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The map label for this gene is mepA [H]

Identifier: 170757400

GI number: 170757400

Start: 2960463

End: 2961884

Strand: Reverse

Name: mepA [H]

Synonym: CLD_1793

Alternate gene names: 170757400

Gene position: 2961884-2960463 (Counterclockwise)

Preceding gene: 170754267

Following gene: 170756372

Centisome position: 74.83

GC content: 29.68

Gene sequence:

>1422_bases
ATGGGAATTGACTACAAGTTATTTTCAAAAGAAAAGGTAGAAAAAGCTTTATTAAAATTTGCAGTTCCAGCTATGATTTC
TTTATTAGTTATGGAATTATATAATATGGTAGATACATTTTTCGTAGGTTTAGCTATAGGGCCGAAAGCCATAGGAGCAT
TAACCATAGCCTTTCCAGTACAAAGACTTATGTCTTCACTGGGGATGATGATAGCAGTGGGTGCATCTACTGCAGTAGCC
AGAAGTTTAGGTAAAAAAGATTATGATAACCTAAAATCGGTAATATTAAACGCTATAAATATTACTATAGTTATAATGGT
AGTTTTAACTTTTATAATTTCAATCTTTAAAAAAGATATGATCACAGGCCTATTAGGTGCTAGTCAATCTATTTATCCTT
ATGCCGAAGAATACATTTCTATAGTAGTACTTGGTGGACTATTTCAAGCCCTAACTTTAGTTATTTGTTATATAATGACA
TCTTTAGGTTATACAAATATAACATTAAAAGCTACTTCGGTAGGAGCTATATTAAATGTTATAATTGACTATTTCTTAGT
TATGCATTTAAACTTTGGAGTAGCAGGAGCAGCTATAGCAACTGTGTTTTCACAAACAGTGGCATTAGTATATGCGATAT
ATAAATTTAATAAGGTTAGAAAGAAGATAGGATTAAATTTAAAATTAAATTTTGAACTTAAATTAGATATATTAAAGCCA
ATTTTAGCAGTAGGATTTTCAACCTTTATTATAGAAATATCTGATGCAGTGGTGGCAGTAATATTAAACAATATACTTTC
TATTTATGGAGGAGATAAGGCGTTGGTTATAGTAGGGGTAACTACCAAAATATCAATGTTCTTATTCATAACAGTTATAG
GCATAAGTTCGGCAATGCAACCTATAGCAGCATTTAACTATGGTGCAAAAAATTTAGTTCGTGTAAAGGAAGTAGTTATA
AAGACTATAGTAGCTGTAACAGGAGCAACTTTAATATTATGGGCAGTAATGCTTATATTTGCAAATCCTATAATAGGATT
ATTTTTAAAGGATAGAAGTCTTTTAGGTGAAACTGTAAAAGCCTTTAGAATAATAATATCTCTATTTCCAACCATAGGGA
TATATTATGTATCCATATATTATTACCAATCTATGGGAAAGGCAAGAACTTCACTTATACTATCTGTATATAGGCAAATG
ATAATATTTATACCATTATTATTTATATTAGTTGGTAAATTTGATATCATGGGAGCTTGGATAGCTTATCCAATTTCAGA
TTTAATATCAGCTATTACAGGAGTAATATATGTAAGAGTAGCATTAAAAGAAAAAAACAAAGCTATAGAAGCTCAAGAAT
ATGAAAAAGAGAAAAAAGATAAAGCATTCAAAGGAAAATCCGTAGAAGTAGGTGGCCTTTAA

Upstream 100 bases:

>100_bases
TTTATATAAGATTATAATTTTAAAAAGAAGGAGTAGATAACAAAATGAGTGCAAAAATGTTACCTAAAAATACAAAATCC
ATTAGAACGGGGTGCTTAAT

Downstream 100 bases:

>100_bases
AGTATATAACAGTAAAGATGATGAAACAGCTTAGGAAAAATATATGGTAATAATAAGAGTAAATAATTTAATAATTAATT
GAAATAAAAAGTATTTTTAT

Product: MATE efflux family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 473; Mature: 472

Protein sequence:

>473_residues
MGIDYKLFSKEKVEKALLKFAVPAMISLLVMELYNMVDTFFVGLAIGPKAIGALTIAFPVQRLMSSLGMMIAVGASTAVA
RSLGKKDYDNLKSVILNAINITIVIMVVLTFIISIFKKDMITGLLGASQSIYPYAEEYISIVVLGGLFQALTLVICYIMT
SLGYTNITLKATSVGAILNVIIDYFLVMHLNFGVAGAAIATVFSQTVALVYAIYKFNKVRKKIGLNLKLNFELKLDILKP
ILAVGFSTFIIEISDAVVAVILNNILSIYGGDKALVIVGVTTKISMFLFITVIGISSAMQPIAAFNYGAKNLVRVKEVVI
KTIVAVTGATLILWAVMLIFANPIIGLFLKDRSLLGETVKAFRIIISLFPTIGIYYVSIYYYQSMGKARTSLILSVYRQM
IIFIPLLFILVGKFDIMGAWIAYPISDLISAITGVIYVRVALKEKNKAIEAQEYEKEKKDKAFKGKSVEVGGL

Sequences:

>Translated_473_residues
MGIDYKLFSKEKVEKALLKFAVPAMISLLVMELYNMVDTFFVGLAIGPKAIGALTIAFPVQRLMSSLGMMIAVGASTAVA
RSLGKKDYDNLKSVILNAINITIVIMVVLTFIISIFKKDMITGLLGASQSIYPYAEEYISIVVLGGLFQALTLVICYIMT
SLGYTNITLKATSVGAILNVIIDYFLVMHLNFGVAGAAIATVFSQTVALVYAIYKFNKVRKKIGLNLKLNFELKLDILKP
ILAVGFSTFIIEISDAVVAVILNNILSIYGGDKALVIVGVTTKISMFLFITVIGISSAMQPIAAFNYGAKNLVRVKEVVI
KTIVAVTGATLILWAVMLIFANPIIGLFLKDRSLLGETVKAFRIIISLFPTIGIYYVSIYYYQSMGKARTSLILSVYRQM
IIFIPLLFILVGKFDIMGAWIAYPISDLISAITGVIYVRVALKEKNKAIEAQEYEKEKKDKAFKGKSVEVGGL
>Mature_472_residues
GIDYKLFSKEKVEKALLKFAVPAMISLLVMELYNMVDTFFVGLAIGPKAIGALTIAFPVQRLMSSLGMMIAVGASTAVAR
SLGKKDYDNLKSVILNAINITIVIMVVLTFIISIFKKDMITGLLGASQSIYPYAEEYISIVVLGGLFQALTLVICYIMTS
LGYTNITLKATSVGAILNVIIDYFLVMHLNFGVAGAAIATVFSQTVALVYAIYKFNKVRKKIGLNLKLNFELKLDILKPI
LAVGFSTFIIEISDAVVAVILNNILSIYGGDKALVIVGVTTKISMFLFITVIGISSAMQPIAAFNYGAKNLVRVKEVVIK
TIVAVTGATLILWAVMLIFANPIIGLFLKDRSLLGETVKAFRIIISLFPTIGIYYVSIYYYQSMGKARTSLILSVYRQMI
IFIPLLFILVGKFDIMGAWIAYPISDLISAITGVIYVRVALKEKNKAIEAQEYEKEKKDKAFKGKSVEVGGL

Specific function: Multidrug resistance efflux protein [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 51768; Mature: 51637

Theoretical pI: Translated: 10.05; Mature: 10.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIDYKLFSKEKVEKALLKFAVPAMISLLVMELYNMVDTFFVGLAIGPKAIGALTIAFPV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
QRLMSSLGMMIAVGASTAVARSLGKKDYDNLKSVILNAINITIVIMVVLTFIISIFKKDM
HHHHHHCCHHEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ITGLLGASQSIYPYAEEYISIVVLGGLFQALTLVICYIMTSLGYTNITLKATSVGAILNV
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHH
IIDYFLVMHLNFGVAGAAIATVFSQTVALVYAIYKFNKVRKKIGLNLKLNFELKLDILKP
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEHHHHHHH
ILAVGFSTFIIEISDAVVAVILNNILSIYGGDKALVIVGVTTKISMFLFITVIGISSAMQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHH
PIAAFNYGAKNLVRVKEVVIKTIVAVTGATLILWAVMLIFANPIIGLFLKDRSLLGETVK
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
AFRIIISLFPTIGIYYVSIYYYQSMGKARTSLILSVYRQMIIFIPLLFILVGKFDIMGAW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
IAYPISDLISAITGVIYVRVALKEKNKAIEAQEYEKEKKDKAFKGKSVEVGGL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEECCCC
>Mature Secondary Structure 
GIDYKLFSKEKVEKALLKFAVPAMISLLVMELYNMVDTFFVGLAIGPKAIGALTIAFPV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
QRLMSSLGMMIAVGASTAVARSLGKKDYDNLKSVILNAINITIVIMVVLTFIISIFKKDM
HHHHHHCCHHEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ITGLLGASQSIYPYAEEYISIVVLGGLFQALTLVICYIMTSLGYTNITLKATSVGAILNV
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHH
IIDYFLVMHLNFGVAGAAIATVFSQTVALVYAIYKFNKVRKKIGLNLKLNFELKLDILKP
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEHHHHHHH
ILAVGFSTFIIEISDAVVAVILNNILSIYGGDKALVIVGVTTKISMFLFITVIGISSAMQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHH
PIAAFNYGAKNLVRVKEVVIKTIVAVTGATLILWAVMLIFANPIIGLFLKDRSLLGETVK
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
AFRIIISLFPTIGIYYVSIYYYQSMGKARTSLILSVYRQMIIFIPLLFILVGKFDIMGAW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
IAYPISDLISAITGVIYVRVALKEKNKAIEAQEYEKEKKDKAFKGKSVEVGGL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA