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The map label for this gene is msrA [H]

Identifier: 170756821

GI number: 170756821

Start: 677802

End: 679460

Strand: Reverse

Name: msrA [H]

Synonym: CLD_0197

Alternate gene names: 170756821

Gene position: 679460-677802 (Counterclockwise)

Preceding gene: 170756110

Following gene: 170754899

Centisome position: 17.17

GC content: 24.65

Gene sequence:

>1659_bases
ATGGTATCAATAAAATTAGATAAAGTAAAAAAATATTATGAAGATAAATTAATTTTAGATATAGACAATTTAGAAATAGA
AGAAAATAGTAGAATCGGAATTGTTGGAGAAAACGGTGCTGGTAAAACAACTCTTATTAAAATTATTTTAGGCGAAATAG
ATATTGATGAAGGAAAAGTATTTTTTCATGCTAATTATTCATATATAAGCCAAAGTGAAAATTATTCTGGATCTTGCAAT
AATAGCAGAGTTAAGAGTATATTAGGTGCACCAGATAATTATAATGAATTTTTATCTGGTGGAGAAAAGATTAAAATTAG
TATTAATCACGCCCTTAGTTCTAATAGCAACTTTCTTATAGCAGATGAACCAACAGCTAATCTTGACACTAATACTATAA
AAAGCATTGAAAAACTTATAAGTGAATATAAAGGAGGACTTTTATTAGTTTCTCATGATAGAAATTTTTTAAATAATCTT
TGTGATAATATACTAGAAATAGAAAATGGAAAAGTTAAATTATATAAGTGTGGTTATTCAAAATACACTATGCTAAAAGC
TAAAGAAAGAGAAGTAGAAAGAAGAGAATATGAAAAGTATATAGCTGAAAAAAAGCGACTTGAAAAAGCTATGATAGTAA
AAGAAAATCAACAGAATTCTATTAAAAAAGCACCTAAAAGAATGGGAAATTCAGAAGCAAGACTTCATAAAATGGGAGAT
CAGAAATCAAAAAAACACTTAGATGGAAATATAAAAGCTTTAAAAAGTAGAATTAATCATCTTGAAGTGAAAGAAAAGCC
TACTTCTAGCAAAGATATTAAGATAAAAATTACTGAAGGTAATAAAATTCCTTCCAAGACAGTAATAGAAGTAAAAAATT
TAGATTTATATATAGGTAATAAACTTCTTATAAAAGATGCAAATTTTAGAATAAAAAACGGTAAAAAGGCAGCTATTATT
GGTGAAAATGGCTGTGGTAAAACAACTTTAATAAAAGAAATATTAAAAAGAGATACAGAAAACATTAGATTATCAAAGTA
TATTTCTATAGGATACTTTGATCAAGATCAAGATATTTTAGATAAAAACAAAACAATATTAGATAATATAAAATCAACTA
GTTCTTATGATGAAAGCTTTATTAGAATACAATTAGCTGGATTTGGGTTTAAGGGGGATACTATATATAAAAATGTTTCT
ATATTAAGTGGAGGCGAAAAGGTTAAAGTTGCACTTTCCAAAATAATTTTAAGTGATACTAATACTTTAATTTTAGATGA
ACCTACCAACTATTTAGATATAAAATCTATTGAATCTTTAGAAAAGGCACTTATTAATACAGACAAAACAATTGTAATGA
TATCTCATGATAGATCCTTTATTTCTAGTATATGTGATTACATAATTGAAATAAAAGATACTAAGCTAAATTGTTTTTCA
GGTACTTATACTGATTTCATTGAAGAAAAGGTAAATTATGAAACTAAAAAACAGGAAAACCATAGTGAGCGTGAAAAAAA
GGGAAAATTATTAATCTTAGAAAATAGACTTTCAAAAATAATTTCAGAAATATCTTTGGAAAAAGATTTAGCCATTAAAG
AAAAGTTAAATGAGGAATATATTAAATTATTAAATGACATTAAATTATTAAAAAAGTAA

Upstream 100 bases:

>100_bases
TGTGCTTAAAATTTGAGAGAGTAAATTATTCTAGGGGATACTTATACCTTTTTACGGAATTATTATATACTCTCTCCTAA
ATTTAAGGAGGGATTTTTTT

Downstream 100 bases:

>100_bases
TCAAACTAAATTATAAAAAAATAACTAAATTCCTACAATAAAAAAGAATGCATATTAAAATAGATTTAGTTTTAATTACG
CAAATAGAAAAAATATATTT

Product: ABC transporter, ATP-binding protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 552; Mature: 552

Protein sequence:

>552_residues
MVSIKLDKVKKYYEDKLILDIDNLEIEENSRIGIVGENGAGKTTLIKIILGEIDIDEGKVFFHANYSYISQSENYSGSCN
NSRVKSILGAPDNYNEFLSGGEKIKISINHALSSNSNFLIADEPTANLDTNTIKSIEKLISEYKGGLLLVSHDRNFLNNL
CDNILEIENGKVKLYKCGYSKYTMLKAKEREVERREYEKYIAEKKRLEKAMIVKENQQNSIKKAPKRMGNSEARLHKMGD
QKSKKHLDGNIKALKSRINHLEVKEKPTSSKDIKIKITEGNKIPSKTVIEVKNLDLYIGNKLLIKDANFRIKNGKKAAII
GENGCGKTTLIKEILKRDTENIRLSKYISIGYFDQDQDILDKNKTILDNIKSTSSYDESFIRIQLAGFGFKGDTIYKNVS
ILSGGEKVKVALSKIILSDTNTLILDEPTNYLDIKSIESLEKALINTDKTIVMISHDRSFISSICDYIIEIKDTKLNCFS
GTYTDFIEEKVNYETKKQENHSEREKKGKLLILENRLSKIISEISLEKDLAIKEKLNEEYIKLLNDIKLLKK

Sequences:

>Translated_552_residues
MVSIKLDKVKKYYEDKLILDIDNLEIEENSRIGIVGENGAGKTTLIKIILGEIDIDEGKVFFHANYSYISQSENYSGSCN
NSRVKSILGAPDNYNEFLSGGEKIKISINHALSSNSNFLIADEPTANLDTNTIKSIEKLISEYKGGLLLVSHDRNFLNNL
CDNILEIENGKVKLYKCGYSKYTMLKAKEREVERREYEKYIAEKKRLEKAMIVKENQQNSIKKAPKRMGNSEARLHKMGD
QKSKKHLDGNIKALKSRINHLEVKEKPTSSKDIKIKITEGNKIPSKTVIEVKNLDLYIGNKLLIKDANFRIKNGKKAAII
GENGCGKTTLIKEILKRDTENIRLSKYISIGYFDQDQDILDKNKTILDNIKSTSSYDESFIRIQLAGFGFKGDTIYKNVS
ILSGGEKVKVALSKIILSDTNTLILDEPTNYLDIKSIESLEKALINTDKTIVMISHDRSFISSICDYIIEIKDTKLNCFS
GTYTDFIEEKVNYETKKQENHSEREKKGKLLILENRLSKIISEISLEKDLAIKEKLNEEYIKLLNDIKLLKK
>Mature_552_residues
MVSIKLDKVKKYYEDKLILDIDNLEIEENSRIGIVGENGAGKTTLIKIILGEIDIDEGKVFFHANYSYISQSENYSGSCN
NSRVKSILGAPDNYNEFLSGGEKIKISINHALSSNSNFLIADEPTANLDTNTIKSIEKLISEYKGGLLLVSHDRNFLNNL
CDNILEIENGKVKLYKCGYSKYTMLKAKEREVERREYEKYIAEKKRLEKAMIVKENQQNSIKKAPKRMGNSEARLHKMGD
QKSKKHLDGNIKALKSRINHLEVKEKPTSSKDIKIKITEGNKIPSKTVIEVKNLDLYIGNKLLIKDANFRIKNGKKAAII
GENGCGKTTLIKEILKRDTENIRLSKYISIGYFDQDQDILDKNKTILDNIKSTSSYDESFIRIQLAGFGFKGDTIYKNVS
ILSGGEKVKVALSKIILSDTNTLILDEPTNYLDIKSIESLEKALINTDKTIVMISHDRSFISSICDYIIEIKDTKLNCFS
GTYTDFIEEKVNYETKKQENHSEREKKGKLLILENRLSKIISEISLEKDLAIKEKLNEEYIKLLNDIKLLKK

Specific function: Confers resistance to 14-membered ring macrolides (like erythromycin) and to B streptogramins, by acting as an ATP- dependent efflux pump [H]

COG id: COG0488

COG function: function code R; ATPase components of ABC transporters with duplicated ATPase domains

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ABC transporter domains [H]

Homologues:

Organism=Homo sapiens, GI148612853, Length=383, Percent_Identity=26.8929503916449, Blast_Score=149, Evalue=6e-36,
Organism=Homo sapiens, GI10947137, Length=396, Percent_Identity=27.020202020202, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI27881506, Length=396, Percent_Identity=27.020202020202, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI10947135, Length=402, Percent_Identity=24.1293532338308, Blast_Score=120, Evalue=5e-27,
Organism=Homo sapiens, GI69354671, Length=402, Percent_Identity=24.1293532338308, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI110832837, Length=267, Percent_Identity=23.5955056179775, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI110832835, Length=267, Percent_Identity=23.5955056179775, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1789751, Length=554, Percent_Identity=26.3537906137184, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI1787041, Length=528, Percent_Identity=27.4621212121212, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI2367384, Length=541, Percent_Identity=26.9870609981516, Blast_Score=185, Evalue=5e-48,
Organism=Escherichia coli, GI1787182, Length=410, Percent_Identity=29.0243902439024, Blast_Score=174, Evalue=1e-44,
Organism=Escherichia coli, GI87081782, Length=568, Percent_Identity=23.4154929577465, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI87081709, Length=209, Percent_Identity=23.9234449760766, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1786398, Length=242, Percent_Identity=26.0330578512397, Blast_Score=63, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17559834, Length=402, Percent_Identity=26.865671641791, Blast_Score=156, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17553372, Length=399, Percent_Identity=28.0701754385965, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17555318, Length=387, Percent_Identity=25.5813953488372, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17567265, Length=244, Percent_Identity=29.9180327868852, Blast_Score=66, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6321121, Length=404, Percent_Identity=29.7029702970297, Blast_Score=175, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6320874, Length=395, Percent_Identity=25.5696202531646, Blast_Score=144, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6323278, Length=194, Percent_Identity=32.4742268041237, Blast_Score=122, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6324314, Length=195, Percent_Identity=32.3076923076923, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6325030, Length=211, Percent_Identity=31.2796208530806, Blast_Score=103, Evalue=9e-23,
Organism=Drosophila melanogaster, GI24666836, Length=376, Percent_Identity=29.2553191489362, Blast_Score=160, Evalue=3e-39,
Organism=Drosophila melanogaster, GI24641342, Length=527, Percent_Identity=26.3757115749526, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24642252, Length=412, Percent_Identity=24.2718446601942, Blast_Score=135, Evalue=8e-32,
Organism=Drosophila melanogaster, GI18859989, Length=412, Percent_Identity=24.2718446601942, Blast_Score=135, Evalue=8e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR003593
- InterPro:   IPR000014 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 62813; Mature: 62813

Theoretical pI: Translated: 9.34; Mature: 9.34

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSIKLDKVKKYYEDKLILDIDNLEIEENSRIGIVGENGAGKTTLIKIILGEIDIDEGKV
CCEEEHHHHHHHHCCEEEEEECCEEEECCCEEEEEECCCCCCEEEEEEEEECEEECCCEE
FFHANYSYISQSENYSGSCNNSRVKSILGAPDNYNEFLSGGEKIKISINHALSSNSNFLI
EEEECCCEEECCCCCCCCCCCHHHHHHHCCCCCHHHHHCCCCEEEEEEEEEECCCCCEEE
ADEPTANLDTNTIKSIEKLISEYKGGLLLVSHDRNFLNNLCDNILEIENGKVKLYKCGYS
ECCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHEECCCEEEEEEECCC
KYTMLKAKEREVERREYEKYIAEKKRLEKAMIVKENQQNSIKKAPKRMGNSEARLHKMGD
CEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHCCCCHHHHHHCCC
QKSKKHLDGNIKALKSRINHLEVKEKPTSSKDIKIKITEGNKIPSKTVIEVKNLDLYIGN
HHHHHHCCCHHHHHHHHHHHEEECCCCCCCCCEEEEEECCCCCCCCEEEEEEEEEEEECC
KLLIKDANFRIKNGKKAAIIGENGCGKTTLIKEILKRDTENIRLSKYISIGYFDQDQDIL
EEEEEECCEEEECCCEEEEEECCCCCHHHHHHHHHHCCCCCEEEEEEEEEEEECCCHHHH
DKNKTILDNIKSTSSYDESFIRIQLAGFGFKGDTIYKNVSILSGGEKVKVALSKIILSDT
HCCCHHHHHHHCCCCCCCEEEEEEEEECCCCCCEEEEEEEEECCCCHHHHHHHHHHCCCC
NTLILDEPTNYLDIKSIESLEKALINTDKTIVMISHDRSFISSICDYIIEIKDTKLNCFS
CEEEEECCCCEECHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHEEEECCEEEEEC
GTYTDFIEEKVNYETKKQENHSEREKKGKLLILENRLSKIISEISLEKDLAIKEKLNEEY
CCHHHHHHHHHCCCHHHHCCHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
IKLLNDIKLLKK
HHHHHHHHHHCC
>Mature Secondary Structure
MVSIKLDKVKKYYEDKLILDIDNLEIEENSRIGIVGENGAGKTTLIKIILGEIDIDEGKV
CCEEEHHHHHHHHCCEEEEEECCEEEECCCEEEEEECCCCCCEEEEEEEEECEEECCCEE
FFHANYSYISQSENYSGSCNNSRVKSILGAPDNYNEFLSGGEKIKISINHALSSNSNFLI
EEEECCCEEECCCCCCCCCCCHHHHHHHCCCCCHHHHHCCCCEEEEEEEEEECCCCCEEE
ADEPTANLDTNTIKSIEKLISEYKGGLLLVSHDRNFLNNLCDNILEIENGKVKLYKCGYS
ECCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHEECCCEEEEEEECCC
KYTMLKAKEREVERREYEKYIAEKKRLEKAMIVKENQQNSIKKAPKRMGNSEARLHKMGD
CEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHCCCCHHHHHHCCC
QKSKKHLDGNIKALKSRINHLEVKEKPTSSKDIKIKITEGNKIPSKTVIEVKNLDLYIGN
HHHHHHCCCHHHHHHHHHHHEEECCCCCCCCCEEEEEECCCCCCCCEEEEEEEEEEEECC
KLLIKDANFRIKNGKKAAIIGENGCGKTTLIKEILKRDTENIRLSKYISIGYFDQDQDIL
EEEEEECCEEEECCCEEEEEECCCCCHHHHHHHHHHCCCCCEEEEEEEEEEEECCCHHHH
DKNKTILDNIKSTSSYDESFIRIQLAGFGFKGDTIYKNVSILSGGEKVKVALSKIILSDT
HCCCHHHHHHHCCCCCCCEEEEEEEEECCCCCCEEEEEEEEECCCCHHHHHHHHHHCCCC
NTLILDEPTNYLDIKSIESLEKALINTDKTIVMISHDRSFISSICDYIIEIKDTKLNCFS
CEEEEECCCCEECHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHEEEECCEEEEEC
GTYTDFIEEKVNYETKKQENHSEREKKGKLLILENRLSKIISEISLEKDLAIKEKLNEEY
CCHHHHHHHHHCCCHHHHCCHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
IKLLNDIKLLKK
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2233255 [H]