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The map label for this gene is ilvA

Identifier: 170757357

GI number: 170757357

Start: 3801037

End: 3802254

Strand: Reverse

Name: ilvA

Synonym: CLD_0999

Alternate gene names: 170757357

Gene position: 3802254-3801037 (Counterclockwise)

Preceding gene: 170756076

Following gene: 170754736

Centisome position: 96.06

GC content: 32.35

Gene sequence:

>1218_bases
ATGGAGTTAAACTTAGATACAATAAAAAAAGCTCAAAATAACATAAAAACAGTAGTTAGAAAAACACCTTTGTTTTATTC
AAGTACTTTTTCTAGAAAAACAGGATATGAAGTATATTTAAAATGTGAAAATAAACAAAAGACCGGAGCTTTTAAATTAA
GAGGCGCATATAACAAGATAGTTTCATTAACTGAGGAAGAAAGAAAAAAGGGGGTCATTGCATCTTCAGCAGGAAATCAT
GCTCAAGGTGTTGCTTATGCAGCTACCGCCTTTGGAATAAAATCTACTATAGCTATGCCTAAAACTGCTCCTCAAGCTAA
GGTTATGGCAACAAAGGGATATGGAGCAGAAGTTGTTCAGCACGGGGAAGTTTATGATGAATGTTATGAAAAAGCATTAG
AAATACAAAAGGCTACAGGAGCTACTTTTGTACATCCTTTTAATGATATACACGTTATGGCGGGTCAAGGTACAATAGCA
TTAGAAATATTAGAAGAAATAGAAGATATAGATGCTATAATAGTTCCAATAGGAGGAGGAGGGCTAATATCAGGAATAGC
TGTAGCAGCTAAATCCATAAAGCCAGATATAAAAATTATAGGAGTTCAATCAGCTATTATAGCCTCTACAAAGGCGTCAT
TAGAAAAAAATGAAATTGTAACTTTGCCAGGAGCTAAGTCTTTAGCAGATGGTATTTCAGTAAAAACTCCAGGGGATATT
GCTTTTAAATATATTAGAGAATATGTAGATGAAGTAGTTACAGTTACAGAAGATGAAATAGCTTATGGAATTTTTGAACT
TATTGAGAAGACGAAAGTTATTGCAGAGGGTGCGGGAGCATCAACTGTTGCAGCTTTATTAGCTAATAAGATTAATATTA
AAGGTAAAAAGGTTGTAGCTCTAATAAGTGGTGGTAATATAGATATAGCTATGATATCTAAAATAATAGATAGACAGCTT
ATAATGCTTAAGAGAAGAATAAGATTTAAAGTAGAATTACAGGATAAAATAGGAGAATTCGAGGATGTTATTTCAAATAT
TGTTTCTACGGGAGCTAATATAGTTAAGGCTAGACAGGATACTAATTGGAGCGAAAAGGGGCTAGAATATGCAAATGTAA
TATTTGAAGTAGAAGTTCAGAGTAAAGAACAAGGAGATAAATTATTGAAACAACTTAGTGAAAAAGGGTATAATATACAA
ACAAATATATGTATGTAA

Upstream 100 bases:

>100_bases
GTATTAAAAGTTTATTGGGTATAGGTTAATAGATTGAATAAAAATATTATATGGTTTATTATAAAAATATAATTTAGAAT
GGGATGGGAGATAGATGATT

Downstream 100 bases:

>100_bases
TAAATTTAGTAAAATAGGAGGTAAATAGATGAAGGTTTACAACACTTTAACTAATAAAAAAGAAGAGTTTCTTACGTTAG
TACCAGGAGAAGTTAAAATG

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MELNLDTIKKAQNNIKTVVRKTPLFYSSTFSRKTGYEVYLKCENKQKTGAFKLRGAYNKIVSLTEEERKKGVIASSAGNH
AQGVAYAATAFGIKSTIAMPKTAPQAKVMATKGYGAEVVQHGEVYDECYEKALEIQKATGATFVHPFNDIHVMAGQGTIA
LEILEEIEDIDAIIVPIGGGGLISGIAVAAKSIKPDIKIIGVQSAIIASTKASLEKNEIVTLPGAKSLADGISVKTPGDI
AFKYIREYVDEVVTVTEDEIAYGIFELIEKTKVIAEGAGASTVAALLANKINIKGKKVVALISGGNIDIAMISKIIDRQL
IMLKRRIRFKVELQDKIGEFEDVISNIVSTGANIVKARQDTNWSEKGLEYANVIFEVEVQSKEQGDKLLKQLSEKGYNIQ
TNICM

Sequences:

>Translated_405_residues
MELNLDTIKKAQNNIKTVVRKTPLFYSSTFSRKTGYEVYLKCENKQKTGAFKLRGAYNKIVSLTEEERKKGVIASSAGNH
AQGVAYAATAFGIKSTIAMPKTAPQAKVMATKGYGAEVVQHGEVYDECYEKALEIQKATGATFVHPFNDIHVMAGQGTIA
LEILEEIEDIDAIIVPIGGGGLISGIAVAAKSIKPDIKIIGVQSAIIASTKASLEKNEIVTLPGAKSLADGISVKTPGDI
AFKYIREYVDEVVTVTEDEIAYGIFELIEKTKVIAEGAGASTVAALLANKINIKGKKVVALISGGNIDIAMISKIIDRQL
IMLKRRIRFKVELQDKIGEFEDVISNIVSTGANIVKARQDTNWSEKGLEYANVIFEVEVQSKEQGDKLLKQLSEKGYNIQ
TNICM
>Mature_405_residues
MELNLDTIKKAQNNIKTVVRKTPLFYSSTFSRKTGYEVYLKCENKQKTGAFKLRGAYNKIVSLTEEERKKGVIASSAGNH
AQGVAYAATAFGIKSTIAMPKTAPQAKVMATKGYGAEVVQHGEVYDECYEKALEIQKATGATFVHPFNDIHVMAGQGTIA
LEILEEIEDIDAIIVPIGGGGLISGIAVAAKSIKPDIKIIGVQSAIIASTKASLEKNEIVTLPGAKSLADGISVKTPGDI
AFKYIREYVDEVVTVTEDEIAYGIFELIEKTKVIAEGAGASTVAALLANKINIKGKKVVALISGGNIDIAMISKIIDRQL
IMLKRRIRFKVELQDKIGEFEDVISNIVSTGANIVKARQDTNWSEKGLEYANVIFEVEVQSKEQGDKLLKQLSEKGYNIQ
TNICM

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=310, Percent_Identity=37.0967741935484, Blast_Score=201, Evalue=7e-52,
Organism=Homo sapiens, GI33469958, Length=321, Percent_Identity=30.2180685358255, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI19923959, Length=327, Percent_Identity=27.82874617737, Blast_Score=86, Evalue=9e-17,
Organism=Escherichia coli, GI1789505, Length=317, Percent_Identity=47.6340694006309, Blast_Score=258, Evalue=4e-70,
Organism=Escherichia coli, GI1790207, Length=383, Percent_Identity=34.2036553524804, Blast_Score=211, Evalue=9e-56,
Organism=Caenorhabditis elegans, GI71991565, Length=384, Percent_Identity=38.0208333333333, Blast_Score=231, Evalue=8e-61,
Organism=Caenorhabditis elegans, GI17537387, Length=393, Percent_Identity=35.1145038167939, Blast_Score=192, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI17508781, Length=311, Percent_Identity=30.8681672025724, Blast_Score=146, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6322631, Length=306, Percent_Identity=39.5424836601307, Blast_Score=204, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6320930, Length=399, Percent_Identity=33.3333333333333, Blast_Score=192, Evalue=9e-50,
Organism=Saccharomyces cerevisiae, GI6319788, Length=305, Percent_Identity=24.2622950819672, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21355833, Length=350, Percent_Identity=40, Blast_Score=209, Evalue=4e-54,
Organism=Drosophila melanogaster, GI24645328, Length=266, Percent_Identity=38.7218045112782, Blast_Score=145, Evalue=4e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005789 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 43937; Mature: 43937

Theoretical pI: Translated: 8.65; Mature: 8.65

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELNLDTIKKAQNNIKTVVRKTPLFYSSTFSRKTGYEVYLKCENKQKTGAFKLRGAYNKI
CCCCHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCEEEEEECCCCCCCCEEECCHHHHH
VSLTEEERKKGVIASSAGNHAQGVAYAATAFGIKSTIAMPKTAPQAKVMATKGYGAEVVQ
HHCCHHHHHCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHH
HGEVYDECYEKALEIQKATGATFVHPFNDIHVMAGQGTIALEILEEIEDIDAIIVPIGGG
CCHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEECCCCCHHHHHHHHHCCCEEEEEECCC
GLISGIAVAAKSIKPDIKIIGVQSAIIASTKASLEKNEIVTLPGAKSLADGISVKTPGDI
HHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHCCCCCCEEECCCCHHHHCCCCCCCCHHH
AFKYIREYVDEVVTVTEDEIAYGIFELIEKTKVIAEGAGASTVAALLANKINIKGKKVVA
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEE
LISGGNIDIAMISKIIDRQLIMLKRRIRFKVELQDKIGEFEDVISNIVSTGANIVKARQD
EEECCCCHHHHHHHHHHHHHHHHHHHHHEEEEEHHHCCHHHHHHHHHHHCCCCEEEECCC
TNWSEKGLEYANVIFEVEVQSKEQGDKLLKQLSEKGYNIQTNICM
CCHHHHCCEEEEEEEEEEECCCHHHHHHHHHHHHCCCEEEEECCC
>Mature Secondary Structure
MELNLDTIKKAQNNIKTVVRKTPLFYSSTFSRKTGYEVYLKCENKQKTGAFKLRGAYNKI
CCCCHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCEEEEEECCCCCCCCEEECCHHHHH
VSLTEEERKKGVIASSAGNHAQGVAYAATAFGIKSTIAMPKTAPQAKVMATKGYGAEVVQ
HHCCHHHHHCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHH
HGEVYDECYEKALEIQKATGATFVHPFNDIHVMAGQGTIALEILEEIEDIDAIIVPIGGG
CCHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEECCCCCHHHHHHHHHCCCEEEEEECCC
GLISGIAVAAKSIKPDIKIIGVQSAIIASTKASLEKNEIVTLPGAKSLADGISVKTPGDI
HHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHCCCCCCEEECCCCHHHHCCCCCCCCHHH
AFKYIREYVDEVVTVTEDEIAYGIFELIEKTKVIAEGAGASTVAALLANKINIKGKKVVA
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEE
LISGGNIDIAMISKIIDRQLIMLKRRIRFKVELQDKIGEFEDVISNIVSTGANIVKARQD
EEECCCCHHHHHHHHHHHHHHHHHHHHHEEEEEHHHCCHHHHHHHHHHHCCCCEEEECCC
TNWSEKGLEYANVIFEVEVQSKEQGDKLLKQLSEKGYNIQTNICM
CCHHHHCCEEEEEEEEEEECCCHHHHHHHHHHHHCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA