGAAAAGAAATTTTTTTAAGTAAGACAGAATTAAAATTACTTCAA
TATTTTATGAAAAATTATCAAAAAATATTATCAATAGAGGACTAA

Upstream 100 bases:

>100_bases
TATTACATTTATAACTGTATTTGATATATTATTTATGTAGAGTATATCTAGAATATTAAAATAAAGCTTATTTAGAGAAA
TTAATTTAAGAGGTGGAATA

Downstream 100 bases:

>100_bases
AGTTAGGGGATATAGTAGAATTAATAGTCTATGAATCAGTAAGTACTGATAAAGAAGGTAGAAAAATTTATGAGGGTAAA
AAAACTATTTATAAATTTAA

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 174; Mature: 174

Protein sequence:

>174_residues
MKSTLLVEDNMSLNRGIQFSLMKEGYNVIATDSIKESQQKLNKEKVDLIILDINLPDGNGFDYCLDIRKTSNIPIIFLTA
LDSEIDVVNSLDMGADDYITKPFRLRELISRVNAIIRRASNDCDFNIIQSKDIVFYINEMKIEKHGKEIFLSKTELKLLQ
YFMKNYQKILSIED

Sequences:

>Translated_174_residues
MKSTLLVEDNMSLNRGIQFSLMKEGYNVIATDSIKESQQKLNKEKVDLIILDINLPDGNGFDYCLDIRKTSNIPIIFLTA
LDSEIDVVNSLDMGADDYITKPFRLRELISRVNAIIRRASNDCDFNIIQSKDIVFYINEMKIEKHGKEIFLSKTELKLLQ
YFMKNYQKILSIED
>Mature_174_residues
MKSTLLVEDNMSLNRGIQFSLMKEGYNVIATDSIKESQQKLNKEKVDLIILDINLPDGNGFDYCLDIRKTSNIPIIFLTA
LDSEIDVVNSLDMGADDYITKPFRLRELISRVNAIIRRASNDCDFNIIQSKDIVFYINEMKIEKHGKEIFLSKTELKLLQ
YFMKNYQKILSIED

Specific function: Member of the two-component regulatory system walK/walR that regulates genes involved in autolysis, biofilm formation and cell wall metabolism [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786911, Length=172, Percent_Identity=32.5581395348837, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1786599, Length=175, Percent_Identity=31.4285714285714, Blast_Score=107, Evalue=5e-25,
Organism=Escherichia coli, GI1787229, Length=175, Percent_Identity=34.8571428571429, Blast_Score=103, Evalue=9e-24,
Organism=Escherichia coli, GI1790552, Length=160, Percent_Identity=33.125, Blast_Score=101, Evalue=4e-23,
Organism=Escherichia coli, GI1789809, Length=175, Percent_Identity=30.8571428571429, Blast_Score=97, Evalue=5e-22,
Organism=Escherichia coli, GI1786784, Length=168, Percent_Identity=32.7380952380952, Blast_Score=92, Evalue=2e-20,
Organism=Escherichia coli, GI1789402, Length=168, Percent_Identity=32.1428571428571, Blast_Score=92, Evalue=2e-20,
Organism=Escherichia coli, GI1790863, Length=175, Percent_Identity=31.4285714285714, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1790860, Length=161, Percent_Identity=30.4347826086957, Blast_Score=87, Evalue=6e-19,
Organism=Escherichia coli, GI1788394, Length=171, Percent_Identity=32.1637426900585, Blast_Score=87, Evalue=9e-19,
Organism=Escherichia coli, GI2367329, Length=180, Percent_Identity=33.8888888888889, Blast_Score=86, Evalue=1e-18,
Organism=Escherichia coli, GI1787375, Length=169, Percent_Identity=30.1775147928994, Blast_Score=83, Evalue=1e-17,
Organism=Escherichia coli, GI87082012, Length=114, Percent_Identity=38.5964912280702, Blast_Score=76, Evalue=1e-15,
Organism=Escherichia coli, GI145693140, Length=101, Percent_Identity=34.6534653465347, Blast_Score=66, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 20138; Mature: 20138

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSTLLVEDNMSLNRGIQFSLMKEGYNVIATDSIKESQQKLNKEKVDLIILDINLPDGNG
CCCEEEEECCCCCCCCEEEEEECCCCCEEEECCHHHHHHHCCCCCEEEEEEEEECCCCCC
FDYCLDIRKTSNIPIIFLTALDSEIDVVNSLDMGADDYITKPFRLRELISRVNAIIRRAS
CEEEEEEEECCCCCEEEEEECCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
NDCDFNIIQSKDIVFYINEMKIEKHGKEIFLSKTELKLLQYFMKNYQKILSIED
CCCCEEEEECCCEEEEEEEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKSTLLVEDNMSLNRGIQFSLMKEGYNVIATDSIKESQQKLNKEKVDLIILDINLPDGNG
CCCEEEEECCCCCCCCEEEEEECCCCCEEEECCHHHHHHHCCCCCEEEEEEEEECCCCCC
FDYCLDIRKTSNIPIIFLTALDSEIDVVNSLDMGADDYITKPFRLRELISRVNAIIRRAS
CEEEEEEEECCCCCEEEEEECCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
NDCDFNIIQSKDIVFYINEMKIEKHGKEIFLSKTELKLLQYFMKNYQKILSIED
CCCCEEEEECCCEEEEEEEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA