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The map label for this gene is cdr [H]

Identifier: 170757317

GI number: 170757317

Start: 219834

End: 222287

Strand: Direct

Name: cdr [H]

Synonym: CLD_0598

Alternate gene names: 170757317

Gene position: 219834-222287 (Clockwise)

Preceding gene: 170756506

Following gene: 170755214

Centisome position: 5.55

GC content: 31.5

Gene sequence:

>2454_bases
ATGAATAAGAAGGTACTAATCATTGGAGGTGTAGCAGGAGGAGCTTCTGCAGCCGCAAGACTTAGAAGACTTGATGAAAA
TGCACAAATAATAATGTTTGAAAGAGGAGAATATATTTCCTTTGCTAATTGTGGATTACCTTATTATATAGGAGAAACTA
TAAAGGAAAGAGATAATCTTTTAGTTCAAACTCCTGAAGCTATGATGGGTAGATTTAACATTGATGTTAGAGTAAATAGT
GAAGTCGTATCAATAAATACCAAGGAAAAGAAAGTTACAGTAAATAGTAAAAGAAAGGGAAACTATGAGGAAACATATGA
TTATATAATAATGTCACCAGGGGCAACACCTATAAAACCACCTATAGAAGGGATAAATAGTTCGAAAATATTTACATTAA
GAAATATTCCAGATACAGATAGAATAAAAGATTATGTAGACAACAAAAATGTTAAGAGTGTGGTAGTTGTTGGTGGAGGA
TATATAGGTATCGAAATGGCAGAGAACCTTAGAGAGAGAGGTATAAATGTGGTATTAGTAGAAGCTGCTCCCCACATATT
AGCACCCTTTGATTCAGATATGGTTACTTTTGCTGAACAGGAACTACAGGACAACGGTGCAGGTTTAATTTTAGGAGATG
GAGTTAAATCTTTTGAAGAAAATAATAACAAAATAAAAGTATCCCTTCAAAGTGGTACTGAGCTAAATACGGATATGATT
ATATTGGCTATAGGTGTGAAAGCGGATACAGAGTTTTTAAAGGGATCTTCAATAGAGATAGGCCCTAGAGGTCATATAAT
AGTGGATAAACATATGAAAACTAATGTAGAGGGCATATATGCCGTAGGGGATGCTATAGAGGTAGTAGACTATATAAATG
AAAATAAAACTGCTATACCATTGGCAGGCCCAGCAAATAAGCAGGGCAGAATAGCAGCAGATAATATATGTGAATTAAAT
TCTTCTTATAAAGGAACTCAAGGAACTGCTATAATTAAAATTTTTGGATTAACAGGTGCTAGTACAGGTAATAATGAAAG
AACTTTATCTAAATTTAATATACCATATAAGGTAGTTTATACTCATTCTCAGTCCCATGCAAGTTACTATCCAGGAGGCA
CGCCAATAAGCTTAAAATTAATATTTGATACTAAAGGTAAGATATTAGGGGCTCAAGCTTTTGGCTATGATGGAGTAGAT
AAGAGAATAGATGATATTGCTATAGTTATAAGATTTGGTGGAACTATATATGATTTAGAAGAGTTAGAATTAGCTTATGC
TCCTCCATATTCTTCGGCTAAGGATCCTGTTAATATGTTAGGGTTTGTAGCAGAAAATGTATTAACAGGTAAAGTAGAAA
CTGTATTGTCTAAAGATATAGATAATAGAGATAAAGATAAAGTTATATTATTGGATGTAAGAGATGATATAGAAATTGAA
AATGGTAAAATAGAGGGCGCAATAGAAATACCAATAAATCAATTAAGAAATAGATTAAGTGAAATTCCAAAGGATAAAGA
AGTATGGATATATTGTCAAATAGGGTTAAGAGGATATATTGCTGCTAGGATATTAATGGCTAATGGTTATAAGGTTAAAA
ATCTTAATGGTGGATATAAAACTTACATTATGAATAAGTTTATACCTGAAAAAATAAATAAGATGCCAGAAGAGAAAATG
AAGGGAAATAATGAAACTAAGGAAGAGGTAGCAGAAACTTTGGAACTAGATGCTTGTGGTTTAAGTTGTCCTGGACCATT
AATGAAAGTAAACAATACTGTAAGTGAAATGAATGAAGGAGAAACTTTAAAAGTAAAAGCTTCAGATCCTGGTTTTTATG
TAGATATACAATCTTGGTGTGAAAGAACAAATAATGAATTGTTAAGTGTATCAAAGGATAAAGGAATAGTAAAAGCTCTT
ATTAAGAAAGGTAAAGAAAAATTACAAGTAGATGAAAAAGAAAGAAAAGGTAAAATCAAAGAAAATGATAATAAGACATT
AGTTGTGTTTAGTGGAGATTTGGATAAAGCAATAGCATCCTTTGTTATAGCAAATGGTGCTGTAGCTATGGGGAAAAAGG
TAACTATGTTCTTTACATTTTGGGGATTAAATATATTAAGAAAGCCAGAAAAAACAAAGATACAAAAAGCATTTATGGAT
AAAATGTTTGCATCAATGATGCCAAGAGGAAGCAAAAAGTTAAAGCTTTCTAAAATGAACATGATGGGAATGGGCTCTAA
AATGATCAGAAAAGTAATGAAAAACAAAAATATATCTTCTCTTGAAGAATTAATACAATCAGCCATAGATTCAGGTATAA
ATATACTTGCATGCCAAATGTCAATGGATGTTATGGGAATAAAAGAAGAGGAATTAATAGATGGAGTAAATATAGGAGGA
GTAGGATATTATTTAGGAGAAGCTGAGGACGCTAATGTAAATTTATTCATATAA

Upstream 100 bases:

>100_bases
AAATTATCATGTTTCCAATAAAAAAGCAGAACAATTGATAAAAATTTTGTTTAATGAGTAATAGTACTAAGAAATTTCTA
TTTAAGTAGGAGGAATTACA

Downstream 100 bases:

>100_bases
ATAAAATAAAAATCCTATGGAACATGTTCATAGGATTTTTATTTTATTTAGAAATCTAGATAAGAATCCCTTTTGGGGTT
TAGTATTATCGATTTCATCA

Product: pyridine nucleotide-disulphide oxidoreductase family protein

Products: NA

Alternate protein names: CoA-disulfide reductase; CoADR [H]

Number of amino acids: Translated: 817; Mature: 817

Protein sequence:

>817_residues
MNKKVLIIGGVAGGASAAARLRRLDENAQIIMFERGEYISFANCGLPYYIGETIKERDNLLVQTPEAMMGRFNIDVRVNS
EVVSINTKEKKVTVNSKRKGNYEETYDYIIMSPGATPIKPPIEGINSSKIFTLRNIPDTDRIKDYVDNKNVKSVVVVGGG
YIGIEMAENLRERGINVVLVEAAPHILAPFDSDMVTFAEQELQDNGAGLILGDGVKSFEENNNKIKVSLQSGTELNTDMI
ILAIGVKADTEFLKGSSIEIGPRGHIIVDKHMKTNVEGIYAVGDAIEVVDYINENKTAIPLAGPANKQGRIAADNICELN
SSYKGTQGTAIIKIFGLTGASTGNNERTLSKFNIPYKVVYTHSQSHASYYPGGTPISLKLIFDTKGKILGAQAFGYDGVD
KRIDDIAIVIRFGGTIYDLEELELAYAPPYSSAKDPVNMLGFVAENVLTGKVETVLSKDIDNRDKDKVILLDVRDDIEIE
NGKIEGAIEIPINQLRNRLSEIPKDKEVWIYCQIGLRGYIAARILMANGYKVKNLNGGYKTYIMNKFIPEKINKMPEEKM
KGNNETKEEVAETLELDACGLSCPGPLMKVNNTVSEMNEGETLKVKASDPGFYVDIQSWCERTNNELLSVSKDKGIVKAL
IKKGKEKLQVDEKERKGKIKENDNKTLVVFSGDLDKAIASFVIANGAVAMGKKVTMFFTFWGLNILRKPEKTKIQKAFMD
KMFASMMPRGSKKLKLSKMNMMGMGSKMIRKVMKNKNISSLEELIQSAIDSGINILACQMSMDVMGIKEEELIDGVNIGG
VGYYLGEAEDANVNLFI

Sequences:

>Translated_817_residues
MNKKVLIIGGVAGGASAAARLRRLDENAQIIMFERGEYISFANCGLPYYIGETIKERDNLLVQTPEAMMGRFNIDVRVNS
EVVSINTKEKKVTVNSKRKGNYEETYDYIIMSPGATPIKPPIEGINSSKIFTLRNIPDTDRIKDYVDNKNVKSVVVVGGG
YIGIEMAENLRERGINVVLVEAAPHILAPFDSDMVTFAEQELQDNGAGLILGDGVKSFEENNNKIKVSLQSGTELNTDMI
ILAIGVKADTEFLKGSSIEIGPRGHIIVDKHMKTNVEGIYAVGDAIEVVDYINENKTAIPLAGPANKQGRIAADNICELN
SSYKGTQGTAIIKIFGLTGASTGNNERTLSKFNIPYKVVYTHSQSHASYYPGGTPISLKLIFDTKGKILGAQAFGYDGVD
KRIDDIAIVIRFGGTIYDLEELELAYAPPYSSAKDPVNMLGFVAENVLTGKVETVLSKDIDNRDKDKVILLDVRDDIEIE
NGKIEGAIEIPINQLRNRLSEIPKDKEVWIYCQIGLRGYIAARILMANGYKVKNLNGGYKTYIMNKFIPEKINKMPEEKM
KGNNETKEEVAETLELDACGLSCPGPLMKVNNTVSEMNEGETLKVKASDPGFYVDIQSWCERTNNELLSVSKDKGIVKAL
IKKGKEKLQVDEKERKGKIKENDNKTLVVFSGDLDKAIASFVIANGAVAMGKKVTMFFTFWGLNILRKPEKTKIQKAFMD
KMFASMMPRGSKKLKLSKMNMMGMGSKMIRKVMKNKNISSLEELIQSAIDSGINILACQMSMDVMGIKEEELIDGVNIGG
VGYYLGEAEDANVNLFI
>Mature_817_residues
MNKKVLIIGGVAGGASAAARLRRLDENAQIIMFERGEYISFANCGLPYYIGETIKERDNLLVQTPEAMMGRFNIDVRVNS
EVVSINTKEKKVTVNSKRKGNYEETYDYIIMSPGATPIKPPIEGINSSKIFTLRNIPDTDRIKDYVDNKNVKSVVVVGGG
YIGIEMAENLRERGINVVLVEAAPHILAPFDSDMVTFAEQELQDNGAGLILGDGVKSFEENNNKIKVSLQSGTELNTDMI
ILAIGVKADTEFLKGSSIEIGPRGHIIVDKHMKTNVEGIYAVGDAIEVVDYINENKTAIPLAGPANKQGRIAADNICELN
SSYKGTQGTAIIKIFGLTGASTGNNERTLSKFNIPYKVVYTHSQSHASYYPGGTPISLKLIFDTKGKILGAQAFGYDGVD
KRIDDIAIVIRFGGTIYDLEELELAYAPPYSSAKDPVNMLGFVAENVLTGKVETVLSKDIDNRDKDKVILLDVRDDIEIE
NGKIEGAIEIPINQLRNRLSEIPKDKEVWIYCQIGLRGYIAARILMANGYKVKNLNGGYKTYIMNKFIPEKINKMPEEKM
KGNNETKEEVAETLELDACGLSCPGPLMKVNNTVSEMNEGETLKVKASDPGFYVDIQSWCERTNNELLSVSKDKGIVKAL
IKKGKEKLQVDEKERKGKIKENDNKTLVVFSGDLDKAIASFVIANGAVAMGKKVTMFFTFWGLNILRKPEKTKIQKAFMD
KMFASMMPRGSKKLKLSKMNMMGMGSKMIRKVMKNKNISSLEELIQSAIDSGINILACQMSMDVMGIKEEELIDGVNIGG
VGYYLGEAEDANVNLFI

Specific function: Catalyzes specifically the NADPH-dependent reduction of coenzyme A disulfide [H]

COG id: COG0446

COG function: function code R; Uncharacterized NAD(FAD)-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI21389617, Length=318, Percent_Identity=28.6163522012579, Blast_Score=124, Evalue=5e-28,
Organism=Homo sapiens, GI65787454, Length=318, Percent_Identity=28.6163522012579, Blast_Score=124, Evalue=5e-28,
Organism=Homo sapiens, GI226437568, Length=318, Percent_Identity=28.6163522012579, Blast_Score=123, Evalue=6e-28,
Organism=Homo sapiens, GI50301238, Length=341, Percent_Identity=25.2199413489736, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1789065, Length=355, Percent_Identity=22.5352112676056, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1789765, Length=331, Percent_Identity=25.3776435045317, Blast_Score=82, Evalue=2e-16,
Organism=Escherichia coli, GI1788892, Length=292, Percent_Identity=22.2602739726027, Blast_Score=76, Evalue=9e-15,
Organism=Escherichia coli, GI1789915, Length=338, Percent_Identity=26.0355029585799, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI87082354, Length=377, Percent_Identity=24.1379310344828, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17559934, Length=242, Percent_Identity=28.099173553719, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24639257, Length=320, Percent_Identity=24.375, Blast_Score=90, Evalue=6e-18,
Organism=Drosophila melanogaster, GI281359715, Length=320, Percent_Identity=24.375, Blast_Score=90, Evalue=6e-18,
Organism=Drosophila melanogaster, GI281359713, Length=320, Percent_Identity=24.375, Blast_Score=90, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24639250, Length=320, Percent_Identity=24.375, Blast_Score=90, Evalue=6e-18,
Organism=Drosophila melanogaster, GI18543267, Length=320, Percent_Identity=24.375, Blast_Score=90, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24639252, Length=320, Percent_Identity=24.375, Blast_Score=90, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24585130, Length=220, Percent_Identity=28.6363636363636, Blast_Score=80, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017758
- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.14 [H]

Molecular weight: Translated: 90102; Mature: 90102

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS50206 RHODANESE_3 ; PS01148 UPF0033

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKKVLIIGGVAGGASAAARLRRLDENAQIIMFERGEYISFANCGLPYYIGETIKERDNL
CCCEEEEEEECCCCHHHHHHHHHCCCCCEEEEEECCCEEEEECCCCCHHHHHHHHCCCCE
LVQTPEAMMGRFNIDVRVNSEVVSINTKEKKVTVNSKRKGNYEETYDYIIMSPGATPIKP
EEECCHHHHCEEEEEEEECCEEEEEECCCEEEEECCCCCCCCCCCEEEEEECCCCCCCCC
PIEGINSSKIFTLRNIPDTDRIKDYVDNKNVKSVVVVGGGYIGIEMAENLRERGINVVLV
CCCCCCCCEEEEECCCCCHHHHHHHHCCCCCCEEEEECCCEEEHHHHHHHHHCCCCEEEE
EAAPHILAPFDSDMVTFAEQELQDNGAGLILGDGVKSFEENNNKIKVSLQSGTELNTDMI
ECCCCEECCCCCCHHHHHHHHHHCCCCEEEEECCCHHHHCCCCEEEEEECCCCCCCCCEE
ILAIGVKADTEFLKGSSIEIGPRGHIIVDKHMKTNVEGIYAVGDAIEVVDYINENKTAIP
EEEEECCCCHHHHCCCCEEECCCCCEEECCCCCCCCCEEEEECHHHHHHHHHCCCCEEEE
LAGPANKQGRIAADNICELNSSYKGTQGTAIIKIFGLTGASTGNNERTLSKFNIPYKVVY
ECCCCCCCCCEECCCHHCCCCCCCCCCCEEEEEEEEECCCCCCCCCCEEEEECCCEEEEE
THSQSHASYYPGGTPISLKLIFDTKGKILGAQAFGYDGVDKRIDDIAIVIRFGGTIYDLE
EECCCCCCCCCCCCCEEEEEEEECCCCEEEEHCCCCCCCCCCCCCEEEEEEECCEEEEHH
ELELAYAPPYSSAKDPVNMLGFVAENVLTGKVETVLSKDIDNRDKDKVILLDVRDDIEIE
HCEEEECCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCEEEEEECCCCEEE
NGKIEGAIEIPINQLRNRLSEIPKDKEVWIYCQIGLRGYIAARILMANGYKVKNLNGGYK
CCEEEEEEECCHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEEEEECCEEEEECCCCEE
TYIMNKFIPEKINKMPEEKMKGNNETKEEVAETLELDACGLSCPGPLMKVNNTVSEMNEG
EEEEHHCCHHHHHCCCHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCEECCCHHHHCCCC
ETLKVKASDPGFYVDIQSWCERTNNELLSVSKDKGIVKALIKKGKEKLQVDEKERKGKIK
CEEEEEECCCCEEEEHHHHHHHCCCCEEEECCCCHHHHHHHHCCHHHCCCCCHHHCCCCC
ENDNKTLVVFSGDLDKAIASFVIANGAVAMGKKVTMFFTFWGLNILRKPEKTKIQKAFMD
CCCCCEEEEEECCHHHHHHHHHHHCCCEECCCEEEEEEEEECHHHHCCCHHHHHHHHHHH
KMFASMMPRGSKKLKLSKMNMMGMGSKMIRKVMKNKNISSLEELIQSAIDSGINILACQM
HHHHHHCCCCCCEEEEEECCHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEEEE
SMDVMGIKEEELIDGVNIGGVGYYLGEAEDANVNLFI
ECCCCCCCHHHHHCCCCCCCEEEEECCCCCCCEEEEC
>Mature Secondary Structure
MNKKVLIIGGVAGGASAAARLRRLDENAQIIMFERGEYISFANCGLPYYIGETIKERDNL
CCCEEEEEEECCCCHHHHHHHHHCCCCCEEEEEECCCEEEEECCCCCHHHHHHHHCCCCE
LVQTPEAMMGRFNIDVRVNSEVVSINTKEKKVTVNSKRKGNYEETYDYIIMSPGATPIKP
EEECCHHHHCEEEEEEEECCEEEEEECCCEEEEECCCCCCCCCCCEEEEEECCCCCCCCC
PIEGINSSKIFTLRNIPDTDRIKDYVDNKNVKSVVVVGGGYIGIEMAENLRERGINVVLV
CCCCCCCCEEEEECCCCCHHHHHHHHCCCCCCEEEEECCCEEEHHHHHHHHHCCCCEEEE
EAAPHILAPFDSDMVTFAEQELQDNGAGLILGDGVKSFEENNNKIKVSLQSGTELNTDMI
ECCCCEECCCCCCHHHHHHHHHHCCCCEEEEECCCHHHHCCCCEEEEEECCCCCCCCCEE
ILAIGVKADTEFLKGSSIEIGPRGHIIVDKHMKTNVEGIYAVGDAIEVVDYINENKTAIP
EEEEECCCCHHHHCCCCEEECCCCCEEECCCCCCCCCEEEEECHHHHHHHHHCCCCEEEE
LAGPANKQGRIAADNICELNSSYKGTQGTAIIKIFGLTGASTGNNERTLSKFNIPYKVVY
ECCCCCCCCCEECCCHHCCCCCCCCCCCEEEEEEEEECCCCCCCCCCEEEEECCCEEEEE
THSQSHASYYPGGTPISLKLIFDTKGKILGAQAFGYDGVDKRIDDIAIVIRFGGTIYDLE
EECCCCCCCCCCCCCEEEEEEEECCCCEEEEHCCCCCCCCCCCCCEEEEEEECCEEEEHH
ELELAYAPPYSSAKDPVNMLGFVAENVLTGKVETVLSKDIDNRDKDKVILLDVRDDIEIE
HCEEEECCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCEEEEEECCCCEEE
NGKIEGAIEIPINQLRNRLSEIPKDKEVWIYCQIGLRGYIAARILMANGYKVKNLNGGYK
CCEEEEEEECCHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEEEEECCEEEEECCCCEE
TYIMNKFIPEKINKMPEEKMKGNNETKEEVAETLELDACGLSCPGPLMKVNNTVSEMNEG
EEEEHHCCHHHHHCCCHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCEECCCHHHHCCCC
ETLKVKASDPGFYVDIQSWCERTNNELLSVSKDKGIVKALIKKGKEKLQVDEKERKGKIK
CEEEEEECCCCEEEEHHHHHHHCCCCEEEECCCCHHHHHHHHCCHHHCCCCCHHHCCCCC
ENDNKTLVVFSGDLDKAIASFVIANGAVAMGKKVTMFFTFWGLNILRKPEKTKIQKAFMD
CCCCCEEEEEECCHHHHHHHHHHHCCCEECCCEEEEEEEEECHHHHCCCHHHHHHHHHHH
KMFASMMPRGSKKLKLSKMNMMGMGSKMIRKVMKNKNISSLEELIQSAIDSGINILACQM
HHHHHHCCCCCCEEEEEECCHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEEEE
SMDVMGIKEEELIDGVNIGGVGYYLGEAEDANVNLFI
ECCCCCCCHHHHHCCCCCCCEEEEECCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA